Serkova N: Effects of immunosuppressive drugs on cell metabolism of neuronal and gill cell lines by multinuclear magnetic resonance spectroscopy (German). ISBN 3-8265-2124-2, Shaker Verlag, Aachen, 1997.
Serkova NJ and Glunde K: “Metabolomics in cancer” in Tumor Biomarker Discovery series Methods in Molecular Biology, ISBN 978-1-60327-810-2, Springer, 2009.
Serkova NJ, Hasebroock KM, Kraft SL: “Magnetic resonance spectroscopy of living tissues” in Tumor Biomarker Discovery series Methods in Molecular Biology, ISBN 978-1-60327-810-2, Springer, 2009.
Boyes SG, Rowe MD, Chang CC, Thamm DH, Kraft SL, Harmon JF, Serkova NJ, Vogt AP, Sumerlin BS: “Surface modification of positive contrast nanoparticle agents with RAFT polymers towards the targeted imaging and treatment of cancer” in Polymeric Delivery of Therapeutics (by S. Morgan and R. Lochhead), ISBN13: 978-084-122-5831, Oxford University Press, 2011.
Peer-Reviewed Articles
B. Selected peer-reviewed publications (total 97):
Flögel U, Niendorf T, Serkowa N, Brand A, Henke J, Leibfritz D: Change in organic solutes, volume, energy state, and metabolism associated with osmotic stress in glial cell line: A multinuclear NMR study. Neurochem Res20: 793-802, 1995 [PMID 7477672]
Serkova N, Brand A, Christians U, Leibfritz D: Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy. Biochim Biophys Acta 1314: 93-104, 1996 [PMID 8972722].
Serkova N, Christians U, Flögel U, Pfeuffer J, Leibfritz D: Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear magnetic resonance (NMR) spectroscopy. Chem Res Toxicol 10: 1359-1363, 1997 [PMID 9437526].
Serkova N, Litt L, James TL, Sadee W, Leibfritz D, Benet LZ, Christians U: Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther289: 800-806, 1999 [PMID 10215655].
Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE: Combined immunosuppression with cyclosporine (NeoralR) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation69: 76-86, 2000 [PMID 10653384].
Hausen B, Gummert J, Berry GJ, Christians U, Serkova N, Ikonen T, Hook L, Legay F, Schuler W, Schreier MH, Morris RE: Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: Induction with chimeric anti-IL-2 receptor monoclonal antibody improves the tolerability and potencies the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin. Transplantation69: 488-496, 2000 [PMID 10708100].
Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U: The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol 129: 485-492, 2000 [PMID 10711346].
Serkova N, Hausen B, Jacobsen W, Berry GJ, Morris RE, Benet LZ, Christians U: Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD in primate lung transplant recipients: Interaction with cyclosporine. J Pharmacol Exp Ther294: 323-332, 2000 [PMID 10871329].
Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI: Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry: Immunosuppressants. J Chromatogr B Biomed Sci Appl748: 41-53, 2000 [PMID 11092585].
Ikonen TS, Gummert JF, Serkova N, Hayase M, Honda Y, Kobayase Y, Hauser B, Yock PG, Christians U, Morris RE: Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening. Transpl Int 13: 314-320, 2000 [PMID 11112022].
Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U: Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc 33: 514-515, 2001 [PMID 11266932].
Serkova N, Jacobsen W, Niemann CU, Benet LZ, Leibfritz D, Christians U: Sirolimus, but not structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol133: 875-885, 2001 [PMID 11454661].
Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U: Comparison of the effects of cyclosporine A on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab 22: 342-352, 2002 [PMID 11891440].
Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N: Close association between the reduction in myocardial energy metabolism and infarct size: dose response assessment of cyclosporine. J Pharmacol Exp Ther302: 1123-1128, 2002 [PMID 12183671].
