Public Health Assessment

1 Cancer Effects Exposure Factor = (2 days/week) (26 weeks/year) (10 years) = 0.02

(70 years) (365 days/year)

Cancer Effects Exposure Dose = (max. contaminant concentration) (ingestion rate) (exposure factor) (1 kg/10⁶ mg)

body weight

= (22,500 mg/kg) (200 mg/day) (0.02) (1 kg/10⁶ mg) = 2.6 x 10^-3 mg/kg/day

35 kg
Cancer Risk = Cancer Effects Exposure Dose x Cancer Slope Factor

= 2.6 x 10^-3 mg/kg/day x 2.0 (mg/kg/day)^-1 = 5 x 10^-3

2 Cancer Effects Exposure Dose = (85 mg/kg) (200 mg/day) (0.02) (1 kg/10⁶ mg) = 1 x 10^-5 mg/kg/day

35 kg
Cancer Risk = 1 x 10^-5 mg/kg/day x 2.0 (mg/kg/day)^-1 = 2 x 10^-5

3 Cancer Effects Exposure Dose = (210 mg/kg) (200 mg/day) (0.02) (1 kg/10⁶ mg) = 2.4 x 10^-5 mg/kg/day

35 kg
Cancer Risk = 2.4 x 10^-5 mg/kg/day x 1.5 (mg/kg/day)^-1 = 4 x 10^-5

4


^ Noncancer Effects Exposure Factor = (2 days/week) (26 weeks/year) (10 years) = 0.14

(10 years) (365 days/year)

Noncancer Effects Exposure Dose = (210 mg/kg) (200 mg/day) (0.14) (1 kg/10⁶ mg) = 1.7 x 10^-4 mg/kg/day

35 kg

Chronic MRL = 3 x 10^-4 mg/kg/day

5 Cancer Effects Exposure Factor = (5 days/week) (50 weeks/year) (30 years) = 0.29

(70 years) (365 days/year)

Cancer Effects Exposure Dose = (22,500 mg/kg) (50 mg/day) (0.29) (1 kg/10⁶ mg) = 4.7 x 10^-3 mg/kg/day

70 kg
Cancer Risk = 4.7 x 10^-3 mg/kg/day x 2.0 (mg/kg/day)^-1 = 9 x 10^-3

6


^ Cancer Effects Exposure Dose = (85 mg/kg) (50 mg/day) (0.29) (1 kg/10⁶ mg) = 1.8 x 10^-5 mg/kg/day

70 kg
Cancer Risk = 1.8 x 10^-5 mg/kg/day x 2.0 (mg/kg/day)^-1 = 4 x 10^-5

7 Cancer Effects Exposure Dose = (210 mg/kg) (50 mg/day) (0.29) (1 kg/10⁶ mg) = 4.4 x 10^-5 mg/kg/day

70 kg
Cancer Risk = 4.4 x 10^-5 mg/kg/day x 1.5 (mg/kg/day)^-1 = 7 x 10^-5

8 Noncancer Effects Exposure Factor = (5 days/week) (50 weeks/year) (30 years) = 0.68

(30 years) (365 days/year)

Noncancer Effects Exposure Dose = (210 mg/kg) (50 mg/day) (0.68) (1 kg/10⁶ mg) = 1 x 10^-4 mg/kg/day

70 kg
Chronic MRL = 3 x 10^-4 mg/kg/day

9 Cancer Effects Exposure Factor = (7 days/week) (50 weeks/year) (18 years) = 0.25

(365 days/year) (70 years)

Cancer Effects Exposure Dose = (58 mg/kg) (200 mg/day) (0.25) (1 kg/10⁶ mg) = 8 x 10^-5 mg/kg/day

35 kg
Cancer Risk = 8 x 10^-5 mg/kg/day x 1.5 (mg/kg/day)^-1 = 1 x 10^-4

10 Noncancer Effects Exposure Factor = (7 days/week) (50 weeks/year) (18 years) = 0.96

(18 years) (365 days/year)

Noncancer Effects Exposure Dose = (58 mg/kg) (200 mg/day) (0.96) (1 kg/10⁶ mg) = 3 x 10^-4 mg/kg/day

35 kg

Chronic MRL = 3 x 10^-4 mg/kg/day

11 Cancer Effects Exposure Dose (Ingestion) = (max. contaminant conc.) (water ingestion rate) (exposure factor)

body weight

= (0.0579 mg/L) (0.05 L/day) (0.02) = 1.7 x 10^-6 mg/kg/day

35 kg
Cancer Effects

Exposure Dose = (max. contam. conc.) (permeability constant) (exposed body surface area) (exposure time) (1L)

(Dermal) (body weight) (1,000 cm³)

= (0.0597 mg/L) (0.21 cm/hr^a) (4,310 cm²) (0.02 hr/day) (1 L) = 3 x 10^-5 mg/kg/day

(35 kg) (1,000 cm³)

^a ATSDR 2003c
Cancer Effects

Exposure Dose = Cancer Effects Exposure Dose (Ingestion) + Cancer Effects Exposure Dose (Dermal)

(Total)

= 1.7 x 10^-6 mg/kg/day + 3 x 10^-5 mg/kg/day = 3.2 x 10^-5 mg/kg/day

12 Margin of Exposure = LOAEL/Cancer Effects Exposure Dose (Total)
= 1000 mg/kg/day = 3 x 10⁷

3.2 x 10^-5 mg/kg/day

13


^ Noncancer Effects Exposure Dose (Ingestion) = (max. contaminant conc.) (water ingestion rate) (exposure factor)

body weight

= (0.0579 mg/L) (0.05 L/day) (0.14) = 1.2 x 10^-5 mg/kg/day

35 kg
Total Noncancer Effects Exposure Dose = 1.2 x 10^-5 mg/kg/day + 3 x 10^-5 mg/kg/day = 4 x 10^-5 mg/kg/day

Acute MRL = 0.2 mg/kg/day

14 The data summarized in this report are drawn from data entered on MCR computer files before March 10, 2004. The numbers presented in this report may change slightly in future reports, reflecting late reported cases, address corrections, or other changes based on subsequent details from reporting facilities.

15 Using slightly different population estimates or statistical methodologies, such as grouping ages differently or rounding off numbers at different points during calculations, may produce results slightly different from those published in this report.

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