Sabet W. Hashim, M. D. Curriculum vitae date of Revision: July 16 th 2015 Name



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Sabet W. Hashim, M.D.

CURRICULUM VITAE



Date of Revision: July 16th 2015

Name: Sabet W. Hashim, M.D, FACS.
Education:

B.S. Baccalauréat in Mathematics: Lycée Français of Beirut (High

Honors) 1968

M.D. St. Joseph’s University School of Medicine, Beirut (Honors) 1975 Ranked 1st in medical school admission exam



Specialized Training:

1983: Mitral Valve Repair, Broussais University Hospital, Paris, France

1984: Heart Transplantation, Stanford University, Palo Alto, CA, University of Pittsburgh, Pittsburgh, PA and Columbia University/New York Presbyterian Hospital, New York, NY

2008: Robotic Cardiac Surgery, St. Joseph’s Hospital, Atlanta, GA and Good Samaritan Hospital, Cincinnati, OH

2009: Minimally Invasive Mitral Valve Repair through Right Thoracotomy, OLV Clinic, Aalst, Belgium and Lankenau Hospital, Wynnewood, PA

2012: Trans-femoral Aortic Valve Replacement (TAVR), Edwards Sapien Course, Vancouver, Canada


Career/Academic Appointments:


1975-76 Internship, General Surgery, St. Luke’s Hospital Medical Center, New York, NY 1976-77 First Year Resident, General Surgery, St. Luke’s Hospital Medical Center, New

York, NY


1977-78 Third Year Resident, General Surgery, St. Luke’s Hospital Medical Center, New York, NY (promoted by bypassing Second Year Residency)

1978-79 Chief Resident, General Surgery, St. Luke’s Hospital Medical Center, New York, NY

Instructor in Surgery, Columbia University School of Medicine 1979-81 Resident, Cardiothoracic Surgery, Yale New Haven Hospital 1981-83 Attending Surgeon, VA Hospital, West Haven, CT

1981-present Attending Surgeon, Yale New Haven Hospital

1981-86 Assistant Professor of Surgery, Yale University School of Medicine

2007-present Associate Professor of Surgery, Yale University School of Medicine



Administrative Positions:


2006-present Director of Cardiac Valve Surgery, Yale New Haven Hospital

2010-11 Surgical Director, Heart and Vascular Center, Yale New Haven Hospital

2010-11 Clinical Chief, Section of Cardiac Surgery, Yale University School of Medicine 1981-86 Co-Director of Cardiac Transplantation, Yale New Haven Hospital

Board Certification:


American Board of Surgery, 1980 American Board of Thoracic Surgery, 1982

American Board of Thoracic Surgery, Recertification, 1992, 2001, 2012



Professional Honors & Recognition:


2014: Nominated for the Thoracic Surgery Residents Association Socrates Award

2010-present Best Doctors in New York, New York Magazine

2010-present NY Metro Area’s Top Doctors, Castle Connolly Medical Ltd. 2010-present America’s Top Doctors, Castle Connolly Medical Ltd.

2010-present Patients' Choice Award, Vitals 2010-present Most Compassionate Doctor, Vitals


Professional Organizations:

American College of Surgeons, Fellow Society of Thoracic Surgeons, Member

American Medical Association, Member Yale Surgical Society, Member

Lebanese American University School of Medicine, Founding Faculty

American-Lebanese Medical Association, Board Member

New Haven Medical Association, Member Connecticut Medical Association, Member



Active Clinical Trials:


Agency: Edwards LifeSciences, Inc.

Title: “Commence” Trial comparing valve preparations: Glutaraldehyde versus dry

preparation

P.I.: Sabet Hashim, M.D.

Role on Project: Yale Site P.I.

Project period: 2015-2020

Cost: $550,000
Agency: Abbott, Inc.

I.D. # NCT01626079

Title: “Clinical Outcomes Assessment of the MitraClip Therapy Percutaneous Therapy for High Surgical Risk Patients (COAPT)”

P.I.: Sabet Hashim, M.D.

Role on Project: Yale Site P.I.

Project period: 2013-2018


Agency: Medtronic, Inc.

