Cotton BA, Podbielski J, Camp E, Welch T, Del Junco D, Bai Y, Hobbs R, Scroggins J, Hartwell B, Kozar RA, Wade CE, Holcomb JB. A Randomized Controlled Pilot Trial of Modified Whole Blood versus Component Therapy in Severely Injured Patients Requiring Large Volume Transfusions. Ann Surg. 2013 Oct;258(4):527-33. Peng Z, Pati S, Potter D, Brown R, Holcomb JB, Grill R, Wataha K, Park PW, Xue H, Kozar RA. Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan-1. Shock. 2013 40(3):195-202. Jun 25. [Epub ahead of print]
Adams SD, Cotton BA, Wade CE, Kozar RA, Dipasupil E, Pdbielski JM, Gill BS, Duke JR, Adams PR, Holcomb JB. Do not resuscitate status, not age, affects outcomes after injury: An evaluation of 15,227 consecutive trauma patients. J Trauma Acute Care Surg 2013, 74(5):1327-30.
Wataha K, Menge T, Deng X, Shah A, Bode A, Holcomb JB, Potter D, Kozar RA, Spinella PC, Pati S. Spray-dried plasma and fresh frozen plasma modulate permeability and inflammation in vitro in vascular endothelial cells. Transfusion 2013 53:Suppl 1:80S-90S. Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, Depasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM, Pati S, Rasmussen T, Sailliol A, Schreiber MA, Sunde GA, van de Watering LM, Ward KR, Weiskopf RB, White NJ, Strandenes G, Spinella PC. THOR Position Paper on Remote Damage Control Resuscitation: Definitions, Current Practice and Knowledge Gaps. Shock. 2014 2014 May;41 Suppl 1:3-12.
Shackelford SR, Kahl JE, Calvo RY, Kozar RA, Haugen CE, Kaups KL, Willey M, Tibbs BM, Mutto SM, Rizzo AG, Lormel CS, Shackford MC, Burlew CC, Moore EE, Cogbill TH, Kallies KJ, Haan JM, Ward J. Gunshot wounds and blast injuries to the face are associated with significant morbidity and mortality: Results of an 11-year multi-institutional study of 720 patients. J Trauma Acute Care Surg. 2014 Feb;76(2):347-52.
Wade CE, Kozar RA, Dyer CB, Bulger EM, Mourtzakis M, Heyland DK. Evaluation of Nutrition Deficits in Adult and Elderly Trauma Patients. JPEN J Parenter Enteral Nutr. 2014 Feb 21. [Epub ahead of print]
Kozar RA, Holcomb JB, Xiong W, Nathens AB. Are all deaths created equally? The impact of hospice care on risk-adjusted mortality. J Trauma Acute Care Surg 2014 Mar;76(3):634-41.
Shalhub S, Starnes BW, Brenner ML, Biffl WL, Azizzadeh A, Inaba K, Skiada D, Zarzaur B, Nawaf C, Eriksson EA, Fakhry SM, Paul JS, Kaups KL, Ciesla DJ, Todd SR, Seamon MJ, Capano-Wehrle LM, Jurkovich GJ, Kozar RA. Blunt abdominal aortic injury: A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2014 Dec;77(6):879-85; discussion 885.
Kozar R. What’s new in Shock? Shock. 2014 Dec;42(6):483-4
Peng Z, Ban K, Wawrose RA, Gover A, Kozar RA. Protection by enteral glutamine is mediated by intestinal epithelial cell peroxisome proliferator-activated receptor gamma during intestinal ischemia/reperfusion. Shock. 2015 Apr;43(4):327-33
McNutt MK, Chinapuvvula NR, Beckmann NM, Camp EA, Laney RW, West OC, Gill BS, Kozar RA, Cotton BA, Wade CE, Adams PR, Holcomb JB. Early Surgical Intervention for Blunt Bowel Injury: The Bowel Injury Prediction Score (BIPS). Journal of Trauma and Acute Care Surgery. 2015 78(1): 105-11.
Shrestha B, Holcomb JB, Camp EA, Del Junco DJ, Cotton BA, Albarado R, Gill BS, Kozar RA, Kao LS, McNutt MK, Moore LJ, Love JD, Tyson GH 3rd, Adams PR, Khan S, Wade CE. Damage-control resuscitation increases successful nonoperative management rates and survival after severe blunt liver injury J Trauma Acute Care Surg. 2015 Feb;78(2):336-41
Kozar RA, Pati S. Syndecan-1 restitution by plasma after hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S83-6.
Potter DR, Baimukanova G, Keating SM, Deng X, Chu JA, Gibb SL, Peng Z, Muench MO, Fomin ME, Spinella PC, Kozar R, Pati S.Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S7-S17.
Camazine MN, Hemmila MR, Leonard JC, Jacobs RA, Horst JA, Kozar RA, Bochicchio GV, Nathens AB, Cryer HM, Spinella PC.Massive transfusion policies at trauma centers participating in the American College of Surgeons Trauma Quality Improvement Program. J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S48-53.
Kozar RA, Arbabi S, Stein D, Shackford SR, Barraco RD, Biffl WL, Brasel KJ, Cooper Z, Fakhry SM, Livingston D, Moore FA, Luchette F. Injury in the aged: Geriatric trauma care at the crossroads. J Trauma Acute Care Surg. 2015, Jun;78(6):1197-209
Ban K, Peng Z, Pati S, Witkov RB, Park PW, Kozar RA. Plasma-mediated gut protection after hemorrhagic shock is lessened in syndecan-1-/- mice. Shock. 2015 Nov;44(5):452-7Aug 10.
Deng X, Cao Y, Huby MP, Duan C, Baer L, Peng Z, Kozar RA, Doursout MF, Holcomb JB, Wade CE, Ko TC. Adiponectin in Fresh Frozen Plasma Contributes to Restoration of Vascular Barrier Function After Hemorrhagic Shock. Shock. January 2016 45(1):5-54. 2015 Aug 10 [Epub ahead of print]
Zarzaur BL, Kozar R, Myers JG, Claridge JA, Scalea TM, Neideen TA, Maung AA, Alacon L, Corcos A, Kerwin A, Coimbra R. The splenic injury outcomes trial: An American Association for the Surgery of Trauma multiinstitutional study. J Trauma Acute Care Surg 2015 Sept; 79(3):335-42.
