An assessment of nucleic acid amplification testing for active mycobacterial infection
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- Meta-analysis of studies assessing the diagnostic accuracy of NAAT compared with culture
| Figure 14 SROC curve for all studies investigating the sensitivity and specificity of AFB plus NAAT versus culture in the diagnosis of TB for all studies based on NAAT methodology (A), and for sputum (B) and non-sputum (C) specimens based on incidence of TB
AUC = area under curve; SROC = summary receiver–operator characteristic Meta-analysis of studies assessing the diagnostic accuracy of NAAT compared with cultureForest plots showing the sensitivity and specificity for the 68 studies that compared the diagnostic accuracy of NAAT with culture in patients suspected of having TB are shown in Figure 41 and Figure 42 (Appendix D). Although the sensitivity ranged from 6% to 100%, it was less variable than for AFB microscopy (Appendix E), with only 12/68 (18%) having a sensitivity below 70%. Meta-analysis showed that the overall pooled sensitivity for NAAT compared with culture was 89% (95%CI 85, 92). There were no significant differences in the pooled sensitivities for in-house compared with the commercial NAAT (Xpert) for any subgroup investigated; however, there was a slight trend suggesting that in-house NAATs were more sensitive than the commercial NAAT for most comparisons (Figure 15). 
Figure 15 Forest plot showing the pooled sensitivity and specificity values for NAAT compared with culture for studies grouped according to the NAAT comparator, specimen type and incidence of TB in the country in which the study was conducted Directory: internet internet -> Applications and limitations internet -> L. and Gossypium barbadense internet -> Natural Resources Conservation Service Conservation Practice Standard internet -> Practice Exercise Created By Stavros Charalambous The Internet internet -> It’s a good Topic internet -> National Preventative Health Strategy – the roadmap for action internet -> Downloading gps gr-3 Surveys Summary of Procedure internet -> 3G300m-how to setup the 3g router Mode? Product line: 3g question categories: Function configurations Note internet -> Installation Work has never been simpler or easier Download 12.08 Mb. Share with your friends:
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