I.D.# NCT01586910

Title: “Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI)”

P.I.: Sabet Hashim, M.D.

Role on Project: Yale Site P.I.

Project period: 2013-2018


Agency: Medtronic, Inc.

I.D.# IDE G100012

Title: “CoreValve Pivotal Clinical trial to evaluate the safety and efficacy of the Medtronic

CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects

necessitating aortic valve replacement, with predicted operative mortality or serious,

irreversible morbidity risk of ≥ 50% at 30 days”

P.I.: Craig Thompson

Role on Project: Sub-investigator

Project period: 2012-2017
Agency: Medtronic, Inc.

I.D.# IDE G100012

Title: “CoreValve Continued Access clinical trial to evaluate the safety and efficacy of the

Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects necessitating aortic valve replacement, with predicted operative mortality or serious, irreversible morbidity risk of ≥15% and <50% (High Risk) or ≥ 50% (Extreme Risk) at 30 days”

P.I Craig Thompson

Role on Project: Sub-investigator

Project period: 2012-2017

Agency: Medtronic, Inc.

I.D.# IDE G100012

Title: “CoreValve Expanded Use clinical trial to evaluate the safety and efficacy of the

Medtronic CoreValve® System in the treatment of symptomatic sever aortic stenosis in subjects with significant comorbidities in whom the risk of surgical aortic valve replacement has a predicted operative mortality or serious, irreversible morbidity risk of ≥ 15% and <50% (high risk) or ≥ 50% (extreme risk) at 30 days”

P.I.: Craig Thompson

Role on Project: Sub-investigator

Project period: 2012-2017



Past Clinical Trials

Agency: Abbott, Inc.

Title: “Indicators of Acute Kidney Injury in Patients Undergoing Cardiac Surgery”

P.I.: Chirag Parikh, M.D.

Role on Project: Collaborator

Project period: 2007-2011









Invited Speaking Engagements, Presentations, Symposia & Workshops Not Affiliated With

Yale:


International/National


2015: AATS 2015 Mitral Conclave, New York City, NY. Session XV, “Repair Techniques: When to do resection”

2014: American University of Beirut Symposium, Beirut, Lebanon. “The role of surgery in ischemic mitral regurgitation”

2013: Edwards LifeSciences Fellow Program, Irvine, CA. “Mitral valve surgery: Helpful techniques to enhance your repair rate”

2009: American Lebanese Medical Association, Beirut, Lebanon. “The future of mitral valve repair”

2008: Symposium Mitral, Medellin, Columbia. “New Techniques of mitral valve reconstruction”

2008: American Association of Thoracic Surgery, San Diego, CA. “Evolving techniques of mitral valve repair”


Regional:

2013: Cardiology Conference Bridgeport Hospital, Bridgeport, CT. “Surgery for ischemic mitral regurgitation”

2013: Homestead Inn, Greenwich, CT. “The role of surgery in ischemic mitral regurgitation”

2009: Seventeenth Annual Bradley Memorial Cardiovascular Symposium, Southington, CT. “Mitral valve repair: The third decade”

2004: American Heart Association, Middletown, CT. “Atrial fibrillation roundtable”

2002: Greenwich Hospital, Greenwich, CT. “Trends in cardiac surgery”

2002: Norwalk Hospital, Norwalk, CT. “Mitral valve repair”

2001: Annual Meeting of Physicians Assistants, Ledyard, CT. “Progress or gimmick in cardiac surgery”



Peer-Reviewed Presentations & Symposia:


International/National


2014: 28th EACTS Annual Meeting, Milan, Italy. “Radial artery versus right internal thoracic artery as the best second conduit in multi arterial CABG: A multi institutional study.”

2012: Annual American Heart Association Scientific Sessions Meeting, Los Angeles, CA. “The free right internal thoracic artery: A versatile and durable conduit.”

2011: American Association for Thoracic Surgeons Mitral Valve Conclave Meeting, New York, NY. “Identification of pseudo-prolapse of the anterior leaflet in a subgroup of patients with chronic ischemic mitral regurgitation and correction with neochordae improves late mid-term outcomes of mitral valve repair.”

