Assessing Readiness to Offer New Degree Programs Master of Science in Biomedical Engineering, 08-05-2013

Name: Barbara Jean Muller-Borer, Ph.D.

1. 
   Rank: Associate Professor, Department of Engineering, East Carolina University
   

Adjunct Professor, Departments of Biology, East Carolina University

2. 
   Degrees:
   

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  Tufts University School of Engineering, Medford, MA.
  

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  The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  

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  The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  

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  The University of North Carolina School of Medicine, Chapel Hill, NC.
  

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  The University of North Carolina School of Medicine, Chapel Hill, NC.
  

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  The University of North Carolina School of Medicine, Chapel Hill, NC
  

3. 
   Teaching Experience related to proposed degree (with emphasis on the past five years):
   

2005 Department of Physiology, Physiological Proteo-Genomics (PHLY-7704), “Stem Cells and Tissue Bioengineering”, Fall Semester, 2 lectures and 1 laboratory.

2005 Division of Cardiology, Electrophysiology Noon Conference,”Cardiac Regenerative Cell Therapy”.

2006 - 2010 Department of Biology, BIOL 6880 Seminar, “Cardiovascular Translational Biology Laboratories”. Fall Semester.

2006 Division of Cardiology Grand Rounds, CME, “Cell-Based Therapy for Cardiovascular Disease”.

2006 Department of Biochemistry, Graduate Seminar, “Plasticity of a Liver Adult Stem Cell in a Cardiac Myocyte Microenvironment”.

2007 - 2010 Department of Physiology, Physiological Proteo-Genomics (PHLY-7704), “Stem Cells and Tissue Bioengineering”, Fall Semester, 2 lectures and 1 laboratory.

2007 Division of Cardiology Grand Rounds, CME, “Cell-Based Therapy for Cardiovascular Disease”.

2008 Department of Pathology, Grand Rounds, CME, “Stem Cell Differentiation into Cardiac Myocytes”.

2008 Department of Anatomy and Cell Biology, Graduate Seminar, “Stem Cell Differentiation in a Cardiac Microenvironment”.

2009 Department of Cardiovascular Sciences, Grand Rounds, CME, “Cardiac Regeneration and Cell-Based therapies for Ischemic Heart Disease”.

2009 - 2010 Department of Physiology, Physiological Proteo-Genomics (PHLY-7704), “Laser Capture Microdissection”, Fall Semester, 1 lecture and laboratory.

2009 - 2010 Department of Physiology, Physiological Proteo-Genomics (PHLY-7704), “Cell Culture Techniques”, Fall Semester, 1 lecture and laboratory.

2009 - 2012 Department of Engineering, BIME 3000, “Introduction to Biomedical Engineering”, Fall Semester. 2 lectures

2010 Department of Cardiovascular Sciences, “Overview of Regenerative Medicine Research and Laser Capture Microdissection”. Lecture to NCState Park Fellows.

2010 Department of Physiology, “Gap Junctions: Intercellular Channels”, Lecture to graduate and undergraduate students in Tulis Laboratory.

2010 - 2011 Instructor, Brody School of Medicine Personal Professional Leadership Program.

2010 - 2013 Instructor, Department of Engineering, BIME 4040, “Physiological Systems and Modeling for Engineering”, Spring Semester, 2 lectures per week, 16 weeks.

2011 Department of Cardiovascular Sciences, Grand Rounds, CME, “The Heart of the Matter: Stem Cells”.

2011 - 2013 Department of Physiology, Physiological Proteo-Genomics (PHLY-7704), “Laser Capture Microdissection”, Spring Semester, 1 lecture and laboratory.

2011 - 2013 Department of Physiology, Physiological Proteo-Genomics (PHLY-7704), “Cell Culture Techniques”, Spring Semester, 1 lecture and laboratory.

2011 - 2013 Department of Physiology, Physiological Proteo-Genomics (PHLY-7704), “Stem Cells and Tissue Bioengineering”, Spring Semester, 1 lecture and laboratory.

2012 Department of Cardiovascular Sciences, Grand Rounds, CME, “Update on Current Cardiovascular Stem Cell Therapies”

Seminars

2004 Department of Physiology, Journal Club, “Stem Cell Trans-Differentiation in a Cardiac Myocyte Microenvironment”, October 2004.

2005 Metabolic Studies Research Group, “Stem Cell Plasticity in the Cardiovascular System”, February 2005.

2005 Department of Surgery, “Cardiovascular Translational Biology Laboratories”, Presentation to visiting professor Frank Selke, MD and surgical residents, October 2005.

2006 Division of Endocrinology and Metabolic Studies Group, “Confocal Fluorescence Microscopy”, January 2006.

2007 Stem Cell Interest Group, “Stem Cell Trans-Differentiation in a Cardiac Myocyte Microenvironment”, February 2007.

2007 East Carolina University Brody School of Medicine Confocal Microscopy Symposium, “Gap Junction Coupling and Calcium Signaling in Live Cell Cultures”, November 2007.

2008 Stem Cell Interest Group, “Review of Symposium on Cardiovascular Regenerative Medicine –October 2007”, February 2008.

2008 Metabolic Studies Research Group, “Mechanisms Controlling the Acquisition of a Cardiac Phenotype by Liver Stem Cells”, March 2008.

