Cv winslow, Raimond L. 2-18-2012 Curriculum Vitae

1. 
   Bober, M. and Winslow, R. L. (2006). Developing Computational Resources in Cardiac Gene Expression. In Methods in Molecular Biology, vol 366: Cardiac Gene Expression: Methods and Protocols. Edited by: J. Zhang and G. Rokosh. Humana Press Inc., Totowa, NJ.
   
2. 
   Winslow, R. L., Greenstein, J. L. and Helm, P. A. (2005), Biophysical Models of the Cardiovascular System. In: Systems Biology, Edts. I. Rigoutsos and G. Stephanopoulos, Springer Verlag Series on Advances in Biochemical Engineering/Biotechnology.
   
3. 
   Winslow, R. L., Hinch, R. and Greenstein, J. L. (2005). Mechanisms and Models of cardiac Excitation-Contraction Coupling. In: Synapses and Muscle. Edt. J. Sneyd and A. Friedman,  Springer-Verlag.
   
4. 
   Winslow R. L. (2004). "Proteomics". The Wiley Interscience Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, Jorde L. B., P. F. R. Little, M. Dunn and S. Subramaniam, Chichester, UK, John Wiley and Sons, Ltd., 3700
   
5. 
   Winslow, R. L. (2003). Modeling Cardiac Function. In: Complex Systems in Biomedicine, Eds. T. Deisboeck, T. Kepler, Y. Kresh, Kluwer Academic Press, New York, NY 10013
   
6. 
   Winslow, R. L. (2003). Cellular Models. In: Databasing the Brain: Data to Knowledge, Eds. S. Subramaniam and S. Koslow, John Wiley & Sons, Ltd.
   
7. 
   Noble, D. and Winslow, R. L. (1994). Reconstructing the heart: Network models of SA node - atrial interactions. In: Computational Biology of the Heart, Eds. AV Panfilov and AV Holden, Academic Publishers: John Wiley.
   
8. 
   Noble, D., Brown, H. F., and Winslow, R. L. (1993). Propagation of pacemaker activity: Interaction between pacemaker cells and atrial tissue. In: Pacemaker Activity and Intercellular Communication, Edts. W. Giles and J. D. Huizinga, CRC Press.
   
9. 
   Noble, D., Denyer, J. C., Brown, H. F., Winslow, R. L., and Kimball, A. (1992). Cardiac pacemaker activity: From single cells to modelling the heart. In: Heart Function in Health and Disease. B. Ostadal, edt. Kluwer Academic Press Publishers, Assinippi Park, MA.
   
10. 
    Noble, D., Denyer, J. C., Brown, H. F., Winslow, R. L., and Kimball, A. (1992). Modelling of cardiac rhythm: from single cells to massive networks. In: Coupled Oscillating Neurons, Eds. J. G. Taylor and C. L. T. Mannion, Springer-Verlag.
    
11. 
    Winslow, R.L., Barta, P.E. and Sachs, M.B. (1987). Rate coding in the auditory-nerve. In: Auditory Processing of Complex Sounds. C.S. Watson and W. Yost, eds., New Jersey: Lawrence Erlbaum Associates, pp. 212-224.
    
12. 
    Sachs, M.B., Winslow, R.L. and Blackburn, C.C. (1986). Representation of speech in the auditory periphery. In: Functions of the Auditory System, S. Hassler, ed., New York: John Wiley and Sons, Inc.
    

Winslow, R. L., Rounds, D., and Scollan, D. "Computational System and Method for Modeling the Heart", US-5947899, issued.

1. 
   Principal Investigator, "An Experimental and Theoretical Study of the Dynamics of a Simple Neural System", July 1, 1987 - June 30, 1990, The Whitaker Foundation, $149,999, TE 41%.
   
2. 
   Principal Investigator, "A Computer Model of the Retinal Horizontal Cell Network", Grant in Aid of Research, The University of Minnesota Graduate School, October, 1988 - September, 1989, $11,500.
   
3. 
   Principal Investigator, "Computer Models of Locally Connected Cellular Networks", 3M Non-Tenured Faculty Grant Award, $30,000, 1990 - 1991.
   
