John I. Clark curriculum Vitae
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JOHN I. CLARK Publications (* indicates student or postdoctoral co-author) DA Albertini & JI Clark (1975) Membrane microtubule interactions:Concanavalin A capping induced redistribution of cytoplasmic microtubules and colchicine binding proteins. Proc. Nat. Acad. Sci. USA 72: 4976 4980. JI Clark & DA Albertini (1976) Filaments, microtubules and colchicine receptors in capped ovarian granulosa cells. Cold Spring Harbor Symposium on Cell Motility, pp. 323 331. JI Clark & D Garland (1978) Fluorescein colchicine: synthesis purification & biological activity. J Cell Biol. 76: 619 627. GB Benedek, JI Clark, E Serrallach, C Young, L Mengel, T Sauke, A Bagg, & K Benedek (1979) Light scattering & reversible cataracts in calf and human lenses. Phil Trans Roy Soc (Lond.) Ser. A 293: 329 340. GB Benedek & JI Clark (1980) Light scattering in the lens: phase transition and opacification. In: Developments in Biochemistry, Vol. 9, Red Blood Cell and Lens Metabolism. SK Srivastava, Ed. pp. 431 435. JI Clark and TN Margulis(1980) Structure of colchicoside: X ray analysis of thiocolchicoside, the sulfur analogue of the glucoside of colchicine. Life Sciences 26: 833 837. JI Clark, L Mengel, A.Bagg & GB Benedek (1980) Cortical opacity, calcium concentration & fiber membrane structure in the calf lens. Exp Eye Res 31: 399 410. JI Clark, L Mengel & GB Benedek (1980) Scanning electron microscopy of opaque and transparent states in reversible calf lens cataracts. Ophthal. Res. 12: 16 33. JI Clark & GB Benedek (1980) Phase diagram for cell cytoplasm. Biochem. Biophys. Res. Comm. 95: 482 489. JI Clark & GB Benedek (1980) The effects of glycols, aldehydes & acrylamide on phase separation & opacification in the calf lens. Invest Ophthal 19: 771 776. DA Albertini & JI Clark (1981) Visualization of assembled and disassembled microtubule protein by double label fluorescence microscopy. Cell Biol. Int. Rep. 5:387 397. JI Clark, M Delaye & GB Benedek (1981) Laser light scattering &cataract. In: Proceedings of the Technical Conference on Electro Optics &Lasers. Industrial & Scientific Conference Pubs, Chicago, IL, p365 370. MA Delaye, JI Clark&GB Benedek (1981) Coexistence curves for phase separation in the calf lens cytoplasm. Biochem Biophys Res Comm 100:908 914. M Delaye, JI Clark & GB Benedek (1981) Light Scattering studies of cataracts. In: Scattering Techniques Applied to Supramolecular & Non Equilibrium Systems. SH Chen, B Chu & R Nossal, Eds., Plenum Press, NY, pp. 879 885. JI Clark, M Delaye, P Hammer & L Mengel (1982) Preparation and characterization of native lens cell cytoplasm. Curr Eye Res. 1:695 704. JI Clark, FJ Giblin, VN Reddy & GB Benedek (1982) Phase separation in X irradiated lenses of the rabbit. Invest Ophthal 22:186 190. M Delaye, JI Clark & GB Benedek (1982) Identification of scattering elements responsible for lens opacification in cold cataracts. Biophys J 37:647 656. JI Clark, JR Neuringer* & GB Benedek (1983) Phase separation and lens cell age. J. Gerontol. 