Personal Research Database Bibliometric

Full Text: 2013\Wor J Gas19, 5565.pdf

Abstract: AIM: To perform a meta-analysis of palliative stent placement vs palliative surgical decompression for management of incurable malignant colorectal obstructions. METHODS: the databases of MEDLINE, Web of Science, Embase, and the Cochrane Central Register of Controlled Trials were searched from their inception to July 2012 for studies (prospective, retrospective, randomized controlled trials, and case-control trials) designed as comparative analyses of patients with incurable malignant colorectal obstructions treated by self-expanding metallic stents (SEMS) or palliative surgery. No language restrictions were imposed. The main outcome measures were hospital stay, intensive care unit admission, clinical success rate, 30-d mortality, stoma formation, complications, and overall survival time. The data extraction was conducted by two investigators working independently and using a standardized form. The Mantel-Haenszel. 2 method was used to estimate the pooled risk ratios with 95% CI under a fixed-effects model; when statistical heterogeneity existed in the pooled data (as evaluated by Q test and I-2 statistics, where P < 0.10 and I-2 < 25% indicated heterogeneity), a random-effects model was used. RESULTS: Thirteen relevant articles, representing 837 patients (SEMS group, n = 404; surgery group, n = 433), were selected for analysis. Compared to the surgery group, the SEMS group showed lower clinical success (99.8% vs 93.1%, P = 0.0009) but shorter durations of hospital stay (18.84 d vs 9.55 d, P < 0.00001) and time to initiation of chemotherapy (33.36 d vs 15.53 d, P < 0.00001), and lower rate of stoma formation (54.0% vs 12.7%, P < 0.00001). Additionally, the SEMS group experienced a significantly lower rate of 30-d mortality (4.2% vs 10.5%, P = 0.01). Stent-related complications were not uncommon and included perforation (10.1%), migration (9.2%), and occlusion (18.3%). Surgery-related complications were slightly less common and included wound infection (5.0%) and anastomotic leak (4.7%). The rate of total complications was similar between these two groups (SEMS: 34.0% vs surgery: 38.1%, P = 0.60), but the surgeryrelated complications occurred earlier than stent-related complications (rate of early complications: 33.7% vs 13.7%, P = 0.03; rate of late complications: 32.3% vs 12.7%, P < 0.0001). The overall survival time of SEMS-and surgery-treated patients was not significantly different (7.64 mo vs 7.88 mo). CONCLUSION: SEMS is less effective than surgery for palliation of incurable malignant colorectal obstructions, but is associated with a shorter time to chemotherapy and lower 30-d mortality. (C) 2013 Baishideng. All rights reserved.

Keywords: Analyses, Analysis, Care, Case-Control, Chemotherapy, Clinical, Colon-Cancer, Colostomy, Complications, Data, Databases, Emergency-Surgery, Expanding Metallic Stents, Extraction, Fixed Effects Model, Groups, Heterogeneity, Hospital, Hospital Stay, Incurable Malignant Colorectal Obstruction, Infection, Initiation, Intensive Care, Intensive Care Unit, Language, Large-Bowel Obstruction, Large-Bowel Obstruction, Management, MEDLINE, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Migration, Model, Mortality, Occlusion, Outcome, Outcome Measures, P, Palliation, Palliative Surgery, Patients, Placement, Primary Tumor, Prospective, Quality-Of-Life, Random Effects Model, Randomized, Randomized Controlled Trials, Restrictions, Rights, Risk, Safety, Science, Self-Expandable Metal Stents, Sem, Statistics, Stents, Success Rate, Surgery, Survival, Treatment, Treatment Outcomes, Web of Science, Wound, Wound Infection

? Ma, Y.Y., Li, L., Yu, C.H., Shen, Z., Chen, L.H. and Li, Y.M. (2013), Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis. World Journal of Gastroenterology, 19 (40), 6911-6918.