2009 Stem Cell Interest Group, “Induced Pluripotent Stem Cells”, December 2009.

2012 Cardiovascular Medicine Interest Group, “Cardiology Research”, November 2012.

Course Director

2007 Liaison to UNC-Chapel Hill, Fall 2007. Webcast, “Stem Cells and Maturational Lineage Biology: Relevance in Quiescent, Regenerative and Diseased Tissues and in Clinical/Commercial Programs in Tissue Engineering and Cell Therapies Course # 625”. Collaborated with Lola Reid, PhD, UNC-Chapel Hill to coordinate the webcast of 3 weekly lectures for 16 weeks. This was the first time the course was taught over the internet using the NCREN system.

2010 East Carolina University Department of Engineering, BIME 4040, “Physiological Systems and Modeling for Engineering”, Spring Semester 2010. Developed and taught course, 2 lectures per week for 15 weeks.

2010 Core Faculty and Research Advisor for Interventional Cardiology Program, Department of Cardiovascular Sciences.

2010 Core Faculty and Research Advisor for Cardiology Fellowship Program, Department of Cardiovascular Sciences.

2011 – BSOM, Graduate Program Co-Director, Interdisciplinary Doctoral Program in Biological Sciences.

2008 – 2010 Member of doctoral student committee, Jessica Dries, PhD Candidate, Department of Physiology, “EphrinA1/EphA Receptor Tyrosine Kinase Signaling in Myocardial Infarct Repair”.

2010 – 2012 Member of doctoral student committee, Drew Rockett, PhD Candidate, Department of Biochemistry.

Doctoral Student Training

2006. 
      Preceptor, Jessica Dries, First year graduate student, Department of Physiology. Doctoral student laboratory rotation.
      

2005 - 2006 Co-advisor, George Hart Tyson, MD. Third year Surgical Resident research project, “Evaluating Microbead Injection Techniques in a Porcine Heart”.

2006 Preceptor, Christopher Karkut, MD, First year Internal Medicine Resident. Laboratory rotation.

2006 - 2007 Co-advisor, Wes Hudson, MD. Third year Surgical Resident research project, “Evaluating Stem Cell Delivery Techniques and Analysis in a Porcine Model”.

2006 - 2007 Co-advisor, Dorian deFreitas, MD. Third year Surgical Resident research project, “Developing a Rodent Bypass Model”.

2008-2009 Preceptor, Jacqueline Carter, MD. Third year Surgical Resident. Laboratory methods and training.

2006 – 2008 Co-Advisor, Master’s student thesis project, Graham V. Byrum III. Research project/thesis. “Role of Thymosin Beta-4 in hMSC engraftment and differentiation in myocardial tissue “. Wake Forest Medical School, Class of 2012

2006 - 2008 Advisor, Master’s student thesis project, Yasmeen Midgette, Department of Biology. Research project/thesis, “The Effect of Mechanical Stress on the Differentiation of Mesenchymal Stem Cells into a Cardiac Phenotype in Vitro “.

2007 - 2008 Advisor, Master’s student, Catherine Gouge, Department of Biology.

2008 – 2009 Advisor, Master’s student thesis project, Maria C. Collins, Department of Biology. Research project/thesis “Expression of cardiogenic markers in bone marrow derived hMSC’s using mechanical strain and treatment with growth factors”.

2010 – 2011 Advisor, Master’s student thesis project, Katherine Crifasi, Department of Biology. Research project/thesis “What Degree of Protection does T4 hold for MSCs against Hypoxia Induced Apoptosis?”

2011 – 2012 Committee member, Divya Devadasan, ECU Department of Biology

2011 – 2012 Committee member, Laura Larion, ECU Department of Biology

2006 Mentor, Christopher Karkut (M4), East Carolina University Brody School of Medicine. Individually designed selective in Cell-Based Therapy and Tissue Engineering Laboratory, “Evaluating Effects of LPS on Gap Junction Expression in Adult Stem Cells”.

2007 Research co-advisor, Brian Burrows, “Cellular loss associated with xenographic mesenchymal stem cell cardiomyopathy”. Brody School of Medicine Summer Scholars Research Program.

2009 Research advisor, Joseph B. Padgett, ”Thymosin Beta 4's Wound Healing Propensity and the Heart “. Brody School of Medicine Summer Scholars Research Program.

2010 Research co-advisor, Richard Elliott Overman, Jr,. “Effects of BAY 41-2272 on Connexin 43 Expression in Vascular Smooth Muscle Cells.” Brody School of Medicine Summer Scholars Research Program.

2012 Research advisor, Vishnupriya Khatri ” Expression of CAMTA genes in cardiac hypertrophy “. Brody School of Medicine Summer Scholars Research Program

1. 
   Publications/Scholarly Activity related to proposed degree:
   

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  Muller-Borer BJ, Erdman D, Buchanan JW. "Electrical Coupling and Impulse Propagation in Anatomically Modeled Ventricular Tissue". IEEE Transactions in Biomedical Engineering (IF 1.857) 1994:41(5);445-454.
  
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  Muller-Borer BJ, Johnson TA, Gettes LS, Cascio WE. "Directional Differences in Propagation in a Modeled Ischemic Border Zone". Journal of Cardiovascular Electrophysiology (IF 3.703) 1995:6(12);1101-1112.
  
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  Hyatt CJ, Lemasters JJ, Muller-Borer BJ, Johnson TA, Cascio WE. "A Superfusion System to Study Border Zones in Confluent Cultures of Neonatal Rat Heart Cells". American Journal of Physiology (IF 4.0) 1998:274;H2001-H2008.
  
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  Muller-Borer BJ, Yang H, Marzouk SA, Lemasters JJ, Cascio WE. "Measurement of Endocardial and Subendocardial pH_i and pH_o in Perfused Rabbit Papillary Muscles by Confocal Fluorescent Microscopy". American Journal of Physiology (IF 4.0) 1998:275(6 pt 2);H1937-H1947.
  