Niemann CU, Stabernack D, Serkova N, Jacobsen W, Christians U, Eger EI: Cyclosporine can increase isoflurane MAC. Anesth Analg95: 930-934, 2002 [PMID 12351270].
Serkova N, Bendrick-Peart J, Alexander B, Tissot van Patot MC: Metabolite concentrations in human term placentae and their changes due to delayed collection after delivery. Placenta 24: 227-235, 2003 [PMID 12566250].
Serkova N, Klawitter J, Niemann CU: Organ-specific metabolic response to cyclosporine treatment in rat liver, kidney and heart. Transplant Int16: 748-755, 2003 [PMID 12827232].
Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, Jeevanandam V, Christians U, Serkova N: Single dose of glutamine preserves myocardial tissue metabolism, glutathione content, and enhances myocardial function following ischemia-reperfusion injury. J Parenter Enternal Nutr 27: 396-403, 2003 [PMID 14621120].
Fuller TF, Freise CE, Serkova N, Niemann CU, Olson JL, Feng S: Sirolimus delays recovery of rat kidney transplants after ischemia/ reperfusion injury. Transplantation 76: 1594-1599, 2003 [PMID 14702530].
Serkova N and Christians U: Transplantation: Toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides. A review. Curr Opinion Invest Drugs4: 1287-1296, 2003 [PMID 14758767].
Fuller TF, Serkova N, Niemann CU, Freise CE: Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts. J Urol171: 1296-1300, 2004 [PMID 14767336].
Serkova NJ, Christians U, Benet LZ: Biochemical mechanisms of cyclosporine neurotoxicity. A review. Mol Interv 4: 97-107, 2004 [PMID 15087483].
Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L: Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 287: 525-532, 2004 [PMID 15132953].
Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N: Alterations in glucose metabolism by cyclosporine link to oxidative stress in rat brain slices: interactions with mTOR inhibitors. Br J Pharmacol143: 388-396, 2004 [PMID 15339861].
Gottschalk S, Anderson N, Hainz C, Eckhardt SG, Serkova NJ: Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL positive cells. Clin Cancer Res10: 6661-6668, 2004 [PMID 15475456].
Boros LG, Serkova NJ, Cascante MS, Lee WNP: Use of metabolic pathway flux information in targeted cancer drug design: A review. Drug Discov Today1: 435-443, 2004.
Serkova N, Fuller TF, Klawitter J, Freise CE, Niemann CU: 1H-NMR-based metabolic signatures of mild and severe ischemia/ reperfusion injury in rat kidney transplants. Kidney Int67: 1142-1151, 2005 [PMID 15698456].
Singleton KD, Serkova N, Banerjee A, Meng X, Gamboni-Robertson F, Wischmeyer PE: Glutamine attenuates endotoxin-induced lung metabolic dysfunction: Potential role of enhanced heat shock protein 70. Nutrition 21: 214-223, 2005 [PMID 15723751].
Singleton KD, Serkova N, Beckey VE, Wischmeyer PE: Glutamine attenuates lung injury and improves survival following sepsis: Role of enhanced heat shock protein expression. Crit Care Med33: 1206-1213, 2005 [PMID 15942332].
Serkova N and Boros LG: Detection of resistance to imatinib by metabolic profiling: Clinical and drug development implication: A review. Am J Pharmacogenomics 5: 293-302, 2005 [PMID 16196499].
Niemann CU, Hirose R, Liu T, Behrends M, Brown JL, Kominsky D, Roberts JP, Serkova N: Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers. Anesth Analg101: 1577-1583, 2005 [PMID 16301222].
Serkova N and Christians U: Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood. Ther Drug Monit27: 733-737, 2005 [PMID 16404806].
Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, Roberts JP, Maher JJ, Niemann CU: Metabolic profiling of livers and blood from obese Zucker rats. J Hepatol 44: 956-962, 2006 [PMID 16223541].
Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH, Niemann CU: Mild hypothermia reduces the inflammatory response and hepatic ischemia/ reperfusion injury in rats. Liver Int 26: 734-741, 2006 {PMID 16842331].
Peng ZY, Serkova NJ, Kominsky DJ, Brown JL, Wischmeyer PE: Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death following injury is dependent on heat shock factor-1 expression. J Parenter Enteral Nutr 30: 373-378, 2006 [PMID 16931604].
Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ: Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Surgery 140: 404-412, 2006 [PMID 16934602].
Serkova NJ and Niemann CU: Pattern recognition and biomarker validation using quantitative 1H-NMR based metabolomics: A review. Expert Rev Mol Diagn 6: 717-731, 2006 [PMID 17009906].
Glunde K and Serkova NJ: Therapeutic targets and surrogate markers in choline phospholipid metabolism in cancer: A review. Pharmacogenomics 7: 1109-1123, 2006 [PMID 17054420].
Park Y, Hirose R, Coatney JL, Ferell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU: The effect of aging on warm ischemia reperfusion injury in the rat liver. J Surg Res137: 96-102, 2007 [PMID 17064732].
Rudolph MC, McManaman JL, Phang TL, Anderson SM, Russell T, Kominsky DJ, Serkova NJ, Neville MC: Metabolic regulation in the lactating mouse: A milk lipid synthesizing machine. Physiol Genomics 28: 323-326, 2007 [PMID 17105756].
Serkova NJ, Zhang Y, Coatney JL, Hunter L, Wachs M, Niemann CU, Mandell SM: Early detection of graft failure using the blood metabolic profile of a liver recipient. Transplantation 83: 517-521, 2007 [PMID 17318087].
Serkova NJ, Rose JC, Epperson LE, Carey HV, Martin SL: Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR. Physiol Genomics31: 15-24, 2007 [PMID 17536023].
Niemann CU and Serkova NJ: Biochemical mechanisms of nephrotoxicity: Application for metabolomics: A review. Exp Opin Drug Metab Toxicol 3: 527-544, 2007 [PMID 17696804].
Troiani T, Serkova NJ, Gustafson DL, Henthorn TK, Lockerbie O, Merz A, Long M, Morrow M, Ciardiello F, Eckhardt SG: Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signaling, in combination with irinotecan in human colon cancer xenograft model. Clin Cancer Res 13: 6450-6458, 2007 [PMID 17975157].
Khan SR, Herman J, Krank J, Serkova NJ, Churchill MEA, Suga H, Farrand SK: PhzR, the quorum-sensing regulator of phenazine gene expression in Pseudomonas chlororaphis strain 30-84 responds to N-(3-hydroxy-hexanoyl)-L-homoserine lactone and N-hexanoyl)-L-homoserine lactone with equal sensitivity. Appl Environ Micribiol73: 7443-7455, 2007 [PMID 17921283].
Serkova NJ, Spratlin JL, Eckhardt SG: NMR-based metabolomics: Translational application and treatment of cancer: A review. Curr Opin Mol Ther 9: 572-585, 2007 [PMID 18041668].
Serkova NJ, Reisdorph NA, Tissot van Patot MC: Metabolic markers of hypoxia: Systems biology application in biomedicine. Toxicol Mech Methods 18: 81-95, 2008 [20020894].
Serkova NJ, Gamito EJ, Jones RH, O’Donnell C, Brown JL, Green S, Sullivan H, Hedlund T, Crawford ED: The metabolites citrate, myo-inositol, and spermine are potential age-dependent markers of prostate cancer in human expressed prostatic secretions. Prostate 68: 620-628, 2008 [PMID 18213632].
Serkova NJ, Van Rheen Z, Tobias M, Pitzer J, Wilkinson JE, Stringer KA: Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for the quantification of inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol 295: L152-L161, 2008 [PMID 18441091].