Full Text: 2013\Wor J Gas19, 6911.pdf

Abstract: AIM: To investigate the relationship between the gutliver axis and nonalcoholic fatty liver disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD. METHODS: We searched PubMed, MEDLINE, Embase, Web of Science, the Cochrane Library and Chinese Biomedicine Database for all relevant randomized controlled trials on probiotics in patients with NAFLD/non-alcoholic steatohepatitis (NASH). A statistical analysis was performed using RevMan 5.0 software. RESULTS: Four randomized trials involving 134 NAFLD/NASH patients were included. The results showed that probiotic therapy significantly decreased alanine aminotransferase (ALT), aspartate transaminase (AST), total-cholesterol (T-chol), high density lipoprotein (HDL), tumor necrosis factor (TNF)-alpha and homeostasis model assessment of insulin resistance (HOMAIR) [ALT: weighted mean difference (WMD) -23.71, 95%CI: -33.46-13.95, P < 0.00001; AST: WMD -19.77, 95%CI: -32.55-7.00, P = 0.002; T-chol: WMD -0.28, 95%CI: -0.55-0.01, P = 0.04; HDL: WMD -0.09, 95%CI: -0.16-0.01, P = 0.03; TNF-alpha: WMD -0.32, 95%CI: -0.48-0.17, P < 0.0001; HOMA-IR: WMD -0.46, 95%CI: -0.73-0.19, P = 0.0008]. However, the use of probiotics was not associated with changes in body mass index (BMI), glucose (GLU) and low density lipoprotein (LDL) (BMI: WMD 0.05, 95%CI: -0.18-0.29, P = 0.64; GLU: WMD 0.05, 95%CI: -0.25-0.35, P = 0.76; LDL: WMD -0.38, 95%CI: -0.78-0.02, P = 0.06). CONCLUSION: Probiotic therapies can reduce liver aminotransferases, total-cholesterol, TNF-a and improve insulin resistance in NAFLD patients. Modulation of the gut microbiota represents a new treatment for NAFLD. (C) 2013 Baishideng. All rights reserved.

Keywords: Alanine Aminotransferase, Analysis, Article, Assessment, Biomedicine, Bmi, Body Mass Index, Changes, China, Chinese, Co, Controlled-Trial, Database, Diet, Disease, Effects, Glucose, Gut, Gut Microbiome, Gut Microbiota, Hdl, Hong-Kong, Humans, Increased Intestinal Permeability, Index, Insulin, Insulin Resistance, Insulin-Resistance, Lactobacillus-Acidophilus, Liver, Liver Function, MEDLINE, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Microbiota, Model, Necrosis, Necrosis-Factor-Alpha, No, Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, Obesity, P, Patients, People, Probiotics, Pubmed, R, Randomized, Randomized Controlled Trials, Resistance, Rights, Room, Science, Software, Statistical Analysis, Steatohepatitis Nash, Therapy, TNF Alpha, TNF-Alpha, Treatment, Tumor, Tumor Necrosis Factor, Web of Science, World

? Chen, Y., Duan, Y.T., Xie, Q., Qin, X.P., Chen, B., Xia, L., Zhou, Y., Li, N.N. and Wu, X.T. (2013), Magnetic endoscopic imaging vs standard colonoscopy: Meta-analysis of randomized controlled trials. World Journal of Gastroenterology, 19 (41), 7197-7204.

