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Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes



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Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes


Non-human primates, such as the rhesus macaques, are the preferred model for down-selecting human malaria vaccine formulations, but the rhesus model is expensive and does not allow for direct efficacy testing ...

Timothy W. Phares, Anthony D. May, Christopher J. Genito, Nathan A. Hoyt, Farhat A. Khan, Michael D. Porter, Margot DeBot, Norman C. Waters, Philippe Saudan and Sheetij Dutta

Malaria Journal 2017 16:115

Combining indoor and outdoor methods for controlling malaria vectors: an ecological model of endectocide-treated livestock and insecticidal bed nets


Malaria is spread by mosquitoes that are increasingly recognised to have diverse biting behaviours. How a mosquito in a specific environment responds to differing availability of blood-host species is largely ...

Laith Yakob, Mary Cameron and Jo Lines

Malaria Journal 2017 16:114

A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria


Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding...

Mirjam Groger, Hannah S. Fischer, Luzia Veletzky, Albert Lalremruata and Michael Ramharter

Malaria Journal 2017 16:112

Resting and feeding preferences of Anopheles stephensi in an urban setting, perennial for malaria


The Indian city of Chennai is endemic for malaria and the known local malaria vector is Anopheles stephensi. Plasmodium vivax is the predominant malaria parasite species, though Plasmodium falciparum is present a...

Shalu Thomas, Sangamithra Ravishankaran, N. A. Johnson Amala Justin, Aswin Asokan, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B. Thomas and Alex Eapen

Malaria Journal 2017 16:111

Burden of malaria in mobile populations in the Greater Accra region, Ghana: a cross- sectional study


The burden of malaria in mobile populations remains poorly documented in sub-Saharan Africa. This study determined the prevalence of malaria among hawkers and long-distance truck drivers in the Greater Accra r...

Nouhoum Diallo, Patricia Akweongo, Ernest Maya, Moses Aikins and Bismark Sarfo

Malaria Journal 2017 16:109

Prevalence and determinants of malaria among children in Zambézia Province, Mozambique


Malaria is the leading cause of death among children in Mozambique. Prevalence and factors associated with malaria are not well studied among children in rural Zambézia Province. Whether prevalence of malaria ...

James G. Carlucci, Meridith Blevins Peratikos, Charlotte B. Cherry, Melanie L. Lopez, Ann F. Green, Lazaro González-Calvo and Troy D. Moon

Malaria Journal 2017 16:108

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms


Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G...

Anna Caroline C. Aguiar, Flávio Jr. B. Figueiredo, Patrícia D. Neuenfeldt, Tony H. Katsuragawa, Bruna B. Drawanz, Wilson Cunico, Photini Sinnis, Fidel Zavala and Antoniana U. Krettli

Malaria Journal 2017 16:110

Preliminary survey on Anopheles species distribution in Botswana shows the presence of Anopheles gambiae and Anopheles funestus complexes


Botswana is one of the four front line malaria elimination countries in Southern Africa, with malaria control activities that include routine vector control. Past and recent studies have shown that Anopheles arab...

Leabaneng Tawe, Pleasure Ramatlho, Kelebogile Waniwa, Charles W. Muthoga, Ntebaleng Makate, Davis S. Ntebela, Isaac K. Quaye, Marco Pombi and Giacomo Maria Paganotti

Malaria Journal 2017 16:106

A systematic review on malaria sero-epidemiology studies in the Brazilian Amazon: insights into immunological markers for exposure and protection


Considerable success in reducing malaria incidence and mortality has been achieved in Brazil, leading to discussions over the possibility of moving towards elimination. However, more than reporting and countin...

Pedro M. Folegatti, André M. Siqueira, Wuelton M. Monteiro, Marcus Vinícius G. Lacerda, Chris J. Drakeley and Érika M. Braga

Malaria Journal 2017 16:107

Rapid diagnostic tests failing to detect Plasmodium falciparum infections in Eritrea: an investigation of reported false negative RDT results


Relatively large number of false-negative malaria rapid diagnostic test (RDT) results for microscopically confirmed Plasmodium falciparum cases were reported from five of the six administrative regions of Eritrea...

Araia Berhane, Mulugeta Russom, Iyassu Bahta, Filmon Hagos, Michael Ghirmai and Selam Uqubay

Malaria Journal 2017 16:105

Passive case detection of malaria in Ratanakiri Province (Cambodia) to detect villages at higher risk for malaria


Cambodia reduced malaria incidence by more than 75% between 2000 and 2015, a target of the Millennium Development Goal 6. The Cambodian Government aims to eliminate all forms of malaria by 2025. The country’s ...

Somony Heng, Lies Durnez, Sokny Mao, Sovannaroth Siv, Sochantha Tho, Vanna Mean, Vincent Sluydts and Marc Coosemans

Malaria Journal 2017 16:104

Should chemoprophylaxis be a main strategy for preventing re-introduction of malaria in highly receptive areas? Sri Lanka a case in point


Imported malaria cases continue to be reported in Sri Lanka, which was declared ‘malaria-free’ by the World Health Organization in September 2016. Chemoprophylaxis, a recommended strategy for malaria preventio...

A. Rajitha Wickremasinghe, Renu Wickremasinghe, Hemantha D. B. Herath and S. Deepika Fernando

Malaria Journal 2017 16:102


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