2011: Annual American Heart Association Scientific Sessions Meeting, Orlando, FL. “Modulation of transforming growth factor-P signaling and extracellular matrix in myxomatous mitral valve degeneration by angiotensin II receptor blocker losartan.”

2011: 6th International Congress on Cardiovascular Diseases, New Delhi, India. “Towards adopting right-sided pacemaker implantation: A safer surgical practice.” (Awarded “Best paper in clinical cardiology”)

2011: 21st World Congress, World Society of Cardio-Thoracic Surgeons, Berlin, Germany. “Durable mitral valve repair in chronic ischemic mitral regurgitation requires identification and correction of pseudo-prolapse of anterior leaflet, when present.”

2010: 90th Annual Meeting of the American Association for Thoracic Surgeons, Toronto, Canada. “Transforming growth factor-B induces the expression of extracellular matrix molecules in myxomatous mitral valves.”

2007: Valves in the Heart of the Big Apple Symposium, New York, NY. “Improved results of tricuspid valve repair using undersized annuloplasty rings.”

1984: New England Surgical Society, NH. “Non-cardiology pulmonary edema following cardiopulmonary bypass: An anaphylactic reaction to fresh frozen plasma.”

1984: American Cardiology of Surgeons, Surgical Forum, San Francisco, CA. “A safer method of cardioplegia delivery in aortic valve surgery.”



Professional Service:


Journal Service:


2010-present Guest Reviewer, Cardiology

2010-present Guest Reviewer, Cardioexchange, An NEJM Practice Community


Professional Service for Professional Organizations:
Abbott Laboratories

2012-2014 Acute Kidney Injury Advisory Board


Edwards LifeSciences LLC

2009-present Consultant


Yale University Service:
Hospital Boards & Committees

2013-present Patient safety and quality subcommittee, Yale Heart and Vascular Center

2010-present Council on cardiothoracic surgery

2009-10 Heart and Vascular service task force

2004-06 Operating room committee

1985: Task force on coronary bypass surgery



Hospital Programs Initiated

2012: Trans-femoral and trans-apical aortic valve replacement (TAVR) using the

Edwards LifeSciences sapien valve, in collaboration with Drs. Cleman,

Thompson, Geirsson and Forrest

2005: Minimally-invasive techniques of mitral valve repair: Mini-sternotomy, sub-

mammary incision and the right mini-thoracotmy approach

2005: Aortic valve replacement using mini-upper sternotomy incision

2001: Atrial fibrillation surgery

1984: Co-directed the heart transplant program and performed the first heart

transplant in Connecticut.



1984: Mitral valve repair program

Bibliography:



Peer-Reviewed Original Research:

  1. Kay H, Barash P, Geha A, Kopf G, Hashim SW and Kopriva C: A Placebo-Controlled Randomized Blind Study of Parenteral Nitroglycerin During Open Heart Operations. Surg Forum 33:251-253, 1982.




  1. Barash PG, Seinfeld F, Kay H, Condos SG, Hashim SW, Tinker J and Geha AS: RPP: May it R.I.P. Anesthesiol 57:A22, 1982.




  1. Stavens B, Hashim SW, Hammond GL, Stansel HC, Gatehouse J, Kopf GS and Geha AS: Optimal Methods of Repair of Descending Thoracic Aortic Disruptions and Aneurysm. Am J Surg 145(4):508-513, 1983.




  1. Hashim SW, Hammond GL, Condos S, Kopf GS and Geha AS: A Safer Method of Cardioplegia Delivery in Aortic Valve Surgery. Surg Forum 35: 286-287, 1984.




  1. Hashim SW, Kay HR, Hammond GL, Kopf GS and Gela AS: Noncardiogenic Pulmonary Edema following Cardiopulmonary Bypass: An Anaphylactic Reaction to Fresh Frozen Plasma. Am J Surg 147(4):560-564, 1984. Chosen for the Year Book of Surgery, 1985




  1. Geha AS, Hashim SW, Kopf GS and Hammond GL: Early and Late Results of Combined Valve Replacement and Myocardial Revascularization: The Problem of Severe Ischemic Mitral Regurgitation. Chest 86:292, 1984.