38: 287 292. I Nishio, JN Weiss, T Tanaka, JI Clark, FJ Giblin, VN Reddy & GB Benedek (1984) In vivo observation of lens protein diffusivity in normal and X irradiated rabbit lenses. Exp. Eye Res. 39: 61 69. JI Clark (1985) Bedeutung der Phase Umwandlung fur die Kataraktentwicklung? In: Biochemie des Auges. O. Hockwin, Ed. Enke Verlag, Stuttgart, pp. 290 299. JR Neuringer*, JI Clark & GB Benedek (1985) Quantitative microprobe analysis of elements in cortical and nuclear cells of calf lens. Anat Rec 211: 329 337. JI Clark & ME Danford* (1985) Low temperature and acrylamide inhibit lens opacification caused by calcium. Ophthalmic Res. 17: 246 250. CR Kissinger*, ET Adman, RE Stenkamp & J.I. Clark (1985) Crystal structure of sorbinil. Acta Cryst. C41: 988 990. TB Osgood*, TW Menard*, JI Clark & K Krohn (1986) Inhibition of lens opacification in X irradiated rats treated with WR 77913. Invest Ophthalmol Vis Sci 27:1780 1784. TW Menard*, TB Osgood*, JI Clark, AM Spence, JE Steele, KA Krohn & JC Livesey (1986) Radioprotection against cataract formation by WR 77913 in gamma irradiated rats. Int J Radiation Oncol Biol Physics 12:1483 1486. JI Clark & DL Carper (1987) Phase separation in lens cytoplasm is genetically linked to cataract formation in the Philly mouse. Proc. Natl. Acad. Sci. USA 84: 122 125. M Delaye, ME Danford Kaplan*, JI Clark, B Krop, T Gulik Krzywicki & A Tardieu (1987) Effect of calcium on lens cytoplasm. Exp. Eye Res. 44: 601-616. S Eccarius* & JI Clark (1987) Effect of aspirin and vitamin E on phase separation in calf lens homogenate. Ophthalmic Res. 19: 65-71. JI Clark, TB Osgood* & SJ Trask* (1987) Inhibition of phase separation by reagents that prevent X irradiation cataract in vivo. Exp. Eye Res. 45: 961-967. CR Kissinger*, S Turley & JI Clark (1988) Crystal structure of WR 3681. Acta Cryst. C44: 512-514. JI Clark, ME Danford-Kaplan* &M. Delaye (1988) Calcium decreases transparency of homogenate from lens cortex and has no effect on nucleus. Exp. Eye Res. 47: 447-455. CF Beaulieu*, JI Clark, RD Brown III, M Spiller & SH Koenig (1988) NMR relaxometry of calf lens homogenates, including cross relaxation by crystallin NH group. Magnetic Resonance in Medicine. 8: 45-57. B Brewitt* & JI Clark (1988) Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF. Science. 242: 777-779. CF Beaulieu,* RD Brown, JI Clark, M Spiller, & SH Koenig (1989) Relaxometry of lens homogenates II: temperature dependence and comparison with other proteins. Magnetic Resonance in Medicine 10:362-372. VN Reddy, H Ikebe, FJ Giblin, JI.Clark & JC Livesey (1989) Effect of Radioprotective Agents on X-ray cataracts. Lens and Eye Toxicity Res 6(4): 573-588. JI Clark & CF Beaulieu* (1989) in EM microprobe analysis to NMRD studies of the lens. Lens & Eye Toxicity Research 6(4): 523-539. S Vaezy*, JI Clark, M Gisselberg* & ME Cantino (1989) Fourier analysis of digital STEM images of rat lens in the study of transparency. Proceedings of IEEE Conference on Engineering in Medicine and Biology 11:369-375. CF Beaulieu* & JI Clark (1990) P-31 NMR and LASER spectroscopic analyses of lens transparency during calcium induced opacification. Invest. Ophthal. Vis. Sci. 31(7):1339-1347. B Brewitt* & JI Clark (1990) A new method for studying normal lens development in vitro using pulsatile delivery of PDGF or EGF in HL-1 serum free medium. In Vitro Cell. Dev. Biol. 26:305-314. JI Clark (1990) Phase Separation and H-Bonding in Cells of the Ocular Lens. Biopolymers 30:995-1000. S Vaezy*, JI Clark & JM Clark (1990) Fourier analysis of two structural organizations in opaque mouse lenses. Proc. Intl. Congress for Electron Microscopy XII:554-559. S Vaezy* & JI Clark (1991) A quantitative analysis of transparency in the human sclera and cornea using Fourier methods. J. Microscopy 163:85-94. M Gisselberg*, JI Clark, S Vaezy* & TB Osgood* (1991) A quantitative evaluation of Fourier components in transparent and opaque calf cornea. Amer. J. of Anatomy 191: 408-418. B. Brewitt*, D. Teller and J.I. Clark (1992) Periods of oscillatory growth in developing ocular lens correspond