A comparative analysis of the merits of topical placental extract over conventional methods of dressings for diabetic foot ulcers


Figure 3: Ulcer healing with Placentrex application



Download 291.89 Kb.
Page2/2
Date23.11.2017
Size291.89 Kb.
#34326
1   2

Figure 3: Ulcer healing with Placentrex application

Photographs taken on 14th day





CONCLUSION

Surgical debridement is the cornerstone of management of diabetic foot ulcers, all patients underwent surgical debridement first followed by daily dressings with topical agents. Purified placental extract dressings showed faster and better healing rates when compared with conventional dressings.Wound granulated faster in the study group.The final area and percentage reduction of the wound was better in placentrex group. There were no adverse effects or reactions noted in any of the patients, when Placentrex gel was applied over the ulcer.



Very few studies have been done to test the efficacy of purified placental extract on foot ulcers; needs studies with larger study groups to test efficacy of placentrex on various wounds.

REFERENCES

  1. Shaw JE, Sicree RA, Zimet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2009;87(1):4-14

  2. Spencer S. Pressure relieving interventions for preventing and treating diabetic foot ulcers. Cochrane Database of Systematic Reviews 2000, Issue 4. [DOI: 10.1002/ 14651858.CD002302]

  3. HM Rathur, AJM. Boulton: Recent advances in the diagnosis and management of diabetic neuropathy, J Bone Joint Surg December 2005 vol. 87:1605-1610.

  4. Foot ulcer in previously undiagnosed diabetes mellitus patient. -Glynn JR, et al British medical journal, 1990 - 300(6731):1046-47.

  5. Singer A.J, Clark RAF: Mechanism of disease, cutaneous wound healing, N Engl J Med; 341:738-746, Sep 2, 1999.

  6. Scottish Intercollegiate Guidelines Network. Management of diabetic Foot Disease. Implementation of the St. Vincent Declaration. The Care of Patients in Scotland 1997

  7. American Diabetes Association. Consensus Development Conference on Diabetic Foot Wound Care. Diabetes Care 22:1354, 1999.

  8. Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Pecoraro RE, Rodeheaver G, Robson MC. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 130:489-493, 1994.

  9. Fang XP, Xia WS: Purification and characterization of an immunomodulatory Peptide from bovine placenta water soluble extract, Prep - Biochem Biotech.2007; 37: 173-84.

  10. O'Keefe, E.J. Pune et al: Keratinocyte growth promoting activity of human placenta-journal of cellular Physiology 1985(439-445).

  11. Carotti D, Allegra E: An approach to chemical characterization of human placental extracts: proteins, peptides, and amino acids analyses, Physiol Chem Phys. 1981; 13(2):129-36.

  12. IDF Diabetes Atlas, 4th edition. International Diabetes Federation, 2009 and A Ramachandran, AK Das, SR Joshi: Current Status of Diabetes in India and Need for Novel Therapeutic Agents, Supplement to japi • June 2010 • Vol. 58.

  13. Falanga V. Wound bed preparation: science applied to practice. European Wound Management Association (EWMA). Position Document: Wound Bed Preparation in Practice, pp 2-5, 2004.

  14. Centers for Disease Control and Prevention. Data and Trends: National Diabetes Surveillance System, Vol. 2006, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, 2005

  15. Aziz Z, Lin WK, Nather A, Huak CY. Predictive factors for lower extremity amputations in diabetic foot infections. Diabetic foot & ankle2011;2:7463-7

  16. Young MJ, Boulton AJM, Williams DRR, McLeod AF, Sonksen PH. A multi-center study of the prevalence of diabetic neuropathy in patients attending UK diabetic clinics. Diabetologia 1993; 36:150-154.

  17. Lipsky BA, Armstrong DG, Citron DM, Tice AD, Morgenstern DE, Abramson MA. Ertapenem versus pipercillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomized, controlled, double-blinded, multicenter trial. Lancet 2005; 366: 1695-703.

  18. Hartemann-Heurtier A, Robert J, Jacqueminet S, Ha Van G, Golmard JL, Jarlier V, Grimaldi A. Diabetic foot ulcer and multidrug-resistant organisms: risk factors and impact. Diabet Med 21:710-715, 2004.

  19. Lipsky BA, Berendt AR, Deery HG, Embil JM, Joseph WS, Karchmer AW, et al. Infectious Diseases Society of America. Diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2004; 39: 885-910.

  20. PD Chakraborty, D Bhattacharya : Isolation of fibronectin type III like peptide from human placental extract used as wound healer, Journal of Chromatography B, 818 (2005) 67–73.

  21. Chakraborty PD, Bhattacharyya D. In vitro growth inhibition of microbes by human placental extract. Curr. Sc. 2005b; 88: 782-786

  22. Navadiya SK, Patel MP, Vaghani YL. Study of Topical Placental Extract versus Povidone Iodine and Saline Dressing in Various Diabetic Wounds. Natl J Med Res. (2012), [cited December 18, 2016]; 2(4): 411-413.

  23. Frykberg RG, Lavery LA, Pham H, Harvey C, Harkless L, Veves A. Role of neuropathy and high foot pressures in diabetic foot ulceration. Diabetes Care 21:1714-1719, 1998.


Download 291.89 Kb.

Share with your friends:
1   2




The database is protected by copyright ©ininet.org 2024
send message

    Main page