Cbe, ma (Oxon), mbchB, bsc (Hons), msc, PhD, md, dsc, frcp (Glasgow,Edinburgh and London), frcgp (hon), fcanSci, fmedSci



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INTERACTION WITH INDUSTRY

I have established board level links with a number of global pharmaceutical and healthcare companies which has led to significant grant funding eg Glaxo Smith Kline (£3 million), Merck (£14 million), Roche (£6.5 million) GE Healthcare (£2 million) and AstraZeneca (£1 million). I was part of the Drug Development Team which won Astra Zeneca’s Oncology and Infections Visions and Values prize in 2005.


Oxford has an impressive record of protecting and developing its IPR and establishing spin out companies. When working in the University of Birmingham, I established one of their first biotechnology spin outs, a gene therapy company, COBRA Therapeutics. In Oxford, I have worked with ISIS to construct a cancer drug development company, Celleron and Oxford Cancer Biomarkers a platform technology-based biotech company which identifies chemotherapy sensitivity biomarkers.

INTERNATIONAL COLLABORATIONS:




USA I sit on NIH’s Translational Research working group as the overseas member and have established a series of collaborations with the USA’s major cancer research centres (Mayo Clinic, MD Anderson, Memorial Sloan Kettering and Dana Farber, Harvard).

INDIA having attracted grant funding from the pharmaceutical company GSK, we have constructed a network of India’s top 10 cancer centres, in partnership with Oxford. This collaboration will provide training opportunities for Indian investigators in Oxford and will build an internationally competitive clinical research network (www.indox.org.uk).

EUROPE I had the opportunity to co-chair the Entente Cordiale Celebrations on behalf of HM the Queen and President Chirac, 2003-2005. As President of ESMO (2010-2012) I am in a strong position to improve standing of Medical Oncology in Europe and sit on the Dutch government’s central committee for translational research with a budget of 1 billion Euros.

AFRICA I have established a consortium comprising the International Atomic Energy Agency, International Agency for Cancer Research, and the Union Internationals Contre Le Cancer to develop cancer control programmes in Sub Saharan Africa and created AfrOx (www.afrox.org) the vehicle to implement change.

FAR EAST I have established OxOnics, a drug development company with my colleague Dr Wenn Sun. It has a mission to bring novel anti-cancer agents to the Asia-pacific rim with a focus on China.


RESEARCH GRANTS RECEIVED



1989





  • Health Board Research Support Group - £10,000.

One year's salary for Research Assistant.


as part of an international collaborative group chaired by Prof S S Davis, Dept. Pharmacy, University of Nottingham


  • Cancer Research Campaign Project Grant - £160,000.

3 years' salary - clinical research fellow & post doctoral scientist for research into use of Mitomycin C microcapsules by intrahepatic arterial administration in hepatic metastatic carcinoma.

Grant Holders - D Kerr, C McArdle, A Whately.


1990


  • Scottish Hospital Endowment Research Trust- £44,000

2 year's salary for research assistant - molecular biology of breast cancer


  • Cancer Research Campaign - £80,000 over 3 years

Joint project with Dr I Pragnell, Beatson Institute for Cancer Research, funding a clinical research fellow to investigate preclinical toxicology of marrow stem cell inhibitor
1991


  • Scottish Hospital Endowment Research Trust - £75,000

3 year salary for senior post-doctoral scientist for project on population pharmacokinetics of cytotoxic drugs in breast cancer therapy


Supervision of programme grant expenditure of CRC Pharmacology Group - 5 year programme Grant.
1992


  • Scottish Hospital Endowments Research Trust - £50,000

2 year's salary for senior post-doctoral scientist for project on formulation of cytotoxic drugs for cerebral implantation in the treatment of brain tumours.

Grant Holders - D J Kerr, T A Whately, R Rampling, J Plumb




  • Queen Elizabeth Endowment Trust - £42,000

Development of Inhibitors of P-Glycoprotein.

Grant Holders - D J Kerr, D R Ferry




  • Queen Elizabeth Endowment Trust - £27,000

Interaction of Platinum with the HIV Promoter Sequence.

Grant Holders - D J Kerr, C J Poole, L Young





  • Cancer Research Campaign - £500,000

Laboratory Refurbishment grant on joining University of Birmingham

Grant Holder – D J Kerr




  • Cancer Research Campaign - £620,000

Molecular Pharmacology Group

Grant Holder – D J Kerr




  • Cancer Research Campaign - £1 million

Programme Grant Supporting Clinical Trials Unit

Grant Holder – D J Kerr


1994


  • Regional Health Authority- £5 million

To house the expanding Institute for Cancer Studies

Grant holder - D J Kerr


September 1995-September 1999


  • Medical Research Council £1,501,304

Gene Therapy of Common Cancers: Immunological & Pharmacological Approaches to Gynaecological Cancer.

