MR Spectroscopy: Animal and Cell Studies
Hall 4
Wednesday: 13:30 - 15:30
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1036.
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Effect of Fasting on 2H-Enrichment Levels of Rat Plasma Glucose as measured by 2H NMR Spectroscopy Following Infusion of 2H2O.
JG Jones1, Dean Sherry1, Craig R. Malloy1
1University of Texas Southwestern Medical Center at Dallas, Southwestern Medical School, Dallas, TX, USA.
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1037.
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The Effects of Intestinal Ischaemia and Reperfusion on Neonatal Liver Metabolites: In Vitro 1H Magnetic Resonance Spectroscopic Study
S. B. Williams1, S. R. Williams2, Agostino Pierro1
1University College London, Institute of Child Health, London, UK; 2University of Manchester, Manchester, England.
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1038.
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Value of MR and 31P MRS in the Evaluation of Experimental Testicular Trauma
M. Srinivas1, Mahaveer Degaonkar1, V. V.S.S. Chandrasekharam1, N. R. Jagannathan1, D. K. Gupta1, D. K. Mitra1
1All India Institute of Medical Sciences, New Delhi, India.
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1039.
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Rosiglitazone Reduces Liver Lipid in Zucker Rat: A 1H MRS Study
Paul D Hockings1, Kumar K Changani1, Alan White1, David G Reid1, C Nigel Toseland1, Jeffrey M Birmingham1, Janette A Osborne1, David Templeton1, Robin E Buckingham1
1SmithKline Beecham Pharmaceuticals, Welwyn, UK.
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1040.
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Metabolic Perturbations in Glucose Perfused Rat Hearts with and without Insulin: A 13C-NMR Study of Aspartate Synthesis Induced by a Sudden Suppression of Insulin
Son Tran-Dinh1, J. A. Hoerter2, P. Mateo2, M. Herve1
1SBPM/DBCM, CEN-Saclay, Gif-sur-Yvette, France; 2Universite Paris Sud, Paris, France.
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1041.
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Ethanol Perfusion Increases Efficiency of Oxidative Phosphorylation in Isolated Liver of Fed Rats
Pierre Tissier1, M. C. Delmas-Beauvieux1, P. Couzigou2, H. Gin1, P. Canioni1, J. L. Gallis1
1RMSB UMR, Bordeaux, France; 2Hopital Haut-Leveque, Pessac, France.
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1042.
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31P and 23Na NMR Spectroscopy Demonstrate Glyburide Effects on Bioenergetics and Na+ Transport in Pancreatic Beta-HC9 Cells
Nicolai Doliba1, Marko Vatamaniuk1, Carol Buettger1, Heather Collins1, Wei Qin1, Suzanne Wehrli2, Franz Matschinsky1
1University of Pennsylvania, School of Medicine, Philadelphia, PA, USA; 2Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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1043.
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Role of Substrate Selection and Intracellular Compartmentation for the Metabolic Trafficking between Astrocytes and Neurons
Claudia Zwingmann1, Christiane Richter-Landsberg2, Roger Frank Butterworth3, Dieter Leibfritz4
1University of Bremen and Hospital Saint-Luc, University of Montreal, Bremen, Germany; 2University of Oldenburg, Oldenburg, Germany; 3Hospital Saint-Luc, University of Montreal, Montreal, Canada; 4University of Bremen, Bremen, Germany.
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1044.
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High Glucose Levels do not Stimulate TCA Cycle Flux in bHC9 Insulinomas Detected with 13C NMR
Anthony Mancuso1, Christophe Desbarats1, Susanne Wehrli2, Franz M Matschinsky1, Jerry Glickson1
1University of Pennsylvania, Philadelphia, PA, USA; 2Children's Hospital of Pennsylvania, Philadelphia, PA, USA.
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1045.
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A Comparison of 87Rb+ and 133Cs+ transport in Perfused Rat Heart
Paul A. Schornack1, Joseph J.H. Ackerman2
1University of Arizona, Arizona Health Sciences Center, Tucson, AZ, USA; 2Washington University, School of Medicine, St. Louis, MO, USA.
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MR Spectroscopy: Human Body and Other
Hall 4
Wednesday: 13:30 - 15:30
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1046.