Larsen BA, Haag MA, Serkova NJ, Shroyer KR, Stoldt CR: Controlled aggregation of superparamagnetic iron oxide nanoparticles for the development of molecular magnetic resonance imaging probes. Nanotechnology19: 265-271, 2008 [PMID 21828671].
Young CD, Nolte E, Lewis A, Serkova NJ, Anderson SM: Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumorigenesis inc mice without activation of ErbB3. Breast Cancer Res 10: R70, 2008 [PMID 18700973].
Lam ET, O’Bryant CL, Basche M, Gustafson DL, Serkova N, Baron A, Holden S, Dancey J, Eckhardt SG, Gore L: A phase I study of gefitinib, capecitabine, and celexocib in patients with advanced solid tumors. Mol Cancer Ther 7: 3685-3694, 2008 [PMID 19074845].
Serkova NJ, Freud AS, Brown JL, Kominsky DJ: Use of the 1-mm TXI micro-probe for metabolic analysis on small volume biological samples. J Cell Mol Med 13: 1933-1941, 2009 [PMID 19267884].
Frey LC, Hellier J, Unkart C, Lepkin A, Hasebroock K, Serkova N, Liang LP, Patel M, Soltesz I, Staley K: A novel apparatus for lateral fluid percussion injury in the rat. J Neurosci Methods 177: 267-272, 2009 [PMID 19022291].
Spratlin JL, Serkova NJ, Eckhardt SG: Clinical application of metabolomics in oncology: a review. Clin Cancer Res 15: 431-440, 2009[PMID 19147747].
Serkova NJ, Garg K, Bradshaw-Pierce EL: Oncologic imaging endpoints for the assessment of therapy response. Recent Pat Anticancer Drug Discov4: 36-53, 2009 [PMID 19149687].
Klawitter J, Anderson N, Klawitter J, Christians U, Leibfritz D, Eckhardt SG, Serkova NJ: Time-dependent effects of imatinib in human leukaemia cells: A kinetic NMR-profiling study. Br J Cancer 100: 923-931, 2009 [PMID 19259085].
Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DJ, Roach RC, Sheen P, Christians U, Henthorn TK, Honigman B: Enhanced leukocyte HIF-1alpha and HIF-1 DNA-binding in humans following rapid ascent to 4300 m. Free Radic Biol Med 46: 1551-1557, 2009[PMID 19303436].
Raina K, Serkova NJ, Agarwal R: Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study (Priority Report). Cancer Res 69: 3731-3735, 2009[PMID 19366793].
Hasebroock KM, Serkova NJ: Toxicity of MRI and CT contrast agents. Expert Opin Drug Metab Toxicol 5: 403-416, 2009[PMID 19368492].
Serkova NJ, Hasebroock KM, Kraft SL: Magnetic resonance spectroscopy of living tissues. Methods Mol Biol 520: 315-327, 2009 [PMID 19381964].
Kominsky DJ, Klawitter J, Brown JL, Boros LG, Melo JV, Eckhardt SG, Serkova NJ: Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL positive cells. Clin Cancer Res15: 3442-3450, 2009 [PMID 19401345].
Klawitter J, Zhang YL, Klawitter J, Anderson N, Serkova NJ, Christians U: Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture. Biomed Chromatogr 23: 1251-1258, 2009 [PMID 19517424].
Klawitter J, Kominsky DJ, Brown JL, Klawitter J, Christians U, Leibfritz D, Melo JV, Eckhardt SG, Serkova NJ: Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells. Br J Pharmacol 158: 588-600, 2009 [PMID 19663881].
Tissot van Patot MC, Murray AJ, Beckey V, Cindrova-Davies T, Johns J, Zwerdlinger L, Jauniaux ER, Burton GJ, Serkova NJ: Human placental adaptation to chronic hypoxia, high altitude: Hypoxic pre-conditioning. Am J Physiol Regul Integr Comp Physiol 298: R166-172, 2010 [PMID 19864339].