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  Henriquez AP, Vogel R, Muller-Borer BJ, Henriquez CS, Weingart R, Cascio WE. "Influence of Dynamic Gap Junction Resistance on Impulse Propagation in Ventricular Myocardium: A Computer Simulation Study". Biophysical Journal (IF 4.507) 2001 Oct;81(4):2112-21.
  
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  Cascio WE, Yang H, Johnson TA, Muller-Borer BJ, Lemasters JJ. "Electrical Properties and Conduction in Reperfused Papillary Muscle". Circulation Research (IF 9.7) 2001 Oct 26;89(9):807-14.
  
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  Muller-Borer BJ, Cascio WE, Anderson PAW, Snowwaert JN, Frye JR, Desai N, Bagnell CR, Coleman WB, Grisham JW, Malouf NN. "Adult Derived Liver Stem Cells Acquire a Cardiac Myocyte Structural and Functional Phenotype in Culture". American Journal of Pathology (IF 6.039) 2004 July;165(1): 135-45.
  
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  Cascio WE, Yang H, Muller-Borer BJ, Johnson TA "Ischemia-Induced Arrhythmia: The Role Of Connexins, Gap Junctions, And Attendant Changes In Impulse Propagation”. Journal of Electrocardiology (IF 1.2) 2005 Oct;38(4 Suppl):55-9.
  
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  Muller-Borer BJ, Cascio WE, Grisham JW, Anderson PAW, Malouf NN “Acquired Cell-to-Cell Coupling and Cardiac-Like Calcium Oscillations in Adult Stem Cells in a Cardiomyocyte Microenvironment”. Proceedings of the 28th IEEE Engineering in Medicine and Biology Society, 2006;1:576-579.
  
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  Muller-Borer BJ, Cascio WE, Esch GL, Kim HS, Coleman WB, Grisham JW, Anderson PAW, Malouf NN. “Mechanisms Controlling The Acquisition Of A Cardiac Phenotype By Liver Stem Cells”. Proceedings of the National Academy of Sciences (IF 10.231) 2007 March; 104(10): 3877-3882.
  
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  Hudson W, Collins MC, Dorian deFreitas D, Sun, YS, Muller-Borer BJ, Kypson AP. “Beating And Arrested Intramyocardial Injections Are Associated With Significant Mechanical Loss: Implications For Cardiac Cell Transplantation”, Journal of Surgical Research (IF 2.087) 2007 Oct;142(2):263-7.
  
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  Anderson PAW, Muller-Borer BJ, Esch GK, Coleman WB, Grisham JW, Malouf NN. “Calcium Signals Induce Liver Stem Cells to Acquire a Cardiac Phenotype”. Cell Cycle (IF 4.087). 2007 Jul;6(13):1565-9.
  
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  Muller-Borer BJ, Collins MC, Gunst PR, Cascio WE, Kypson AP. “Quantum Dot Labeling of Mesenchymal Stem Cells”. Journal of Nanobiotechnology (IF 5.09) 2007 Nov. 7, 5-9.
  
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  Carter, J. J., Manwaring, M.L. , Salleng, K.J. , Muller-Borer, B.J. , Collins, M.C., Stoner, M.C. “Paralysis and Cell Death from Thoracic Aortic Stenting Ameliorated by Peroxynitrite Decomposition Catalyst.” Journal of the American College of Surgeons, 2008, 207 (3 sup), 22.
  
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  Burrows, B.J., Collins, M.C., Muller-Borer, B.J.,Kypson, A.P. “Cellular Cardiomyoplasty: Results of Injected Human Mesenchymal Stem Cell Survival Rates in a Beating Rat Heart Model”. Journal of Surgical Research, 2008, 144 (2), 274-5.
  
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  Collins MC, Moore JL, Burrows BJ, Kypson AP, Muller-Borer BJ. ““Early cell loss associated with mesenchymal stem cell cardiomyoplasty””, The Open Tissue Engineering and Regenerative Medicine Journal, 2012, April; 5: 17-24
  
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  Muller-Borer BJ, Esch GL, Aldina R, Woon, Fox R, Bursac N, Hiller S, Maeda N, Shepherd N, Jin JP, Hutson M, Anderson PAW, Kirby M, Malouf NN. “Calcium Dependent CAMTA1 in Adult Stem Cell Commitment to a Myocardial Lineage”, PLoS One. 2012;7(6):e38454. Epub 2012 Jun 8.
  
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  Joshi C, Martin DN, Shaver P, Madamanchi C, Muller-Borer BJ, Tulis DA. “Control of Vascular Smooth Muscle Cell Growth by Connexin 43”, Front Physiol. 2012;3:220. Epub 2012 Jun 21.
  

2. 
   Status of Grants & Contracts submitted related to proposed degree (including agency names, years of funding, collaborative partners):
   

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  Consultant, “EphrinA1-Fc Attenuates Myocardial Infarct Injury”, North Carolina Biotechnology Center, Biotechnology Research Grant (PI: Jitka I. Virag, PhD, ECU Department of Physiology). $75,000. (6/2012 – 12/2013)
  
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  Collaborating Investigator “High speed low cost spectral domain optical coherence tomography system for intravascular imaging” NSF-SBIR (PI: Brian Cabarrus, MD, ECU Department of Cardiovascular Sciences). $80,000. (1/2013 – 12/2014 )
  
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  Collaborating Investigator “Surgical Assessment of Bone Wax Material in a Porcine Model” Pioneer Surgical Orthobiologics. Inc.(PI: Alan Kypson, MD, ECU Department of Cardiovascular Sciences). $8000. (1/2013 – 12/2013 )
  
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  Collaborating Investigator, “NO-independent cGMP Regulation of Vascular Remodeling”. National Heart, Lung and Blood Institute R01 (PI: Dave Tulis, PhD, ECU Department of Physiology), Annual Direct Costs $252,325 (04/2010 – 04/2012).
  

