Definition of Diabetes mellitus (DM)



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3) Corticosteroids: Cause peripheral insulin resistance and gluconeogenesis.
҉ Mechanism of D.M influence on various tissues ةمهم
A. Formation of advanced Glycation End Products (AGEs):
- Glycations are products of non-enzymatic reaction of free reducing sugars with free amino groups of body proteins & lipids. Fibroblasts, endothelial cells & monocytes have receptors for AGEs
- Binding of AGEs to their receptors on fibroblasts production of collagen.
- Binding of AGEs to their receptors on endothelial cells → thrombosis and vasoconstriction.
- Binding of AGEs to their receptors on monocytes →↑ cytokines → bone resorption, collagen destruction.

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