Table 7.3 Use of antimalarial drugs for treatment of uncomplicated malaria in travellers (continued) Use in special groups Generic name Dosage regimen Pregnancy Breastfeeding Children Main contraindications a Comments a Quinine 8 mg base/kg 3 times daily for 7 days Safe Safe Safe Hypersensitivity to quinine or quinidine; tinnitus optic neuritis haemolysis; myasthenia gravis. Use with caution in persons with atrial fibrillation, with cardiac conduction defects or heart block. Quinine may enhance effect of cardiosuppressant drugs. Use with caution in persons using beta-blockers, digoxin, calcium channel blockers, etc. In areas of emerging resistance to quinine, give in combination with doxycycline, tetracycline or clindamycin. Quinine may induce hypoglycaemia, particularly in (malnourished) children, pregnant women and patients with severe disease. a See package insert for full information on contraindications and precautions.