Kutcher ME, Weis JJ, Siada SS, Kaups KL, Kozar RA, Summers JI, Eriksson EA, Leon SM, Carrick MM, Mallory G, Sperry JL. The role of computed tomographic scan in ongoing triage of operative hepatic trauma: A Western Trauma Association multicenter retrospective study. J Trauma Acute Care Surg. 2015 76(9):951-6. Sept 2 [Epub ahead of print]
Moore LJ, Brenner M, Kozar R, Pasley J, Wade CE, Baraniuk MS, Scalea T, Holcomb JB. Implementation of resuscitative endovascular balloon occlusion of the aorta as an alternative to resuscitative thoracotomy for noncompressible truncal hemorrhage J Trauma Acute Care Surg. 2015 Oct;79(4):523-32.
Matijevic N, Wang YW, Holcomb JB, Kozar R, Cardenas JC, Wade CE. Microvesicle phenotypes are associated with transfusion requirements and mortality in subjects with severe injuries. J Extracell Vesicles. 2015 Dec 17;4:29338. doi: 10.3402/jev.v4.29338. eCollection 2015.
Bruns B, Kozar RA. Feeding the Postoperative Patient on Vasopressor Support: Feeding and Pressor Support. Nutr Clin Pract. 2016 Feb;31(1):14-7. doi: 10.1177/0884533615619932. Epub 2015 Dec 24.
Paris MT, Mourtzakis M, Day A, Leung R, Watharkar S, Kozar R, Earthman C, Kuchnia A, Dhaliwal R, Moisey L, Compher C, Martin N, Nicolo M, White T, Roosevelt H, Peterson S, Heyland DK. Validation of Bedside Ultrasound of Muscle Layer Thickness of the Quadriceps in the Critically Ill Patient (VALIDUM Study): A Prospective Multicenter Study. JPEN J Parenter Enteral Nutr. 2016 Mar 9.
Pusateri AE, Given MB, Schreiber MA, Spinella PC, Pati S, Kozar RA, Khan A, Dacorta JA, Kupferer KR, Prat N, Pidcoke HF, Macdonald VW, Malloy WW, Sailliol A, Cap AP. Dried plasma: state of the science and recent developments. Transfusion. 2016 Apr;56 Suppl 2:S128-39.
Bruns BR, Ahmad SA, O’Meara L, Tesoriero R, Lauerman M, Klyushnenkova E, Kozar R, Scalea TM, Diaz JJ. Non-Trauma Open Abdomens: A Prospective Observational Study. J Trauma Acute Care Surg. 2016 Apr;80(4):631-6.
Peng Z, Ban K, LeBlanc A, Kozar RA. Intraluminal Tranexamic Acid Inhibits Intestinal Sheddases and Mitigate Gut and Lung Injury and Inflammation in a Rodent Model of Hemorrhagic Shock. J Trauma Acute Care Surg. 2016 Aug;81(2):358-65. 154.
McDonald D, Ackermann G, Khailova L, Baird C, Heyland D, Kozar R, Lemieux M, Derenski K, King J, Vis-Kampen C, Knight R, Wischmeyer PE. Extreme dysbiosis of the microbioime in critical illness. mSphere. 2016 Aug 31;1(4). pii: e00199-16. doi: 10.1128/mSphere.00199-16.
Kozar RA, Sanddal ND. Role of level IV trauma centers in an inclusive trauma system: the injured elderly. Am J Surg. 2016 Sep;212(3):377-8.
Moisey LL, Mourtzakis M, Kozar RA, Compher C, Heyland DK. Existing equations to estimate lean body mass are not accurate in the critically ill: Results of a multicenter observational study. Clin Nutr. 2016 Sep 23. pii: S0261-5614(16)31251-1.
Jenkins DH, Winchell RJ, Coimbra R, Rotondo MF, Weireter LJ, Bulger EM, Kozar RA, Nathens AB, Reilly PM, Henry SM, Jimenez MF, Chang MC, Coburn MC, Dodd J, Neal ML, Rosen J, Clemency J, Hoyt DB, Stewart RM; American College of Surgeons Committee on Trauma. Position statement of the American College of Surgeons Committee on Trauma on the National Academies of Sciences, Engineering and Medicine report, A National Trauma Care System: Integrating Military and Civilian Trauma Systems to Achieve Zero Preventable Deaths after Injury. Trauma Acute Care Surg. 2016 Nov;81(5):819-823. PubMed PMID: 27533902.
Peng Z, Pati S, Fontaine MJ, Hall K, Herrera AV, Kozar RA. Lack of Species Specific Difference in Pulmonary Function When Using Mouse Versus Human Plasma in a Mouse Model of Hemorrhagic Shock. J Trauma Acute Care Surg. 2016 2016 Nov;81(5 Suppl 2): 171-176.
Coimbra R, Kozar RA, Smith JW, Zarzaur BL, Hauser CJ, Moore FA, Bailey JA, Valadka A, Jurkovich GJ, Jenkins DH, Davis KA, Price MA, Maier RV. The Coalition for National Trauma Research (CNTR) Supports the Call for a National Trauma Research Action Plan. J Trauma Acute Care Surg. 2016 Dec 23. [Epub ahead of print]
Wu F, Peng Z, Park PW, Kozar RA. Loss of syndecan-1 abrogates the pulmonaryprotective phenotype induced by plasma after hemorrhagic shock. Shock. 2017 Jan 19. [Epub ahead of print]
Book Chapters
Kozar RA, Roslyn JJ: Appendix. In Schwartz SI (Ed.): Principles of Surgery, 7th edition. McGraw-Hill, Inc., 1999: 1383-1394.
Kozar RA, Cipolla J: Chylothorax. In Plantz S (Ed): Medicine, Ob/Gyn, Psychiatry, and Surgery. On-line reference text. (http://www.emedicine.com). Boston Medical Publishers.