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  Co-PI, “Intramyocardial EphrinA1-Fc Reduces Acute Injury and Chronic Remodeling”. National Heart, Lung and Blood Institute R21, (PI: Jitka I. Virag, PhD, ECU Department of Physiology). $300,000. Submitted 08/2012
  

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  PI of ECU Subaward (Sole ECU Investigator), “Mechanisms For Stem Cell Differentiation Into Cardiac Myocytes” National Heart, Lung and Blood Institute R01 (PI: Margaret Kirby, PhD, Duke University), Annual Direct Costs $357,612 (07/2009 - 06/2011).
  

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  Principal Investigator, “Stem Cell Engraftment And Trans-Differentiation In A Cardiac Cell Microenvironment”. University Research Council Grant, The University of North Carolina at Chapel Hill. $4,000 (05/2003 – 04/2005).
  
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  Principal Investigator, “A Proteomic Study of Stem Cell Engraftment and Trans-differentiation to a Cardiac Phenotype”. Junior Faculty Development Award, The University of North Carolina at Chapel Hill, Committee on Faculty Research. $5,000 (01/2004 – 12/2004).
  
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  Co-PI, “Assessment of Myocardial Cellular Transplantation via Multiple Delivery Modes”, Murray and Sydell Rosenberg Foundation, A Joint Project of The Eastern Carolina Cardiovascular Institute & East Carolina University Brody School of Medicine. $125,000 (01/2005).
  
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  Principal Investigator, “Role of Thymosin β4 in Stem Cell Engraftment and Myocardial Tissue Regeneration”. Research Development Grant, East Carolina University Division of Research and Graduate Studies. $40,000 (07/2006 – 06/2007).
  
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  Collaborating Investigator, “Effects of Cardiopulmonary Bypass on Adult Stem Cell Transplantation”. Research Development Grant, East Carolina University Division of Research and Graduate Studies (PI: Alan P. Kypson, MD, Department of Surgery). $25,000 (07/2006 – 06/2007).
  

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  Co-PI, “Laser Capture Microdissection: Advanced Technology for Biomedical Research”. North Carolina Biotechnology Center Institutional Development Grant. $163,539 (01/2007).
  
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  Co-Chair, “Laser Technologies and Applications Group (Laser TAG”). North Carolina Biotechnology Center (NCBC), NCBC Science & Technology Development Program, Intellectual Exchange Group. Total funding support: $3000 per year, Awarded September 2009, Renewed September 2010.
  
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  Co- PI, “Acquisition of a Confocal Laser Scanning Microscope to Enhance Research Infrastructure”, North Carolina Biotechnology Center Institutional Development Grant, $200,000 (04/2013).
  

3. 
   Invited research presentations outside ECU:
   

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  Living Proof: Senior Faces of Research: Documentary video about the benefits of biomedical research. North Carolina Association for Biomedical Research. October 2005 (interview).
  
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  Gordon Research Conference in Cardiac Arrhythmia Mechanisms. “Cardiac-Like Calcium Transients in Liver Stem Cells Co-Cultured with Cardiac Myocytes”. Muller-Borer BJ, Cascio WE, Esch GL, Graff DW, Lemasters JJ, Anderson PAW, Grisham JW, Malouf NN. Beullton, CA, February 2005.
  
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  78^th Scientific Sessions of the American Heart Association. "Calcium-Driven Transcription of a Cardiac Specifying Gene Program in Liver Stem Cells ", Muller-Borer BJ, Cascio WE, Esch GL, Graff DW, Aghajanian A, Kim HS, Lemasters JJ, Kim JS, Coleman WB, Grisham JW, Anderson PA, Malouf NN. Dallas, TX, November 16, 2005.
  
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  28th IEEE EMBS Annual International Conference. Invited Speaker. Muller-Borer BJ, Cascio WE, Grisham JW, Anderson PAW, Malouf NN, “Acquired Cell-to-Cell Coupling and Cardiac-Like Calcium Oscillations in Adult Stem Cells in a Cardiomyocyte Microenvironment”. New York City, NY, August 2006 (oral presentation).
  
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  2006 Scientific Sessions of the American Heart Association. “Long-Term Labeling of Mesenchymal Stem Cells Using Quantum Dot Bioconjugates”. Muller-Borer BJ, Gunst PR, Collins MC, Cascio WE, Kypson AP, Chicago, IL, November 2006 (oral presentation).
  
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  Sigma Xi – ECU Chapter, Awards Banquet, Invited Speaker, “Mechanisms Controlling the Acquisition of a Cardiac Phenotype by Liver Stem Cells”. Muller-Borer BJ, Cascio WE, Esch GL, Kim HS, Coleman WB, Grisham JW, Anderson PAW, NN Malouf. January 2008 (oral presentation).
  
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  Keystone Symposia on Molecular and Cellular Biology, Cardiac Disease: Development, Regeneration and Repair (D1). “Thymosin β4 Pretreatment of Human Mesenchymal Stem Cells and Rat Neonatal Cardiomyocytes”. Collins MC, Gunst PR, Byrum G, Virag JI, Muller-Borer BJ, March 17, 2009.
  