with cell cycle times. J Cell Physiol 150:586-592. JI Clark & JE Steele (1992) Phase separation inhibitors, PSI & prevention of selenite cataract. Proc Natl Acad Sci USA 89:1720-1724. JI Clark, JC Livesey and JE Steele (1993) Phase separation inhibitors and lens transparency. Optometry and Vision Sci. 70: 873-879. JI Clark (1994) Development and maintenance of lens transparency in "Principles and Practice of Ophthalmology," Ed. DM Albert & FA Jakobiec, WB Saunders Co. Philadelphia, PA, pp. 114-123 JI Clark (1994) Lens cytoplasmic protein solutions: Analysis of a biologically occurring aqueous phase separation, in "Aqueous Two-Phase Systems," eds. H Walter & G Johansen. Methods in Enzymology 228:525-537. S Vaezy* & JI Clark (1994) Quantitative analysis of the microstructure of the human cornea and sclera using 2-D Fourier methods. J of Microscopy 175: 93-99. S Vaezy*, JI Clark & JM Clark (1995) Quantitative analysis of lens cell microstructure in selenite cataract using a two-dimensional Fourier analysis. Exp. Eye Res. 60: 245-255. S Vaezy* & JI Clark (1995) Characterization of the cellular microstructure of ocular lens using 2-D power-law analysis. Ann. Biomed. Eng. 23: 482-490. (Published erratum appears in Ann Biomed. Eng. (1995) 23:707-709) S Vaezy*, LT Smith, A Milaninia & JI Clark (1995) 2-D Fourier analysis of electron micrographs of human skin for quantification of the collagen fiber organization in the dermis. J. Electron Microsc. 44: 358-364. T Hiraoka* & JI Clark (1995) Inhibition of opacification during early stages of cataract formation. Invest. Ophthalmol. Vis. Sci. 36: 2550-2555. T Hiraoka*, JI Clark, XY Li & GM Thurston (1996) Effect of selected anti-cataract agents on opacification in the selenite cataract model. Exp. Eye Res. 62: 11-21. J.I. Clark, J.C.Livesey, and J.E. Steele (1996) Delay or inhibition of rat lens opacification using pantethine and WR-77913. Exp. Eye Res. 62: 75-85. JI Clark, and QL Huang. (1996) Modulation of chaperone-like activity of bovine alpha crystallin. Proc. Natl. Acad. Sci. USA. 93: 15185-15189. GM Thurston, DL Hayden, P Burrows, JI Clark, VG Taret, J Kandel, M Courogen, JA Peetermans, MS Bowen, D Miller, KM Sullivan, R Storb, H Stern and GB Benedek. (1997) Evidence for increased interprotein association as a function of age in the living human lens using quasielastic light scattering. Curr Eye Res. 16: 197-207. H Matsushima*, LL David, T Hiraoka & JI Clark (1997) Loss of cytoskeletal proteins and lens cell opacification in the selenite cataract model. Exp. Eye Res. 64: 387-395. PJ Muchowski*, JA Bassuk, NH Lubsen & JI Clark. (1997) Human alpha B crystallin: Small heat shock protein and molecular chaperone. J. Biol. Chem. 272:2578-2582. H Matsushima*, ES Peskind, JM Clark, JB Leverenz, CW Wilkinson & JI Clark (1997) Protein changes during aging and the effects of long term cortisol treatment on macaque monkey lens. Optometry & Vis Sci 74:190-199. JI Clark. (1997) Introduction of George B. Benedek: 1997 Proctor Medal. Invest Ophthalmol Vis Sci 38: 1909-1910. K Norose, JI Clark, NA Syed, A Basu, E Heber-Katz, EH Sage. & CC Howe. (1998) sparc deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci 139: 2674-2680. PJ Muchowski* & JI Clark. (1998) ATP enhanced molecular chaperone functions of the small heat shock protein B crystallin. Proc. Natl. Acad. Sci. USA 95: 1004-1009. P Parsons-Wingerter, B Lwai, MP Yang, KE Elliott, A Milaninia, A Redlitz, JIClark & EH Sage. (1998) a novel assay of angiogenesis in the quail chorioallantoic membrane: Stimulation by bFGF and inhibition by angiostatin