Kozar RA, McQuiggan MM, Moore FA. Nutritional Support of Trauma Patients. In Shikora SA, Martindale RG, Schwaitzberg SD (Eds.): Nutritional Considerations in the Intensive Care Unit. Science, Rationale, and Practice. Kendall/Hunt Publishing Co., Dubuque, IO, 2002:229-244.
Kozar RA, Moore FA,: Postinjury Multiple Organ Failure. In Moore EE, Feliciano DV, Mattox KL (Eds.): Trauma Handbook, 4th edition. McGraw-Hill, Inc., 2002: (56) 501-506.
Kozar RA, Haenel JB, Moore FA. Flail Chest and Pulmonary Contusion. In Parsons PE, Wiener-Kronish JP (Eds.): Critical Care Secrets, 3rd edition, Lippincott, 2003: 403-408 and 4th edition, 2007: 447-451.
Kozar RA, McQuiggan MM, Moore FA. Trauma. In Rolandelli R (Ed): Clinical Nutrition (Volume I): Enteral and Tube Feeding, 4th edition, Saunders, 2004:364-372.
Kozar RA, McQuiggan MM, Moore FA. Trauma. In Merritt R (Ed): A.S.P.E.N. Nutrition Support Practice Manual, 2nd Edition, ASPEN, 2005:271-276.
Kozar RA, McQuiggan MM, Moore FA. Trauma In Cresci G (Ed): Nutrition Support in the Critically Ill Patient: A Guide to Practice, CRC Press, 2005:421-434.
Kozar RA, Moore FA. Fluid and Electrolyte Management of the Surgical Patient. In Brunicardi FC (Eds): Schwartz’s Principles of Surgery, 8th edition, McGraw-Hill, 2005;43-59.
Kozar RA, McQuiggan MM, Moore FA. Surgical Nutrition. In Miller T (Ed): Modern Surgical Care: Physiologic Foundations and Clinical Applications, 3rd Edition, Informa Healthcare, 2006: 49-64.
Kozar RA, Weisbrodt NW, Moore FA. Gut Failure in the Critically Injured Patient. In Feliciano DV, Mattox KL, Moore EE (Eds): Trauma, 6th edition, McGraw-Hill, 2008:1281-1290.
Gonzalez EA, Jastrow KM, Holcomb JB, Kozar RA. Hemostasis, Surgical Bleeding, and Transfusion. In Schwartz’s Principles of Surgery, 9th Edition, McGraw-Hill, 2009:67-87
Bick1 RJ, Poindexter BJ, Sheikh-Hamad D, Santora RJ, Kozar RA, Klein GL. Changes in the calcium-sensing receptor and stanniocalcin-1 in rat small intestine in response to ischemia-reperfusion injury. Current Topics in Peptide & Protein Research. 2010
Kozar RA, Moore FA. Gastrointestinal Failure in the Critically Injured Patient. In Feliciano DV, Mattox KL, Moore EE (Eds): Trauma, 7th edition, McGraw-Hill, 2012, 1073-1083.
Sixta S, Kozar RA. Management of the Severely Injured Trauma Patient. In Comprehensive Critical Care: Adult. Roberts PR, Todd SR (Eds). Society of Critical Care Medicine, 2012:805-821.
Schwartz D, Kozar RA. Nutrition in the Surgical Patient. In Moore LJ, Turner KL. Todd SR (Eds): Common Problems in Acute Care Surgery. Springer, New York, 2013, 119-129.
Kozar RA, McNutt MK. Disorders of Calcium and Magnesium Metabolism. In Textbook of Critical Care. 6th edition. Shoemaker. Part 6; 112 page 865. 2012
Gordy S, Kozar RA. Metabolism in the Trauma Patient. In Surgical metabolism: the Metabolic Care of the Surgical Patient. Davis K and Rosenbaum S (Eds); Springer, 2014.
Cotton B, Holcomb JB, Pommering M, Jastrow KM, Kozar RA. Hemostasis, Surgical Bleeding, and Transfusion. In Schwartz’s Principles of Surgery, 10 th Edition, McGraw-Hill, 2014, page 85-107.
Kozar RA, McNutt MK. Liver Injury Severity Score. Encyclopedia of Critical Care Medicine. 2014.
Kozar RA, McNutt MK. Disorders of Calcium and Magnesium Metabolism. In Textbook of Critical Care. 7th edition. Shoemaker. Chapter 108, 2016, in press.
Bruns B, Kozar RA. Liver and Biliary Tract. In Feliciano DV, Mattox KL, Moore EE (Eds): Trauma, 8th edition, McGraw-Hill, 2015, in press.
Berry C, Kozar RA. Solid Organ Injury. In Trauma Geriatrics 2nd edition, 2015, in press.
Schwartz D, Tannous A, Kozar RA. Nutrition in the Surgical Patient. In Moore LJ, Turner KL. Todd SR (Eds): Common Problems in Acute Care Surgery, 2nd edition. Springer, New York, 2016, in press.
Sixta S, Kozar RA. Management of the Severely Injured Trauma Patient. In Comprehensive Critical Care: Adult. Roberts PR, Todd SR (Eds). Society of Critical Care Medicine, 2nd edition 2016, in press.
Published Abstracts
Kozar RA, Abedin ZR, Abedin MZ, Trooskin SZ. Expression of epidermal growth factor in Type II Pneumocytes: A potential mechanism for recovery from acute lung injury. Investigative Medicine. 1998; 463 (3):223A.
Hassoun HT, Weisbrodt NW, Kozar RA, Mercer DW, Moody FG, Moore FA. Inducible nitric oxide synthase mediates impaired small intestinal transit after severe gut
ischemia/reperfusion. J Surg Res. 2000; 91 (2): 353.
Kozar RA, Kaplan LJ, Cipolla J, Meija J, Haber M. Laparoscopic repair of traumatic diaphragmatic injuries. J Surg Res. 2000; 91(2):358-359.
Kozar RA, Schultz SG, Weisbrodt N, DeSoignie R, Hassoun HT, Moore FA.
Intraluminal nutrients enhance gut ischemia/reperfusion injury. Shock. 2000; 13 supp;28.
Kozar RA, Moore EE, Kudsk K, Jurkovich G, Moore FA. Enteral tolerance following
severe trauma is reliably achieved by a standardized protocol. J Surg Res. 2001; 100 (2):292-293.