Full Text: 2013\Wor J Gas19, 7197.pdf

Abstract: AIM: To assess the theoretical advantages of magnetic endoscope imaging (MEI) over standard colonoscopies (SCs) and to compare their efficacies. METHODS: Electronic databases, including PubMed, EMBASE, the Cochrane library and the Science Citation Index, were searched to retrieve relevant trials. In addition, abstracts from papers presented at professional meetings and the reference lists of retrieved articles were reviewed to identify additional studies. The meta-analyses were performed using RevMan 5.1. A random effect model with the Mantel-Haenszel method was used for pooling dichotomous and continuous data. A sensitivity analysis was performed by excluding the trials with a small number of patients and by excluding the trials performed by inexperienced providers. RESULTS: Eight randomized controlled trials (RCTs), including 2967 patients, were included in the meta-analysis to compare cecal intubation rates and times, sedation dose, abdominal pain scores and the use of ancillary maneuvers between MEI and SC. The overall OR was 1.92 (95% CI: 1.13-3.27, eight RCTs), as indicated by the cecal intubation rate of MEI compared with SC, but MEI did not have any distinct advantage over SC for cecal intubation time (MD=-0.07, 95% CI:-0.16-0.02; three RCTs). MEI did not generally result in lower pain scores. Outcomes were also analyzed for the two subgroups based on the endoscopists’ experience level to evaluate cecal intubation rates. MEI presented better outcomes for non-experienced colonoscopists than experienced colonoscopists. CONCLUSION: the real-time magnetic imaging system is of benefit in training and educating inexperienced endoscopists and improves the cecal intubation rate for experienced and inexperienced endoscopists. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

Keywords: Abdominal, Analysis, Article, Cancer, Cecal Intubation, China, Citation, Co, Colonoscope, Data, Databases, Embase, Endoscope, Experience, Gastrointestinal, Hong-Kong, Imaging, Improvement, Magnetic, Magnetic Endoscope Imaging, Maneuvers, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Model, No, Nov, Outcomes, Pain, Papers, Patients, People, Perforation, Performance, Providers, Publishing, Pubmed, R, Randomized, Randomized Controlled Trials, Rates, Reference, Reference Lists, Rights, Room, Science, Science Citation Index, Sedation, Sensitivity, Sensitivity Analysis, Small, Standard, Standard Colonoscope, Surgery, Theoretical, Training, Unsedated Colonoscopy, World

? Yang, H. and Chen, Y.X. (2013), Improvement analysis of article quality in World Journal of Gastroenterology during 2008-2012. World Journal of Gastroenterology, 19 (44), 7830-7835.

Full Text: 2013\Wor J Gas19, 7830.pdf

Abstract: AIM: To understand the changes and development of World Journal of Gastroenterology (WJG) in recent years. METHODS: the Journal Citation Report (JCR) and SCI-E database of the ISI Web of Knowledge were used to search the articles and data of related indices in WJG during 2008-2012. Bibliometric methods were used for statistical analysis of the author’s degree of collaboration, collaboration rate, the first author’s publications, high-productivity authors, the authors’ origins in each year; the distribution of the countries and journals of the authors citing WJG papers was also analyzed. In addition, the indices related to this journal in each year were compared with the data from 6 SCI journals in the field of gastroenterology in the 2012 volume. RESULTS: A total of 4409 papers in WJG were examined in this study. For the period 2008-2012, the self-citation rate was 8.59%, 6.02%, 5.50%, 4.47% and 5.21%. of a total of 3898 first authors, 3526 published 1 paper, 291 published 2 papers, 59 published 3 papers, and 22 published 4 or more papers. The origin of WJG authors covered the six continents, and the majority came from Asia, Europe and North America. The number of countries of origin of WJG authors was 65, 66, 61, 65 an 60 for the period 2008-2012. Authors from 66 countries cited a total of 3194 of the 4409 papers, and these citations were found in 1140 journals. CONCLUSION: the results suggest that WJG has stayed on the track of normal international publication and all the indices of this journal are stable and reasonable. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

Keywords: Analysis, Asia, Author Analysis, Authors, Bibliometric, Bibliometric Methods, Bibliometrics, Changes, Citation, Citations, Co, Collaboration, Data, Database, Development, Distribution, Europe, Field, First, Gastroenterology, Improvement, Indices, International, ISI, Jcr, Journal, Journal Citation Report, Journals, Knowledge, Methods, Normal, North, North America, Nov, Origin, Papers, Publication, Publications, Publishing, Quality, Recent, Rights, SCI, Scie, Science Citation Index, Self-Citation, Statistical Analysis, Volume, Web of Knowledge, World Journal of Gastroenterology

? Xiong, J.J., Nunes, Q.M., Huang, W., Tan, C.L., Ke, N.W., Xie, S.M., Ran, X., Zhang, H., Chen, Y.H. and Liu, X.B. (2013), Laparoscopic vs open total gastrectomy for gastric cancer: A meta-analysis. World Journal of Gastroenterology, 19 (44), 8114-8132.