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Proton Magnetic Resonance Spectroscopy for Assessment of Human Body Composition
Masayuki Kamba1, Wei Chen1, Koji Kimura2, Masahiko Koda2, Toshihide Ogawa2
1University of Minnesota, Minneapolis, MN, USA; 2Tottori University Faculty of Medicine, Nishi-machi, Yonago, Japan.
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1047.
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Short Acquisition Time 2D COSY Localised in Human Bone Marrow
Andrew P Prescot1, David J Collins1, Andrzej Dzik-Jurasz1, Martin O Leach1
1Royal Marsden Hospital, Sutton, Surrey, England, UK.
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1048.
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The Use of in Vivo 31P Magnetic Resonance Spectroscopy for the Evaluation of Age Related Effects in Human Skin
Francis Vial1, Sébastien Savard1, Lieve Declercq2, Fabrice Perin3, Patrick Beau3, Daniel Maes2
1INSERM-FRANCE, Faculté de Médecine, Tours, France; 2Estee Lauder Coordination Center, Belgium; 3Spincontrol Society, Tours, France.
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1049.
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Effect of Oral D-tagatose on Liver Volume and Hepatic Glycogen Accumulation in Healthy Male Volunteers
Chris Boesch1, Michael Ith1, Bruno Jung1, Karin Bruegger1, Sidona Erban1, Ioannis Diamantis2, Roland Kreis1, Albert Bär3
1University & Inselspital, Bern, Switzerland; 2Inselspital, Bern, Switzerland; 3Bioresco Ltd., Basel, Switzerland.
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1050.
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31P-MR Spectroscopy of the Human Kidney Graft by 2D-CSI Sequence. Preliminary Clinical Results.
Pavlina Harantova1, Monika Dezortova2, Zdenek Tosner2, Jiri Lacha2, Petr Taborsky2, Milan Hajek2
1Institut of Clinical and Experimental Medicine, Prague, Czech Republic; 2IKEM, Czech Republic.
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1051.
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Heterogeneity of Normal Breast Investigated by In Vivo MR Spectroscopy: Determination of W/F Ratios and T1 Relaxation Times
Mahesh Kumar1, N. R. Jagannathan1
1All India Institute of Medical Sciences, New Dehli, India.
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1052.
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High Resolution 1H NMR Study of Hepatic Bile from Donors and Recipients in Human Liver Transplantation
H. G. Parkes1, H. V. Melendez2, M. Rela2, G. M. Murphy3, N. D. Heaton2
1Institute of Child Health, University College London, London, England, UK; 2King's College Hospital, London, England, UK; 3King's College London, Guy's, King's and St. Thomas's School of Medicine, London, England, UK.
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1053.
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Measurement of the Astrocytic TCA Cycle Flux in Humans Using 13C Labeled Acetate
Vincent Lebon1, Kitt F. Petersen1, Gary W. Cline1, Jun Shen2, Graeme F. Mason1, Sylvie Dufour1, Kevin L. Behar1, Gerald I. Shulman1, Douglas L. Rothman1
1Yale University, School of Medicine, New Haven, CT, USA; 2Nathan S. Kline Institute, Orangeburg, NY, USA.
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1054.
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Assessment of Cerebral Acetate Oxidation and Glial Metabolism in Human Brain by 13C MRS
Stefan Bluml1, Angel Moreno-Torres1, Brian Ross2
1Rudi Schulte Research Institute, Santa Barbara, CA, USA; 2Huntington Medical Research Institutes, Pasadena, CA, USA.
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1055.
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The Effects of Moderate Hypothermia on Intestinal Ischaemia-Reperfusion: High Resolution 1H and 31P Magnetic Resonance Spectroscopy Study
Paisarn Vejchapipat1, Stephen R. Williams2, Edward Proctor1, Lewis Spitz1, Agostino Pierro1
1Institute of Child Health, University College London, London, UK; 2University of Manchester, Manchester, UK.
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Cardiovascular MR Spectroscopy
Hall 4
Wednesday: 13:30 - 15:30
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1056.
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NMR and Biomechanical Characteristics of Normal and Aneurysm Aortas: In Vitro Study
Simeon Ivanov Petkov1, Philippe Vinee2
1Technical University og Gabrovo, Gabrovo, Bulgaria; 2Centre d’Imagerie Médicale, Selestat, France.
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1057.