Kozar RA, Schultz SG, Hassoun HT, DeSoignie R, Moore FA. Intraluminal nutrients alter gut permeability following gut ischemia/reperfusion. Shock 2001;15 supp:65.
Von Maszewski M, Cocanour CS, McKinley B, Kozar RA, DeSoignie R, Weisbrodt N,
Moore FA. MMC’s exist after trauma and predict enteral tolerance. J Trauma
2001; 50 (1):178.
Kozar RA, Hu S, Schultz SG, Hassoun HT, Moore FA. Specific enteral nutrients alter
mucosal blood flow during gut ischemia/reperfusion. JPEN 2001; 25 (1):S11.
Kozar RA, Lucci A, Azzizadeh A, Miller CC, Cocanour CS, Potts J, Fischer C, Brundage SI. A brief intervention by surgeons can influence medical students towards a career in surgery. J Surg Res. 2002; 107 (4): 268.
Kozar RA, Holcomb JB, Macatis J, DeSoignie R, Moore FA. Superior mesenteric artery occlusion (SMAO) models shock-induced gut Ischemia/reperfusion. J Surg Res. 2002;107 (P55): 321.
Attuwaybi BO, Hassoun H, Kozar RA, Moore FA. Hypothermia protects against gut ischemia-reperfusion (I/R) induced impaired intestinal transit by inducing impaired intestinal transit by inducing heme oxygenase-1 (HO-1). J Surg Res. 2002; 107 (81): 294.
Balogh Z, McKinley BA, Holcomb JB, Miller CC, Cocanour CS, Kozar RA, Moore FA. Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of bad outcome. J Trauma. 2002;53(1):198.
McKinley BA, Cocanour CS, Kozar RA, Ware DN, Sailors RM, Marquez A, Moore FA. Normal vs supranormal O2 delivery goals in shock resuscitation: the response is the same. J Trauma 2002; 53(1): 825-832.
Holcomb JB, McMullin NR, Kozar RA, Lygas MH, Macaitis JM, Moore FA. Morbidity from rib fractures increases after age 45. J Trauma. 2002; 52 (1):200.
Kozar RA, Anderson K, Chaves-Escobar S, Theil M, Brundage S. Preclinical students who are surgeons? J Surg Res. 2003; 114 (2):259.
Attuwaybi B, Kozar RA, Moore-Olufemi S, Sato N, Weisbrodt N, Hassoun H, Moore FA.Heme-oxygenase-1 (HO-1) induction by hemin protects against gut ischemia/reperfusion injury. J Surg Res. 2003; 114 (2):289.
Sato N, Kozar RA, Zou L, Moore-Olufemi S, Weisbrodt NW, Moore FA. Cyclooxygenase-2 (COX-2) plays a role in mediating impaired internal transit after gut ischemia/reperfusion (I/R). J Surg Res. 2003; 114 (2):287.
Attuwaybi B, Kozar RA, Sato N, Moore-Olufemia S, Weisbrodt NW, Moore FA. Hypertonic saline prevents inflammation and impaired intestinal transit after gut ischemia/reperfusion by inducing heme oxgenase 1(H0-1) enzyme. J Trauma 2003; 55(1): 205.
Kozar RA, Schultz SG, Bick R, DeSoignie R, Moore FA. Metabolizable solutes maintain integrity of the actin cytoskeleton and membrane barrier function following mesenteric ischemia/reperfusion. Shock. 2003; (19):217.
Moore-Olufemia S, Kozar RA, DeSoignie R, Attuwaybi B, Gates K, Moore FA. Hypertonic saline enhances mucosal blood flow and lessens mucosal injury following gut ischemia/reperfusion. Shock. 2003; 19: 200.
Attuwaybi BO, Kozar RA, Moore-Olufemi S, Gates K, Hassoun HT, Moore FA. Hypertonic saline induces HO-1 expression and abrogates gut inflammation and dysfunction following shock-induced gut ischemia/reperfusion. Shock. 2003; 19:194.
Marr AB, McKinley BA, Sailors RM, Valdivia A, Kozar RA, Cocanour CS, Moore FA. Starling curve generation during shock resuscitation: Can it be done? Shock. 2003; 19:78.
Cocanour CS, Weisbrodt N, Kozar RA, Messick C, Moore FA. Gastric emptying following traumatic shock. Shock. 2003; 19:18.
Cocanour CS, Dial ED, Kozar RA, Lichtenberger LM, Messick C, Moore FA. Gastric Alkalinization following major trauma. J Trauma.2003;54(1):211.
Suliburk JW, Ware DN, Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Moore FA. Vacuum assisted wound closure (VAWC) allows for early abdominal fascial closure in severely injured trauma patients requiring aggressive resuscitation. J Trauma. 2003; 54(1):207.
Domonoske B, Cocanour C, Valdivia A, Kozar, RA, Pousman R, Moore F.
Aggressive Glucose Control: Implementation in an ICU. Critical Care Medicine. 2003;
451: A108.
Gonzalez EA, Kozar RA, Suliburk JW, Moore FA, Mercer DW. The isomeric composition of Lactated Ringer’s has no differential effect of gastric dysfunction after mesenteric ischemia/reperfusion. J Surg Res. 2004;121:334.
Moore-Olufemi, Kozar RA, Moore FA, Hassoun HT, Sato N, Cox CS, Kone BC.
Ischemic preconditioning protects against intestinal ischemia/reperfusion injury. Shock. 2004; 21:179.
Gonzalez E, Kozar RA, Suliburk J, Mercer D, Moore FA. Presence of D-Lactate increases ileal mucosal injury after mesenteric ischemia/reperfusion. Shock. 2004; 21:172.
McKinley B, Gonzalez E, Balldin B, Majid T, Valdivia A Cocanour CS, Kozar RA.
Revisiting the “Bloody Vicious Cycle. Shock. 2004; 21:137.
Sato N, Kozar RA, Smith M, Zou L, Moore-Olufemi S, Schultz SG, Moore FA. Immune enhancing enteral agents differentially modulate the early pro-inflammatory transcription factors mediating gut ischemia/reperfusion. J Trauma. 2004; 57(2):449.
