Exploiting species differences to understand the cftr cl channel



Download 57.84 Kb.
Date conversion03.03.2018
Size57.84 Kb.
Exploiting species differences to understand the CFTR Cl- channel
Samuel J. Bose, Toby S. Scott-Ward, Zhiwei Cai and David N. Sheppard

SUPPLEMENTARY MATERIAL

Supplementary Material Table 1 lists the accession numbers of the CFTR homologues used to construct the cladogram shown in Figure 2 and indicates their percentage shared amino acid identity to human CFTR.


Supplementary Material Table 1: Shared amino acid sequence identity of CFTR homologues

Common Name

Latin name

GenBank Accession No.

Shared amino acid identity with human CFTR

Human

Homo sapiens

NM_000492.3

100.00

Chimpanzee

Pan troglodytes

NM_001079917.1

99.73

Sumatran Orangutan

Pongo abelii

NM_001168545.1

98.92

Cynomolgus Monkey (Crab-eating Macaque)

Macaca fascicularis

XM_005550598.1

98.31

Rhesus Macaque

Macaca mulatta

AF013753.1

98.18

Horse

Equus caballus

NM_001110510.1

94.06

Pig

Sus scrofa

AY585334.1

92.31

Arabian Camel

Camelus dromedarius

XM_010975581.1

91.84

Cattle

Bos taurus

M76128.1

89.94

Sheep

Ovis aries

U20418.1

90.75

Rabbit

Oryctolagus cuniculus

AF189720.1

92.23

Brandt’s Bat

Myotis brandtii

XM_005871579.1

90.42

Chinese Tree Shrew

Tupaia chinensis

XM_006162386.1

85.48

African Savanna Elephant

Loxodonta africana

XM_003407018.1

90.01

Domestic Ferret

Mustela putorius furo

XM_004789405.1

91.78

Giant Panda

Ailuropoda melanoleuca

XM_011222604

89.59

Domestic Cat

Felis catus

AAR16237.1

91.02

Dog

Canis lupus familiaris

AY780429.1

89.89

Tammar Wallaby

Macropus eugenii

ABA02588.1

85.88

Common Bushtail Possum

Trichosurus vulpecula

AY916796.2

85.27

Platypus

Ornithorhynchus anatinus

NM_001242734.1

83.09

Chinese Alligator

Alligator sinensis

XM_006023627.1

79.62

Chicken

Gallus gallus

DP000235.1

79.45

Adelie Penguin

Pygoscelis adeliae

XM_009324103.1

77.94

Timber Rattlesnake

Crotalus horridus

GBKC01000886.1

76.55

House Mouse

Mus musculus

NM_021050.2

79.05

Norwegian Rat

Rattus norvegicus

NM_031506.1

77.84

African Clawed Frog

Xenopus laevis

X65256.1

76.43

Spiny Dogfish

Squalus acanthias

M83785.1

71.11

Atlantic Salmon 1

Salmo salar

AF155237.1

57.08

Atlantic Salmon 2

Salmo salar

AF161070.1

57.44

Fugu rubripes (Japanese Pufferfish)

Takifugu rubripes

AB362833.1

57.71

Mummichog (Killifish)

Fundulus heteroclitus

AF000271.1

59.08

Zebrafish

Danio rerio

NM_001044883.1

53.87


Supplementary Material Table 1: Shared amino acid sequence identity of CFTR homologues Details of the amino acid sequences used to generate the cladogram shown in Figure 2 are provided. Amino acid sequences with GenBank accession numbers carrying the prefix ‘XM_’ are predicted based on genomic sequence data; all other amino acid sequences have been experimentally determined. Shared amino acid residue identity with human CFTR was calculated following ClustalO alignment.




The database is protected by copyright ©ininet.org 2016
send message

    Main page