Full Text: 2013\Wor J Gas19, 8114.pdf

Abstract: AIM: To conduct a meta-analysis comparing laparoscopic total gastrectomy (LTG) with open total gastrectomy (OTG) for the treatment of gastric cancer. METHODS: Major databases such as MEDLINE (PubMed), Embase, Academic Search Premier (EBSCO), Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library were searched for studies comparing LTG and OTG from January 1994 to May 2013. Evaluated endpoints were operative, postoperative and oncological outcomes. Operative outcomes included operative time and intraoperative blood loss. Postoperative recovery included time to first flatus, time to first oral intake, hospital stay and analgesics use. Postoperative complications comprised morbidity, anastomotic leakage, anastomotic stenosis, ileus, bleeding, abdominal abscess, wound problems and mortality. Oncological outcomes included positive resection margins, number of retrieved lymph nodes, and proximal and distal resection margins. The pooled effect was calculated using either a fixed effects or a random effects model. RESULTS: Fifteen non-randomized comparative studies with 2022 patients were included (LTG - 811, OTG - 1211). Both groups had similar short-term oncological outcomes, analgesic use (WMD -0.09; 95% CI: -2.39-2.20; P = 0.94) and mortality (OR = 0.74; 95% CI: 0.24-2.31; P = 0.61). However, LTG was associated with a lower intraoperative blood loss (WMD -201.19 mL; 95% CI: -296.50-105.87 mL; P < 0.0001) and overall complication rate (OR = 0.73; 95% CI: 0.57-0.92; P = 0.009); fewer wound-related complications (OR = 0.39; 95% CI: 0.21-0.72; P = 0.002); a quicker recovery of gastrointestinal motility with shorter time to first flatus (WMD -0.82; 95% CI: -1.18-0.45; P < 0.0001) and oral intake (WMD -1.30; 95% CI: -1.84-0.75; P < 0.00001); and a shorter hospital stay (WMD -3.55; 95% CI: -5.13-1.96; P < 0.0001), albeit with a longer operation time (WMD 48.25 min; 95% CI: 31.15-65.35; P < 0.00001), as compared with OTG. CONCLUSION: LTG is safe and effective, and may offer some advantages over OTG in the treatment of gastric cancer. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

Keywords: Abdominal, Academic, Analgesic, Analgesics, Anastomotic Leakage, Assisted Total Gastrectomy, Bleeding, Blood, Blood Loss, Cancer, Citation, Clinical-Trials, Co, Complication, Complications, Databases, Distal Gastrectomy, Effects, First, Flatus, Gastric, Gastric Cancer, Groups, Hospital, Hospital Stay, Ileus, Intraoperative Blood Loss, Laparoscopic, Laparoscopic Assisted Total Gastrectomy, Laparoscopic Total Gastrectomy, Lymph-Node Dissection, MEDLINE, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Model, Morbidity, Mortality, Motility, Nov, Open, Open Total Gastrectomy, Operation, Operative, Oral, Outcomes, P, Patients, Postoperative, Publishing, Pubmed, Quality, Random Effects Model, Recovery, Resections, Rights, Science, Science Citation Index, Science Citation Index Expanded, Search, Stenosis, Surgical Outcomes, Survival, Treatment, Wound

? Chen, W., Fan, J.H., Luo, W., Peng, P. and Su, S.B. (2013), Effectiveness of interferon-gamma release assays for differentiating intestinal tuberculosis from Crohn’s disease: A meta-analysis. World Journal of Gastroenterology, 19 (44), 8133-8140.