Grant holders - LS Young, PF Searle, D. Luesley, AB Rickinson, PH. Gallimore




Departments Expenses-Core Funding 1995-1999

Grant holders - AB Rickinson and DJ Kerr


September 1994-September 1997


  • Glaxo Research and Development Limited (plc) - £75,000

A Co-administration of rising oral GG918 Dose Levels with Doxorubicin Phase 1 Study

Grant holders - DJ Kerr


January 1995-January 1998


  • M.L. Laboratories plc - £75,794

Adjuvant Intraperitoneal Chemotherapy with 5-fluorouracil in Duke’s Stage B and C Colic Adenocarcinoma (VICTOR)

Grant holder - DJ Kerr


November 1995-November 1997


  • Special Trustees of the Former UBH Trust £49,233

Investigation of Phospholipase Signal Transduction Pathways in Human Breast Cancer

Grant holders - DJ Kerr and MJO Wakelam


March 1997-March 1998


  • Takeda Chemical Industries Ltd. (Japan) £42,000

A Phase II Open Label Study to Determine the Safety Tolerability and Efficacy of CV6504(HCI) in Patients with pancreatic cancer

Grant holders - DJ Kerr


September 1996-September 1999


  • Glaxo-Wellcome R and D £120,000

Immunological and Pharmacological Aspects of Gene Therapy

Grant holders - DJ Kerr


1996-2001


  • Cancer Research Campaign £616,335

Core Clinical Fellowships

Grant holders - DJ Kerr



1997-2001


  • Cancer Research Campaign £1,102,030

Clinical Trials Unit – Core Support

Grant holders - DJ Kerr


1995-1998


  • Cancer Research Campaign £68,526

West Midlands Trials of Adjuvant Treatment in Early Breast Cancer

Grant holder - DJ Kerr


1998-2003


  • Cancer Research Campaign £534,695

Pre-Clinical and Clinical Pharmacology and Macromolecular Drug Targeting

Grant holder - DJ Kerr


1998-2002


  • Cancer Research Campaign £135,690

ATTOM UKCCCR Randomised Trial to Establish Optimum Length of Adjuvant Tamoxifen

Grant holder - DJ Kerr


1994-1997


  • Ministry of Agriculture, Fisheries and Food £200,742

Evaluation of Non-Nutrient Dietary Constituents in Prevention of Breast Cancer

Grant holders - DJ Kerr, A Gescher, K. Chipman


1997


  • The Higher Education Funding Council Capital £249,640

Research and Development for a Boron Cancer Therapy Clinical Facility

Grant holders - DJ Kerr, N James, D. Beynon


1996-2001


Foundation of a Regional Clinical Trials Unit

Grant holders - DJ Kerr, R Hobbs, L Ward, J Dunn, J Kenkre


1994-1999


  • Medical Research Council £1.36 million

QUASAR Adjuvant Trial of Colorectal Cancer Chemotherapy

Grant holders - DJ Kerr and R Gray


1998


  • Wellcome Trust £2.8 million

Construction of a clinical research facility

Grant holders – M Sheppard, P Stewart, DJ Kerr, M Wakelam, LS Young, AB Rickinson, C Savage


1998-2003


  • Medical Research Council £403,608

Co-operative Group – Translational Research: Gene and Immunotherapy of Cancer.

Grant holders: DJ Kerr, DH Adams, PAH Moss, V Mautner, PF Searle, L Seymour and LS Young




  • Medical Research Council £68,240

Joint Research Equipment Initiative Award

Grant Holders: P Moss, A Rickinson, D Kerr, J Gordon, L Young C Bunce




1997-2002


  • Zeneca Pharmaceuticals £1,130,000

Clinical Trials Grant for Adjuvant Colorectal Cancer Trial: PETACC


  • Medical Research Council £600,000

FOCUS : trial of chemotherapy in advanced colorectal cancer

Grant Holders: M Seymour, R James, D J Kerr, T Maugham and R Stephens


Recently awarded grants
MERCK – Cancer Research Campaign £12.6 million – 2002 – 2009

Trial of adjuvant therapy with cyclooxygenase inhibitors in colorectal cancer

Grant Holder: D J Kerr
Roche/Aventis – Cancer Research Campaign £4 million – 2004 - 2009

Adjuvant trial of chemotherapy for colorectal cancer

Grant Holder: D J Kerr
Genomic Healthcare £83,330 - 2006-2008

Proteomic investigation of colorectal cancer

Grant holder: D J Kerr
NHS R & D £20 million - 2001 – 2006

To establish the National Translational Cancer Research Network (NTRAC) and the National Cancer Tissue Resource (NCTR).

Grant Holder: D J Kerr

E-Science Pilot Project in Integrative Biology - £ 1,244 310

Lead investigator: D Gavaghan

Co-investigator: D J Kerr

CRUK Gene Therapy Programme Grant - £1.2 million - 2004 - 2009

Lead investigator: L Seymour

Co-investigator: D J Kerr
Genomic and proteomic approaches to identify novel Markers of Colorectal Cancer, MRC Co-operative Grant:

£215,788 – 2004 -2007

Lead investigators: D J Kerr and I Tomlinson


GE Healthcare: Molecular Basis of Colorectal Cancer - £2.4 million – 2005-2007

Lead Investigator: D J Kerr


Cancer Research UK, Research Grant, ECMC Award - CRUK funding for the experimental cancer medicine centre - £3,070,410 - 2007 – 2012

Lead investigator: A Harris

Co-investigator: D J Kerr
EUROCAN: £80,421- 2005 – 2007

Lead investigator: P Boyle

Co-investigator: D J Kerr

SCOT Study ad adjuvant colorectal cancer chemotherapy: MRC £1,798,433 – 2006- 2014

Lead investigator: J Cassidy

Co-investigator: D J Kerr


Roche Ltd: £1.5 million – 2012 – current

Lead Investigator: DJ Kerr


Oxford Cancer Biomarkers: £3.25 million – 2011- current



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