The promise of melatonin targets/ receptors as therapeutic targets in multiple therapy areas

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Feng & Zhang	2004	beta-amyloid-induced apoptosis	astroglioma C6 cells	100 nM to 10 µM	rat cells	[128]
Flora et al.	2004	Lead induced oxidative stress	plasma & liver	50 mg/kg (x5)	rats	[129]
Batcioglu et al.	2005	7,12-dimethylbenz(a)anthracene-induced damages	brain	4.2 mg/kg	mice	[130]
Karabay et al.	2005	thioacetamide-induced oxidative and nitrosative stress	liver	10 mg/kg	rats	[131]
Topal et al.	2005	cyclophosphamide-induced damage	bladder	10 mg/kg	rats	[132]
Aydin et al.	2005	experimental subarachnoid hemorrhage-induced vasopasm	brain	5 mg/kg	rabbits	[133]
Oktem et al.	2005	900-MHz-emitted mobile phone-induced oxidative damage	kidney	100 mg/kg	rats	[134]
Kratsovnik et al.	2005	ischemic/reperfused-induced oxidative injury	neuronal cultures	1 mM	rats	[135]
Wang et al.	2005	ischemic/reperfused-induced oxidative injury	muscles	10 mg/kg	rats	[136]
Leaden & Catala	2005	ascorbate-Fe2+ -induced lipid peroxidation	liver, kidney and brain	0.5 - 1.5 mM	rats	[137]
Korde et al.	2005	(enhance) humoral and cellular immune responses		100 µg/kg	rats	[138]
Brzozowski et al.	2005	stress-induced damage	stomach	1.25 - 10 mg/kg	rats	[139]
Carrillo-Vico et al.	2005	septic shock	whole animal	10 mg/kg	mice	[140]
Zhao & Liu	2005	oxygen stress	umbilical blood	0.1 to 100 mM	humans	[141]
Tang et al.	2006	Graves' disease	plasma	100 µM	humans	[142]
García-Rubio et al.	2006	paraquat-induced cytotoxicity	hepatocytes	0.5 - 2 mM	rats	[143]
Greish et al.	2006	doxorubicin cytotoxicity	peripheral blood hematopoeitic stem cells	10 µM	humans	[144]
Fischer et al.	2006	UV-induced apoptosis	keratinocytes	1 nM to 1 mM	humans	[145]
Lochner et al.	2006	ischemia-reperfusion injury	heart	25 to 50 µM	rats	[146]
Escames et al.	2006	nitric oxide synthase-dependent mitochondrial dysfunction	muscles	30 mg/kg (x3)	mice	[147]
Lee et al.	2006	kainic acid-induced neuronal death	hippocampus	10 mg/kg	mice	[148]
Han et al.	2006	ischemia/reperfusion-induced apoptosis	neuronal mitochondria	1 nM to 10 µM	rats	[149]
Petrosillo et al.	2006	ischemia-/reperfusion mitochondrial dysfunction	heart	50 µM	rats	[150]
Sharma & Haldar	2006	X-ray irradiation induced oxidative damage	plasma & spleen	2.5 µg/kg	squirrels	[151]
Sadir et al.	2007	cyclophosphamide-induced oxidative damage	bladder	10 mg/kg	rats	[152]
Ganguly et al.	2006	indomethacin-induced acute ulceration	stomach	60 mg/kg	rats	[153]
Matsura et al.	2006	acetaminophen-induced injury	liver	50 to 100 mg/kg	mice	[154]
Luchetti et al.	2007	apoptosis-induced intramitochondrial cardiolipin early changes	U937 cells	1 mM	human cells	[155]
Suresh et al.	2006	lead-induced changes	neuroblastoma cells	10 µM	human cells	[156]
Zou et al.	2004	photothrombosis-indued infarct size	brain	15 mg/kg	mice	[157]
El-Sokkary	2007	phenobarbital-induced oxidative stress	liver	10 mg/kg	rats	[158]
Matejovská et al.	2008	hypobaric hypoxia-induced cortical photothrombotic ischemic lesion	brain	100 mg/kg	rats	[159]
Chetsawang et al.	2007	MPP+-induced caspase-mediated death pathway	SK-N-SH cells	1 mM	rats	[160]
