Sino-American Pharmaceutical Professionals Association-New England (sapa-ne)



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Sino-American Pharmaceutical Professionals Association-New England (SAPA-NE)
















SAPA-New England 4th Annual Conference 2001


Drug Discovery: Industry Trends and Business Climate

Co-organized by Harvard Business School Healthcare and Biotech Club

Lead Sponsor: ArQule, Inc.

In Part Sponsored by Northeastern Section of ACS

PROGRAM
June 8-9, 2001

Burden Hall Auditorium, Harvard Business School

Soldiers Field Road

Boston, MA 02163

Website: http://www.sapa-ne.org

or

www.sapaweb.org



Conference Chair:


Jenny Li, Staff Investigator

ArQule, Inc.


Conference Co-Chair and Section Chair:


Shiwen Lin, Ph.D.

InfiMed Therapeutics Inc.

Tel: 617-864-0807, e-mail: slin@infimedrx.com



Cheng Zhang, Ph.D.

Millennium Pharmaceuticals, Inc.

Tel: 617-577-3574, e-mail: czhang@mpi.com



Jun Xian, Ph.D.

Genome Therapeutics Corporation

Tel: 781-398-2343, e-mail: jun.xian@genomecorp.com




Conference Organizing Committee:


Huimin Chen, Ph.D.

Genetics Institute, SAPA-NE, Director of Membership

Li Chen, Ph.D.

Hoffman-La Roche, SAPA, President-elect

Daming Gou, Ph.D.

Rhodia ChiRex, SAPA-NE, Treasurer

Jun Huangpu, Ph.D. MBA

Harvard Business School, Healthcare & Biotech Club

Gang Li, Ph.D.

Prime Organics, Inc., SAPA-NE, Director of Public Relation

Ms. Jenny Li

ArQule Inc., SAPA-NE, President-elect

Mr. Kechun Li

Eisai Research Institute, SAPA-NE, 1999 Term President


Shiwen Lin, Ph.D.

InfiMed Therapeutics Inc., SAPA-NE, Director of Fund-Raising

Sean Lu, Ph.D.

Sigma-RBI, SAPA-NE, Director of Scientific Symposium

Mr. Wuchun Shen

The Boston Consulting Group, SAPA-NE Web Master

Yongchun Shen, Ph.D.

Eisai Research Institute, SAPA-NE, 2000 Term President

Wenge Wang, Ph.D.

Genetics Institute, SAPA-NE, Director of Social Event

Yihan Wang, Ph.D.

ARIAD Pharmaceuticals, Inc., SAPA-NE, President

Erxi Wu, Ph.D.

Harvard Medical School, SAPA-NE, Coordinator

Mr. Dong Wang,

Ph.D. Candidate



Dept. of Chem., MIT, SAPA-NE, Coordinator

Jun Xian, Ph.D.

Genome Therapeutic Corporation, SAPA-NE, Director of Career Development

Yibin Xiang, Ph.D.

Genome Therapeutic Corporation, SAPA-NE, Chair of Advisory Committee

Yajun Xu, Ph.D.

Millennium Pharmaceuticals, Inc., SAPA-NE, Coordinator

Cheng Zhang, Ph.D.

Millennium Pharmaceuticals, Inc., SAPA-NE, Secretary General

Zhongli Zheng, Ph.D.

Biogen, Inc., SAPA-NE, Co-Chair of Advisory Committee

Xiaotian Zhu, Ph.D.

Amgen, Inc., SAPA-NE, 1999-2000 Term Director



Greetings from Conference Chair

Welcome to SAPA-NE (Sino-American Pharmaceutical Professionals Association, New England Section) 4th Annual Conference: Drug Discovery: Industry Trends and Business Climate.