according to fractal dimension and grid intersection. Microvascular Research 55: 201-214. JI Clark & T Hiraoka (1999) “Evaluation of anticataractogenic reagents”, in: Nutritional & Environmental Influences on the Eye, A Taylor, Ed. CRC Press, Boca Raton, FL. pp. 117-134 PJ Muchowski*, GS Wu*, JN Liang, ET Adman & JI Clark (1999) Site-directed mutations in the core “-crystallin”domain of the sHsp, human B–crystallin decrease molecular chaperone function. J.Mol. Biol.289:397-411. JA Bassuk, T Birkebak, JD Rothmier, JM Clark, A Bradshaw, PJ Muchowski, CC Howe, JI Clark & E.H.Sage. (1999) Disruption of the Sparc locus in mice alters the differentiation of the lenticular epithelium and leads to cataract formation. Exp. Eye Res. 68: 321-332. PJ Muchowski* MA Valdez* & JI Clark. (1999) B-crystallin selectively targets intermediate filament proteins during thermal stress. Invest. Ophthalmol. Vis. Sci. 40: 951-959. GB Benedek, J Pande, GM Thurston & JI Clark (1999) Theoretical and experimental basis for the inhibition of cataract. Prog. Retin. Eye Res. 18: 391-402. JI Clark, H Matsushima, LL David & JM Clark(1999) Lens cytoskeleton and transparency: a model. Eye 13:417-424 PJ Muchowski*, LG Hays, JR Yates III & J.I. Clark. (1999) ATP and the core “α-crystallin” domain of the small heat shock protein B-crystallin. J Biol Chem. 274:30190-30196 MD Perng, PJ Muchowski*, P van Den IJssel, GJ Wu, AM Hutcheson, JI Clark &RA Quinlan. (1999) The cardiomyopathy & lens cataract mutation in B-crystallin alters its protein structure, chaperone activity & interaction with intermediate filaments in vitro. J Biol Chem 274:33235-33243 JR Kuszak, JI Clark and JM Rae. (1999) Lens transparency, embryology, anatomy, & physiology, in Principles & Practice of Ophthalmology, DM Albert & FA Jakobiec Eds WB.Saunders Co., Philadelphia, PA pp.1305-1409. JI Clark & JM Clark. (2000) Lens cytoplasmic phase separation. Int. Rev. Cytol. 192:171-87. H Matsushima, K Mukai, Y Obara and JI Clark (2000) Analysis of cytoskeletal proteins in rat selenium cataract using 2-D electrophoresis. J. Japanese Ophthalmological Soc. 104:299-305. JI Clark & PJ Muchowski. (2000) sHSP and their potential in human disease. Curr Opinions in Struct. Biol. 10:52-59 H Matsushima, K Mukai, Y Obara, H Cai, Y Ito & J.I. Clark (2000) Analysis of proteins from lens opacity in selenite cataract model using Sprague Dawley and Wistar Rats. J Japanese Ophthalmological Soc 104:377-383 P Parsons-Wingerter, KE Elliott*, AG Farr, K Radhakrishnan, JI Clark, and EH Sage. (2000) Generational analysis reveals that TGF-1 inhibits the rate of angiogenesis in vivo by selective decrease in the number of new vessels. Microvasc Res.59:221-32. P Parsons-Wingerter, KE Elliott*, JI Clark, and AG Farr. (2000) FGF-2 stimulates selectively the angiogenesis of small vessels in the arterial tree. Arteriosis, Thrombosis and Vascular Biology. 20:1250-1256 H Matsushima, K Mukai, Y Obara and JI Clark (2000) Analysis of cytoskeletal proteins in rat selenium cataract using 2-dimensional electrophoresis. Nippon Ganka Gakkai Zasshi. 104(5):299-305. Q Yan*, JI Clark and EH Sage (2000) Expression and characterization of SPARC in human lens and in the aqueous and vitreous humors. Exp. Eye Res. 71:81-90. TR Klesert*, DH Cho*, JI Clark, J Maylie, J Adelman, L Snider, EC Yuen, P Soriano, and SJ Tapscott. (2000) Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy. Nature Genetics. 