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  International Society for Stem Cell Research ” Thymosin Beta-4 Provides Enhanced Environment for Human Stem Cell Transplantation”. Collins MC, Gunst PR, Moore JL, Virag JI, Muller-Borer BJ, June 2010.
  
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  International Society for Stem Cell Research. “Simulated Cardiac Micromechanical Environment Increases Cx43 Expression and Proliferation in Human Mesenchymal Stem Cells”. Collins MC, Midgette YA, Gunst PR, Muller-Borer BJ, June 2010.
  
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  Regenerative Medicine: Harnessing Biology for Regeneration “Growth Factors Enhance Adult Stem Cell Mitochondrial Function”, Ajmera A, Collins MC; Pradhan PV; Thayne K; Anderson E; Muller-Borer BJ, Hilton Head, SC, March 2012.
  
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  International Society for Stem Cell Research. “The Role of Mitochondrial Biogenesis in Human Mesenchymal Stem Cell Differentiation and Acquisition of a Cardiac Phenotype”, Ajmera A, Collins MC, Pradhan PV, Anderson EJ, Muller-Borer BJ, Boston, MA, June 2013.
  
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  International Society for Stem Cell Research. “Dynamic Behavior of Mesenchymal Stem Cells in a Cardiac Microenvironment: A High Resolution Time-Lapse Imaging Study”, Coltrain L, Collins MC, Pradhan P, Muller-Borer BJ, Boston, MA, June 2013.
  

4. 
   Book Chapters
   

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  Gettes LS, Cascio WE, Johnson TA, Muller-Borer BJ, and the Experimental Cardiology Group. Characteristics and causes of conduction changes associated with 1a and 1b arrhythmias in acute ischemia. In: Discontinuous Conduction in the Heart. Spooner PM, Joyner RW, Jalife J, editors. American Heart Association Monograph Series. Futura Publishing Company, Inc., Armonk, New York, 1997, pp 441-452.
  
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  Lemasters JJ, Qian T, Trollinger DR, Muller-Borer BJ, Elmore SP, Cascio WE. Laser Scanning Confocal Microscopy Applied to Living Cells and Tissue. In: Methods in Cellular Imaging. Periasamy A, editor. Published for the American Physiological Society by Oxford University Press, New York, NY, 2001, Chapter 5 (pp 66-87).
  
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  Collins MC, Gunst PR, Cascio WE, Kypson AP, Muller-Borer BJ. Labeling and Imaging Mesenchymal Stem Cells with Quantum Dots. Nanoparticles in Biology and Medicine. Methods Mol Biol. 2012;906:199-210, Humana Press, USA.
  
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  Collins MC, Gunst PR, Muller-Borer BJ. Functional Integration of Quantum Dot Labeled Stem cells in a Cardiac Microenvironment. Methods in Molecular Biology. Humana Press, USA pending
  

5. 
   Refereed Papers Presented at Major International or National Technical Meetings
   

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  Muller-Borer BJ, Cascio WE, Esch GL, Graff DW, Lemasters JJ, Anderson PAW, Grisham JW, Malouf NN. “Cardiac-Like Calcium Transients in Liver Stem Cells Co-Cultured with Cardiac Myocytes”, Proceedings of the Gordon Research Conference in Cardiac Arrhythmia Mechanisms, February 2005.
  
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  Graff DW, Cascio WE, Muller-Borer BJ, Aghajanian A,. Sama P, Yan GX,. Devlin RB. "Zinc Produces a Transmural Voltage Gradient and Disruption of Intercellular Communication in the Heart”. Society of Toxicology, March 2005.
  
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  BJ Muller-Borer, WE Cascio, GL Esch, DW Graff , JJ Lemasters, PAW Anderson, JW Grisham, NN Malouf. “Cardiac-Like Calcium Transients in Liver Stem Cells Co-Cultured with Cardiac Myocytes”. Proceedings of the 2005 BSOM Department of Internal Medicine Research Day, May 2005.
  
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  Lindsey CW, Muller-Borer BJ, Yang H, Cascio WE. "BAYK8644 Enhances Longitudinal Conduction Velocity in Depolarized Ischemic Myocardium: Possible Role for I_Ca in Impulse Propagation". Proceedings of the 2005 BSOM Department of Internal Medicine Research Day, May 2005.
  
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  Muller-Borer BJ, Cascio WE, Esch GL, Graff DW, Aghajanian A, Kim HS, Lemasters JJ, Kim JS, Coleman WB, Grisham JW, Anderson PAW, Malouf NN, “Calcium Driven Transcription of a Cardiac Specifying Gene Program in Liver Stem Cells”. Circulation, 2005:112(17); II-266.
  
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  Muller-Borer BJ, Cascio WE, Esch GL, Graff DW, Kim HS, Lemasters JJ, Kim JS, Coleman WB, Grisham JW, Anderson PAW, Malouf NN, “Cardiac-Like Oscillations in Liver Stem Cells Induce Their Acquisition of a Cardiac Phenotype”. Proceedings of the American Society of Cell Biology, Dec. 2005.
  
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  Tyson GH, Muller-Borer BJ, Cascio WE, Chitwood WR, Kypson AP, “Cell Therapy Infusion Device”. Proceedings of the 9^th Annual NewEra Cardiac Care Meeting, January 2006.
  
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  Burrows BJ, Gunst PR, Muller-Borer BJ, Cascio WE, Johnson TA, “Identification Of Border Zones In Swine Cardiac Tissue With The Use Of A Typhoon Variable Mode Imaging System”. Proceedings of the 2006 BSOM Department of Internal Medicine Research Day, May 2006.
  