4. 
   Principal Investigator, "Models of the Processing of Acoustic Stimuli in Stellate Cells of the Antero-Ventral Cochlear Nucleus" Office of Naval Research, Single Neuron Computation Initiative, 11/1/91 - 10/30/94, $303,066.
   
5. 
   Principal Investigator, "Computational Models of the Sino-Atrial Node Implemented on a Massively Parallel Processor" NSF Computational Biology Activities, BIR 91- 17874, 7/1/92 – 6/30//95 $272,500.
   
6. 
   Principal Investigator, "Single Neuron Computation Conference", Office of Naval Research, $18,394, awarded March 1993, conference on May 23-26, 1993.
   
7. 
   Principal Investigator, "Modeling Acoustic Processing in the Ventral Cochlear Nucleus on the CM-5 Massively Parallel Processor", Office of Naval Research, Augmentation Awards for Science and Engineering Research Training, 9/1/93-8/31/96, $73,351.
   
8. 
   Co-Principal Investigator, "Supercomputer for Modeling in Biomedical Engineering", NCRR-BRS Shared Instrumentation Grant 5/18/94 - 5/31/95 $399, 543 (PI: E. Young)
   
9. 
   Principal Investigator, "Effects of Sodium Overload on Cardiac Single Cell and Network Dynamics", NSF Division of Advanced Scientific Computing ASC-9404844 $40,030
   
10. 
    Principal Investigator, "Models of Dynamic Interactions between Sinus Node and Atria", NSF Computational Biology Activities, $250,000, 7/1/95 - 6/30/97
    
11. 
    Principle Investigator, "Three-Dimensional Computational Models of Cardiac Atria and Ventricles" Physiome Sciences Inc. 1/1/96 - 12/31/97 $256,000
    
12. 
    Principle Investigator, “Research and Equipment Loan Agreement” Physiome Sciences Inc. 1/1/96 - 12/31/98 $471,777
    
13. 
    Principle Investigator, Computer Models of the Cardiac Ventricles Based on In Vivo Measurement of Fiber Organization Using Magnetic Resonance Imaging: Preliminary Algorithm Development, Physiome Sciences, Inc., 7/1/97 6/30/99, $127,636, 17% T&E
    
14. 
    Principal Investigator, Computational Modeling of Cardiac Microanatomy, Physiome Sciences Inc., 4/1/98 9/30/99, $82,486, 0% T&E
    
15. 
    Principle Investigator, Experimental and Modeling Study of the Cellular Basis of Arrhythmia in Heart Failure, NHLBI RO1HL60133-01, 4/1/98 3/31/01, $476,260
    
16. 
    Investigator, Biomedical Engineering at Johns Hopkins Merging Biology and Engineering to Cure Disease, Falk Foundation, 1/1/98 12/31/01, $600,000 (PI: M. B. Sachs).
    
17. 
    Principle Investigator, Addendum to Computational Modeling of Cardiac Microanatomy, Physiome Sciences Inc., 5/1/99-6/30/99, $112,497.
    
18. 
    Principal Investigator, “IBM SP-3 Night Hawk 1 Parallel Computer”, NIH/NCRR Shared Instrumentation Grant, 3/15/00 - 3/14/01, $323,968.
    
19. 
    Principal Investigator, Consortium for Integrative Modeling of Biological Systems, NIGMS Large-Scale Collaborative Projects Award Phase I, R24GM63239-01, 9/1/00 1/17/01, $25,000.
    
