3) Corticosteroids: Cause peripheral insulin resistance and gluconeogenesis. ҉ Mechanism of D.M influence on various tissues ةمهم A. Formation of advanced Glycation End Products (AGEs): - Glycations are products of non-enzymatic reaction of free reducing sugars with free amino groups of body proteins & lipids. Fibroblasts, endothelial cells & monocytes have receptors for AGEs - Binding of AGEs to their receptors on fibroblasts production of collagen. - Binding of AGEs to their receptors on endothelial cells → thrombosis and vasoconstriction. - Binding of AGEs to their receptors on monocytes →↑ cytokines → bone resorption, collagen destruction.