Israel state records י"ב באדר התשס"ו March 12, 2006



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[57] A 2-aryl-8-oxodihydropurine derivative of the formula



wherein W is a hydrogen atom, a C1-6 alkyl group, a halogen atom, a C1-6 alkoxy group, an amino group, a mono-or di-C1-4 alkylamino group, or a phenyl group which may optionally be substituted by one or two groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a trifluoromethyl group, a hydroxy group, an amino group, a mono- or di-C1-4 alkylamino group, a cyano group and a nitro group; X is a hydrogen atom, a C1-6 alkyl group, a cycloalkyl-C1-4 alkyl group, an alkyl group having 1 to 4 carbon atoms which is substituted by a phenyl group being optionally substituted by one or two groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a trifluoromethyl group, a hydroxy group, an amino group, a mono- or di-C1-4 alkylamino group, a cyano group and a nitro group, a C3-6 alkenyl group, a carbamoyl group, a di-C1-4 alkylcarbamoyl group, or a group of the formula (Q):

-CH(R3)CON(R1)(R2) (Q)




(wherein R1 is a C1-6 alkyl group, a C3-6 alkenyl group, a cycloalkyl group, a cycloalkyl-C1-4 alkyl group, or a hydroxy-C1-6 alkyl group, R2 is a C1-6 alkyl group, a cycloalkyl group, a phenyl group which may optionally be substituted by one or two groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a trifluoromethyl group, a hydroxy group, an amino group, a mono-or di – C1-4 alkylamino group, a cyano group and a nitro group, an alkyl group having 1 to 4 carbon atoms which is substituted by a phenyl group being optionally substituted by one or two groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a trifluoromethyl group, a hydroxy group, an amino group, a mono- or di-C1-4 alkylamino group, a cyano group and a nitro group, or a 5-membered or 6-membered monocyclic heteroaryl group or a 5-membered or 6-membered bicyclic heteroaryl group, each of which heteroaryl groups may optionally be substituted by a C1-3 alkyl group or a trifluoromethyl group and has at least one of nitrogen atom, an oxygen atom and a sulfur atom, or R1 and R2 may combine together with the adjacent nitrogen atom to form a piperidine ring, a pyrrolidine ring, a morpholine ring or a piperazine ring, and these rings may optionally be substituted by one or two C1-3 alkyl groups, and R3 is a hydrogen atom, a C1-6 alkyl group, or a hydroxy-C1-6 alkyl group);

Y is a hydrogen atom, a C1-6 alkyl group, a cycloalkyl group, a cycloalkyl-C1-4 alkyl group, a C3-6 alkenyl group, an alkyl group having 1 to 4 carbon atoms which is substituted by a phenyl group being optionally substituted by one or two groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a trifluoromethyl group, a hydroxy group, an amino group, a mono- or di-C1-4 alkylamino group, a cyano group and a nitro group, or a group of the formula (Q):

-CH(R3)CON(R1) (R2) (Q)

(wherein R1, R2 and R3 are as defined above); and

A is a phenyl group which may optionally be substituted by one or two groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a trifluoromethyl group, a hydroxy group, an amino group, a mono-or di-C1-4 alkylamino group, a cyano group and a nitro group or a 5-membered or 6-membered monocyclic heteroaryl group or a 5-membered or 6-membered bicyclic heteroaryl group, each of which heteroaryl groups may optionally be substituted by a C1-3 alkyl group or a trifluoro-methyl group and has at least one of a nitrogen atom, an oxygen atom and a sulfur atom; provided that one of X and Y of the above formula (I) is a group of the formula (Q) and the other of X and Y is other than a group of the formula (Q), or a pharmaceutically acceptable acid addition salt thereof.

__________





136136

[21][11]

תחל חשמלי לכדור


CARTRIDGE ELECTRIC PRIMER


[54]




10.12.1998

[22]




US

[33]

11.12.1997

[32]

988898

[31]

Int. Cl.7 F42B 005/08

[51]




RA BRANDS, L.L.C., U.S.A.

