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Livres ou chapitres de livresJasseron C, Warszawski J. L’accès à la prévention de la transmission mère-enfant du VIH en France. In : De La Rochebrochard, E. De la Pilule au bébé éprouvette. Choix individuels ou stratégie médicale INED 2008 Posters, communications orales dans des conférences nationales et internationalesBriand N, Viard JP, Dollfus C, Boufassa F, Le Chenadec J, Goujard J, Seng R, Blanche S, Meyer L, Warszawski J, and ANRS EPF, COVERTE, PRIMO, SEROCO, COPANA study-groups. Current HIV-1 Viral Load Is Less Often Undetectable in Young Adults Infected Perinatally Than in Older Patients Infected During Adulthood, in France. 20ème Conference on Retroviruses and Opportunistic Infections. Atlanta, GA. 3-6 Mars 2013-Young Investigator Award Briand N, Warszawski J, Faye A, Le Chenadec J, Dollfus C, Teglas JP, Tubiana R, Rouzioux C, Mandelbrot L, Blanche S, ANRS EPF study group. Is Intrapartum Prophylaxis for Mother-to-Child HIV-1 Transmission Still Useful in the HAART Era? 20ème Conference on Retroviruses and Opportunistic Infections. Atlanta, GA. 3-6 Mars 2013-Young Investigator Award Sibiude J, Mandelbrot L, Blanche S, Le Chenadec J, Bouallag N, Faye A, Dollfus C, Tubiana R, Khoshnood B, Warszawski J; for the ANRS French Perinatal Cohort. Birth Defects and Antiretroviral Therapy in the EPF French Perinatal Cohort, a prospective exhaustive study among 13,124 live births from 1994 to 2010. Communication orale, 20ème Conference on Retroviruses and Opportunistic Infections. Atlanta, GA. 3-6 Mars 2013 Blanche S, Scott-Algara D, Le Chenadec J, Avettand-Fenoel V, Bouallag N, Rouzioux C, Viard J-P, Dollfus C, Warsawski J, Buseyne F. Preservation of Naive CD4 and CD8 T Lymphocytes 15 Years or More after Perinatal HIV Infection - The ANRS-EP38-IMMIP study. 20ème Conference on Retroviruses and Opportunistic Infections. Atlanta, GA. 3-6 Mars 2013 Briand N, Viard JP, Le Chenadec J, Dollfus C, Firtion G, Arvieux C, Funck-Brentano I, Reliquet V, Jeantils V, Boufassa L, Chrétien F, Ferey C, Ramos E, Blanche S, Meyer L, Warszawski J, ANRS CO19 Coverte group. Clinicians Underestimate Sexual Risk Behaviour in Female Patients with Perinatally Acquired Human Immunodeficiency Virus Infection. ANRS CO19 COVERTE cohort. 4th International Workshop on HIV Pediatrics. Washington, DC, Etats-Unis. 20-21 Juillet 2012 Briand N, Viard JP, Le Chenadec J, Dollfus C, Firtion G, Arvieux C, Funck-Brentano I, Reliquet V, Jeantils V, Boufassa L, Chrétien F, Ferey C, Ramos E, Blanche S, Meyer L, Warszawski J, ANRS CO19 Coverte group. Clinicians Underestimate Sexual Risk Behaviour in Female Patients with Perinatally Acquired Human Immunodeficiency Virus Infection. ANRS CO19 COVERTE cohort. 19e Congrès International sur le Sida. Washington, DC, Etats-Unis. 22-27 Juillet 2012 J Warszawski, J Le Chenadec, L Mandelbrot, A Faye, C Dollfus, Z Assoul, R Tubiana,,S Blanche, and The French Perinatal Cohort (ANRS CO1/CO11). Infant Mortality Among HIV-Uninfected Children During the HAART Era in France – The ANRS French Perinatal Cohort. 19th CROI, Seattle 2012 Aupiais C, Faye A, Le Chenadec J, Dollfus C, Rouzioux C, Bouallag N, Laurent C, Blanche S, Warszawski J, ANRS EPF French Pediatric Cohort. Unplanned interruption of cART in HIV1-infected children: frequency, context, and subsequent immunological outcomes in the ANRS French Pediatric Cohort. 