Kozar RA, Schultz SG, Verner-Cole E, Bick R, DeSoignie R, Poindexter B, Moore FA. Enternal arginine, an immune enhancing agent, impair gut barrier function following mesenteric ischemia/reperfusion. J Trauma. 2004; 56 (2):463.
Moore FA, Hassoun HT, Kozar RA, Weisbrodt NW. Shock Induced Ileus: Issues and consequences. Shock. 2004; 21:82.
Gonzalez EA, Kozar RA, Suliburk JW, Mercer DW, Moore FA. Conventional dose hypertonic-saline provides optimal immunodulation. J. Trauma. 2005;59(2) 532.
Gonzalez EA, Kozar RA, Suliburk JW, Mercer DW, Moore FA. Low volume hypertonic saline abrogates mesenteric ischemia/reperfusion induced remote organ injury. J. Trauma. 2005;59(2) 532.
N Sato, Childs MA, Moore FA, Zou L, Kone BC, Schultz SG, Kozar RA. GW9662 inhibition of PPAR abrogates the protective function of enteral glutamine. Shock. 2005;23:51.
Sato N, Zou L, Attuwaybi B, Kozar RA, Moore FA, Kone BC. Alpha-melanocyte stimulating hormone preserves HO-1 expression induced by postischemic gut injury in rats. Gastroenterology 2005;4(suppl 2):A658.
McKinley BA, Balogh Z, Kozar RA, Valdiva A, Moore FA. GI tonometry is a monitor of onset of ACS. Shock. 2005;23:69.
Gonzalez E, Kozar RA, Suliburk J, Mercer D, Moore F. Hypertonic saline abrogates mesenteric ischemia/reperfusion. Shock. 2005 23, suppl 3, 31.
Gonzalez EA, Kozar RA, Suliburk JW, Tweardy DJ, Mercer DW, Moore FA. Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis via cytochrome C pathway. J Trauma. 2005;58(1): 215
Kozar RA, Moore JB, Miles SE, Holcomb JH, Moore EE, Cothern C, Moore FA. Complications of nonoperative management of high grade blunt hepatic injuries. J Trauma. 2005;58(1):222.
Gonzalez EA, Hunter R, Kozar RA, Weisbrodt N, Field E, Moore FA.Poloxamer 188 resuscitation after mesenteric ischemia/reperfusion abrogates neutrophil mediated ileal mucosal injury. Journal of Trauma. 2006;61:514.
McKinley B, Gonzalez E, Todd SR, Sucher J, Vercruysee G, Kozar RA, Cocanour C, Ware N, Motschall D, Sailors M, Moore FA. Mis-triage to central venous pressure directed resuscitation is associated with poor outcome. Shock. 2006;25:88.
Kozar R, SR Todd, Selby J, Cocanour C, Kozar RA, Vercruysee, Gonzalez E, Ware N, Moore F. Acute lower extremity compartment syndrome (ALECS) screening. J Trauma. 2006 60;251.
Moore-Olufemi SD, Lott S, Olufemi S, Sato N, Kozar RA, Moore FA, Radhakrishna RS, Cox CS, Kone BC. Transcriptional profiling of ischemic preconditioning in rat intestine following ischemia/reperfusion injury. JACS. 2006;203(3):S45
Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, Cocanour CS, McKinley BA. Fresh frozen plasma should be given earlier to patients who require massive transfusion. J Trauma. 2006; 60:258.
Sato N, Moore FA, Zou L, Kozar RA. Reactive Oxygen species promotes TNF-alpha induced cytotoxicity in IEC-6 cells. J Surg Res. 2006;130:330.
Ban K, Gonzalez EA, Kone BC, Kozar RA. Enteral arginine modulates the effect of pharmacologic inhibition of AP-1 on iNOS in the postischemic gut. Shock. 2007;27(S1):78.
Moore-Olufemi SD, Moore FA, Gonzalez EA, Ban K, Fields E, Kone BC, Kozar RA. Transcriptional profiling of hypertonic saline in rat small intestine. Shock. 2007;27(S1):79.
McKinley B, Gonzalez E, Kozar R, Todd R, Ware N, Sailors M, Moore F. Central venous pressure vs pulmonary artery catheter directed shock. Shock. 2007;27(S1):56.
Kozar RA, Kao LS, Miller CC, Schenarts KD. Preclinical predictors of surgery shelf exam performance. J Surg Res 2007; 137:(2)159.
Gonzalez EA, Hunter R, Kozar RA, Moore FA. Poloxamer 188-Hypertonic saline provides optimal ileal protection after mesenteric ischemia/reperfusion. J Surg Res. 2007;137:337.
McQuiggan M. Kozar R, Sailors M, McKinley B, Weisbrodt N., Moore F. Techniques for determining gastric residual volume: is never better? JPEN.2008;32:341.
Gonzalez EA, Zhang R, Kozar RA, Moore FA, Hunter RL. Poloxamer hypotensive resuscitation. Shock. 2008;28(S1)8-9.
Ban K, Sprunt JM, Kozar RA. Glutamine: A novel ligand dependent activator of PPARγ.
Shock. 2008;28(S1)56.
Harting MT, Jimenez F, Kozar RA, Moore FA, Mercer DW, Hunter R, Cox CS, Gonzalez EA. Direct effects of poloxamer 188 on human PMN cells. J Surg Res. 2008. 144;214.
Gonzalez EA, Mercer DW, Kozar RA. Isovolemic plasma resuscitation during shock. J Surg Res. 2008; 144, (2):432
Deng X, Cao Y, Pati S, Kozar RA, Holcomb JB, Ko TC. Fresh Frozen Plasma Activates Kinase Pathways in Endothelial Cells. Shock 2009, Vol. 31, (S1), 34.
Matijevic N, Wang W, Pati S, Kozar R, Conyers J, Holcomb J. Phenotypic Assessment of Cellular Microparticles in Fresh Frozen Plasma During Storage. Shock 2009, Vol. 31, (S1), 36.
Kozar R, R. Zhang, J. Holcomb, J. Sondeen, E. Gonzalez, S. Pati, T. Ko, J.F. Dong, A. Paredes. Plasma Restoration of Endothelial Glycocalyx After Hemorrhagic Shock. Shock 2009 Vol. 31, (S1), 49.