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  Gunst PR, Collins M, Burrows BJ, Kypson AP, Muller-Borer BJ, “Viability Of Mesenchymal Stem Cells Labeled With Quantum Dot Nano Particles”. Proceedings of the 2006 BSOM Department of Internal Medicine Research Day, May 2006.
  
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  Muller-Borer BJ, Gunst PR, Collins MC Cascio WE, Kypson AP, “Long-Term Labeling of Mesenchymal Stem Cells Using Quantum Dot Bioconjugates”. Circulation, 2006:114(18); II-662.
  
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  Kypson A, Tyson H, Collins M, Sun Y, Nifong W, Muller-Borer B. “Significant Mechanical Loss Is Associated With Direct Intramyocardial Injection For Cellular Cardiomyoplasty”. Journal of Surgical Research, 2007:137(2);.295.
  
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  Collins MC, Hudson W, deFreitas D, Sun YS, Muller-Borer BJ, Kypson AP. “Beating And Arrested Intramyocardial Injections Are Associated With Significant Mechanical Loss: Implications For Cardiac Cell Transplantation”, Proceedings of the 2007 BSOM Department of Internal Medicine Research Day, May 2007.
  
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  Muller-Borer BJ, Cascio WE, Esch GL, Kim HS, Coleman WB, Grisham JW, Anderson PAW, Malouf NN, Mechanisms Controlling the Acquisition of a Cardiac Phenotype by Liver Stem Cells”. Proceedings of the 2007 BSOM Department of Internal Medicine Research Day, May 2007.
  
• 
  Burrows BJ, Collins MC, Muller-Borer BJ, Kypson AP.”Cellular Cardiomyoplasty: Results of Injected Human Mesenchymal Stem Cell Survival Rates in a Beating Rat Heart Model”. Journal of Surgical Research, 2008: 144(2);274-5
  
• 
  Carter JJ, Manwaring ML, Salleng KJ, Muller-Borer BJ, Collins MC, Stoner MC.” Paralysis and Cell Death from Thoracic Aortic Stenting Ameliorated by Peroxynitrite Decomposition Catalyst”. Journal of the American College of Surgeons 2008; 207(3 sup.):22.
  
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  Collins MC, Gunst PR, Virag JI, Muller-Borer BJ. “Thymosin-4 Treatment of Human Mesenchymal Stem Cells and Cardiomyocytes”. Proceedings of the 2008 BSOM Department of Internal Medicine Research Day, May 2008.
  
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  Byrum GV, Collins MC, Muller-Borer BJ, Virag JI. “ Role of Thymosin-4 in Human Mesenchymal Stem Cell Engraftment, survival and Differentiation in Murine Myocardium”. Proceedings of the 2008 BSOM Department of Internal Medicine Research Day, May 2008.
  
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  Midgette YA, Collins MC, Gunst PR, Muller-Borer BJ, “The Effects of Mechanical Strain on the Differentiation of Mesenchymal Stem Cells into a Cardiac Phenotype In Vitro”. Proceedings of the 2008 BSOM Department of Internal Medicine Research Day, May 2008.
  
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  Collins MC, Muller-Borer BJ, “Expression of Cardiogenic Markers in Bone Marrow Derived hMSC’s using Mechanical Strain and Treatment with Growth Factors”. Proceedings of the 2009 BSOM Department of Internal Medicine Research Day, April 2009.
  
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  Collins MC, Gunst PR, Byrum G, Virag JI, Muller-Borer BJ, “Thymosin β4 Pretreatment of Human Mesenchymal Stem Cells and Rat Neonatal Cardiomyocytes”, Proceedings of the Keystone Symposia on Molecular and Cellular Biology. Cardiac Disease: Development, Regeneration and Repair (D1), June 2009.
  
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  Moore JL ,Collins MC, Virag, JI, Muller-Borer BJ, ”Exploring Intramyocardial Stem Cell Engraftment with Laser Capture Microscopy”. Proceedings of the 2010 BSOM Department of Internal Medicine Research Day, May 2010.
  
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  Collins MC, Gunst PR, Moore JL, Virag JI, Muller-Borer BJ, ” Thymosin Beta-4 Provides Enhanced Environment for Human Stem Cell Transplantation”, Proceedings of the International Society for Stem Cell Research, 2010.
  
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  Collins MC, Midgette YA, Gunst PR, Muller-Borer BJ, ” Simulated Cardiac Micromechanical Environment Increases Cx43 Expression and Proliferation in Human Mesenchymal Stem Cells”, Proceedings of the International Society for Stem Cell Research, 2010.
  

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  Ajmera AA ,Collins MC, Pradhan PV, Anderson EJ, Muller-Borer BJ, ”The Effects of Growth Factors on the Mitochondrial Physiology of Human Mesenchymal Stem Cells”. Proceedings of the 2011 BSOM Department of Internal Medicine Research Day, April 2011.
  
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  Crifasi K, Collins MC, Muller-Borer BJ, ”Serum Deprivation and Hypoxia in Human Mesenchymal Sem Cells, and the Protective Role of Thymosin Beta-4”. Proceedings of the 2011 BSOM Department of Internal Medicine Research Day, April 2011.
  
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  Ajmera A, Collins MC; Pradhan PV; Thayne K; Anderson E; Muller-Borer BJ, “Growth Factors Enhance Adult Stem Cell Mitochondrial Function” Regenerative Medicine: Harnessing Biology for Regeneration, March 2012.
  
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  Collins MC, Sullivan ST, Muller-Borer BJ, “Integration and Differentiation of Human Mesenchymal Stem Cells on 3D Electrospun Nanofiber Scaffolds”. Proceedings of the 2012 BSOM Department of Internal Medicine Research Day, May 2012.
  