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Singlet Oxygen Energy effect in a Hamster to Rat Heart Xenotransplantation Model, Measured by In Vivo 31P NMR Spectroscopy
Ann Lindgård1, Olivier Rakotonirainy, Jacob Wilton, Andreas Lundgren, Daniel Lukes, M Olausson, Bassam Soussi
1Wallenberg Laboratory, Sahlgrenska Hospital, Gothenburg, Sweden.
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1058.
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Cellular Glucose Uptake in the Isolated Rat Heart is not Altered in Heart Failure due to Chronic Coronary Ligation
Jens Höning1, Lisa Bauer1, Michael Horn1
1Medizinische Klinik, Würzburg, Germany.
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1059.
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Susceptibility to Ischemia/Reperfusion Injury is not Increased in Rat Hearts post Myocardial Infarction
Michael Horn1, Stephanie Hügel1, Kai Hu1, Stefan Neubauer2
1Medizinische Universitaetsklinik, Wuerzburg, Germany; 2John Radcliffe Hospital, Oxford, UK.
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1060.
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Influence of Ischemic Preconditioning on Intracellular Sodium and pH in Isolated Perfused Heart
Andriy Babsky1, Shahryar K. Hekmatyar1, Suzanne Wehrli2, Mary Osbakken3, Navin Bansal1
1University of Pennsylvania, Philadelphia, PA, USA; 2Children's Hospital, Philadelphia, PA, USA; 3Aventis, Bridgewater, NJ, USA.
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1061.
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Ischemic Blockade of the Cardiac Na+/H+-Exchanger: A Simultaneous 23Na and 31P Study
Michiel Ten Hove1, Jan G. Van Emous1, Cees J.A. Van Echteld1
1ICIN and University Medical Center, Utrecht, The Netherlands.
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1062.
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Intracellular Na Concentration in a Rodent Heart during Multiple Dose Cardioplegia. Effects of Oxygen and Carbon Dioxide
Victor D. Schepkin1, William M. DeCampli2, Isaac O. Choy3
1University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2Children's Hospital of New Jersey, Newark, NJ, USA; 3University of California at San Francisco, San Francisco, CA, USA.
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1063.
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Effects of Energy Deprivation on Sarcolemmal and Mitochondrial Potassium Fluxes in Rat Hearts: 87Rb and 31P NMR study.
Olga Jilkina1, Bozena Kuzio2, Valerie Kupriyanov2
1University of Manitoba, Winnipeg, MB, Canada; 2National Research Council, Winnipeg, MB, Canada.
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1064.
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Myocardial Substrate Oxidation During Cardioplegic Arrest With Potassium Chloride or Tetrodotoxin
Timothy T. Hamilton1, Paul E. Meyer1, M. Peter Tauriainen1, Robert Y. Chao1, Michael E. Jessen1
1University of Texas Southwestern Medical Center, Dallas, TX, USA.
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1065.
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Effects of Magnesium on Myocardial Energy Metabolism: Assessment in Dahl Salt- Sensitive Rats by 31P NMR
Kunio Tanaka1, Nobuyuki Akita1, Mitsutosi Kusakabe1, Takashi Haneda1, Kenjirou Kikuchi1
1Asahikawa Medical College, Asahikawa, Japan.
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1066.
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The Effects of NHE Inhibition in a Canine Cardiac Ischemia/Reperfusion Model: A MRI/MRS Study
Kerry Thompson1, R. Terry Thompson1, Jane Sykes1, Gerald Wisenberg1
1University of Western Ontario, London, ON, Canada.
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1067.
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Variability and Reproducibility of Quantitative 31P NMR Spectroscopy of the Human Heart
Michael Bunse1, Oliver Schmidt1, Otto Lutz2, Günther J. Dietze1, Wulf-Ingo Jung1
1Max Grundig Clinic, Bühl, Germany; 2Physikalisches Institut der Universität Tübingen, Tübingen, Germany.
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1068.
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Increased Phosphocreatine Depletion in Early Exercise in the Marfan Syndrome: A Clinical Model of Endothelial Dysfunction
Jenifer Crilley1, E.A. Boehm1, David Bendahan1, Balasubramanian Rajagopalan2, Peter Styles1, Wordsworth P3, Kieran Clarke1
1University of Oxford, Oxford, England, UK; 2Dept. of Radiological Sciences, Oklahoma City, OK, USA; 3Nuffield Orthopaedic Centre, Oxford, England, UK.
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