19th CROI, Seattle 2012 -Young Investigator Award A. Rachas, J. Warszawski, J. Le Chenadec, C. Legeai, J.P. Teglas, C. Goujard, C. Rouzioux, L. Mandelbrot, R. Tubiana, L. Meyer. One Third of Women Beginning cART During Pregnancy Do Not Reach Undetectable (<50 copies/mL) Viral Load at Delivery: Does Pregnancy Affect Response to cART? 19th CROI, Seattle 2012 - Young Investigator Award J Sibiude, J Warszawski, R Tubiana, C Dollfus, A Faye, C Rouzioux, J Teglas, D Ekoukou, S Blanche, L Mandelbrot, and the ANRS French Perinatal Cohort (ANRS CO1/CO11). Large Increase in Prematurity between 1990 and 2009 in HIV-Infected Women in the National ANRS French Perinatal Cohort: does Ritonavir Boost Play a Role? 18th CROI, San Francisco 2011, Young Investigator Award pour communication orale + poster Jérôme Le Chenadec, Stéphane Blanche, Véronique Avettand-Fenoel, Naima Bouallag, Christine Rouzioux, Jean-Paul Viard, Catherine Dollfus, Daniel Scott-Algara, Josiane Warszawski, and Florence Buseyne. Infrequent Gag-specific CD4 and CD8 T Cell Proliferation Capacity following 15 Years of Perinatal HIV Infection - The ANRS-EP38-IMMIP Study. 18th CROI, San Francisco 2011 R Tubiana, S Matheron, J Le Chenadec, C Dollfus, A Faye, S Blanche, C Rouzioux, V Benhammou, L Mandelbrot, J Warszawski. Extremely Low Risk of Mother-To-Child Transmission of HIV in Women Starting HAART before Pregnancy in the French Perinatal Cohort (ANRS EPF CO1/11). 18th CROI, San Francisco 2011 V. Avettand-Fenoel, S. Blanche, J. Lechenadec, C. Dollfus, D. Scott-Algara4 J.-P. Viard, N. Bouallag, Y. Benmebarek, Y. Rivière, J. Warszawski, C. Rouzioux, F. Buseyne. The cell-associated HIV-1 DNA level after 15 years of perinatal infection is strongly correlated with lifetime viral replication - The ANRS-EP38-IMMIP Study. AIDS 2010 International Conference, Vienna, July 2010 , communication orale Warszawski J, Faye A, Ecochard E, Dollfus C, Tubiana R, Rouzioux C, Mandebrot L, Blanche S; For the ANRS CO1-EPF. Effects of intensified prophylaxis during the post-natal phase on mother-to-child transmission of HIV-1. The ANRS CO1- French Perinatal Cohort EPF. AIDS 2010 International Conference, Vienna, July 2010 Tejiokem M., J. Warszawski, A Kfutwah, F. Ateba, C. Same Ekobo, I. Penda, G. Guemkam, JA Ndongo, G. Chewa, D. Rousset, P Boisier, A Faye. The impact of different antiretroviral regimens on prevention of HIV mother to child transmission in routine practice in Cameroon (ANRS 12140-PEDIACAM)”. abstract number: MOPE0271. 18th AIDS 2010 International Conference, Vienna, July 2010 Tejiokem M, Warszawski J, Kfutwah A, Francis A, Same Ekobo C, Penda I, Guemkam G, Boisier P, Rousset D, Faye A. Faisabilité des multithérapies anti-rétrovirales précoces systématiques chez les nourrissons âgés de moins de 7 mois infectés par le VIH dans un pays à ressources limitées : ANRS 12140 – PEDIACAM. 