Public Health Assessment



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1 Cancer Effects Exposure Factor = (2 days/week) (26 weeks/year) (10 years) = 0.02

(70 years) (365 days/year)


Cancer Effects Exposure Dose = (max. contaminant concentration) (ingestion rate) (exposure factor) (1 kg/106 mg)

body weight


= (22,500 mg/kg) (200 mg/day) (0.02) (1 kg/106 mg) = 2.6 x 10-3 mg/kg/day

35 kg
Cancer Risk = Cancer Effects Exposure Dose x Cancer Slope Factor


= 2.6 x 10-3 mg/kg/day x 2.0 (mg/kg/day)-1 = 5 x 10-3


2 Cancer Effects Exposure Dose = (85 mg/kg) (200 mg/day) (0.02) (1 kg/106 mg) = 1 x 10-5 mg/kg/day

35 kg
Cancer Risk = 1 x 10-5 mg/kg/day x 2.0 (mg/kg/day)-1 = 2 x 10-5




3 Cancer Effects Exposure Dose = (210 mg/kg) (200 mg/day) (0.02) (1 kg/106 mg) = 2.4 x 10-5 mg/kg/day

35 kg
Cancer Risk = 2.4 x 10-5 mg/kg/day x 1.5 (mg/kg/day)-1 = 4 x 10-5



4


 Noncancer Effects Exposure Factor = (2 days/week) (26 weeks/year) (10 years) = 0.14

(10 years) (365 days/year)


Noncancer Effects Exposure Dose = (210 mg/kg) (200 mg/day) (0.14) (1 kg/106 mg) = 1.7 x 10-4 mg/kg/day

35 kg


Chronic MRL = 3 x 10-4 mg/kg/day

5 Cancer Effects Exposure Factor = (5 days/week) (50 weeks/year) (30 years) = 0.29

(70 years) (365 days/year)


Cancer Effects Exposure Dose = (22,500 mg/kg) (50 mg/day) (0.29) (1 kg/106 mg) = 4.7 x 10-3 mg/kg/day

70 kg
Cancer Risk = 4.7 x 10-3 mg/kg/day x 2.0 (mg/kg/day)-1 = 9 x 10-3



6


 Cancer Effects Exposure Dose = (85 mg/kg) (50 mg/day) (0.29) (1 kg/106 mg) = 1.8 x 10-5 mg/kg/day

70 kg
Cancer Risk = 1.8 x 10-5 mg/kg/day x 2.0 (mg/kg/day)-1 = 4 x 10-5




7 Cancer Effects Exposure Dose = (210 mg/kg) (50 mg/day) (0.29) (1 kg/106 mg) = 4.4 x 10-5 mg/kg/day

70 kg
Cancer Risk = 4.4 x 10-5 mg/kg/day x 1.5 (mg/kg/day)-1 = 7 x 10-5




8 Noncancer Effects Exposure Factor = (5 days/week) (50 weeks/year) (30 years) = 0.68

(30 years) (365 days/year)


Noncancer Effects Exposure Dose = (210 mg/kg) (50 mg/day) (0.68) (1 kg/106 mg) = 1 x 10-4 mg/kg/day

70 kg
Chronic MRL = 3 x 10-4 mg/kg/day



9 Cancer Effects Exposure Factor = (7 days/week) (50 weeks/year) (18 years) = 0.25

(365 days/year) (70 years)


Cancer Effects Exposure Dose = (58 mg/kg) (200 mg/day) (0.25) (1 kg/106 mg) = 8 x 10-5 mg/kg/day

35 kg
Cancer Risk = 8 x 10-5 mg/kg/day x 1.5 (mg/kg/day)-1 = 1 x 10-4




10 Noncancer Effects Exposure Factor = (7 days/week) (50 weeks/year) (18 years) = 0.96

(18 years) (365 days/year)


Noncancer Effects Exposure Dose = (58 mg/kg) (200 mg/day) (0.96) (1 kg/106 mg) = 3 x 10-4 mg/kg/day

35 kg


Chronic MRL = 3 x 10-4 mg/kg/day


11 Cancer Effects Exposure Dose (Ingestion) = (max. contaminant conc.) (water ingestion rate) (exposure factor)

body weight


= (0.0579 mg/L) (0.05 L/day) (0.02) = 1.7 x 10-6 mg/kg/day

35 kg
Cancer Effects

Exposure Dose = (max. contam. conc.) (permeability constant) (exposed body surface area) (exposure time) (1L)

(Dermal) (body weight) (1,000 cm3)


= (0.0597 mg/L) (0.21 cm/hra) (4,310 cm2) (0.02 hr/day) (1 L) = 3 x 10-5 mg/kg/day

(35 kg) (1,000 cm3)



a ATSDR 2003c
Cancer Effects

Exposure Dose = Cancer Effects Exposure Dose (Ingestion) + Cancer Effects Exposure Dose (Dermal)

(Total)

= 1.7 x 10-6 mg/kg/day + 3 x 10-5 mg/kg/day = 3.2 x 10-5 mg/kg/day





12 Margin of Exposure = LOAEL/Cancer Effects Exposure Dose (Total)
= 1000 mg/kg/day = 3 x 107

3.2 x 10-5 mg/kg/day



13


 Noncancer Effects Exposure Dose (Ingestion) = (max. contaminant conc.) (water ingestion rate) (exposure factor)

body weight


= (0.0579 mg/L) (0.05 L/day) (0.14) = 1.2 x 10-5 mg/kg/day

35 kg
Total Noncancer Effects Exposure Dose = 1.2 x 10-5 mg/kg/day + 3 x 10-5 mg/kg/day = 4 x 10-5 mg/kg/day



Acute MRL = 0.2 mg/kg/day

14 The data summarized in this report are drawn from data entered on MCR computer files before March 10, 2004. The numbers presented in this report may change slightly in future reports, reflecting late reported cases, address corrections, or other changes based on subsequent details from reporting facilities.

15 Using slightly different population estimates or statistical methodologies, such as grouping ages differently or rounding off numbers at different points during calculations, may produce results slightly different from those published in this report.



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