ContactMultiCad plugin is a modified version of ContactLocalProduct plugin. In this case users can use several cadherins and describe how they translate into contact energy.
The energy formula used by this plugin is given below:
where indexes i, jlabel pixels, denotes contact energy between cell types and , exactly as in “regular” contact plugin and indexes m,n label cadherins in cells composed f pixels i and j respectively.
The syntax for this plugin is as follows:
0
0
0
0
0
-10
-12
-1
0.0
2
Entries of the type 0 have the same meaning as in “regular” contact energy. Specificity parameters specification are enclosed between tags and . The names NCad0 and Ncad1 are arbitrary. However the matrix will be ordered according to lexographic order of Cadherin names. For that reason we recommend that you name cadherins in such a way that makes it easy what the order will be. As in the example above using NameNumber
(e.g. NCad0, NCad1) makes it easy to figure out what the order will be (NCad0 will get index 0 and NCad1 will get index 1). This is important because cadherins will be set in Python and if you won't keep track of the ordering of the specificity you might wrongly assign cadherins in Python and get unexpected results. In the example the order of cadherins is clear based on the definition of cadherin specificity parameters.