Cbe, ma (Oxon), mbchB, bsc (Hons), msc, PhD, md, dsc, frcp (Glasgow,Edinburgh and London), frcgp (hon), fcanSci, fmedSci



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Hosie KB, Kerr DJ, Gilbert JA, Downes M, Lakin G, Pemberton G, Timms K, Young A and Stanley A. A Pilot study of adjuvant intraperitoneal 5-fluororuarcil using 4% icodextrin as a novel carrier solution. European Journal of Surgical Oncology. (2003) 29: 254-260

Pendlebury S, Duchesne F, Reed K, Smith JL and Kerr DJ. A trial of adjuvant therapy in colorectal cancer: The VICTOR Trial. Clinical Colorectal Cancer. (2003) Vol 3:1. 58-60

Van Cutsem E, Dicato M, Wils J, Cunningham D, Diaz-Rubio E, Glimelius B, Haller D, Johnston P, Kerr D, Koehne CH, Labianca R, Minsky B, Nordlinger B, Roth A, Rougier P and Schmoll HP. Adjuvant treatment of colorectal cancer (current expert opinion derived from the Third International Conference: Perspectives in Colorectal Cancer, Dublin 2001) European Journal of Cancer. 2002, 38, 1429-1436.
Maughan TS, James RD, Kerr DJ, Ledermann JA, McArdle C, Seymour MT, Cohen D, Hopwood P, Johnston C, Stephens RJ. Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial. Lancet 2002, 359, 1555-1563
Midgley RS, Kerr DJ (2002) Ras as a target in Cancer Therapy. Critical Reviews in Haematology and Oncology 44(2):109-120
Tebutt NC, Cattell E, Midgley RS, Cunningham D, Kerr DJ. (2002) Systemic therapy of colorectal cancer. Eur.J.Oncol. 38(7): 1000-1015
Nicum S, Midgley RS, Kerr DJ (2002) Chemotherapy and Radiotherapy for Colorectal Cancer. In:Recent Advances in Coloproctology-Volume 2. In press

Kerr, D.J.,and Midgley, R.S. (2002). Immunotherapy for colorectal cancer: potential application in an adjuvant setting. Semin Oncol 27, 132-7.


Hussain, S.A., Ferry, D.R., El-Gazzas, G., Mirza, D.F., James, N.D., McMaster, P., and Kerr, D.J. (2001). Hepatocellular carcinoma. Ann Oncol 12, 161-72.

Kerr DJ. A United Kingdom Coordinating Committee on Cancer Research Study of Adjuvant Chemotherapy for Colorectal Cancer: Preliminary Results. Seminars in Oncology, 28(1): 31-34 (2001)

Hosie K, Gilbert JA, Kerr D, Brown CB, Peers EM. Fluid Dynamics in Man of an Intraperitoneal Drug Delivery Solution: 4% Icodextrin. Drug Delivery, 8: 9-12 (2001).
Neoptolemos JP, Dunn JA, Moffitt DD, Almond J, Link K, Beger H, Bassi C, Pederzoli P, Dervenis C, Fernandez-Cruz L, Lacaine F, Spooner D*, Kerr DJ*, Friess H, Buchler M. European Study Group for Pancreatic Cancer-1 interim results: a European randomized study to assess the roles of adjuvant chemotherapy and chemoradiation in resectable pancreatic cancer. British Journal of Surgery 2001;88(3):475-
Neoptolemos, J.P; Dunn,J.A; Stocken,D.D; Almond,J; Link,K; Beger,H; Bassi,C; Falconi,M; Pederzoli,P; Dervenis,C; Fernandez-Cruz,L; Lacaine,F; Pap,A; Spooner,D; Kerr,D.J; Friess,H; Buchler,M.W. Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial. European-Study-Group-for-Pancreatic-Cancer. Lancet. 2001 Nov 10; 358(9293): 1576-85
Snow,P.B; Kerr,D.J; Brandt,J.M; Rodvold, D.M Neural network and regression predictions of 5-year survival after colon carcinoma treatment. Cancer. 2001 Apr 15; 91: 1673-8
Grumett,S.A; Archer,V.R; Midgley,R; Mulholland,P; Nicum,S; Blewitt,L; Kerr,D.J. The role of mitomycin C in the treatment of patients with advanced colorectal cancer resistant to 5-fluorouracil-folinic acid chemotherapy. Ann-Oncol. 2001 Apr; 12(4): 575
Kerr, D.J. Two cultures or two faces? Ann-Oncol. 2001 Jan; 12(1): 7-8
Young,A.M; Kerr,D.J. Home delivery: chemotherapy and pizza? British Medical Journal. 2001 Apr 7; 322(7290): 809-10
Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials. Lancet. 2001; 358:1291-1304
Gray RG, Kerr DJ, McConkey CC, et al. On behalf of QUASAR Collaborative Group. Comparison of fluorouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: a randomised trial. The Lancet, 355, 1588-96 (2000)