  1. Breisblatt WM, Berger RB, Cabin HS, Cleman MW, Cerqueira MD, Neumann RD, Ezekowitz MD, Hashim SW and Berger HJ: Unsuspected Left Ventricular Pseudoaneurysm in a Patient with Coronary Artery Disease. Am J Roent 142:680-682, 1984.




  1. Geha AS, Francis CK, and Hammond GL, Laks H, Kopf GS and Hashim SW: Combined Valve Replacement and Myocardial Revascularization. J Vasc Surg 1:27-35, 1984.




  1. Zahler R, Breisblatt W, Hashim SW, Kleinman C, Langou R: Isolated Right Atrial Tamponade by Serous Fluid Simulating Tricuspid Stenosis. Am J Med 79:531-534, 1985.




  1. Kopf GS, Hume AL, Durkin MA, Hammond GL, Hashim SW and Geha AS: Measurement of Central Somatosensory Conduction Time in Patients Undergoing Cardiopulmonary Bypass: An Index of Neurological Function. Am J Surg 149:445-448, 1985.




  1. Gertler J, Elefteriades JA, Kopf GS, Hammond GL, Hashim SW, and Geha AS: Predictors of Outcome following Early and Delayed Revascularization for Acute Myocard Am J Surg 149:441-444, 1985.




  1. Hashim SW: Safe Technique for Aortic Anastomosis in Orthopedic Canine Cardiac Transplantation. Ann Thorac Surg 39:389-390, 1985.




  1. Morse SS, Strauss ED, Hashim SW, Greenwood CH, Denny DF and Sniderman KW: Percutaneous Retrieval of an Unusually Large Nonopaque Intravascular Foreign Body. Am J Radiol 146:863-864, 1986.




  1. Kopf GS, Hammond GL, Geha AS, Elefteriades JE and Hashim SW: Long Term Performance of St. Jude Medical Valve: Low Incidence of Thromboembolism and Hemorrhagic Complications with Modest Doses of Warfarin. Circulation 76 (3 Pt 2): III 132-136, 1987.




  1. Hammond GL, Geha AS, Kopf GS, and Hashim SW: Biological Versus Mechanical Valves: Analysis of 1,116 valves inserted in 1,012 adult patients with a 4,818 patient-year and a 5,327 valve year follow up. J Thorac Cardiovas Surg 93:182-198, 1987.




  1. Passik CS, Hashim SW: Right Ventricular Failure. Ann Thorac Surg 62: 630,1996.




  1. Jovin A, Hashim SW, Jovin IS, Clancy JF, Klovekorn WP and Muller-Berghaus G: Atrial Fibrillation at Discharge from the Hospital in Patients Undergoing Mitral Valve Repair. J Thorac Cardiovasc Surg 53: 41-45, 2005.




  1. Oprea D, Memet R, Jovin A, Duggal M, Collazo S, Jovin IS, Hashim SW, Clancy JF: Anticoagulation at Discharge after Mitral Valve Repair and Long-Term Mortality. Circulation 114 (Suppl.): II-734, 2006.




  1. Kurup V, Perrino A, Barash P, Hashim SW: Echo Rounds: Infundibular Pulmonary Stenosis. Anesthes Analges 104, 507-508, 2007.




  1. Hashim SW, Rousou AJ, Geirsson A, Sigurdur R: Solving the Puzzle of Chronic Ischemic Mitral Regurgitation. Yale J Bio Med 81; 167-173, 2008.




  1. Jovin A, Oprea D, Jovin IS, Hashim SW, Clancy JF: Atrial Fibrillation and Mitral Valve Repair. Pacing and Clinical Electrophysiology 31;1057-62, 2008.




  1. Hashim SW, Youssef SJ, Ayyash B, Ragnarsson S, Collazo S, Geirsson A: Pseudo- Prolapse of the Anterior Leaflet in Chronic Ischemic Mitral Regurgitation: Identification and Repair. J Thorac Cardiovasc Surg 143 (4 suppl): S33-7, 2012.




