Blood coagulation factors, their sources and function
|
Factor
|
source
|
function
|
1
|
Factor I (Fibrinogen)
|
Plasma protein made in the liver and usually converted to fibrin
|
Converted to fibrin
|
2
|
Factor II (Prothrombin)
|
Plasma protein made in the liver with the help of vitamin K
|
Converted to thrombin
|
3
|
Factor III(Tissue factor) or Thromboplastin)
|
Is released from the damaged tissues
|
Essential in activating in-vitro coagulation
|
4
|
Factor IV (Calcium ions)
|
Is inorganic iron in plasma derived from diet or bone
|
Essential for coagulation process
|
5
|
Labile factor (Factor V)
|
Plasma protein made in the liver. Also released from platelets
|
Co-factor involved in the conversion of prothrombin to thrombin
|
6
|
No factor VI
|
|
|
7
|
Factor VII (Proconvertin) stable factor
|
Plasma protein made in the liver with the help of vitamin K
|
Activates factor IX
|
8
|
Factor VIII (Antihaemophilic
factor)
|
Globulin made in the liver, deficiency causes haemophilia A
|
Co-factor involved in activating factor X
|
9
|
Factor IX (Christmas factor)
|
Plasma protein made in the liver with the help of vitamin K. Deficiency causes haemophilia B
|
In activating factor X
|
10
|
Factor X (Stuart-power factor)
|
Plasma protein made in the liver with the help of vitamin K.
|
Converts Prothrombin to thrombin
|
11
|
Factor XI (Plasma
thromboplstin antecedent
factor)
|
Plasma protein made in the liver with the help of vitamin K.
In vivo activated by thrombin and factor IV.
|
|
12
|
Factor XII (Hageman (glass or
contact factor)
|
Plasma protein made in the liver with the help of vitamin K
|
Converts plasminogen to plasmin and activating factor IX in fibrinolysis.
In vitro it initiates clotting process.
|
13
|
Factor XIII (Fibrin stabilizing
factor)
|
Plasma protein made in the liver with the help of vitamin K.
Also released by platelets
|
Converts fibrin polymer to form insoluble particles.
|