Perez et al.	2007	maternal cholestasis-induced oxidative stress	fetal liver-placenta-maternal liver	50 mg/kg	rats	[161]
Parlakpinar et al.	2007	pinealectomy-induced oxidative stress	kidneys	4 mg/kg	rats	[162]
Leaden & Catalá	2007	ascorbic-Fe(2+)-induced lipid peroxidation	liver microsomes	0.3 to 1.5 mM	rats	[163]
Sharma et al.	2007	6-hydroxydopamine model of Parkinson's disease	brain & C17.2 neural stem cells	4.0 μg/mL	rats	[164]
Jou et al.	2007	H2O2-induced toxicity	cells	100 µM	/	[165]
Albendea et al.	2007	aluminium-induced oxidtaive damage	synaptosomes	1 to 10 mM	rats	[166]
Fischer et al.	2008	UVR-induced damages	HaCaT keratinocytes	1 mM	human cells	[167]
Mathes et al.	2008	hemorrhagic shock-induced liver dysfunction	liver	10 mg/kg	rats	[168]
Carloni et al.	2008	neonatal hypoxic-ischemic-induced injury	brain	5 mg/kg	rats	[169]
Paul et al.	2008	endometriosis-induced MMP9 expression	uterus	48 mg/kg	mice	[170]
Das et al.	2008	glutamate excitotoxicity	C6 astroglial cells	150 nM	rats	[171]
Yildirim et al.	2008	irradiation-induced injury	central nervous system	1 mg/kg	rats	[172]
Chetsawang et al.	2009	hydrogen peroxide- and MPP-treated	SH-SY5Y neuroblastoma cells	0.1 & 0.5 mM	human cells	[173]
Valero et al.	2009	venezuelan equine encephalomyelitis virus-induced death	whole animals	0.5 mg/kg (x8)	mice	[174,175]
Ozan et al.	2007	cigarette smoke-induced damage	kidneys	4 mg/kg	rats	[176]
Genade et al.	2008	myocardial ischaemia/reperfusion-induced injury	heart	50 µM	rats	[177]
Mathes et al.	2008	hemorrhagic shock-induced liver dysfunction	liver	1 mg/kg (ramelteon)	rats	[178]
Konturek et al.	2008	aspirin-induced acute gastric mucosal damage	stomach	5 mg	humans	[179]
Petrosillo et al.	2008	age-related mitochondrial dysfunction	brain	150 µg/mL	rats	[180]
Luchetti et al.	2009	UVB-induced apoptosis	U937 cells	1 mM	human cells	[181]
Ceyran et al.	2008	ischemia-reperfusion injuries	heart	50 mg/kg	rats	[182]
Bas et al.	2009	noise-induced hearing loss	outer hair cell	1 mg/kg (x14)	rats	[183]
Lahiri et al.	2009	experimental reflux esophagitis	stomach	10 to 40 mg/kg	rats	[184]
Chen et al.	2009	ischemia/reperfusion-induced apoptosis	heart	150 μg/kg	mice	[185]
Diez et al.	2009	mild cardiac ischemia_induced ventricular arrhythmias	heart	5 to 50 µM	rats	[186]
Ling et al.	2009	constant illumination-induced endoplasmic reticulum damage	brain	0.1 to 10 mg/kg	rats	[187]
Bertuglia & Reiter	2009	chronic intermittent hypoxia-induced microvascumlar damages	several organs	10 mg/kg	hamsters	[188]
Sokullu et al.	2009	cardiopulmonary bypass-induced ischemia-reperfusion injury	heart	natural levels	humans	[189]
Assayed & Abd El-Aty	2009	gamma radiation-induced damage	bone-marrow	2.5 mg/kg (x5)	rats	[190]
Huang et al.	2009	MPP(+)-induced neuron death	brain	10 mg/kg	rats	[191]
Olcese et al.	2009	Alzheimer disease model-induced memory deficit and neurogeneration	brain	100 mg/L drinking water	rats	[192]
Simko et al.	2009	spontaneously hypertension-induced ventricular remodelling	heart	10 mg/kg	rats	[193]
Hibaoui et al.	2009	oxidative stress-mediated mitochondrial permeability	muscle	1 to 100 µM	mice	[194]
Tapias et al.	2010	rotenone Parkinson's disease model-induced neurodegeneration	brain	20 mg/kg

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