Merz AL and Serkova NJ: Use of NMR-based metabolomics in detecting drug resistance in cancer. Biomark Med 3: 289-306, 2009 [PMID 20160999].
Spratlin JL, Cohen RB, Eadens M, Gore L, Camidge DR, Diab S, Leong S, O’Bryant C, Chow LQ, Serkova NJ, Meropol NJ, Lewis NL, Chiorean EG, Fox F, Youssoufian H, Rowinsky EK, Eckhardt SG: Phase I pharmacologic and biologic study of Ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 28: 780-787, 2010 [PMID 20048182].
Klawitter J, Gottschalk S, Hainz C, Leibfritz D, Christians U, Serkova NJ: Immunosuppressant neurotoxicity in rat brain models: Oxidative stress and cellular metabolism. Chem Res Tox 23: 608-619, 2010 [PMID 20148532].
Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM: Renal inflammation: Targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology255: 517-526, 2010 [PMID 20332377].
Editorial: Mahmood U: Science to practice: can a targeted nanoparticle be used to image autoimmune nephritis? Radiology 255: 309-310, 2010 [PMID 20413745].
Doctor RB, Serkova NJ, Hasebroock KM, Zafar I, Edelstein CL: Distinct patterns of kidney and liver cyst growth in pkd2(WS25-/-) mice. Nephrol Dial Transplant 25: 3496-3504, 2010 [PMID 20388629].
Tentler JJ, Bradshaw-Pierce EL, Serkova NJ, Hasebroock KM, Pitts TM, Diamond JR, Fletcher GC, Bray MR, Eckhardt SG: Assessment of the in vivo antitumor effects of ENMD-2076, a novel multitargeted kinase inhibitor, against primary and cell line-derived human colorectal cancer xenograft models. Clin Cancer Res 16: 2989-2998, 2010 [PMID 20406842].
Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez S, Liu T, Serkova NJ, Niemann CU: Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats. J Gastroenterol 45: 1103-1110, 2010 [PMID 20549254].
Cohen MJ, Serkova NJ,Wiener-Kronish J, Pittet JF, Niemann CU: 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients – beyond lactate and base deficit. J Trauma 69: 31-40, 2010 [PMID 20622576].
Boyes SG, Rowe MD, Serkova NJ, Kim FJ, Lambert JR, Werahera PN: Polymer-modified gadolinium nanoparticles for targeted magnetic resonance imaging and therapy. NanoLife1: 263-275, 2010.
Stringer KA, Serkova NJ, Karnovsky A, Guire K, Paine R III, Standiford TJ: Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol 300: L4-L11, 2011 [PMID 20889676].
Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Serkova NJ, Niemann CU: Donor-pretreatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model. Nephrol Dial Transplant 26: 1813-1820, 2011 [PMID 21068143].
Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ: Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology 32: 50-57, 2011 [PMID 21075140].
Ramasamy K, Nield L, Serkova NJ, Hasebroock KM, Tyagi A, Raina K, Singh RP, Malkinson AM, Agarwal R: Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: Potential of real-time microCT in lung cancer chemoprevention studies. Clin Cancer Res 17: 753-761, 2011 [PMID 21148748].
Hatakeyama WM, Sanchez TJ, Rowe MD, Serkova NJ, Liberatore MW, Boyes SG: Synthesis of gadolinium nanoscale metal-organic framework with hydrotropes: Manipulation of particle size and magnetic resonance imaging capability. ACS Appl Mater Interfaces3: 1502-1510, 2011 [PMID 21456529].
Spratlin JL, Pitts TM, Kulikowski GN, Morelli MP, Tentler JJ, Serkova NJ, Eckhardt SG: Synergistic results of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines. Anticancer Res31: 1093-1103, 2011 [PMID 21508352].
Serkova NJ: Translational imaging endpoints to predict treatment response to novel targeted anticancer agents. Drug Resist Updat14: 224-235, 2011 [PMID 21640633].