25:105-109. K Norose, WK Lo, JI Clark, EH Sage and CC Howe (2000) Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface. Exp. Eye Res. 71:295-307. SJ Tumminia, JI Clark, DM Richiert, KP Mitton, Y Duglas-Tabor, JA Kowalak, DL Garland and P Russell (2001) Three stages of lens opacification in transgenic mice expressing the HIV-1 protease. Exp. Eye Res. 72:115-125. BK Derham, MA van Boekel, PJ Muchowski, JI Clark, J Horwitz, HW Hepburne-Scott, WW de Jong, MJ Crabbe and JJ Harding (2001) Chaperone function of mutant versions of alpha A- and alpha B-crystallin prepared to pinpoint chaperone binding sites. Eur J Biochem. 268:713-722. AF Clark, HT Steely, JE Dickerson Jr, S.English-Wright, K Stropki, MD McCartney, N Jacobson, AR Shepard, JI Clark, H Matsushima, ER Peskind, JB Leverenz, CW Wilkinson, RE Swiderski, JH Fingert, VC Sheffield, & EM Stone (2001) Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells & Tissues. Invest. Ophthalmol. Vis. Sci. 42: 1769-1780. JI Clark (2001) Fourier and power law analysis of structural complexity in cornea and lens. Micron. 32: 239-251. JI Clark (2001) Therapeutic applications of heat shock proteins and molecular chaperones. Expert Opin. Ther. Patents. 11:1053-1062. MM Valdez*, JI Clark, GJ Wu and PJ Muchowski (2002) Functional similarities between Mycobacterium tuberculosis HSP16.3 and human alpha-B crystallin. Eur. J. Biochem. 269: 1806-1813. S Hu, Y Mingliang, G Surh*, JI Clark & N Dovichi (2002) Analysis of Proteins by Capillary SDS-DALT Electrophoresis with Laser Induced Fluorescence Detection. LC-GC Technology Europe. March: pp 2-6. JI Clark (2002) sHsps: the neglected chaperones: Progress in Molecular & Subcellular Biol.J Cell Sci 115:2255-2257. Q Yan, JI Clark, TN Wight and EH Sage (2002) Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice. J. Cell Sci 115:2447-56. MJ MacCoss, EW Hayes-Macdonald, A Saraf, ER Sadygovl, JM Clark, JJ Tasto, KL Gould, D Wolters, M Washburn, A Weiss, JI Clark, and JR Yates (2002) Shotgun identification of protein modifications from protein complexes and lens tissues. Proc Natl Acad Sci 99:7900-7905. V Zderic*, S Vaezy, RW Martin and JI Clark (2002) Ocular drug delivery using 20 kHz ultrasound. Ultrasound in Med. & Biol. 28: 823-829. A Avakian, RE Kalina, EH Sage, AH Rambhia*, KE Elliott*, EL Chuang, JI Clark, JN Hwang, P Parsons-Wingerter. (2002) Region-based morphometry of the retinal vascular tree in human eyes with non-proliferative diabetic retinopathy. Curr Eye Res 24:274-280. A Alizadeh*, JI Clark, T Seeberger*, J Hess, T Blankenship, A. Spicer and P.G. Fitzgerald (2002)Targeted genomic deletion of the lens specific intermediate filament protein CP49. Invest. Ophthalmol. Vis. Sci. 43:3722-3727. Q Yan, D Blake*, JI Clark & EH Sage (2003) Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for structural integrity of capsular basement membrane. J. Histochem. Cytochem. 51:503-511. A Alizadeh*, JI Clark, TM Seeberger*, J Hess, T Blankenship & PG Fitzgerald (2003) Targeted deletion of the lens fiber cell specific intermediate filament protein filensin. Invest.Ophthalmol. & Vis.Sci. 44:5252-5258. RR Ansari, J F King, T Seeberger* & JI Clark (2003) Early detection of cataract and response to pantethine therapy with non-invasive static and dynamic light scattering. Proc. SPIE 4951:168-76; Ophthalmic Technology XIII TM Seeberger*, Y Matsumoto, A Alizadeh*, P G Fitzgerald & JIClark (2004) Digital image capture and quantification of subtle lens opacities in rodents. J. of Biomed Optics. 