5ème Conférence Francophone VIH/SIDA, Casablanca 2010 F Buseyne, V Avettand-Fenoel, J Lechenadec, C Dollfus, D Scott, JP Viard, N Bouallag, Y Benmebarek, Y Rivière, J Warszawski, C Rouzioux, S Blanche. Histoire de l’infection périnatale par le VIH, 15 ans après la contamination périnatale: quantité d’ADN-VIH et nombre de lymphocytes T CD4 -Etude ANRS-EP38-IMMIP. Colloque ANRS, Institut Pasteur Beltzer N, Bigot R, Beck F, Toulemon L, David C, Gremy I, Warszawski J. Vers une nouvelle méthodologie des enquêtes en santé réalisées à partir d’abonnés au téléphone. Colloque francophone sur les sondages. Tanger 2010. Frange P, Burgard M, Lachassinne E, Warszawski J, Dollfus C, Le Chenadec J, Benhammou V, Guillot F, Rouzioux C, Blanche S. Infection postnatale tardive à VIH-1 en France en l’absence d’allaitement maternel : l’expérience de la cohorte périnatale ANRS CO01. 5ème Conférence Francophone VIH/SIDA, Casablanca 2010 Briand N, Mandelbrot L, Blanche S, Tubiana R, Faye A, Dollfus C, Le Chenadec J, Benhammou V, Rouzioux C, Warszawski J ; for the ANRS French Perinatal Cohort (ANRS EPF-CO1) Response to PI-based HAART in pregnant women previously exposed to ART for PMTCT. 17th CROI, San Francisco 2010 C Jasseron, L Mandelbrot, C Dolfus, N Trocmé, R Tubiana, JP Teglas, A Faye, C Rouzioux, S Blanche, Warszawski J; for the ANRS French Perinatal Cohort EPF - Non-disclosure of maternal HIV status to the father during pregnancy : risk factors and consequences. 17th CROI, San Francisco 2010 Tubiana R, Rouzioux C, Lechenadec J, Hamrene K, Mandelbrot L, Dollfus C, Faye A, Blanche S, Delaugerre C, Warszawski J; and ANRS French Perinatal Cohort Study Group. Delayed Control of Maternal Viral Load during Pregnancy Is Associated with Higher Risk of MTCT despite Viral Loads of <500 Copies/mL at Delivery: A Case/Control Study in the ANRS French Perinatal Cohort CO1/10/11. 16th CROI, Montreal 2009 Jasseron C, Mandelbrot L, Blanche S, Tubiana R, Le Chenadec J, Teglas JP, Dolfus C, Faye A, Rouzioux C, Warszawski J. Is marital status and information of the father associated with access to prevention of mother-to-child HIV transmission? 5th International Dominique DORMONT Conference, Paris 2009 Tejiokem M, Guemkam G, Same Ekobo C, Penda I, Nga A, Mbida P, Belinga ML, Tocko C, Ateba Ndongo F, Ndongo JA, Mekoudjou M, Kfutwah A, Rousset D, Warszawski J, Faye A. Why do HIV negative mothers refuse to participate in a clinical research involving HIV positive mothers in Cameroon? 5th International Dominique DORMONT Conference, Paris 2009 Kfutwah A, Tejiokem M, Faye A, Yonga M, Warszawski J, Blanche S, Rekacewicz C, Ateba F, Ndongo J, Guemkam G, Same-Ekobo C, Rouzioux C, Leruez-Ville M, Boisier P. Rousset D. Perinatal transmission of Cytomegalovirus (CMV) in children born to HIV positive and negative women in Cameroon. 5th International Dominique DORMONT Conference, Paris 2009 Briand N, Le Chenadec J, Blanche S, Teglas JP, Dollfus C, Faye A, C Rouzioux, Tubiana R, Warszawski J, Mandelbrot L ; for the ANRS French Perinatal Cohort. Lack of association between birthweight and prepartum exposition to highly active antiretroviral therapy in HIV-uninfected neonates born to HIV-infected mothers. Poster discussion. XVII International AIDS Conference Mexico City, 3-8 August 2008 Mandelbrot L, Jasseron C, Ekoukou D, Batallan A, Bongain A, Pannier E, Blanche S, Tubiana R, Rouzioux C, Warszawski J ; The ANRS French Perinatal Cohort EPF. Amniocentesis and Mother-to-Child HIV Transmission: The French ANRS EPF Cohort CO1/11. 