Recent advances in genomics are bringing about a revolution in our understanding of the molecular mechanisms of disease and creating an explosive number of new biological targets for the development of new drugs. Fulfilling the promise of genomics, however, will require similar advances in the technology and systems used to discover and test small molecules interacting with these targets. Advances in drug discovery technologies hold the key to unlock the value of genomics. Things are changing more rapidly than ever. “High through-put lead optimization”, a relatively new term a few years ago, has become a popular phrase everywhere in our industry.
If you believe the trend is clear, the classical questions are still here. How to optimize ADMET properties? How to interpret and handle the enormous information generated by our tremendous efforts? How to improve the efficiency of the discovery process? These are no simple questions and most importantly, people who discover the niche will be successful in their career endeavor. Have you heard the discovery story of Merck’s VIOXX, an anti-inflammatory drug and Celebrex’s rival? Dr. Peppi Prasit, the key scientist who is responsible for its discovery, got the idea from a local conference. “Although the compound (in the poster) wasn’t chemically fit in people. Dr. Prasit immediately went back to his lab, cooked up the mysterious molecule and put it to Merck’s new test…” Information exchange helps! SAPA-NE has organized this conference by bringing together leaders from east to west, who will share their experiences and discuss current trends and strategies in the drug discovery industry. Our program includes presentations from a variety of perspectives including senior management from the pharmaceutical and biotechnology industries, research scientists, and business development professionals. The conference also includes an exhibition of new products and technologies for drug discovery and a career fair. I encourage you to take advantage of this tremendous opportunity to hear the latest trends in drug discovery and get some ideas of significant innovations in the drug discovery process that address these challenges.
SAPA is a federally registered non-profit organization striving to promote and facilitate the exchange of scientific information and to contribute to the whole society. On behalf of SAPA-NE, I’d like to take this opportunity to thank our speakers whose sole compensation is the satisfaction of the ultimate contribution to the improvement of well being of human beings. SAPA-NE is grateful to the lead sponsor, ArQule, Inc. and other corporate sponsors for their vision and strong support in many ways and for their generous funding to this conference and other SAPA-NE activities all year round. Special thanks go to NESACS and Harvard Business School Healthcare and Biotech Club for their shared value and support. And congratulations to you for your smart decision to participate this conference. I hope you will meet some outstanding leaders in our industry and make new friends at this conference. Together we can make a better world. Thank you very much.

Jenny Li, Conference Chair

President-elect, SAPA-NE


Drug Discovery – Industry Trends and Business Climate
Time: 8:00 am - 5:30 pm , June 8-9, 2001

Place: Burden Hall Auditorium, Harvard Business School

Soldiers Field Road, Boston, MA 02163

8:00 am - 9:00 am Registration

9:00 am - 12:00 am Morning Session

12:00 am –1:30 pm Lunch

1:30 pm - 5:30 pm Afternoon Session

5:30 pm - 6:30 pm Social hour

10:00 am - 5:30 pm Exhibition and Job Fair

6:30 pm - 8:00 pm Reception

8:00 pm – 9:30 pm Dinner
Morning Session (Plenary Speeches)
Host: Dr. Michael Singer, Group Leader, Sigma-RBI

Secretary of Northeastern Section of ACS (NESACS)


9:00 am - 9:10 am Conference Chair’s Announcement, Jenny Li, President-elect of SAPA-NE, Staff Investigator, ArQule, Inc.

Opening Remark: Dr. Tim B. Frigo, President of NESACS

9:10 am – 10:00 am Dr. Stephen A. Hill, President & CEO, ArQule, Inc.

“The New Medicines of the Future - Where Will They Come From?”


10:00 am - 10:40 am Dr. Donna M. Huryn, Director, Department of Chemical Sciences, Wyeth-Ayerst Research, Princeton, NJ

“Design and Synthesis of VLA-4 Antagonists”


10:40 am - 10:55 am Coffee Break
10:55 am - 11:35 am Dr. Maria Webb, VP of Discovery Biology, Pharmacopeia, Inc.

“Applications and Successes of Large, Diverse Combinatorial Libraries in Drug Discovery”


11:35 am - 11:50 am SAPA-NE 2000-2001 Outstanding Contribution Awards

11:50 am - 1:30 pm Lunch


Afternoon Session (Plenary Speeches)
Host: Dr. Yaping Hong, Associate Research Fellow, Sepracor Inc.
1:30 pm - 2:10 pm Dr. Ken Korzekwa, VP of Research, Camitro Corporation

“Modeling Biochemistry’s Versatile Processes: Cytochrome P450 Models for Drug Discovery and Development”


2:10 pm - 2:50 pm Dr. Bingfang Yan, D.V.M., Associate Professor, Dept. of Biomedical Sciences, University of Rhode Island

“Regulation of Drug-Metabolizing Enzymes by Nuclear Receptor Activation: Serious Considerations in Drug Development”


2:50 pm - 3:10 pm Coffee Break
3:10pm - 3:50 pm Dr. Kelvin W. Chan, Head, eADME, Drug Metabolism & Pharmacokinetics, Aventis Pharmaceuticals, Inc.