9: 116-120. H Matsushima, K Mukai, Y Obara, S Yoshida & JI Clark (2004) Analysis of cytoskeletal proteins in posterior capsule opacification after implantation of acrylic & hydrogel IOLs. J. Cataract Refract. Surg. 30:187-197. A Alizadeh*, JIClark, TMSeeberger*, J Hess, T Blankenship & PG Fitzgerald (2004) Characterization of a mutation in the lens specific CP49 in the 129 strain of mouse. Invest.Ophthalmol. & Vis.Sci. 45:884-892. JI Clark (2004) Order and disorder in the transparent media of the eye. Exptl. Eye Res. 78:427-435. V Zderic*, JI Clark, RW Martin & S Vaezy (2004) Ultrasound & transcorneal drug delivery. Cornea 23:803-812. C Fong*, C Rosse, JI Clark, LG Shapiro & JF Brinkley (2004) Ontology-Based Image Repository for a Biomedical Research. Proceedings of Med Info. 37:1598-1604. V Zderic*, J.I. Clark & S.Vaezy (2004) Drug delivery into the eye with the use of ultrasound. J. of Ultrasound in Medicine 23:1349-61. JG Ghosh* & JI Clark (2005) Insights into the domains required for dimerization and assembly of human B crystallin. Protein Science 14:684-696. JG Ghosh*, MR Estrada* & JIClark (2005) Interactive domains for chaperone activity in the sHSP, human B crystallin. Biochemistry 44:14854-69. H Matsushima, K Mukai, N Gotoh*, S Yoshida, T Yoshida, M Sawano, T Senoo, Y Obara & JI Clark (2005) The effects of drug delivery via hydrophilic acrylic (hydrogel) intraocular lens systems on the epithelial cells in culture. Ophthalmic Surg Lasers Imaging. 36:386-392. JG Ghosh*, MR Estrada*, SA Houck* & JI Clark (2006) The function of the beta3 interactive domain in the sHSP & molecular chaperone, human alphaB crystallin. Cell Stress and Chaperones 11:187-198 RO Emerson*, EH Sage, JG Ghosh*, & JI Clark (2006) Chaperone-like activity revealed in the matricellular protein, SPARC. J. Cell Biochem 98:701-705. JG Ghosh*, MR Estrada* & JI Clark (2006) Structure based analysis of the β8 interactive sequence of human αB crystallin. Biochemistry 45:9878-9888. JG Ghosh*, AK Shenoy Jr*, & JI Clark (2006) N- and C-terminal motifs in human αB-crystallin play an important role in the recognition, selection, and solubilization of substrates. Biochemistry 45:13847-13854 L Liu* JG Ghosh* JI Clark & S Jiang (2006) Studies of B crystallin dynamics by surface plasmon resonance (SPR). Anal Biochem. 350(2):186-95. JG Ghosh*, SA Houck*,CE Doneanu & JI Clark (2006) The β4-β8 groove is an ATP-interactive site in the α crystallin core domain of the small heat shock protein, human αB crystallin. J. Mol. Biol. 364:364-375. JG Ghosh*, SA Houck*& JI Clark (2007) Interactive domains in the molecular chaperone, human αB crystallin modulate microtubule assembly and disassembly. PloS ONE 2:e498 N Gotoh*, NR Perdue, H Matsushima, EH Sage,Q Yan, & JI Clark (2007) An in vitro model of posterior capsular opacity: SPARC and TGF-β2 minimize epithelial-to-mesenchymal transition in lens epithelium. Invest Ophthalmol Vis Sci 48:4679-87. JG Ghosh*, SA Houck* & JI Clark (2007) Interactive sequences in the stress protein and molecular chaperone human B crystallin recognize and modulate the assembly of filaments. Int J of Biochem & Cell Biol 39:1804-1815 ZY Park, R Sadygov, JM Clark, JI Clark & JR Yates III (2007) Assigning in vivo carbamylation & acetylation in human lens proteins using tandem mass spectrometry & database searching. Intl J Mass Spectrometry 259:161-173. JG Ghosh*, AK Shenoy Jr*.& JI Clark (2007) Interactions between important regulatory proteins and human αB crystallin. Biochemistry. 