Full Text: 2013\Wor J Gas19, 8133.pdf

Abstract: AIM: To investigate the clinical usefulness of interferon-gamma release assays (IGRAs) in the differential diagnosis of intestinal tuberculosis (ITB) from Crohn’s disease (CD) by meta-analysis. METHODS: A systematic search of English language studies was performed. We searched the following databases: MEDLINE, Embase, Web of Science and the Cochrane Library. The Standards for Reporting Diagnostic Accuracy initiative and Quality Assessment for Studies of Diagnostic Accuracy tool were used to assess the methodological quality of the studies. Sensitivity, specificity, and other measures of the accuracy of IGRAs in the differential diagnosis of ITB from CD were pooled and analyzed using random-effects models. Receiver operating characteristic curves were applied to summarize overall test performance. Two reviewers independently judged study eligibility while screening the citations. RESULTS: Five studies met the inclusion criteria. The average inter-rater agreement between the two reviewers for items in the quality checklist was 0.95. Analysis of IGRAs for the differential diagnosis of ITB from CD produced summary estimates as follows: sensitivity, 0.74 (95% CI: 0.68-0.80); specificity, 0.87 (95% CI: 0.82-0.90); positive likelihood ratio, 5.98 (95% CI: 3.79-9.43); negative likelihood ratio, 0.28 (95% CI: 0.18-0.43); and diagnostic odds ratio, 26.21 (95% CI: 14.15-48.57). The area under the curve was 0.92. The evaluation of publication bias was not significant (P = 0.235). CONCLUSION: Although IGRAs are not sensitive enough, they provide good specificity for the accurate diagnosis of ITB, which may be helpful in the differential diagnosis of ITB from CD. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

Keywords: Accuracy, Adenosine-Deaminase Activity, Analysis, Assessment, Bias, Cd, Citations, Clinical, Co, Colonic Tuberculosis, Criteria, Crohn’S Disease, Databases, Diagnosis, Diagnostic-Accuracy, Disease, Epidemiology, Estimates, Evaluation, Guidelines, Interferon-Gamma, Intestinal Tuberculosis, Language, Likelihood Ratio, Management, Measures, MEDLINE, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Models, Mycobacterium-Tuberculosis, Nov, Odds Ratio, P, Performance, Peritonitis, Pleurisy, Publication, Publication Bias, Publishing, Quality, Quality Of, Release, Rights, Science, Screening, Sensitivity, Specificity, Standards, Tuberculosis, Web of Science

? Yang, X.M. and Hu, B. (2013), Endoscopic sphincterotomy plus large-balloon dilation vs endoscopic sphincterotomy for choledocholithiasis: A meta-analysis. World Journal of Gastroenterology, 19 (48), 9453-9460.

Full Text: 2013\Wor J Gas19, 9453.pdf

Abstract: AIM: To perform a meta-analysis of large-balloon dilation (LBD) plus endoscopic sphincterotomy (EST) vs EST alone for removal of bile duct stones. METHODS: Databases including PubMed, EMBASE, the Cochrane Library, the Science Citation Index, and important meeting abstracts were searched and evaluated by two reviewers independently. The main outcome measures included: complete stone removal, stone removal in the first session, use of mechanical lithotripsy, procedure time, and procedure-related complications. A fixed-effects model weighted by the Mantel-Haenszel method was used for pooling the odds ratio (OR) when heterogeneity was not significant among the studies. When a Q test or I 2 statistic indicated substantial heterogeneity, a random-effects model weighted by the DerSimonian-Laird method was used. RESULTS: Six randomized controlled trials involving 835 patients were analyzed. There was no significant heterogeneity for most results; we analyzed these using a fixed-effects model. Meta-analysis showed EST plus LBD caused fewer overall complications than EST alone (OR = 0.53, 95% CI: 0.33-0.85, P = 0.008); sub-category analysis indicated a significantly lower risk of perforation in the EST plus LBD group (Peto OR = 0.14, 95% CI: 0.20-0.98, P = 0.05). Use of mechanical lithotripsy in the EST plus LBD group decreased significantly (OR = 0.26, 95% CI: 0.08-0.82, P = 0.02), especially in patients with a stone size larger than 15 mm (OR = 0.15, 95% CI: 0.03-0.68, P = 0.01). There were no significant differences between the two groups regarding complete stone removal, stone removal in the first session, post-endoscopic retrograde cholangiopancreatography pancreatitis, bleeding, infection of biliary tract, and procedure time. CONCLUSION: EST plus LBD is an effective approach for the removal of large bile duct stones, causing fewer complications than EST alone. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