  1. Coca S, Jammalamadaka, D, Sint K, Thiessen Philbrook H, Shlipak M, Zappitelli M, Devarajan P, Hashim SW, Garg A, MD, Parikh C: Preoperative Proteinuria Predicts Acute Kidney Injury in Patients Undergoing Cardiac Surgery. J Thorac Cardiovasc Surg 143 (2): 497-502, 2012.




  1. Dodson J, Wang Y, Desai MM, Filho J, Sugeng L, Hashim SW, Krumholz HM: Outcomes for Mitral Valve Surgery among Medicare Fee-for Service Beneficiaries, 1999- 2008. Circ Cardiovasc Qual Outcomes 5(3); 298-307, 2012.




  1. Geirsson A, Singh M, Ali R, Abbas H, Li W, Sanchez J, Hashim SW, Tellides G. Modulation of TGF-B signaling and Extracellular Matrix Production in Myxomatous Mitral Valves by Angiotensin II Receptor Blockers. Circulation 126: S189-S197, 2012.




  1. Hashim PW, Hashim SW:Aortic Cannulation with a Single Purse-String Suture. J Thorac Cardiovasc Surg 147(4):1430-31, 2014.




  1. Hashim PW, Hashim SW: Liver Laceration from a Diaphragmatic Suture in Minithoracotomy Mitral Valve Repair. J Card Surg 29(4):476-7, 2014.




  1. Khan UA, Coca SG, Hong K, Koyner JL, Garg AX, Passik CS, Swaminathan M, Garwood S, Patel UD, Hashim SW, Quantz MA, Parikh CR. Blood Transfusions Are Associated with Urinary Biomarkers of Kidney Injury in Cardiac Surgery. J Thorac Cardiovasc Surg 148(2):726-32, 2014.




  1. Hashim PW, Assi R, Hashim SW. The Imbrication Technique: An Alternative to the Sliding Leaflet Technique. Ann Thorac Surg 98:1124-26, 2014.




  1. Assi R, Youssef SJ, Almarzooq Z, Al-Raweshidy Y, Hashim PW, Geirsson A, Hashim SW: The “Free” Right Internal Thoracic Artery: A Versatile and Durable Conduit. J Card Surg 29(5):609-15, 2014.




  1. Schwann TA, Hashim SW, Badour S, Obeid M, Engoren M, Tranbaugh RF, Bonnell MR, Habib RH. Equipoise between Radial Artery and Right Internal Thoracic Artery as the Second Arterial Conduit in LITA based CABG: A Multi Institutional Study. Eur J Cardiothoracic Surg. Epub ahead of print. March 2015.




  1. Dodson JA, Wang Y, Murugiah K, Dharmarajan K, Cooper Z, Hashim S, Nuti SV, Spatz E, Desai N, Krumholz HM. Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999-2010. PLoS One 10(7):e0132470, 2015.



Chapters, Books, and Reviews



  1. Hashim SW, Baue AE and Geha AS: The Role of Mediastinoscopy and Mediastinotomy in Lung Cancer. Clin Chest Med 3:353-359, 1982.




  1. Rafferty TD, Hasel R, Tousignant G, Woodruff A, Braxton JH, Hashim SW: Transesophageal echocardiographic diagnosis of excessive motion of the mitral valve leaflets. Video J. Echocardiogr. 1995; 5: 59-77 (110 mins).




  1. Rafferty TD, Hasel R, Tousignant G, Woodruff A, Braxton JH, Hashim SW: Transesophageal echocardiographic evaluation of the result of mitral valve repair. Video J. Echocardiogr. 1996; 6: 33-60 (62 mins).



Invited Editorial and Commentaries



  1. Adams D, Hashim SW, Sarano ME, Elefteriades JA: Mitral Valve Surgery and Mitral Prolapse. Medical Roundtable-CV Edition 1(2) 79-85, 2010.




  1. Hashim SW, Hashim PW: Minimally Invasive Repair with Gore-Tex for Barlow’s Disease: Will it Fly? Cardiology 128:95-96, 2014.





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