46:6308-6317 TMS Greiling* & JI Clark (2008) The transparent lens & cornea in the mouse & zebra fish eye. Seminars in Cell & Developmental Biology 19:94-99. JG Ghosh*, SA Houck* & JI Clark (2008) Interactive sequences in the molecular chaperone, human αB crystallin modulate the fibrillation of amyloidogenic proteins. Int J of Biochem & Cell Biol 40:954-966 PJ. Muchowski, R Ramsden, QV Nguyen, EE. Arnett,T Greiling*, SK. Anderson & JI. Clark (2008) Noninvasive Measurement of Protein Aggregation by Mutant Huntingtin Fragments or -Synuclein in the Lens. J Biol Chem 283:6330-6336 J Yuen*, Y Li*, LG Shapiro, JI Clark, E Arnett, EH Sage & J Brinkley (2008) Automated, Computerized, Feature-Based Phentoype Analysis of Slit Lamp Images of the Mouse Lens. Exp Eye Res 86:562-57 S Zigler, PF Kador, JI Clark & M Datiles, (2009) Medical Treatment of Cataract.in Duane's Ophthalmology, W. Tasman & EA Jaeger, eds. Vol 1, Chapt 75, TMS Greiling*,B Stone,JI Clark(2009) Absence of SPARC leads to impaired lens circulation. Exp Eye Res.89:416-425 TMS Greiling* JI Clark (2009) Early lens development in the zebrafish: a 3-dimensional time-lapse analysis. Dev Dyn 238:2254-2266 TMS Greiling* SA Houck, JI Clark (2009) Proteomic analysis of developing zebrafish lens. Mol Vis 15:2313-2325 TMS Greiling*, M Aose, JI Clark (2010) Cell Fate and Differentiation of the Developing Lens. Inv Ophthalmol. & Vis Sci. 51:1540-1548. JA Moncaster*, R Pineda, RD Moir, S Lu, MA Burton, JG Ghosh, M Ericsson, SJ Soscia, A Mocofanescu, RD Folkerth, RM Robb, JM Kuszak, JI Clark, RE Tanzi, DG Hunter, LE Goldstein (2010) Alzheimer’s disease amyloid-beta lins lens & brain pathology in Down’s syndrome PLoS ONE 5(5):e10659. SA Houck, JI.Clark (2010) Dynamic subunit exchange and the regulation of microtubule assembly by the stress protein human αB crystallin PLoS ONE 5(7):e11795. SA Houck*, JG Ghosh*, JI Clark (2010) Small stress proteins and their therapeutic potential. in Small Stress Proteins and Human Diseases. S. Simon & A-P Arrigo, eds. in the Protein Science and Engineering Series, Nova Science Publishers, New York, pp 417-438. SA Houck*, A.Landsbury*, JI Clark, & RA Quinlan (2011) Multiple sites in alphaB crystallin modulate interactions with desmin filaments assembled in vitro. PLoS ONE 6:e25859 A Landsbury,* Q Bo, HB Schonthaler, R Dahm, Y Liu, JI Clark, AR Prescott. RA Quinlan. (2012) Evolution of the vertebrate beaded filament protein, Bfsp2: comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue. Exp Eye Res. 94:192-202. TM Greiling* & JI Clark (2012) New insights into the mechanism of lens development using zebrafish. Int Rev Cell Mol Biol. 2012;296:1-61 TJW Clark, SA Houck*, JI Clark (2012) Hemoglobin interactions with aB crystallin: a direct test of sensitivity to protein instability PLoS One 7:e40486. PMCID.3399823 DS Gokhin, RB Nowak, NE Kim, EA Arnett, AC Chen, RL Sah, JI Clark, & VM Fowler (2012) Tmod1 and CP49 synergize to control fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. (PLoS One 7(11):e48734 PMCID 3492431 JI Clark (2013) Self –assembly of protein aggregates in ageing disorders. Phil. Trans. Roy Soc. Lond. B Biol Sci. 368(1617): 20120104. doi: 10.1098/rstb.2012.0104. PMID:23530262 A Kumar, M Dougherty, GM Findlay, M Geisheker, J Klein, J Lazar, H Machkovech, J Resnick, R Resnick, AI Salter, F Talebi-Liasi, C Arakawa, J Baudin, A Bogaard, R Salesky, Q Zhou, K Smith, JI Clark, J Shendure, MS Horwitz. (2014) Genome Sequencing of Idiopathic Pulmonary Fibrosis in Conjunction with Medical School Human Anatomy PLOS One 9(9): e106744; doi:10.1371/journal.pone.0106744 DMG Anderson, KA Floyd, S Barnes, JM Clark, JI Clark, H Mchaourab & KL Schey (2015) A Method to Prevent Protein Delocalization in Imaging Mass Spectrometry of Non-adherent Tissues: Application to Small Vertebrate Lens Imaging. Anal Bioanal Chem. 407(8):2311-20. doi: 10.1007/s00216-015-8489-5. JI