20. 
    Investigator, “Cross Modulation of Excitability and Ca in Heart Failure” NHLBI RO1HL61711-01 1/1/99-12/31/02 $708,680 (PI: B. ORourke)
    
21. 
    Co-Principal Investigator, “Distributed Simulation of Integrated Human Function”, NSBRI 99-02, 10/1/00 - 9/30/03 $1,094,692 (PI: J. E. Coolahan)
    
22. 
    Principal Investigator, “Modeling Core E, SCOR in Sudden Cardiac Death” NHLBI P50 HL52307 1/1/00 - 12/31/04 $434,178 (PI: E. Marban)
    
23. 
    Principal Investigator, “The Physiologic Genomics of Heart Failure”, The Falk Medical Trust, 9/1/02 - 8/31/06 $1,000,000
    
24. 
    Principal Investigator, IBM Institutes of Innovation Award, $1,140,000, 8/1/03 - 7/31/06
    
25. 
    Principal Investigator, IBM Shared University Research Grant, equipment valued at $166,626, 10/21/05.
    
26. 
    Principal Investigator, IBM Shared University Research Grant, equipment valued at $1,445,796, 8/1/03.
    
27. 
    Principal Investigator, IBM Shared University Research Grant, equipment valued at $1,500,000, 9/1/02.
    
28. 
    Principal Investigator, “Calcium Cycling and Regulation of the Cardiac AP” NHLBI RO1HL60133, 4/1/02 - 3/30/07, $800,000
    
29. 
    Principal Investigator, “Biomedical Engineering Training Program, NIH5T32 GM007057-29, 7/01/04 – 8/17/07, TDC $3,507,440
    
30. 
    Investigator, “Applied Genomics in Cardiopulmonary Disease”, NHLBI U01HL66583, 9/30/00 - 9/29/04, $14,000,000 (PI: J. Garcia)
    
31. 
    Investigator, A Biomedical Engineering Institute, The Whitaker Foundation 11/1/98-10/31/04, $17,317,790 (PI: M. B. Sachs)
    
32. 
    Principal Investigator, Anatomical and Electrical Remodeling in Heart, 10/01/02-9/30/07, RO1HL70894, $1,000,000 TDC
    
33. 
    Principal Investigator, Bioinformatics Core, Expression Profiling in Canine Models of Cardiopulmonary Disease, NHLBI RO1-HL72488, $862,655, 10/1/02-9/30/07
    
34. 
    Principal Investigator, Bioinformatics Core, The D. W. Reynolds Cardiovascular Clinical Research Center at Johns Hopkins University, $655,000, 6/1/03-5/31/07
    
35. 
    Investigator, Core F: Biomarkers/Proteomics Core, SCCOR: Ventilator-Associated Lung Injury: Molecular Approaches (PI: J. N. Garcia), NIH/NHLBI P50 HL73994-1, 5% T&E.
    
36. 
    Investigator, Cardiovascular Systems Regulation Program, NIH 7/1/01- 6/30/06 $522,701 (P.I. A. Shoukas)
    
37. 
    Principal Investigator, Algorithms for Detecting Changes in Heart Shape and Motion that Predict Risk for Sudden Cardiac Death, American Heart Association, 7/1/07 – 6/30/09, $70,000.
    
38. 
    Principal Investigator, NCRR Shared Equipment Grant, ”Large-Scale Computing Cluster for the Institute for Computational Medicine”, 7/1/08 – 6/30/09, $2,000,000
    
39. 
    Co-Director, Core C: Cellular, Molecular and Microscopy Core, “Pathobiology of Cardiac Dyssynchrony & Resynchronization” (PI: David Kass), P01-HL077180 $1,400,632, 9/15/04 – 8/31/09
    
40. 
    Director, Computational Modeling Core, Mitochondrial Function in Ischemic Heart Disease, PO1- HL081427, TDC $559,316, 8/10/05 – 6/30/10
    
41. 
    Principal Investigator, Bioinformatics Core & Technology Innovation Project 3, The Johns Hopkins University - NHLBI Proteomics Center, NO1-HV-28180, 10/1/02-6/30/10, $1,412,361.
    