Holcomb J, Gerber M, Kozar R, Parthasarthy R, Matijevic N, Doursout MF, Ko T, Hartwell B, Conyers J, Pati S. Protective Effects of Plasma (FFP) on Pulmonary and Lymphatic Endothelial Permeability Diminishes Between Day 0 Through Day 5 After Thaw. Shock 2009 Vol. 31, (S1), 52.
E. Gonzalez, S. Pati, R. Kozar, B. Hartwell, J. Conyers, J. Holcomb. Effect of Activated Human Plasma on Syndecan-1 Expression. Shock 2009 Vol. 31, (S1), 55.
Y. Cao, X. Deng, X. Liu, S. Pati, R.A. Kozar, E.A. Gonzalez, J.B. Holcomb, T.C. Ko. Standard Storage of Fresh Frozen Plasma Increases TGF-β/SMAD3 Signaling. Shock 2009 Vol. 31, (S1), 56.
Ban K, Kozar RA. PPARγ mediates the regulation of INOS expression by C-JUN/AP-1. Shock 2010, Vol 33, (S1), 34.
Matijevis N, Wang Y-W W, Kozar RA, Gonzalez EA, Holcomb JB. Low levels of latelet microparticles correlate with poor outcomes in shock patients. Shock 2010, Vol 33, (S1), 45.
Deng X, Cao Y, Doursout MF, He G, Kozar RA, Holcomb JB, Ko TC. Standard storage of fresh frozen plasma (FFP) reduces its anti-apoptotic effects during hemorrhagic shock (HS) resuscitation. Shock 2010, Vol 33, (S1), 49.
Duan C, Cao Y, Deng X, Yang W, Kozar RA, Gonzalez EA, Holcomb JB, Ko TC. Plasma adiponectin levels decrease after hemorrhagic shock (HS). Shock 2010, Vol 33, (S1), 49.
Peng Z, Haywood-Watson, Pati S, Dong J, Vijayan V, Holcomb JB, Ko T, Kozar RA. Restitution of syndecan-1 is modulated by age of fresh frozen plasma (FFP). Shock 2010, Vol 33, (S1), 61.
Haywood-Watson R 2nd, Pati S, Kozar R, Faz G, Holcomb J, Gonzalez E. Human micro-vascular barrier disruption after hemorrhagic shock. J Surg Res. 2010 Feb;158(2):313.
Santora RJ, Medhus KA, Pati S, Holcomb JB, Kozar RA. Fresh plasma reverses hypoxia induced endothelial cell dysfunction. J Surg Res. 2010 Feb;158(2):296
Brown RM, Peng Z, Pati S, Holcomb JB, Park P, Kozar RA. Fresh frozen plasma reduces pulmonary Syndecan-1 shedding and inflammation after hemorrhagic shock. Shock 2011 Vol. 35, (S1), 43.
Doursout MF, Pati S, Kozar RA, Xiyun D, Ko TC, Holcomb JB. Assessment of endothelium integrity in hemorrhaged and/or resuscitated rats. Shock 2011 Vol. 35, (S1), 124.
Deng X, Cao Y, Doursout M, He G, Kozar RA, Wade CE, Holcomb JB, Ko TC. The role of amp-activated protein kinase (AMPK) in mediating fresh frozen plasma (FFP)’s protective effects in endothelial cells (ECS). Shock 2011 Vol. 35, (S1), 179.
Kozar RA, Dyer C, Bulger E, Mourtzakis M, Wade CE, Heyland DK. Elderly trauma patients: Highest risk, fewest calories. JPEN 2011, Vol. 35, S26.
Peng Z, Ban K, Kozar RA. Prevention of Hypoxia/Reoxygenation induced IEC-6 cell injury by Glutamine via Syndecan-1. JPEN 2011, Vol. 35, S35-3.
Ban K, Peng Z, Kozar RA. Arginine decreases peroxisome proliferator-activatd receptor gamma activity via c-Jun in both ligand-dependent and independent fashions. JPEN 2011, Vol. 35, S35-2.
Ban K, Sen A, Peng Z, Kozar RA. Syndecan-1 Mediates Gut Protection by Enteral Glutamine in a Rodent Model of Gut Ischemia/Reperfusion. Shock 2012 37(S): 21.
Peng Z, Ban K, Kozar RA. Crosstalk between intracellular PPAR gamma and cell surface syndecan-1 in a rodent model of gut ischemia/reperfusion: a novel observation. Shock 2012 37, supplement:32.
Peng Z, Ban K, Kozar RA. Glutamine mitigates lung injury induced by gut ischemia/ reperfusion via intestinal PPAR-gamma. Shock 2013 39(Suppl 2),30.
Ban K, Peng Z, Kozar RA. Detrimental effects of ERK ½ inhibition on the intestine during ischemia/reperfusion. Shock 2013 39(Suppl 2),30.
Lee JC, Kozar RA, Miller CC, Moore LJ. Optimizing Enteral Nutrition Delivery in a Level I
Trauma Intensive Care Unit by Using a Physician-Driven Catch-Up Feeding Protocol. JPEN 2015 39(2): 243-244
Kozar R, Peng Z, LeBlanc A, Ban K. Oral Tranexamic Acid: A gut protease inhibitor that mitigates local and distant organ injury after hemorrhagic shock. Shock 2015 43(1): S108-109.
Kozar R, Peng Z, LeBlanc A, Ban K. Oral Tranexamic Acid: A gut protease inhibitor that mitigates local and distant organ injury after hemorrhagic shock. Shock 2015 43(1): S108-109.
Wu F, Kozar R. Plasma activates a novel Syndecan1-Pak1 pathway to enhance endothelial barrier integrity. Shock 2016 45(1):S1 87.
Kozar R, Wu F. MiR inhibits Syndecan-1 expression an enhances endothelial barrier dysfunction. Shock 2016. 45(1):S1 87.
Wu F, Pati S, Kozar R. Fibrinogen contributes to stabilization of cell surface Syndecan-1: A novel mechanism for endothelial protection by plasma. Shock 2016 45(1):S1 116.