Clark (2015) Functional Sequences in Human alpha B Crystallin. Biochim Biophysica Acta (accepted) SA Houck*, JG Ghosh & JI Clark (2015) Interactive domains on the stress response protein and sHSP MTB 16.3 Exp Eye Res. (in review) JA Moncaster*, RD Moir, L Fu, A Mocofanescu, S Lu, W Xu, O Chadwick, JT Rogers, E Arnett, M Ericsson, JV Li, M Sadowski , T Wisniewski, WE Klunk, CA Mathis, JI Clark, RE Tanzi & LE Goldstein (2015) Early Detection of Alzheimer’s Disease-Associated Aβ Peptide Accumulation in the Lens by Non-Invasive Quasi-Elastic Light Scattering (in review) JG Ghosh*, AD Taylor*, S Jiang and JI Clark (2015) Dynamic regulation of the protective function of the stress protein, human αB crystallin, against protein unfolding and aggregation (submitted) M Aose*, D Hajidi, JM Clark & JI Clark (2015) Localization of antibodies for frozen and embedded sections in zebrafish and mouse lenses (submitted) SELECTED PATENTS JI Clark, L Mengel, GB Benedek, Process for preventing or reversing cataract formation using acrylamides. (US No. 4351826). JI Clark, L Mengel, GB Benedek. Process for preventing or reversing cataract formation using aldehydes. (U.S. No. 4351350). JI Clark, L Mengel, GB Benedek. Utility of glycols in reversal of cataract. (US No. 4474817) JI Clark, LS Mengel, GB Benedek Process for preventing or reversing cataract formation (US No. 4526789) JI Clark, GB Benedek, RJ Siezen, JA Thomson Chemical Prevention of Cataract using OC-2, a Phase Separation Inhibitor (US No. 5091421) JI Clark, GB Benedek, RJ Siezen, JA Thomson, SH Friedman Chemical prevention or reversal of cataract by phase separation inhibitors (US No. 5290813) JI Clark, GM Thurston, XY Li, Chemical prevention or reversal of cataract by phase separation inhibitors (US No.5338545) JI Clark, GB Benedek, Chemical prevention or reversal of cataract by phase separation inhibitors (US No. 5284874) JI Clark, AG Farr, SA Smith Immunoregulatory agents (US No. 5340829) JI Clark, KW Fowler, MW Orme, LJ Theodore. Chemical prevention or reversal of cataract by phase separation inhibitors. (US No. 5401880) JI Clark and S Vaezy, Order Based Analysis of cell and tissue structure (US No.5719784) PJ Muchowski, JI Clark Non-invasive methods and related compositions for identifying compounds that modify in vivo aggregations of disease-related polypeptides. (US No.20080168569) JG Ghosh, JI Clark Compositions and Methods for Treatment of Protein Misfolding and Protein Aggregation Diseases (US No. 20080227700) JG Ghosh, JI Clark, SA Houck Compositions and Methods for Treatment of Cancer or Neurodegenerative Disease with Peptide Based Microtubule Stabilizers or Inhibitors (US No. 20080280824) Clinical Studies S.Minoshima, TT Shen & JI Clark (2010-12) Help Eliminate Alzheimer’s Disease II (HEAD2) Study: Multidimensional Scalable, Computer Assisted Diagnostic System Using PET, MRI, Slit Lamp Imaging and Non-Imaging Biomarkers for the Diagnosis and Management of Dementia (IRB approved) J.I. Clark, T.D. Lindquist, D. Miller, K.M. Sullivan, R. Storb, J.C. Livesey, R.E. Kalina and P. Burrows (1989-1992) Quantitative study of early stage of cataract formation in humans. G.M. Thurston, J.I. Clark, V.Taret, J. Peetermanns, G.B. Benedek et al., (1990-92) Oculon Corporation FDA approved clinical trial: Use of P.S.I. for protection against lens opacification following vitrectomy surgery. (NOTE: This was the first clinical trial of a non-surgical, anti-cataract treatment approved by the FDA.) Download 160.62 Kb. Share with your friends:
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