P. knowlesi On microscopy examination, the mature forms of P. knowlesimay be mistaken for P. malariae, while its ring forms may resemble P. falciparum. Knowlesi malaria can be treated with a standard regimen of chloroquine or with the antimalarials recommended for uncomplicated falciparum malaria. The clinical condition of patients infected with P. knowlesi may deteriorate quickly. Severe P. knowlesi malaria with organ failure may occur treatment should be as for severe falciparum malaria. P. knowlesi infection should always be considered inpatients with a microscopy diagnosis of P. malariae and a history of travel to forested areas of southeast Asia, including areas where malaria is not normally present. The dosage regimens for the treatment of uncomplicated malaria are given in Table 7.3. Details of the clinical management of severe malaria are addressed in other WHO publications (see Further reading at the end of this chapter.