Keywords: Analysis, Approach, Balloon Dilation, Bias, Bile-Duct Stones, Bleeding, Cholangiopancreatography, Choledocholithiasis, Citation, Clinical-Trials, Co, Complete, Complications, Databases, Difficult, Embase, Endoscopic Retrograde, Endoscopic Sphincterotomy, First, Fixed Effects Model, Groups, Heterogeneity, Infection, Lithotripsy, Measures, Mechanical Lithotripsy, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Model, Odds Ratio, Outcome, Outcome Measures, P, Pancreatitis, Patients, Procedure, Publishing, Pubmed, Random Effects Model, Randomized, Randomized Controlled Trials, Reduce, Removal, Rights, Risk, Science, Science Citation Index, Size

? Guo, X.F., Wang, J., Yu, S.J., Song, J., Ji, M.Y., Cao, Z., Zhang, J.X., Wang, J. and Dong, W.G. (2013), TNF--308 polymorphism and risk of digestive system cancers: A meta-analysis. World Journal of Gastroenterology, 19 (48), 9461-9471.

Full Text: 2013\Wor J Gas19, 9461.pdf

Abstract: AIM: to evaluate the association between the tumour necrosis factor alpha-308 (TNF-alpha-308) gene polymorphism and the risk of digestive system cancers. METHODS: All eligible case-control studies published up to December 2012 were identified by searching PubMed, Web of Science, Embase and China National Knowledge Internet without language restrictions. The risk of digestive system cancers associated with the TNF-alpha-308 polymorphism was estimated for each study using odds ratio (OR) together with its 95% CI, respectively. Cochrane Collaboration RevMan 5.1 was used to perform the analysis. A chi(2)-test-based Q statistic test and an I 2 test were performed to assess the between-study heterogeneity. When the Q test was significant (p < 0.05) or I-2 > 50%, the random effects model was used, otherwise the fixed effects model was used. RESULTS: Fifty-eight studies from fifty-five publications with a total of 9986 cancer patients and 15511 healthy controls were included. Overall, a significant association was found between the TNF-alpha-308 polymorphism and the risk of digestive system cancers [dominant model: OR = 1.23, 95% CI: 1.09-1.39, (G/A) vs (G/G): OR = 1.15, 95% CI: 1.02-1.28, (A/A) vs (G/G): OR = 1.44, 95% CI: 1.19-1.73, recessive model: OR = 1.38, 95% CI: 1.15-1.66]. Furthermore, when the analysis was stratified by ethnicity, similar results were observed in both the Asian and Caucasian populations, except for the dominant model and heterozygote comparisons in the Asian population [dominant model: OR = 1.24, 95% CI: 0.99-1.56, (G/A) vs (G/G): OR = 1.09, 95% CI: 0.96-1.24]. When the cancer type subgroups were examined, similar results were detected in gastric and hepatocellular carcinomas; however, no significant association was observed among other digestive system cancers. CONCLUSION: the TNF-alpha-308 gene polymorphism may be significantly associated with the risk of gastric and hepatocellular carcinomas, but not colorectal, pancreatic, or oesophageal cancer, in the Asian population. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