Wischmeyer P, Kozar R, Dhaliwal R, Jiang X, Day A, Heyland D. The TOP-UP Trial: a randomized trial of supplemental parenteral nutrition in under and overweight ICU patients. Shock 2016. 45(1):S171.
Yang S, Li R, Kozar R, Mackensie C, miller C, Parimi N, Stansbury L, Stein D, Scalea T, Hu P. New prehospital vital signs triage threshold for better prediction of emergency blood transfusion in geriatric in geriatric trauma patients. Shock 2016. 45(1):S1 86.
Parimi N, Yang S, Hu P, Li H, Mackenzie C, Kozar R, Fontain MJ, Miller C, Scalea T, Stein D. Emergency blood transfusion following trauma- selecting the right patient. Shock 2016. 45(1):S1 90.
Presentations: (Invitation)
International
Invited speaker. Endotheliopathy of Trauma. Trauma Hemostasis and Oxygenation Research Network. Bergen, Norway, June 2014.
National
Invited speaker. Staying in academics: Learning how to SWIM (surgeon, women, investigator, and mom). 37th annual meeting of the Association of Academic Surgery, Sacramento, CA. November 2003.
Invited speaker. Education Research. Fundamentals of Surgical Research Course. 37th annual meeting of the Association of Academic Surgery, Sacramento, CA, November 2003.
Moderator for the Education session at the 37th annual meeting of the Association of Academic Surgery, Sacramento, CA, November 2003.
Invited speaker. Nutrition. AACP Critical Care Board Review Course, Phoenix, AZ, August 2003.
Invited speaker. Abdominal Infections. AACP Critical Care Board Review Course, Phoenix, AZ, August 2003.
Invited speaker. Early goal-directed monitoring of the trauma patient. Postgraduate course: Resuscitation and the immediate care of the trauma patient. American College of Surgeons, April 2003.
Invited speaker. Moderator for the Critical Care session at the 64th annual meeting of the Society of University Surgeons, Houston, TX February 2003.
Invited speaker. Sodium coupled solutes modulate small bowel function after ischemia/reperfusion injury. 64th annual meeting of the Society of University Surgeons, Houston, TX February 2003.
Moderator for Critical Care Oral Poster Session at the 38th annual meeting of the Association of Academic Surgery, Houston, TX, November 2004.
Invited speaker. Nutrition in the ICU. AACP Critical Care Board Review Course, Orlando, FL, August 2004.
Invited speaker. Abdominal Infections. AACP Critical Care Board Review Course, Orlando, FL, August 2004.
Invited speaker. Role of the Gut in Multiple Organ Failure. 33rd Critical Care Congress of the Society of Critical Care Medicine. February 2004
Moderator for Critical Care Session at the 65th Annual Meeting of the Society of University Surgeons, St. Louis, MO., February 2004.
Invited speaker. Philadelphia Annual Day of Trauma, December 19th, 2005.
Invited speaker. Implications of Pregnancy on a Surgical Career. Career Development Course sponsored by the Association of Academic Surgeons and held in conjunction with the 91st Annual Clinical Congress of the American College of Surgeons. October 2005.
Invited speaker. Education Research. Fundamentals of Surgical Research Course sponsored by the Association of Academic Surgeons and held in conjunction with the 91st Annual Clinical Congress of the American College of Surgeons. October 2005.
Invited speaker. Enteral Support in Critically Ill Surgical Patients: Problems, Placement, and Pitfalls. 33rdrdAnnual Meeting of the American College of Surgeons. April 2005.
Moderator for general session of the South Texas Chapter of the American College of Surgeons, Houston, TX March 2005.
Moderator for the Education Session at the 66th Annual Meeting of the Society of University Surgeons, Nashville, TN, February 2005.
Visiting Professor. US Army Institute of Surgical Research, Fort Sam Houston, TX July 2006.
Invited speaker. Nutritional Support in Critically Ill Trauma Patients. Translating Evidence-Based Nutrition into Effective Clinical Care. ASPEN’s Clinical Nutrition Week, February 2006.
Moderator for Critical Care session and Education session at the first annual Academic Surgical Congress meeting, San Diego, CA February 2006.
Invited Speaker, Society of Leukocyte Biology. Glutamine, a novel PPAR gamma agonist, abrogates gut injury and inflammation in the postischemic gut. Boston, MA. October 2007.
Invited Speaker, American College of Surgeons, Review Course in General Surgery. Critical Care. New Orleans, October 2007.
Visiting Professor and Speaker, 8th Annual Trauma Symposium, Controversies in Fluid Resuscitation, Medical College of Virginia, April 2007.
Invited Speaker, Western Trauma Association, Current Challenges in ICU staffing. February 2007.
Visiting Professor, Updates and Upheavals in Nutrition Practice in The Critically Ill. University of California- Davis, Sacramento, CA. May 2008.
Invited Speaker, Southwestern Surgical Congress. Glutamine as an isolated immunonutrient. Acapulco, Mexico. March 2008.
Invited Speaker, Clinical Nutrition Week. Nutrition in the trauma patient. Chicago, IL. January 2008.
Update on Resuscitation Strategies. The Hobert Trauma Symposium, Methodist Health System, Dallas, TX, October 2008.
Visiting Professor, Wright State University, Boonshoft School of Medicine. Endowed Lectureship in Trauma Surgery at Miami Valley Hospital, November 11-12, 2009
Invited Speaker, Western Trauma critical decisions in trauma: Liver Injury. Mt. Crested Butte, Co. February 2009.
Invited Speaker, Academic Surgical Congress. Career advice I wish I’d been given. Fort Meyers, Fl. February 2009.
Invited Speaker, Clinical Nutrition Week. Update on antioxidants, glutamine, and the ideal diet in SICU Patients (M25). New Orleans. February 2009.
Invited speaker. General Surgery Update: Sea Pines Resort, Hilton Head Island, South Carolina. June 7-10, 2010.
Session chair and speaker for critical care topics. American College of Surgeons General Surgery Review Course 2007-2013.
Session chair and speaker for trauma.American College of Surgeons free standing General Surgery Review Course 2010 - 2013.