Midgley RS, Kerr DJ. Towards post-genomic investigation of colorectal cancer. Lancet, Feb 26; 355 (9205): 669-70 (2000)

Sobrero A, Kerr D, Glimelius B, Van Cutsem E, Milano G, Pritchard DM, Rougier P, Aapro M. New directions in the treatment of colorectal cancer: a look to the future. European Journal of Cancer, 36, 559-566 (2000)

Nicum S, Midgley RS, Kerr DJ. Chemotherapy of colorectal cancer. Journal of the Royal Society of Medicine, 93, 416-419 (2000)

Midgley, R, Kerr D. Immunotherapy for colorectal cancer: a challenge to clinical trial design. The Lancet, 159-168 (2000)

Chung-Faye, G.A.,and Kerr, D.J. (2000). ABC of colorectal cancer: Innovative treatment for colon cancer. British Medical Journal 321, 1397-9.

Midgley, R.S. and Kerr, D.J. (2000). ABC of colorectal cancer: adjuvant therapy. British Medical Journal 321, 1208-11.

Kerr DJ, Gray R, McConkey C, Barnwell J. Adjuvant chemotherapy with 5-fluorouracil, L-folinic acid and levamisole for patients with colorectal cancer: non-randomised comparison of weekly versus four-weekly schedules--less pain, same gain. QUASAR Colorectal Cancer Study Group. Annals of Oncology 2000;11(8):947-955

Kerr, D.J., Midgley, R.J., and McArdle, C.S. (2000). Hepatic arterial chemotherapy; Still on trial. Journal of Clinical Oncology 18, 1806-1807.

Kerr, D.J. (1999). Cost of treating colorectal cancers. European Journal of Cancer 35, 187.


Midgley R, Kerr D, Seminar on Colorectal Cancer. Lancet Vol. 353: 391-99 (1999)
Koehne CH, Midgley R, Seymour M, Kerr DJ. Advanced colorectal cancer: which regimes should we recommend? Annals of Oncology Aug; 10(8):877-82 (1999)

Ingleby, S., Barnwell, J., Baker, J.,Harvey, P., kerr, D.J., Law, V., and Young, A. (1999). A pilot study of a feasibility and economic analysis of home based chemotherapy in advanced colorectal cancer. European Journal of Cancer 35, 214.

Jessop, J.M., Snow, P., Brandt, J., Bellucco, C., Menck, H.R., and Kerr, D.J. (1999). Artificial neural network prediction of 5-year survival from colon cancer. European Journal of Cancer 35, 211.

Jankowski JA, Wright NA, Meltzer SJ, Triadafilopoulos G, Geboes K, Casson AG, Kerr D, Young LS. Molecular Evolution of the Metaplasia-Dysplasia-Adenocarcinoma sequence in the esophagus. American Journal of Pathology Vol. 154 (4) (1999)

Langman MJS, Dunn JA, Whiting JL, Burton A, Hallissey MT, Fielding JWL, Kerr DJ. Prospective, double-blind, placebo-controlled randomised trial of cimetidine in gastric cancer. British Journal of Cancer, 81(8), 1356-1362 (1999)

Howell JD, Warren HW, Anderson JH, Kerr DJ, and McArdle CS. Intra-arterial 5-fluorouracil and intravenous folinic acid in the treatment of liver metastases from colorectal cancer. European Journal of Surgery 1999; Vol 165.652-8.

Young AM, Kerr DJ Novel Treatments for Colorectal Cancer, Oncology Today – 1999 18-26

Young AM, Daryanani S, and Kerr DJ. Can pharmacokinetic monitoring improve clinical use of fluorouracil? Clinical Pharmacokinetics 1999; 36.391-8.

Ingleby, S., Baker, J., Young, A., and Kerr, D.J. (1999). Health economics analysis of home based vs. hospital based chemotherapy: Discussion of results. British Journal of Cancer 80, 332.

Kerr, D. (1999). Safety of Raltitrexed. Lancet 354, 1825.


