Personal Research Database


Title: Veterinary Dermatology



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Title: Veterinary Dermatology


Full Journal Title: Veterinary Dermatology

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? Olivry, T., Foster, A.P., Mueller, R.S., Mcewan, N.A., Chesney, C. and Williams, H.C. (2010), Interventions for atopic dermatitis in dogs: A systematic review of randomized controlled trials. Veterinary Dermatology, 21 (1), 4-22.

Full Text: 2010\Vet Der21, 4.pdf

Abstract: The objective of this systematic review, which was performed following the guidelines of the Cochrane collaboration, was to assess the effects of interventions for treatment of atopic dermatitis (AD) in dogs. Citations identified from three databases (MEDLINE, Thomson’s Science Citation Index Expanded and CAB Abstracts) and trials published by December 2007 were selected. Proceedings books from the major veterinary dermatology international congresses were hand searched for relevant citations. The authors selected randomized controlled trials (RCTs), published from January 1980 to December 2007, which reported the efficacy of topical or systemic interventions for treatment or prevention of canine AD. Studies had to report assessments of either pruritus or skin lesions, or both. Studies were selected and data extracted by two reviewers, with discrepancies resolved by a third arbitrator. Missing data were requested from study authors of recently published trials. Pooling of results and meta-analyses were performed for studies reporting similar interventions and outcome measures. A total of 49 RCTs were selected, which had enrolled 2126 dogs. This review found some evidence of efficacy of topical tacrolimus (3 RCTs), topical triamcinolone (1), oral glucocorticoids (5), oral ciclosporin (6), subcutaneous recombinant gamma-interferon (1) and subcutaneous allergen-specific immunotherapy (3) to decrease pruritus and/or skin lesions of AD in dogs. One high-quality RCT showed that an oral essential fatty acid supplement could reduce prednisolone consumption by approximately half. Additional RCTs of high design quality must be performed to remedy previous flaws and to test interventions for prevention of flares of this disease.

Keywords: Acvd Task-Force, Antipruritic Agent, Books, Canine Atopy, Citation, Citations, Clinical-Trial, Collaboration, Cross-Over, Databases, Dermatology, Diagnostic-Criteria, Double-Blind, Evening Primrose Oil, Fish-Oil, Medline, Review, Science, Science Citation Index, Systematic Review, Tacrolimus Ointment, Treatment

Title: Veterinary and Human Toxicology


Full Journal Title: Veterinary and Human Toxicology

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? Hammond, G.M., Loewen, M.E. and Blakley, B.R. (2004), Diagnosis and treatment of zinc poisoning in a dog. Veterinary and Human Toxicology, 46 (5), 272-275.

Abstract: Acute zinc poisoning has been observed in dogs following the ingestion of metallic zinc objects. A 11/2-y-old female miniature bull terrier exhibiting anorexia, vomiting, depression, fever (39.9C), icterus and intravascular hemolysis was diagnosed with acute zinc poisoning. Anemia, Heinz body production, azotemia and bilirubinemia were also evident. Abnormal pancreatic, hepatic and renal functions were also apparent. A radio opaque object was observed in the stomach. Based upon an elevated plasma zinc level of 28.6 ppm, a tentative diagnosis of zinc poisoning was made. Following surgical removal of the metallic zinc object, a blood transfusion and fluid therapy were given to restore the normal blood volume. Heparin, Cephazolin and Raniditine were also given, although chelation therapy was not provided. Zinc levels in the plasma declined in a steady fashion (half-life = 7.6 d). Complications, such as disseminated intravascular coagulation, chronic pancreatitis, renal or hepatic failure, were not observed. By 20 d post surgery, on mild elevation of liver enzymes was evident. Measurements of the half-life of zinc may provide a useful indication of prognosis and the success of treatment.

Keywords: Induced Hemolytic-Anemia, Ingestion, Toxicity, Toxicosis, Pennies


Title: Veterinary Microbiology


Full Journal Title: Veterinary Microbiology

ISO Abbreviated Title: Vet. Microbiol.