[71]




WO/1999/030104

[87]

ריינהולד כהן ושותפיו,

רחוב אחד העם 21 , ת.ד. 4060, תל אביב



REINHOLD COHN AND PARTNERS,

21 AHAD HA'AM ST.,

P.O.BOX 4060,

TEL AVIV 61040



[74]




[57] An electric primer for small arms ammunition comprising:

(a) an electrically conductive cup (10) having a top (10A) and a bottom (11) having an aperture (12) formed in the bottom;

(b) at least one electrically conductive explosive composition (13) within the cup;

(c) a disc (14) in the bottom of the cup, the disc comprising top and bottom surfaces and a central conductive portion (15) adjacent the aperture in the bottom of the cup, the central conductive portion having conductive surfaces on the top and bottom surfaces of the disc, and wherein a maximum diameter of at least the conductive surface on the bottom surfaces of the disc is smaller than a diameter of the aperture, the disc further comprising an annular portion of electrically insulating material (16) separating the cup from the central conductive portion; and

(d) a retaining means (17) on top of the explosive.


__________




136226

[21][11]

שתל וסת זרימה, שיטה ליצורו וכלי התקנה


FLOW REGULATING IMPLANT, METHOD OF MANUFACTURING AND DELIVERY DEVICE


[54]




18.11.1998

[22]




US

[33]

20.11.1997

[32]

975386

[31]

Int. Cl.7 A61F 009/00

[51]

אופטונול בע"מ

OPTONOL LTD.

[71]




WO/1999/026567

[87]

איתן, פרל, לצר וכהן צדק,

רחוב שנקר 7 , ת.ד. 12688, הרצליה



EITAN, PEARL, LATZER AND COHEN ZEDEK,

P.O.B. 12688,

HERZLIYA 46733


[74]




[57] A method for manufacturing an implant comprising the steps of: selecting a first tube having a longitudinal bore and a second tube having a longitudinal bore and dimensioned to fit inside the longitudinal bore of the first tube; placing the second tube inside the longitudinal bore of the outer tube; cutting the first tube and the second tube to form the implant.

__________





136353

[21][11]

מערכת זרימה ותהליך לשימוש ביצור יציקת סגסוגת מגנזיום תחת לחץ


FLOW SYSTEM AND PROCESS FOR USE IN PRODUCING MAGNESIUM ALLOY PRESSURE CASTING


[54]




30.11.1998

[22]




AU

[33]

28.11.1997

[32]

PP0604

[31]

Int. Cl.7 B22D 021/04

[51]




COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, AUSTRALIA

[71]




WO/1999/028065

[87]

וולף, ברגמן וגולר,

רחוב קרן היסוד 19ב' , ת.ד. 1352, ירושלים



WOLFF, BREGMAN AND GOLLER,

19B KEREN HAYESOD ST.

P.O.B. 1352,

JERUSALEM 91013



[74]




[57] A metal flow system, for use in pressure casting of magnesium alloy in a semi-solid or thixotropic state using a pressure casting machine having a supply
of the alloy in a molten state and a mould or die which defines a die cavity (14), wherein the system includes a die or mould tool means which defines at least one
runner (26) of the system into which molten magnesium alloy is able to be received for injection of alloy into the die cavity, the flow system is of a form providing for control of alloy flow velocities therein, whereby substantially all of the alloy flowing throughout the die cavity is in a semi-solid state, and said form results from the system including at least one controlled expansion region in which region the alloy flow is able to spread laterally, with respect to its direction of injection, with a resultant reduction in its flow velocity relative to its velocity in the runner, wherein the sate of the alloy is changed from said molten state to said semi-solid state.


__________





136482

[21][11]

תהליך להכנת טטראברומוביפנול–A


PROCESS FOR THE PREPARATION OF TETRABROMOBISPHENOL-A


[54]




31.05.2000

[22]




US

[33]

10.06.1999

[32]

329374

[31]

Int. Cl.7 C07C 037/62, 039/367

[51]




ALBEMARLE CORPORATION, U.S.A.