42. 
    Principal Investigator, T15-HL088964 Short Course on Integrative Modeling of the Cardiac Myocyte, 4/1/07 – 3/31/11, $797, 396
    
43. 
    Principal Investigator, The Cardiovascular Research Grid, R24HL085343, $6,462,693, 1/1/07-12/31/10
    
44. 
    Investigator, SCCOR in Pulmonary Vascular Disease (PI: K. Barnes), $267,816, 1/12/07 – 12/31/11
    
45. 
    Principal Investigator, The Systems Biology of Sudden Cardiac Death, R33HL87345, Exploratory Program in Systems Biology, TDC $1,800,000; 9/1/07 – 8/31/11
    
46. 
    Principal Investigator, U54HG004028 Driving Biomedical Project Subcontract Ontology-Based Annotation of Biomedical Time-Series Data, 1/1/09 – 8/31/11, $917, 636
    
47. 
    Principal Investigator S10RR028004 Two-photon Microscope Adapted for Automated 3D Tissue Reconstruction at High Spatial Resolution, 7/1/10 – 6/30/11, NIH/NCRR $487, 647
    

1. 
   Investigator, P20HL101397 (Investigator) Primary ECG-MRI Risk Stratification, 4/1/10 – 3/31/12, NIH/NHLBI, $188,887 TDCs
   
2. 
   Principal Investigator R24HL085343 The CardioVascular Research Grid, 3/7/11 – 3/06/2016, NIH/NHLBI $6,901,902 TDCs
   
3. 
   Principal Investigator RO1HL105216 Redox Modification of the Arrhythmic Substrate In Heart Failure, 4/1/11 – 12/31/2014 NIH/NHLBI $764,376 TDCs
   
4. 
   Principal Investigator RO1HL105239 Calcium-Entrained Arrhythmias, 4/1/11 – 12/31/15, $1,030,125 TDCs
   
5. 
   Principal Investigator R01HL103727 Tools for Cardiac Electrophysiological Data Dissemination and Management, 7/1/11 – 6/30/15, $1,966,442 TDCs
   

1. Co-Principal Investigator, “Cloud-Computing Cardiac Radiomics” (PI Kooresh Shoghi, Washington University in St. Louis) $1,250,000 TDCs

2. Investigator, “Personalized Shape-Based Analysis of Hypertrophic Cardiomyopathy” (PI Ron Kikinis, Harvard Brigham and Womens Hospital), 7/10/2012 – 6/30/2017, $250,000 TDCs
Teaching

Theoretical Foundations of Neural Modeling: Single Neurons, 1991 - 1994. Graduate level course, primary instructor

Theoretical Foundations of Neural Modeling: Networks, 1992 - 1994. Graduate level course, primary instructor

High Performance Computing in Biology, 1995 - 1997. Graduate level course, primary instructor

BME 580.682 Computational Modeling of the Cardiac Myocyte, 2001 - Present. Annual graduate level course covering modeling of ion channels, membrane transporters, calcium-cycling, calcium-induced calcium-release, ion homeostasis, metabolism, intracellular signaling, and methods for mathematical and computational modeling of the cardiac myocyte. Primary instructor

BME 580.421 Systems Bioengineering I, 1996 – present. Fall Semester Junior year undergraduate core course. Give two lectures on modeling the cardiac myocyte. Primary instructor.

BME 580.421 Systems Bioengineering I Laboratory, 1996 – present. Fall semester Junior year undergraduate core course. Run one laboratory session on computer modeling in biology. Primary instructor.

BME 580.223 Biological Models and Simulation Part II: Nonlinear Dynamical Systems Models in Biology, 2006- Present. Sophomore BME core course. Teach one-half of the semester, covering nonlinear systems theory and applications to modeling biological systems. Primary instructor.

 

Trainees:

Dr. Winslow has trained 12 post-doctoral fellows, 13 Ph.D., and 7 M.Sc. students. Nine of the post-doctoral fellows currently have faculty appointments, 1 has had faculty appointments and is currently a program director at NSF, and 3 have positions in industry. Three Ph.D. students have faculty positions, one directs space sciences at Los Alamos National Laboratory, one is a research staff member at the IBM T.J. Watson Research Center, five have positions in industry, two are practicing physicians, and one is a post-doctoral fellow. Two M.Sc. students have faculty positions, 1 is a cardiology fellow training as a clinician-scientist, and 2 have positions in industry. He currently has 6 Ph.D. and 3 M.Sc. trainees in his lab. A new post-doctroal fellow is joining the lab.

Trainees – MSc: