Contrast Mechanisms
Hall 4
Thursday: 13:30 - 15:30
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850.
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Enhanced Sensitivity to Molecular Diffusion with Intermolecular Multiple-Quantum Coherences (iMQCs) and its Potential Applications
Jianhui Zhong1, Wing-Chi Edmund Kwok, Zhong Chen, Scott Kennedy1
1University of Rochester, Rochester, NY, USA.
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851.
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Quantitative Investigation of Optimized RF Flip Angles for Different Intermolecular Multiple-Quantum Coherences
Zhiwei Chen1, Shaokuan Zheng, Zhong Chen, Jianhui Zhong2
1Xiamen University, Xiamen, Fujian, P. R. China; 2University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
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852.
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Quantitation of Transverse Relaxation Time of Intermolecular Multiple-Quantum Coherences
Zhong Chen1, Shaokuan Zheng2, Zhiwei Chen2, Jianhui Zhong1
1University of Rochester, Rochester, NY, USA; 2Xiamen University, Xiamen, Fujian, China.
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853.
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SNR Potential of Intermolecular Double-Quantum Coherence Imaging at High Magnetic Fields
Edward J. Auerbach1, Jianhui Zhong2, Edmund Kwok2, Xiaoping Hu1
1University of Minnesota, Minneapolis, MN, USA; 2University of Rochester, University of Rochester Medical Center, Rochester, NY, USA.
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854.
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Effects of Proton Exchange and Cross-Relaxation on the On-Resonance T1 Relaxation in the Protein Phantoms: Search for the Mechanism of T1 Contrast in Tissue
Heidi Mäkelä1, Olli Gröhn1, Mikko Kettunen1, Risto Kauppinen1
1University of Kuopio, Kuopio, Finland.
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855.
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Vascular Imaging Using T1rho Weighting and Spin-Lock Labeling
Haim Azhari1, Charles A McKenzie2, Robert R. Edelman2
1Technion- Israel Institute of Technology, Technion City, Haifa Israel; 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
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856.
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Examination of Susceptibility Effects by Spin-Locking Technique
Petros Martirosian1, Michael Deimling2, Axel Haase3
1University of Tübingen, Tübingen, Germany; 2Siemens Medical Systems, Erlangen, Germany; 3Insitute of Physics, Würzburg, Germany.
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857.
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True Carr-Purcell Imaging for High Resolution and Novel Contrast
Robert Bartha1, Shalom Michaeli1, Hellmut Merkle1, Gregor Adriany1, Peter Andersen1, Wei Chen1, Kamil Ugurbil1, Michael Garwood1
1The University of Minnesota, Minneapolis, MN, USA.
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858.
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Protein Mediated MT of Small Molecules
Scott D. Swanson1
1University of Michigan, Medical School, Ann Arbor, MI, USA.
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859.
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Serial Investigation of Magnetization Transfer in New Multiple Sclerosis Lesions
Cornelia Laule1, Irene Vavasour1, Alex MacKay1, Kenneth Whittall1, DKB Li1, DW Paty1
1University of British Columbia, Vancouver, BC, Canada.
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860.
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Histogram Analysis of Magnetization Transfer Measurements Reveals Calf-Muscle Abnormalities in Venous Leg Ulcer Patients
Nigel Davies1, Alan Bainbridge1, Matthew Clemence1, William Vennart2
1University of Exeter, Exeter, UK; 2Pfizer Central Research, Sandwich, UK.
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861.
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Rapid Quantitation of Magnetisation Transfer Using Echo Planar Imaging
Damian Tyler1, Penny Gowland1
1University of Nottingham, Nottingham, England, UK.
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862.
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SIR-PGSE: a Two-Dimensional MT-Diffusion Pulse Sequence
Daniel F. Gochberg1, John C. Gore1
1Yale University, New Haven, CT, USA.
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863.
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Impact of Tensile Load on Rabbit Achilles Tendon Characterized by MRI Spatial Differentiation of T1, T2 and ADC Parameters
Jeremy Wellen1, Karl Helmer2, Peter Grigg3, Christopher Sotak2
1Worcester Polytechnic Institute, University of Massachusetts Medical School, Worcester, MA, USA; 2Worcester Polytechnic Institute, Worcester, MA, USA; 3University of Massachusetts Medical School (Worcester), Worcester, MA, USA.
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864.
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Multi-Inversion Technique For Robust T1 Suppression in Conjunction with Blood-Labeled Inflow
Puneet Sharma1, W. Thomas Dixon2, John Oshinski2
1Georgia Institute of Technology, Atlanta, GA, USA; 2Emory University, Atlanta, GA, USA.
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865.
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Magnetization Driven Preparation Scheme for Selective Enhancement of Short T1 Species Suitable for Fast Imaging of Contrast Enhanced Tissue.
Yun Gao1, Erbil Akbudak1, Nikolaos V. Tsekos1
1Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA.
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866.
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A Quantitative Model for Brain Iron Imaging Using R2
Jim M. Wild1, W. R. Wayne Martin2, Peter S. Allen2
1University of Alberta, Sheffield, England, UK; 2University of Alberta, Edmonton, Alberta, Canada.
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867.
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Analysis of Echoes in Missing Pulse Steady State Free Precesssion by Phase Encoding Separation
Ken-Pin Hwang1, Jeffrey L. Duerk1
1Case Western Reserve University / University Hospitals of Cleveland, Cleveland, OH, USA.
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868.
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Water T1 Dispersion is Influenced by Amide Protons at Physiologic pH
A. Goldberg1, U. Duvvuri1, L. Hoang1, S. W. Englander1, Felix Wehrli1, R. Reddy1, J. S. Leigh1
1University of Pennsylvania, Philadelphia, PA, USA.
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New Contrast Agents and Applications
Hall 4
Thursday: 13:30 - 15:30
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869.
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Development of a New MRI Contrast Agent for the Targeting of the Endothelial Leukocyte Adhesion Molecule ELAM-1
Jean-Marie Colet1, Sophie Laurent1, Y. Fu1, Robert Muller1
1University of Mons-Hainaut, Mons, Belgium.
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870.
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Paramagnetic PLGA Microspheres for the Monitoring of Drug Delivery with MRI
Anthony Z. Faranesh1, Cristina Perez de la Cruz1, Michael F. Haller1, Kam W. Leong1, Elliot R. McVeigh2
1The Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA.
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871.
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Detection of Cationic-Polymer-Based Gene Delivery Systems Without Paramagnetic Metals
Nick Goffeney1, Jeff Bulte2, Jeff Duyn2, L. H. Bryant Jr.2, Peter C. Van Zijl1
1Johns Hopkins University, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA.
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872.
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USPIO-Enhanced Dynamic MRI: Evaluation of Normal and Transplanted Rat Kidneys
Dewen Yang1, Qing Ye1, Tom Hu1, Mangay Williams1, Donald Williams1, Chien Ho1
1Carnegie Mellon University, Pittsburgh, PA, USA.
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873.
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Detection and Grading of Acute Transplant Rejection with Magnetic Resonance Imaging using a Blood Pool Contrast Agent in the Rat
Eva Penno1, Lars Johansson1, Atle Bjornerud2, Cecilia Johnsson1, Hakan Ahlstrom1
1Uppsala University Hospital, Uppsala, Sweden; 2Nycomed Imaging AS, Oslo, Norway.
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874.
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Contrast-Enhanced High Resolution MRI of Atherosclerotic Plaque in Watanabe Rabbits
Linda Chaabane1, Philippe Douek2, Francis Contard3, Claire Corot4, Daniel Guerrier3, André Briguet1, Emmanuelle Canet2
1Université Lyon 1, Villeurbanne, France; 2Hôpital Cardiologique, Lyon, France; 3Lipha SA, Lyon, France; 4Laboratoire Guerbet, Paris, France.
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875.
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Influence of Tangential Plasma Flow on Fibrinolysis of Non-occlusive Thrombi: Study by MR Microscopy
Igor Sersa1, Mitja Strukelj2, Ales Blinc2
1Jozef Stefan Institute, Ljubljana, Slovenia; 2University of Ljubljana Medical Center, Ljubljana, Slovenia.
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876.
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T1-weighted Dynamic MRI for Blood Volume Quantification in Rat Liver Tumors Using Sinerem and Resovist
Christiane Poeckler-Schoeniger1, Julian Koepke1, Olaf Gunnar Schueler2, Wolfgang Guenther Schreiber3, Peter Bannasch4, Christoph Dueber1
1Klinikum Mannheim gGmbH, Mannheim, Germany; 2University of Heidelberg, Munich, Bavaria, Germany; 3Johannes Gutenberg-University, Mainz, Germany; 4German Cancer Research Center Heidelberg, Heidelberg, Germany.
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877.
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High Field Trasverse Relaxivity of Dy-complexes: An Example of Limited Transverse Relaxivity by the Water Exchange Rate
Luce L. Vander Elst1, Shanrong Zhang2, A. Sherry2, Robert Muller1
1University of Mons-Hainaut, Mons, Hainaut Belgium; 2University of Texas at Dallas, TX, USA.
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878.
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The Use of Starburst Dendrimers as pH Contrast Agents
Peter C. Van Zijl1, Nick Goffeney1, Jeff Duyn2, L. H. Bryant Jr.2, Jeff Bulte2
1Johns Hopkins University, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA,
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879.
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Tissue Distribution of 153Gd-Labeled Gadoversetamide in Mice
Paul Wedeking1, S. Eaton1, Karen E. Linder1, J. Johnstone1, Michael F. Tweedle1
1Bracco Research USA, Princeton, NJ, USA.
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880.
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Quantitative Analysis of SPIO and USPIO Uptake Rate by Macrophages: Effects of Particle Size, Concentration, and Labeling Time
Xiaowei Zhang1, Chris V. Bowen1, Paula Gareau1, Brian K. Rutt1
1The John P. Robarts Research Institute, London, Ontario, Canada.
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881.
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Synthesis and Relaxometric Analysis of P760, a New Macromolecular Contrast Agent with High Relaxivity and Particular Pharmacokinetic Properties.
Marc Port1, Isabelle Raynal, Luce L. Vander Elst2, Olivier Rousseaux, Christian Simonot, Alexandra Metois, Robert Muller2
1Guerbet, Roissy, France; 2University of Mons-Hainaut, Mons, Belgium.
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882.
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Synthesis, Kinetic Stability, Relaxometry and X-ray Crystal Structures of Cu(II), Mn(II), and Gd(III) 18-Membered Hexaazamacrocyclic Complexes as Potential MR Contrast Agents
L. Henry Bryant, Jr.1, E. Dadachova1, Martin W. Brechbiel1, Joseph Frank1
1National Institutes of Health, Bethesda, MD, USA.
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883.
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Synthesis, Thermodynamic, Water-exchange, Electronic Relaxation and Relaxivity Studies for the Complexation of Gd3+ by TTDA, TTDA-PY, TTDA-HP, TTDA-H1P and TTDA-H2P as Contrast Agents for MRI
Yun-Ming Wang1, Tsann Hwang Cheng Stude1, Gin Chung Liu1, Reu Sheng Sheu1, Twei Shiun Jaw1
1Kaohsiung Medical University, Kaohsiung, Taiwan.
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884.
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Novel Intravascular Macromolecular MR Contrast Agents with Generation-4 Polyamidoamine Dendrimer Core: Accelerated Renal Excretion of with Co-Injection of Lysine
Noriko Sato1, Hisataka Kobayashi1, Satomi Kawamoto2, Tsuneo Saga1, Akira Hiraga3, Takayoshi Ishimori1, Kaori Togashi1, Junji Konishi1, Martin W Brechbiel4
1Kyoto University Graduate School of Medicine, Kyoto, Japan; 2Otsu Municipal Hospital, Otsu, Shiga Japan; 3Kyoto University Hospital, Kyoto Japan; 4National Institutes of Health, Bethesda, MD, USA.
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885.
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Positive Effects of Polyethylene Glycol Conjugation to Generation-4 Polyamidoamine Dendrimers Employed as Macromolecular MR Contrast Agents
Hisataka Kobayashi1, Satomi Kawamoto2, Tsuneo Saga1, Noriko Sato1, Akira Hiraga3, Takayoshi Ishimori1, Tabassum Laz Haque1, Junji Konishi1, Kaori Togashi1, Martin W. Brechbiel4
1Kyoto University, Graduate School of Medicine, Kyoto, Japan; 2Otsu Municipal Hospital, Otsu, Shiga Japan; 3Kyoto University Hospital, Kyoto Japan; 4National Institutes of Health, Bethesda, MD, USA.
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886.
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Enumeration of Diamagnetic and Paramagnetic Liposomes by Multinuclear NMR and Photon Correlation Spectroscopy
Luce L. Vander Elst1, C. Piérart1, S. Fossheim2, J. C. Raux1, A. Roch1, Robert Muller1
1University of Mons-Hainaut, Mons, Hainaut, Belgium; 2School of Pharmacy, Oslo, Norway.
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887.
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Comparison of Vascular Permeability Between Ischemic Tissue and Tissue Over Expressing VEGF Using High Relaxivity Polymerized Vesicles as MR Contrast Agents
Samira Guccione1, Yi-Shan Yang1, Matthew L. Springer1, Helen M. Blau1, King C. Li1, Mark Bednarski1
1Stanford University, Stanford, CA, USA.
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888.
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Safety Assessment of Gadobenate Dimeglumine (MultiHance®): Extended Clinical Experience from Phase II Studies to Post-Marketing Surveillance
Miles Andrew Kirchin1, Pirovano Gianpaolo2
1Medical & Regulatory Affairs, Milan, Italy; 2Bracco Diagnostics Inc., Princeton, NJ, USA.
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889.
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Approval Status of MR Contrast Media World-Wide
Val M. Runge1, Michael V. Knopp2
1University of Kentucky, Lexington, KY, USA; 2The German Cancer Research Center (dkfz), Heidelberg, Germany.
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