Kerr DJ, Ferry DR, Novel therapeutic strategies for colorectal cancer. Hospital Medicine, Vol. 59, No. 8: 617-621, (1998)

Cocconi G, Cunningham, D, Van Cutsem E, Francois E, Gustavsson B, van Hasal G, Kerr D, Possinger K, Hietschold SM. Open, randomized , multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. J. Clin. Onc. 16, 9 : 2943-2952, (1998)

Zalcberg J, Kerr D, Seymour L, Palmer M. Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is signjificantly associated with gender, increasing age and cycle number. Tomudex International Study Group. European Journal of Cancer, 34 (12): 1871-5 (1998)

Wils J, Sahmoud T, Sobrero A, Bleiberg H, Ahmedzai S, Blazeby J, Blijham G, Conroy T, Cunningham D, Curran D, Diaz-Rubio E, Ducreux M, Evans J, Glimelius B, Hutchinson G, Kerr D et al. Evaluation of clinical efficacy of new medical treatments in advanced colorectal cancer. Results of a workshop organised by the EORTC GITCCG. European Organisation for Research and Treatment of Cancer. Gastrointestinal Tract Cancer Cooperative Group. Tumori 1998; 84.335-47.


Baker, J., Bleiberg, H., Hutchison, G., Jackman, A., Kerr, D., Labianca, R., Macdonald, J., Meyer, H.J., Minsky, B., Nordlinger, B., Rougier, P., Smits, S., Sobrero, A., Taylor, I., and Verweijm J. An international multidisciplinary approach to the management of advanced colorectal cancer (First of two parts) (Reprinted from Eur J Surg Oncol, Vol 23, Suppl A, August 1997) Annales Chirurgiae Et Gynaecologiae 87, 255-264. (1998).
Nemunaitis J, Poole C, Primrose J, Rosemurgy A, Malfetano J, Brown P, Berrington A, Cornish A, Lynch K, Rasmussen H, Kerr D, Cox D, Miller A. Combined Analysis of studies of the effects of the matrix metalloprote4inase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies. Clinical Cancer Research. Vol. 4: 1101-1109, May 1998

Seymour LW, Olliff SP, Poole CJ, de Takats PG, Orme R, Ferry DR, Maeda H, Konno T, Kerr DJ. A novel dosage approach for evaluation of SMANCS [poly-(styrene-co-maleyl-half-n-butylate) – neocarzinostatin] in the treatment of primary hepatocellular carcinoma. International Journal of Oncology 12: 1217-12223, (1998).