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  Brown DA, Hale SL, Del Rio C, Hamlin R, Frasier CR, Stewart LM, Patel HD, Collins MC, Muller-Borer BJ, Shaikh SR, Harris M, Fisher-Wellman KH, P. Neufer PD, Kloner RA. “Bendavia, a mitochondria-targeting peptide, reduces reperfusion injury and reactive oxygen species levels through a mechanism independent of direct oxygen radical scavenging: a multicenter study”, submitted for publication Circulation, 2012
  

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  Report of Invention -Cell Therapy Infusion Device, GH Tyson, MD, Co-Advisors Alan P. Kypson, MD, Barbara J. Muller-Borer, Ph.D. Submitted and presented to the East Carolina University’s Office of Technology Transfer and the University Committee on Intellectual Property/Patents, January 2006.
  

1. 
   Participation in scholarly collaborations with other universities, laboratories, & centers:
   

2. 
   Service on related state/national/international boards or committees:
   

Grant Peer Review

American Institute of Biological Sciences, New York State Department of Health and the Empire State Board NYSTEM Program, October 2008

Ad Hoc Peer Reviewer

1992-1994 IEEE Transactions Engineering in Medicine and Biology

2005 Cardiovascular Research

2005 Journal of Cardiac Electrophysiology

2006 - present Engineering in Medicine and Biology Society

2008 – 2009 Molecular Vision

2009 – 2010 Connective Tissue Research

Sigma Xi, Scientific Research Society – East Carolina University Chapter

2006. 
      – 2008 Membership Committee
      

2009-2011 Executive Committee Secretary

2009 - present Science Café, Steering Committee Member

North Carolina Tissue Engineering and Regenerative Medicine Society

2012 – 2014 - Executive Committee Secretary

Employment History

1979-1982 Human Factors Engineer, New Product Development, Eastman Kodak Co., Rochester, NY.

1985-1986 Masters Candidate and Research Assistant, Curriculum in Biomedical Engineering and Mathematics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

1988-1991 Predoctoral Fellow Duke/North Carolina National Science Foundation, Engineering Research Center for Emerging Cardiovascular Technologies, Curriculum in Biomedical Engineering and Mathematics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

1991-1994 Postdoctoral Research Fellow, Department of Internal Medicine/Division of Cardiology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

1994-1996 NIH Postdoctoral Research Fellow, Department of Internal Medicine/Division of Cardiology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

1996-1998 Postdoctoral Research Assistant, Department of Internal Medicine/Division of Cardiology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

1998-2001 Research Associate, Department of Internal Medicine/Division of Cardiology UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Professional Honors and Awards

2009 East Carolina University Chancellor’s Leadership Academy.

2009 Bridges Academic Leadership for Women, William and Ida Friday Center for Continuing Education, The University of North Carolina at Chapel Hill.

Professional Societies

1997 – present Tau Beta Pi, Engineering Honor Society

1990 – present Biomedical Engineering Society

1990 – present Institute of Electrical and Electronics Engineers (IEEE)

1993 – present American Heart Association

1997 – present Cardiac Electrophysiology Society

1999 – present Sigma Xi, Scientific Research Society

2005 – present International Society for Stem Cell Research

2005 – present Society of Women Engineers

2009 – present International Society for Heart Research

University Committees and Service

2005 – present Member, Course Committee, Physiological Proteo-Genomics (PHLY-7704).

2006 – present Member, Engineering Advisory Board, Department of Engineering.

2006 – present Member, Biomedical Engineering Concentration Planning Committee, Department of Engineering.

2006 – present Member, Brody Women Faculty Committee.

2006 – present Program Committee Co-Chair, Stem Cell Interest Group. Co-organize and arrange monthly meetings and speakers.

2006 – present Member, Brody School of Medicine Laser Capture Microdissection Advisory Board.

2008 Member, Senior Design Capstone Project Review and Evaluation Committee, Department of Engineering.

2009 Member, Senior Design Capstone Project Review and Evaluation Committee, Department of Engineering.

2009 – 2010 Program Committee Co-Chair, Brody Women Faculty Committee. Co-organized and arranged monthly meetings and speakers. Co-organized Women in Science and Medicine Conference with the BSOM Office of Academic and Faculty Development, ECU Brody School of Medicine, March 2009.

2009 – 2010 Member, Faculty Search Committee, College of Health and Human Performance, Department of Exercise and Sport Science.

2009 – present Member, Biomedical Engineering Master’s Program Committee, Department of Engineering.

2009 – present Member, Industrial Outreach Committee, Department of Engineering.

2009 – present Steering Committee Vice Chair, North Carolina Biotechnology Center Intellectual Exchange Group for Laser Capture Microdissection (Laser TAG).

2009 – 2011 Elected Member, ECU Faculty Senate Faculty Information Technology Review Committee, East Carolina University.

2010 – 2011 Member, Brody School of Medicine Graduate Studies Committee.

2010 – 2011 Chair Brody Women Faculty Committee.

2011 – present Co-Program Director for Interdisciplinary Studies Program in Biological Sciences, Biomedical Science Graduate Program

Undergraduate Student Advising

2009. 
      Instructor, Megan Watkins, Independent Study, “Analysis of Cardiac Calcium Signaling”, Department of Engineering undergraduate student, ECU College of Technology and Computer Sciences.
      