15th CROI 2007, Boston 2008. Desquilbet L, Hoen B, Goujard C, Deveau C, Warszawski J, Meyer L ; and the ANRS PRIMO Cohort study group. Early Short-course HAART Initiated at the Time of Primary HIV Infection Provides No Sustained Benefit in Terms of Time to CD4 Decline below 350/mm3: Results of a Propensity Analysis within the ANRS PRIMO Cohort. 15th CROI 2007, Boston 2008. Guibert G, Warszawski J, Le Chenadec J, Benmebarek Y, Teglas J P, Blanche S, Mandelbrot L, Tubiana R, Rouzioux C, Leruez-Ville M, and The ANRS French Perinatal Cohort EPF. Congenital Cytomegalovirus Infection in Infants Born to HIV-infected Mothers, Prevalence and Risk Factors: ANRS French Perinatal EPF Cohort CO1/10/11. 15th CROI 2007, Boston 2008. Jasseron C, Burgard M, Teglas J P, Matheron S, Damond F, Hamrene K, Blanche S, Rouzioux C, Warszawski J, Mandelbrot L, and The ANRS French Perinatal Cohort EPF. Mother-to-Child Transmission of HIV-2: The French ANRS Perinatal Cohort EPF-CO1/11. 15th CROI 2007, Boston 2008. Delaugerre C, Cornet D, Chaix ML, Warszawski J, Dollfus C, Burgard M, Faye A, Mandelbrot L, Tubiana R, Blanche S, Rouzioux C. Analyse moléculaire des mécanismes d’acquisition de virus résistants lors de la primo-infection du nouveau-né exposé. Communication orale. 4ème conférence francophone VIH/Sida Paris 2007 aux antirétroviraux Mandelbrot L, Palladino C, Berrebi A, Rouzioux C, Teglas JP, Blanche S, Faye A, Tubiana R, Warszawski J, (ANRS) Co1 Enquête Périnatale Française (EPF). Particularités de la transmission mère-enfant du VIH-1 dans les grossesses gémellaires. 4ème conférence francophone VIH/Sida Paris 2007 Jasseron C, Mandelbrot L, Teglas JP, Tubiana R, Le Chenadec J, Rouzioux C, Blanche S, Warszawski J, ANRS-EPF. Enquête Périnatale Française. Accès à la prévention de la transmission mère-enfant du VIH selon l’origine géographique des femmes enceintes en France. 4ème conférence francophone VIH/Sida Paris 2007 Warszawski J, Tubiana R, Le Chenadec J, Blanche S, Teglas JP, Dollfus C, Faye A, Burgard M, Rouzioux C, Mandelbrot L ; ANRS-EPF. Enquête Périnatale Française2 . Transmission mère-enfant du VIH à l’ère des multithérapies dans l’Enquête Périnatale Française (ANRS-EPF). Communication orale. 4ème conférence francophone VIH/Sida Paris 2007 Jasseron C, Warszawski J, Blanche S, Rouzioux C, Le Chenadec J, Dolfus C, Faye A, Hamrene K, Teglas J.P, Tubiana R, Mandelbrot L, ANRS French Perinatal Cohort (EPF). Prevention of mother-to-child HIV transmission in France : is access to care different for women from sub-Saharan Africa than for French women ? Communication orale. 4ème conférence internationale Dominique Dormont, Paris 2007. Avettand-Fenoel V, Chaix ML, Blanche S, Burgard M, Warszawski J, Rouzioux C. Early diagnosis of HIV-1 infection in newborns, in the context of prevention of mother-to-child transmission with HAART (Perinatal Cohort ANRS Co 01). Communication orale. 4ème conférence internationale Dominique Dormont, Paris 2007. Goetghebuer T, Haelterman E, Hainaut M, Warszawski J, Le Chenadec J, Dollfus C, Gibb D.M, Giaquinto C, Levy J. for the European Infant Collaboration Group. Early versus deferred highly active antiretroviral therapy in HIV infected infants : a European collaborative cohort study. Communication orale. 