Rougier P, Ducreux M, Kerr D, Carr BI, Francois E, Adenis E and Seymour LA Phase II study of raltitrexed ‘Tomudex’ in patients with hepatocellular carcinoma. Annals of Oncology 8: 500-502 (1997)
Kerr DJ, O’Connor K.M. The costs of managing advanced colorectal cancer: a broad perspective. Anti-Cancer Drugs Vol. 8, Suppl 2 1997 S23 (1997)
Neoptolemos JP, Kerr DJ, Beger H, Link K, Pederzoli P, Bassi C, Dervenis C, Fernandez-Cruz L, Laçaine F, Freiss H, Büchler M. ESPAC-1 Trial Progress Report. The European randomised adjuvant study comparing radiochemotherapy, six months chemotherapy and combination therapy versus observation in pancreatic cancer. Digestion: 56: 570-577 (1997)
Midgley RS, Kerr DJ. Adjuvant Therapy of Colorectal Cancer. Cancer Treatment Reviews 23:135-152. (1997)
Blesing, CH, Julyan, PJ, Barnwell, JM, Parker, DJ, Mountford, PJ, Kerr, DJ, and Harding LK Quantitative whole body counter distribution studies of 18f-5 fluorouracil following hepatic arterial and IV infusion. Br. J. Radiology, 32, 14-19 (1996)
Blesing, CH; Kerr, DJ. Intra-hepatic arterial drug delivery. J Drug Targeting 3: 341-347 (1996)
Green, NK, Searle, PF, Young, LS, Kerr, DJ and Neoptolamos JP Gene Therapy for gastrointestinal cancer, GI Cancer, 2, 43-53 (1996)
De Takats, PG and Kerr DJ Is intra-arterial chemotherapy worthwile in the treatment of patients with unresectable hepatic colorectal cancer metastases? Eur.J.Cancer 32 13, 2195-2205 (1996)
Kerr, DJ, Young, AM, Neoptolamos, JP, Sherman, J, Van-Geere, P, Stanley, A, Ferry, D, Dobbie, JW, Vincke, B, Gilbert, J, Dombros, N, and Fountzilos, G.. Prolonged Introperitoneal infusion of 5-FU using a novel carrier solution. Brit. J. Cancer, 74, 2032-2035 (1996)
McArdle, CS; Anderson, JH; Warren, H; Doughty, J; Kerr, DJ. Intra-arterial 5-FU modulated by folinic acid for colorectal liver mets.Regional Cancer Treat. 9: 27-29 (1996)
Kerr, DJ. Tomudex ZD 1694, a new direct and specific thymidylate synthase inhibitor, has resource saving implications in the management of colorectal cancer. Quality of Life Research 4 6: 576 (1995)
Kerr, DJ; de Takats, PG Chemotherapy for gastrointestinal cancer: teaching old drugs new tricks. GI Cancer 1: 3-7 (1995)
Kerr, DJ; Ledermann, JA; McArdle, CS; Buckels, J; Neoptolemos, J; Seymour, M; Doughty, J; Budden, J; Taylor, I. Phase I clinical and pharmacokinetic study of leucovorin and infusional hepatic arterial fluorouracil. J Clin Oncol 1312: 2968-2972 (1995)
Kerr, DJ; Rustin, GJ; Kaye, SB; Selby, P; Bleehen, NM; Harper, P; Brampton, MH.Phase II trials of rhizoxin in advanced ovarian, colorectal and renal cancer. Br J Cancer 72: 1267-1269 (1995)
Cunningham, D; Zalcberg, JR; Rath, U; Olver, I; Van Cutsem, E; Svensson, C; Seitz, JF; Harper, P; Kerr, D; Perez-Mango, G; Azab, M; Seymour, L; Lowery, K & the ‘Tomudex’ Colorectal Cancer Study Group Tomudex ZD1694: Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. Eur J Cancer 31A 12: 1945-1954 (1995)
Jodrell, DI; Oster, W; Kerr, DJ; Canney, PA; Yosef, H; Steward, WP; Kaye, SB; Cassidy, J. A phase I/II study of N-phosphonacetyl-L-Aspartic Acid PALA added to 5-Fluorouracil and folinic acid in advanced colorectal cancer. Eur J Cancer 30a 7: 950-954 (1994)
de Takats, PG; Kerr, DJ; Poole, CJ; Warren, HW; McArdle, CS. Hepatic arterial chemotherapy for metastatic colorectal carcinoma.Br J Cancer 69: 372-378 (1994)
McArdle, CS; Kerr, DJ; O’Gorman, P; Wotherspoon, HA; Warren, H; Watson, D; Vinke, BJ; Dobbie, JW; El Eini, DID. Pharmacokinetic study of 5-fluorouracil in a novel dialysate solution: a long-term intraperitoneal treatment approach for advanced colorectal carcinoma. Br J Cancer 70: 762-766(1994)
Warren, HW; Anderson, JH; O’Gorman, P; Kane, E; Kerr, DJ; Cooke, TG; McArdle, CS. A phase II study of regional 5-fluorouracil infusion with intravenous folinic acid for colorectal liver metastases. Br J Cancer 70: 677-680 (1994)

Warren, HW; Anderson, JH; O'Gorman, P; Kerr, DJ; Cooke, TG; McArdle, CS. Ambulatory infusion pumps for intrahepatic arterial chemotherapy. Regional Cancer Treat 2: 77-78 (1993)


McArdle, CS. Glass yttrium-90 microspheres for patients with colorectal liver metastases. Anderson, JH; Goldberg, JA; Bessent, RG; Kerr, DJ; McKillop, JH, Stewart, I; Cooke, TG; Radiotherapy and Oncology 25: 137-139. 1992
Anderson, JH; Kerr, DJ; Cooke, TG; McArdle, CS. A phase I study of regional 5-Fluoruracil and systemic folinic acid for patients with colorectal liver metastases. Br J Cancer 65: 913-915. 1992
Anderson, JH; Kerr, DJ; Setanoians, A; Cooke, TG; McArdle, CS. A pharmacokinetic comparison of intravenous versus intra-arterial folinic acid.Br J Cancer 65: 133-135. 1992
Kaye, SB; Brampton, M; Harper, P; Smyth, J; Kerr, DJ; Gore, M; Green, JA; Gilby, E; Crawford, SM; Rustin, GJ. Phase II trials of fosquidone, GR63178A in colorectal, renal and non-small cell lung cancer. Br J Cancer 65: 624-625. 1992
Kerr, DJ 5-fluorouracil and folinic acid - interesting biochemistry or effective treatment?Brit J Cancer 60 6: 807-809. 1989

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