2010 – present Mentor/research advisor, Arun Ajmera, recipient of ECU Early Assurance Award 2010, ECU Department of Biology. 2012 Recipient of ECU Undergraduate Research and Creative Activity Award

2011 Mentor, Daniel Deters, Summer Intern, Department of Engineering undergraduate student, ECU College of Technology and Computer Sciences.

2011 – 2012 Mentor, Shareh Hallaji, ECU Department of Biology

2011 – present Mentor, Richard Steiner, ECU Department of Engineering. 2013 Recipient of ECU Undergraduate Research and Creative Activity Award

2012 – present Faculty Advisor, Senior Engineering Capstone Project, ECU Department of Engineering

2012 – present Project Leader and Faculty Advisor, Senior Engineering Capstone Project, ECU Department of Engineering

2013 – present Mentor, Coriyon Arrington, ECU Department of Engineering

2013 – present Mentor, Layne Barefield, ECU Department of Engineering

Other Teaching Activities

2005 Preceptor, Undergraduate, 3 month laboratory rotation. Freshman undergraduate, Amherst University, Amherst, MA..

2006 Preceptor, Undergraduate, 3 month laboratory rotation. Park Fellow undergraduate student, North Carolina State University, Raleigh, NC.

2006 Preceptor, Undergraduate, 1 month laboratory rotation. Senior undergraduate in Biomedical Sciences, University of South Florida, Tampa, FL.

2006 Preceptor, High school student, 3 month laboratory rotation. Senior, JH Rose High School, Greenville, NC.

2006- 2007 Preceptor, Senior, JH Rose High School Medical Honors program. Greenville, NC.

2008. 
      Member, Review Committee, Senior Capstone Project, Department of Engineering, ECU College of Technology and Computer Sciences.
      
2009. 
      Member, Review Committee, Senior Capstone Project, Department of Engineering, ECU College of Technology and Computer Sciences.
      
2010. 
      Judge, Graduate Student Oral Presentation, 2010 Department of Internal Medicine Research Day.
      

2010 Preceptor, High school student ,1 month laboratory rotation. Junior, Chantilly HS, Chantilly, VA.

2010 – 2011 Preceptor, Senior, D.H. Conley High School Medical Honors program, Greenville, NC.

Professional Development

• 
  MATLAB Fundamentals and Programming Techniques, Raleigh, NC. April 2003
  
• 
  Lecture and Presentation Skills, Office of Academic and Faculty Development , ECU Brody School of Medicine. October 2004.
  
• 
  Virtual Cell Short Course, University of Connecticut Health Center, Farmington, CT. June 2006.
  
• 
  Basic Statistical Skills and Advanced Statistical Skills, Summer Workshop, Center for Faculty Development, East Carolina University. June 2006.
  
• 
  NIH Regional Seminar on Grant Preparation, Research Triangle Park, NC. April 24-26, 2007.
  
• 
  International Society of Computerized Electrocardiography, Riverside, CA. May 1 – 5, 2008.
  
• 
  Integrative Computational Modeling of the Cardiac Myocyte, NHLBI-JHU T15 Short course on Myocyte Modeling, Baltimore, MD. August 18 – 22, 2008.
  
• 
  East Carolina University Chancellor’s Leadership Academy, Office of Academic Affairs Special Projects. Jan – May 2009.
  
• 
  9^th Annual Coherent – Zeiss Workshop and Multiphoton Users Group Meeting, David H. Murdock Research Institute, Kannapolis, NC. August, 27-28, 2009.
  
• 
  Bridges Academic Leadership for Women, William and Ida Friday Center for Continuing Education, The University of North Carolina at Chapel Hill, September – November 2009.
  
• 
  Medical Education Grand Rounds, Blackboard, BSOM Office of Academic and Faculty Development, ECU Brody School of Medicine. November 2009.
  
• 
  Preparing a Personnel Action Dossier, BSOM Office of Academic and Faculty Development, ECU Brody School of Medicine, March 2005, October 2009.
  
• 
  Accreditation Board for Engineering and Technology (ABET) Faculty Workshop on Sustainable Assessment Processes – January 2010.
  

Research and Teaching Honors and Awards

2005 W. James Metzger, Jr. MD, Brody School of Medicine, Department of Internal Medicine Research Day, Junior Faculty Presentation Award.

2006 Best Drawing Board Invention, “Cell Therapy Infusion Device”, Tyson GH, Co-Mentors Muller-Borer BJ & Kypson AP. 9^th Annual NewEra Cardiac Care Meeting.

2007 Best Research Poster, 2007 BSOM Department of Internal Medicine Research Day. “Beating And Arrested Intramyocardial Injections Are Associated With Significant Mechanical Loss: Implications For Cardiac Cell Transplantation”, Co-Authors Collins MC, Hudson W, deFreitas D, Co-Mentors Muller-Borer BJ & Kypson AP. Greenville, NC.

2006 Faculty Author Recognition Award, East Carolina University, Division of Health Sciences.

2007 Faculty Author Recognition Award, East Carolina University, Division of Health Sciences.

2008 Sigma Xi, 2008 Helms Award for Faculty Research in Biological Sciences, East Carolina University Chapter.
Faculty Information Sheet

Directory: cs-acad -> gcc -> upload
upload -> Assessing Readiness to Offer New Degree Programs
upload -> Math: Mathematics
upload -> Ms in computer science
cs-acad -> 2012 summer biomedical research program (sbrp) for undergraduates at Brody School of Medicine
upload -> DR. jack e. Karns
cs-acad -> University Curriculum Committee Course Proposal Form for Courses Numbered 0001 – 4999
cs-acad -> University Curriculum Committee Course Proposal Form for Courses Numbered 0001 – 4999

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