JCR Abbreviated Title: Vet Microbiol

ISSN: 0378-1135

Issues/Year: 14

Journal Country/Territory: Netherlands

Language: English

Publisher: Elsevier Science BV

Publisher Address: PO Box 211, 1000 AE Amsterdam, Netherlands

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Microbiology Veterinary Sciences: Impact Factor

Herrera, P., Burghardt, R.C. and Phillips, T.D. (2000), Adsorption of Salmonella enteritidis by cetylpyridinium-exchanged montmorillonite clays. Veterinary Microbiology, 74 (3), 259-272.

Full Text: 2000\Vet Mic74, 259.pdf

Abstract: Recent experiments in our laboratory have suggested that certain montmorillonite clays, when exchanged with the cationic surfactant cetylpyridinium (CP), may be useful in removing bacteria from aqueous solution. During an initial study, screening various CP-exchanged products for potential antibacterial activity, three CP-exchanged clays-CP*AAM (acid-activated montmorillonite), CP*STx-1 (Ca++-montmorillonite), and CP*SWy-2 (Na+-montmorillonite), proved to be the most effective. Binding studies were performed using 1 mgeach of CP-exchanged AAM, STx-1, and SWy-2 with a standardized Salmonella enteritidis solution containing approximate to 40,000 colony forming units (CFU)/ml. The modified clays reduced bacterial numbers 98.1, 97.6, and 95.2%, respectively. In contrast, the parent clays only produced reductions of 39.8, 16.9, and 16.6%, respectively. Attempts were made to desorb CP from the modified clays by washing in sterile physiological saline for 24 h. The resulting wash solutions failed to produce any significant reduction in bacterial colony counts; while, the washed clays retained their full antimicrobial activity. These findings suggested that the antibacterial effect of the clays is localized on the clay surface and is not due to CP dissociating from the clay. Electron microscopy revealed that the bacteria adhered to the surface of the CP-exchanged clays, but not the parent clays. Results from timed binding studies showed that the antibacterial effect was stable over the period observed. Rates of binding were positively influenced by increasing temperature, not affected by changes in pH, and negatively influenced by the presence of organic contaminants. The mechanism by which bacterial counts are reduced may involve the enhanced hydrophobicity and affinity of the CP-exchanged clay for Salmonella and the antibacterial activity of CP. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

Keywords: Broiler Carcasses, Water, Salmonella Enteritidis, Antimicrobials, Public Health

? Pereira, U.P., Oliveira, D.G.S., Mesquita, L.R., Costa, G.M. and Pereira, U. (2011), Efficacy of Staphylococcus aureus vaccines for bovine mastitis: A systematic review. Veterinary Microbiology, 148 (2-4), 117-124.

Abstract: Bovine mastitis is the main cause of economic loss in milk production worldwide and Staphylococcus aureus is the agent most frequently associated with the disease. The aim of this systematic review was to assess the efficacy of vaccines for bovine mastitis caused by S. aureus and suggest the immunotherapeutic protocols that have achieved the best and/or most promising results. An electronic search was made of the PUBMED and Web of Science databases in November 2009. Only studies that tested vaccines in vivo in cows were included. The experimental design, methodological quality, type of vaccine and results of the studies were analyzed. Twenty-four papers were selected for this review. In general, bacterin-toxoid vaccines, vaccines of DNA-recombinant protein and recombinant protein alone were investigated in the studies selected. This systematic review suggests that vaccines that employ new technologies (DNA and/or recombinant protein vaccines) and some long-standing bacterins have achieved good results, which supports their use in the prevention and control of bovine mastitis caused by S. aureus. However, methodological differences and in some cases, a lack of more severe scientific criteria (such as double blind protocols) hinder the assessment of the effectiveness of these vaccines. (C) 2010 Elsevier B.V. All rights reserved.

Keywords: Adjuvant, Antibody-Production, Assessment, Bovine, Bovine Mastitis, Cattle, Control, Dairy-Cows, Databases, Design, Disease, DNA, Effectiveness, Efficacy, Field Trial, Immune-Responses, Immunization, In Vivo, Mammary Epithelial-Cells, Milk, Papers, Prevention, Prevention and Control, Pubmed, Review, Science, Staphylococcus Aureus, Systematic, Systematic Review, Vaccination, Vaccine, Vaccines, Web of Science




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