“The Role of ADME/PK in Drug Discovery”

3:50 pm - 4:30 pm Dr. Chris H. Senanayake, Senior Director of Chemical Process Research, Sepracor Inc.

“Rapid Access to Drug Synthesis via Catalytic and Asymmetric Processes”
4:30 pm - 5:10 pm Dr. Fred J. Vinick, Senior Vice President of Drug Discovery, Genzyme Corporation

“Small Molecule Drug Discovery at Genzyme Corporation”


5:30 pm – 6:30 pm Social Hour
Parallel Session

Section Chair: Dr. Jun Xian, Genome Therapeutics Corporation

10:00 am - 5:30 pm Trade Exposition of Novel Technology and New Products for Drug Discovery
10:00 am - 5:30 pm Job Clearing House
The 2nd Day Business Development
8:30 am - 9:00 am Registration and Breakfast
9:00 am - 9:10 am Conference Chair Opening Remark for Business Development

Host: Dr. Jun Huangpu, MBA, Harvard Business School


9:10 am – 9:50 am Dr. Roland R. Franke, CEO, Natural Pharmaceuticals, Inc.

“Success Factors in Technology Commercialization”

9:50 am - 10:30 am Dr. Joseph C. Hogan, President and CEO, Alveus Systems, Inc.

“A Molecular Level Systems Engineering Approach to Chemical Markets”
10:30 am - 10:40 am Coffee Break
10:40 am - 11:20 am Dr. Sheila DeWitt, Director, Business Development, ArQule, Inc.

“A Career Transition from Science to Business Development - from Big Pharma to Biotech”


12:00 pm - 1:30 pm Lunch

Afternoon Session (Plenary Speeches and Penal Discussions)

Host: Dr. Yibin Xiang, Director of Chemistry, Genome Therapeutics Corp., Chair of SAPA-NE Advisory Committee


1:30 pm - 2:10 pm Dr. Kenneth I. Kaitin, Director, Tufts Center for the Study of Drug Development

“The Changing Environment for Pharmaceutical Innovation”

2:10 pm - 2:50 pm Ms. Rongling Deng, WHO Fellow, Tufts Center for the Study of

Drug Development, SDA Officer

“New Drug Approval and Innovative Atmosphere in China”

2:50 pm – 3:00 pm Coffee Break


3:00 pm - 5:30 pm Discussion with Delegation of China Senior Pharmaceutical Executives and Government Regulatory Agencies

Wang Jian Ping, Director, Dept. of Biotech. and Pharmaceutical Science & Technology Commission of Shanghai Municipality

Fu Da Xu, Assoc. Director of Project Management, Shanghai Center of Research & Development of New Drugs

Wang Huisheng, VP, Shanghai Clone Biotech. Co., Ltd.

Jiang Guangping, General Manager, Biolink Informatics Inc.

Cheng Yong, Vice President of Marketing & Sale, United Gene Holdings, Ltd.

Chen Qi Yu, VP, Shanghai Fortune Industrial Joint-Stock Co., Ltd.

Dr. Qi Bao, Senior Consultant and Manager Pharmaceuticals

Group, China Concept

Guo Chungang, Assoc. Prof., the State Dept. Of Toxicology


Wang Kaimin, Prof. & Consultant of SDA, China
Parallel Session

Section Chair: Dr. Jun Xian, Genome Therapeutics Corporation

10:00 am - 5:30 pm Trade Exposition of Novel Technology and New Products for Drug Discovery
10:00 am - 5:30 pm Job Clearing House

The New Medicines of the Future – Where Will They Come from ?

Stephen A. Hill, President & CEO

ArQule, Inc.

19 Presidential Way

Woburn, MA 01801

Tel: 781 994 0311

Fax: 781 503 0009

Email: sahill@arqule.com









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