Keywords: Analysis, Asian, Association, Cancer, Case-Control, Case-Control Studies, Caucasian, China, Chinese Population, Chronic Atrophic Gastritis, Co, Cochrane Collaboration, Collaboration, Colorectal-Cancer, Cytokine Gene Polymorphisms, Digestive System Cancer, Effects, Ethnicity, Fixed Effects Model, Gastric, Gene, Gene Polymorphism, Helicobacter-Pylori Infection, Hepatitis-B-Virus, Hepatocellular-Carcinoma, Heterogeneity, Internet, Knowledge, Language, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Model, Necrosis, Necrosis-Factor-Alpha, Odds Ratio, Pancreatic Adenocarcinoma, Patients, Polymorphism, Population, Populations, Publications, Publishing, Pubmed, Random Effects Model, Restrictions, Rights, Risk, Rs1800629, Science, Tnf-A Genes, Tumour Necrosis Factor Alpha, Web of Science

? Du, J., Ma, Y.Y., Yu, C.H. and Li, Y.M. (2014), Effects of pentoxifylline on nonalcoholic fatty liver disease: A meta-analysis. World Journal of Gastroenterology, 20 (2), 569-577.

Full Text: 2014\Wor J Gas20, 569.pdf

Abstract: AIM: To evaluate the effects of pentoxifylline therapy in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: We searched PubMed, Medline, Google Scholar, Embase, Web of Science, the Cochrane Library and the Chinese Biomedicine Database for all relevant controlled trials of pentoxifylline in patients with NAFLD from 1997 to July 2013. Five studies (3 randomized, double-blind, placebo-controlled trials and 2 prospective cohort studies with concurrent controls) were included in this meta-analysis. Statistical analysis was performed using RevMan 5.0 software. RESULTS: Five randomized trials of 147 patients with NAFLD/nonalcoholic steatohepatitis (NASH) were included. The results showed that compared to placebo, pentoxifylline therapy resulted in a significant decrease in body weight (P = 0.04), alanine aminotransferase (P < 0.00001), aspartate transaminase (P = 0.0006), glucose (P = 0.0008) and tumor necrosis factor-alpha (P = 0.007), but did not significantly affect body mass index (P = 0.28), total cholesterol (P = 0.80), triglyceride (P = 0.98), alkaline phosphatase (P = 0.29), gamma-glutamyl transferase (P = 0.39) and interleukin-6 (P = 0.38). With regard to histological changes, pentoxifylline only reduced the NAFLD activity score (P < 0.00001) and improved lobular inflammation (P < 0.0001). Improvements in steatosis grade (P = 0.11), ballooning (P = 0.10) and fibrosis (P = 0.50) were not obvious. CONCLUSION: Pentoxifylline therapy results in weight loss, improved liver function and histological changes in patients with NAFLD/NASH. Therefore, pentoxifylline may be a new treatment option for NAFLD. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

Keywords: Activity, Alanine Aminotransferase, Analysis, Biomedicine, Body Mass Index, Body Weight, Changes, Children, Chinese, Cholesterol, Co, Cohort, Controlled-Trial, Database, Diet, Disease, Double-Blind, Effects, Fibrosis, Function, Glucose, Google, Google Scholar, Index, Inflammation, Interleukin-6, Liver, Medline, Meta Analysis, Meta-Analysis, Metaanalysis, Metformin, Methods, Necrosis, Necrosis-Factor-Alpha, Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, Obesity, P, Patients, Pentoxifylline, Placebo, Prospective, Publishing, Pubmed, Randomized, Rights, Science, Software, Statistical Analysis, Steatohepatitis Nash, Therapy, Treatment, Treatment Option, Triglyceride, Tumor, Tumor Necrosis Factor-Alpha, Ursodeoxycholic Acid, Web of Science, Weight Loss

? Huang, V.W., Reich, K.M. and Fedorak, R.N. (2014), Distance management of inflammatory bowel disease: Systematic review and meta-analysis. World Journal of Gastroenterology,