Supplementary Table 1: Patients with chronic kidney disease only
A: Multivariable regression model for *LncPP (no adjustment for brachial blood pressure)
Variable
|
Estimate (Std Err)
|
p value
|
Age (/10 years)
|
0.10 (0.01)
|
<0.001
|
Heart rate (beats/min)
|
-0.07 (0.01)
|
<0.001
|
Gender (male)
|
-0.18 (0.03)
|
<0.001
|
Estimated GFR (ml/min/1.73m2)
|
-0.02 (0.01)
|
0.01
|
B: Multivariable regression model for *LncPP (adjusted for brachial pulse and mean arterial pressure)
Variable
|
Estimate (Std Err)
|
p value
|
LnpPP (mmHg)
|
0.97 (0.02)
|
<0.001
|
AIx (%)
|
0.01 (0.00)
|
<0.001
|
Mean arterial pressure (/10 mmHg)
|
0.02 (0.00)
|
<0.001
|
Age (/10 years)
|
0.01 (0.00)
|
0.003
|
Haemoglobin
|
-0.01 (0.00)
|
0.007
|
Heart rate (10 beats/min)
|
-0.01 (0.00)
|
0.007
|
C: Stepwise change in multivariate regression model R2 for LncPP (from Supplementry Table 1B).
Variable
|
Model R2
|
LnpPP
|
0.828
|
LnpPP + AIx
|
0.932
|
LnpPP + AIx + MAP
|
0.939
|
LnpPP + AIx + MAP + Age
|
0.940
|
LnpPP + AIx + MAP + Age + Hb
|
0.941
|
LnpPP + AIx + MAP + Age + Hb + Heart rate
|
0.942
|
Abbreviation: LncPP: natural log-transformed central pulse pressure; LnpPP: natural log-transformed peripheral pulse pressure; AIx: augmentation index; MAP: mean arterial pressure; Hb: Haemoglobin
Supplementary Table 2: Renal transplant recipients only
A: Multivariable regression model for *LncPP (no adjustment for brachial blood pressure)
Variable
|
Estimate (Std Err)
|
p value
|
Age (/10 years)
|
0.09 (0.01)
|
<0.001
|
Heart rate (beats/min)
|
-0.09 (0.01)
|
<0.001
|
Height
|
-0.07 (0.02)
|
<0.001
|
B: Multivariable regression model for *LncPP (adjusted for brachial pulse and mean arterial pressure)
Variable
|
Estimate (Std Err)
|
p value
|
LnpPP (mmHg)
|
0.86 (0.03)
|
<0.001
|
AIx (%)
|
0.01 (0.00)
|
<0.001
|
Mean arterial pressure (10 mmHg)
|
0.04 (0.01)
|
<0.001
|
Heart rate (10 beats/min)
|
-0.03 (0.01)
|
<0.001
|
C: Stepwise change in multivariable model R2 (from Supplementary Table 2B).
Variable
|
Model R2
|
LnpPP
|
0.623
|
LnpPP + AIx
|
0.841
|
LnpPP + AIx + MAP
|
0.852
|
LnpPP + AIx + MAP + Heart rate
|
0.861
|
Abbreviation: LncPP, natural log-transformed central pulse pressure; LnpPP, natural log-transformed peripheral blood pressure; Aix: augmentation index; MAP, mean arterial pressure.
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