4ème conférence internationale Dominique Dormont, Paris 2007. Guibert G, Leruez-Ville M, Rouzioux C, Tubiana R, Mandelbrot L, Blanche S, Teglas JP, BenMebarek Y, Le Chenadec J, Warszawski J, ANRS French Perinatal Cohort (EPF). High prevalence of cytomegalovirus (CMV) infection in infants born to HIV infected mothers–ANRS French Perinatal Cohort (EPF). Communication orale. 4ème conférence internationale Dominique Dormont, Paris 2007. Warszawski J, J lechenadec, C Dollfus, C Rouzioux, J Teglas, A Faye, S Blanche, and ANRS-EPF study group. Long term non progression : Children too ! Prospective evaluation in the ANRS French Pediatric Cohort. 14th CROI 2007, Los Angeles 2007 C Dollfus, J Le Chenadec, A Faye, S Blanche, C Rouzioux, J Tricoire, G Firtion, E Lachassinne, J Warszawski, and the French Pediatric Cohort EPF. Long-term Clinical and Biological Outcomes in Children Vertically Infected with HIV. 13th CROI 2006, Denver 2006 C. Delaugerre, D Cornet, M L Chaix, J Warszawski, C Dollfus, M Burgard, L Mandelbrot, R Tubiana, S Blanche, and C Rouzioux. Mechanisms of Acquisition of ART Drug-resistant Virus in HIV-1-infected Newborns in the French Perinatal Cohort (EPF-ANRS). 13th CROI 2006, Denver 2006 Abstracts AIDS. 2013 Jan 28;27(3):357-67. Does pregnancy affect the early response to cART? Rachas A, Warszawski J, Le Chenadec J, Legeai C, Teglas JP, Goujard C, Rouzioux C, Mandelbrot L, Tubiana R, Meyer L. OBJECTIVE A part of women starting antiretroviral therapy during pregnancy fail to attain undetectable viral load by delivery. Here we studied whether pregnancy affects the early immunovirological response to combined antiretroviral therapy (cART), taking into account treatment duration and baseline characteristics. DESIGNAntiretroviral-naive women initiating cART since 2004 and followed in three French ANRS multicenter HIV cohorts (French Perinatal Cohort, PRIMO and COPANA). METHODSThe early virological response (at 1, 3 and 6 months) and immunological increase after cART initiation were compared between women starting cART during (n = 708) and outside (n = 110) pregnancy. Relative risks were estimated in multivariate models adjusted for treatment duration, baseline viral load and CD4, sociodemographic factors and chronic hepatitis B. CD4 increases were compared by using mixed models. RESULTSOnly 63.8% of treated pregnant women attained a viral load less than 50 copies/ml by delivery. Similarly to nonpregnant women, nearly 90% of pregnant women reached a viral load less than 400 copies/ml at M3 [adjusted RR: 1.0 (95% confidence interval 0.7-1.4)], and nearly 100% at M6 following cART initiation [0.9 (0.4-1.9)]. viral load less than 50 copies/ml was attained by 61.5% of pregnant versus 67.9% of nonpregnant women at M3 (P = 0.26), and by 82.1 versus 87.0% at M6 (P = 0.48). CD4 recovery (both number and percentage) was similar in pregnant and nonpregnant women. Results were similar for the subset of women starting a boosted protease inhibitor-containing cART. CONCLUSIONPregnancy does not affect the virological response to cART below 400 copies/ml, or CD4 increase. The main reason for pregnant women not achieving viral load less than 50 copies/ml at delivery appears to be a short duration of treatment. AIDS Behav. 2013 Feb;17(2):488-97. Download 474.84 Kb. Share with your friends:
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