Invited speaker. Update in Critical Care Nutrition: Are We Really Changing the Outcome? American Society for Parenteral and Enteral Nutrition. Las Vegas, NV February 8, 2010.
Invited speaker. Austin Trauma and Critical Care Conference. Tranexamic acid and Hepatic Trauma. Austin, TX, June 2011.
Invited speaker. American Association of Immunologists. Sensing intestinal nutritive signals within the injured gut. San Francisco, CA, May 2011.
Session chair, organizer, and speaker ASPEN: Clinical Nutrition Week.. Pharmaconutrients. Vancouver, CA January 2011.
Invited speaker. Shock Society. Glutamine: Changing Outcomes in the ICU, but why? Miami, FL June 2012.
Invited speaker. American Association for the Surgery of Trauma. Challenging Cases. Koloa, HI, September 2012
Visiting Professor. Department of Surgery. The University of British Columbia, Vancouver, Canada. May 2012
Visiting Professor. New York University Department of Surgery, December 2011
Invited speaker. ASPEN: Clinical Nutrition Week. Update in critical care nutrition – What is state of the art? Optimal route and timing of nutrient delivery. Orlando, FL, January 2012.
Invited speaker. Trauma Quality Improvement Program. Role of TEG based resuscitation. Phoenix, AR, November 2013.
Invited speaker. American Association for the Surgery of Trauma. Hemostatic resuscitation for traumatic hemorrhage: What is the role of TXA, PCC, and fibrinogen in treating acute traumatic coagulopathy. San Francisco, CA, September 2013.
Visiting Professor. Department of Surgery. Hofstra North Shore-LIJ School of Medicine. April 2013.
Visiting Professor, Department of Surgery, Texas Tech Health Science Center, speaker at the 20th annual Trauma and Critical Care Symposium, November 2014.
Invited speaker. Trauma Quality Improvement Program. Changes in Trauma Verification. Chicago, IL November 2014.
Invited speaker. 22nd Annual Trauma Symposium sponsored by Memorial Healthcare System. Hollywood, FL February 2015.
Visiting Professor, Department of Surgery. University of Colorado, Denver Co. May 2015.
Visiting Scientist, NAMRU, San Antonio, TX, September 2015
Invited speaker, 74th Annual Meeting of the American Association for the Surgery of Trauma, How to develop and manage a research career and obtain funding, Las Vegas, NV September 2015.
Invited speaker, 63rd Annual Detroit Trauma Symposium. Detroit, MI November 2015.
Founders Basic Science Lecturer. Western Trauma Association. Squaw Creek, CA February 2016.
Invited Speaker. Trauma, Critical Care, and Acute Care Surgery Conference. Las Vegas, NV March 2016.
Invited Speaker. Medical Disaster Response Conference. Las Vegas, NV March 2016.
Invited Speaker. 18th Annual AtlantiCare Trauma Symposium. Atlantic City, NJ May 2016.
Visiting Professor for the Milton A. Lunda Memorial Lecture. Gunderson Health System, LaCrosse, Wisconsin. May 2016
Visiting Professor, Medical College of Wisconsin, Milwaukee, Wisconsin May 2016.
Visiting Professor, East Carolina University, Greenville, NC, May 2016
Key Note Faculty, Harborview Medical Center EMS & Trauma Conference. September 2016.
Key Note Speaker, Southwest Trauma and Acute Care Symposium; November 2016.
Regional
Invited speaker. Nutrition in the Surgical ICU. Texas Society for Parenteral and Enteral Nutrition, Dallas, TX, September, 2003.
Invited speaker. Enteral Feeding Protocol, Society for Parenteral and Enteral Nutrition, Houston, Texas, April 2004.
Invited speaker. Glutamine, a novel PPAR gamma mediator. Digestive Disease Center, Houston, TX, 2007
Invited speaker and moderator. Committee on Women’s Issues, American College of Surgeons. Women in Surgery: Career Development Seminar. Houston, Texas November 19 – 20, 2009
Invited speaker. Austin Trauma & Critical Care Conference. Austin, TX, June 2 – 3, 2011.
Local
Pancreaticoduodenal Trauma. Surgical Grand Rounds, Allegheny University of the Health Sciences, Philadelphia, PA, October 1996.
Abdominal Trauma. Surgical Grand Rounds, Crozier Chester Medical Center, Philadelphia, PA, October 1997.
Pancreatic and Duodenal Trauma. Surgical Grand Rounds, Mercy Catholic Medical Center, Philadelphia, PA, September 1997.
Penetrating Trauma. Division of Emergency Medicine, St. Christopher’s Hospital for Children, Philadelphia, PA, February 1998.
Gut Absorptive Capacity Following Shock-Induced Gut Ischemia. Red Duke Professorship Day, University of Texas-Houston, Houston, TX, January 2000.
Trauma Critical Care Overview. Department of Emergency Medicine,
University of Texas-Houston School of Medicine, Houston, TX, May 2001.
Effect of Intraluminal Nutrients on Gut Ischemia/Reperfusion. Red Duke Professorship Day, University of Texas-Houston, TX, January 2001.
Intraluminal Nutrients Modulate Gut Ischemia/Reperfusion Injury. Red Duke Professorship Day, University of Texas-Houston, Houston, TX, January 2002.
Education Research. Grand Rounds. Department of Surgery, University of Texas-Houston, Houston, TX November 2003.
ICU considerations of the morbidly obese. Grand Rounds, Department of Surgery, University of Texas-Houston, Houston, TX, January, 2003.
Enteral Nutrition. From Bedside to Benchwork. Grand Rounds. Department of Surgery, University of Texas-Houston, Houston, TX, February 2006.
Update on Enteral Nutrition. Grand Rounds, Pulmonary and Critical Care, Department of Medicine, University of Texas-Houston, Houston, TX April 2007.
Challenges in ICU Staffing. Grand Rounds. Department of Surgery. University of Texas-Houston, Houston, TX 2008
Potential therapeutics to mitigate trauma-hemorrhagic shock induced gut and lung dysfunction. Center for Vascular and Inflammatory Diseases, University of Maryland, Baltimore. December 2014.
Plasma based resuscitation. Grand Rounds. Department of Surgery. University of Maryland Baltimore. December 2015.
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