[71]

איתן, פרל, לצר וכהן צדק,

רחוב שנקר 7 , ת.ד. 12688, הרצליה



EITAN, PEARL, LATZER AND COHEN ZEDEK,

P.O.B. 12688,

HERZLIYA 46733


[74]






[57] A process of producing tetrabromobisphenol-A which comprises:

(a) contacting, during a period of time, bromine and a continuous or substantially continuous feed of bisphenol-A and/or underbrominated bisphenol-A in a reaction mass having a temperature within the range of from about 30 ˚C to about 100˚C and having a liquid phase comprised of a water-miscible organic solvent and water, in which liquid phase, tetrabromobisphenol-A is relatively insoluble;

(b) during all or substantially all of said period of time, maintaining in the liquid phase of the reaction mass, an amount of HBr which will protect the color of the tetrabromobisphenol-A precipitate in d) from being adversely affected by the intentional or unintentional variance of the unreacted bromine concentration described in c) to about about 20,000 ppm and up to about 80,000 ppm;

(c) during all or substantially all of said period of time, having in the liquid phase of the reaction mass, a presence of from about 50 ppm to about 80,000 ppm unreacted bromine; and

(d) during all or substantially all of said period of time, precipitating tetrabromobisphenol-A from the reaction mass.

__________





136585

[21][11]

שיטה ליצירת איזואוריאות


METHOD FOR PRODUCING ISOUREAS


[54]




22.12.1998

[22]




JP

[33]

24.12.1997

[32]

9-354735

[31]




JP




31.07.1998




10-217192




Int. Cl.7 C07D 207/335, 213/36, 231/12, 233/61, 249/02, 257/04, 261/08, 263/32, 271/10, 275/02, 277/28, 285/02, 307/52, 333/20

[51]




SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED, JAPAN

[71]




WO/1999/033809

[87]

סנפורד ט. קולב ושות',,

שער הגיא 4, מרמורק , ת.ד. 2273, רחובות



SANFORD T.COLB & CO.,

P.O.B. 2273,

REHOVOT


[74]










[57] A method for producing a compound of the formula



wherein R1 represents an optionally substituted hydrocarbon group; R2 represents a hydrogen atom or an optionally substituted hydrocarbon group; and q represents an optionally substituted heterocyclic group, or a salt thereof which comprises subjecting a compound of the formula






wherein R1 has the same meaning as defined above, or a salt thereof to the nitration reaction (a), and further subject- ting the resulting mixture without isolating/purifying the resulting compound of the formula




wherein R1 has the same meaning as defined above, or a salt thereof to the reaction (b) with a compound of the formula:

Q-CH2-NH-R2



wherein each symbol has the same meaning as defined above, or a salt thereof, and wherein the reaction (b) is carried out under pH 5-8.

__________




136712

[21][11]

מעגל מבטל רעש וממיר ניצב מטה


NOISE CANCELLATION CIRCUIT AND QUADRATURE DOWNCONVERTER


[54]




11.01.1999

[22]




US

[33]

09.01.1998

[32]

005355

[31]

Int. Cl.7 H03M 003/02

[51]




QUALCOMM INCORPORATED, U.S.A.

[71]




WO/1999/035746

[87]

סנפורד ט. קולב ושות',,

שער הגיא 4, מרמורק , ת.ד. 2273, רחובות



SANFORD T.COLB & CO.,

P.O.B. 2273,

REHOVOT


[74]

[57] A noise cancellation circuit comprising: at least two bandpass decimators (602, 604), each bandpass decimator comprising an error cancellation filter (608, 610) for receiving a signal from an analog-to-digital converter (ADC) and a filter (612a, 612b) connected to the error cancellation circuit for filtering an output from the error cancellation filter; and a summer (616) connected to each of the at least two bandpass decimators for summing the outputs of the bandpass decimators; wherein a transfer function of the error cancellation filter is convolved with a transfer function of the filter to generate a convolved transfer function of the respective bandpass decimator.




__________





136732

[21][11]

אנלוגים טראציקליים של קמפטותצין, הכנתם ותכשירי רוקחות המכילים אותם


CAMPTOTHECIN TETRACYCLIC ANALOGUES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM


[54]




16.12.1998

[22]




FR

[33]

24.12.1997

[32]

97/16461

[31]

Int. Cl.7 A61K 031/4745, A61P 031/12, 033/00, 035/00, C07D 213/64, 471/14

[51]




SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.), FRANCE

[71]




WO/1999/033829

[87]

ריינהולד כהן ושותפיו,

רחוב אחד העם 21 , ת.ד. 4060, תל אביב



REINHOLD COHN AND PARTNERS,

21 AHAD HA'AM ST.,

P.O.BOX 4060,

TEL AVIV 61040



[74]





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