Curriculum vitae name: Harumi Jyonouchi, M. D



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  1. Gollob JA, Veenstra KG, Jyonouchi, H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Casanova JL, Fieschi C, Frank DA, and Mier JW. Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections. J. Immunol. 163: 4120-4126. 2000.




  1. Jyonouchi H, Sun S, Winship T, and Kuchan MJ: Dietary nucleotides modulate type 1 vs. type 2 T cell responses against ovalbumin in young BALB/c mice. J. Nutr. 131: 1165-1170, 2001




  1. Jyonouchi H: Immunomodulating actions of dietary nucleotides – any clinical implication? (Review). Recent Res. Develo. Allergy & Clin. Immunol. 1: 121-128, 2001.




  1. Jyonouchi H, Sun S, K. Porter VA, and Cornfield DN: Polycyclic aromatic hydrocarbon (PAH) diol epoxides increase cytosolic Ca2+ concentrations of human small airway epithelial cells. Am J Res Cell Mol Biol. 25: 78-83. 2001




  1. Jyonouchi H, Sun S, Le H.: Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 120: 170-179, 2001




  1. Jyonouchi H, Sun S, Le H, and Rimell, FD: Evidence of dysregulated cytokine production by sinus lavage and peripheral blood mononuclear cells in patients with treatment-resistant chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg. 127: 1488-1494. 2001




  1. Jyonouchi H, Sun S, and Itokazu N: Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorders. Neuropsychobiology 46: 76-84, 2002.




  1. Jyonouchi H, Sun S, Whiship T, and Kuchan MJ: Dietary ribonucleotides increase antigen-specific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ mice. Nutrition. 19: 41-46, 2003




  1. Jyonouchi H, Sun S, Kelly A, and Rimell FL: The effects of exogenous interferon-γ (IFN-γ) on patients with treatment-resistant chronic rhinosinusitis and dysregulated IFN-γ production – A pilot study. Arch Otolaryngol Head Neck Surg 129: 563-569, 2003.




  1. Jyonouchi H, Geng L, Ruby A, and Zimmerman-Bier, B: Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders (ASD): Their Relationship to Gastrointestinal (GI) Symptoms and Dietary Intervention. Neuropsychobiology 2005;51:77-85 (DOI: 10.1159/000084164)




  1. Jyonouchi H, Geng L, Ruby A, Reddy C, and Zimmerman-Bier, B: Evaluation of possible association between gastrointestinal (GI) symptoms and cytokine production against common dietary proteins (DPs) in children with autism spectrum disorders (ASD). J. Pediatrics 146: 605-610, 2005.




  1. Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A, and Heyes MP. CSF AND SERUM MARKERS OF INFLAMMATION IN AUTISM Ped Neurology 33: 195-201, 2005.




  1. Jyonouchi H, Lien KW, Aguila H, Spinnato, GG, Sabharwal S, and Pletcher BA: Garre’s osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndrome. Eur. J. Pediatrics 2006; 165:370-374.




  1. Ward CM, Jyonouchi H, Kotenko S, Patel R, Aguila H, McSherry G, Dashefsky B, and Holland SM: Adjunctive treatment of disseminated MAC infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 defect. Eur. J. Pediatr 166:981-985, 2007.




  1. Ward CM, Geng L, and Jyonouchi H: Fetal sensitization to milk protein and wheat: milk protein and wheat-specific TNF-α production by umbilical cord blood cells and subsequent decline of TNF-α but not IL-10 production by peripheral blood mononuclear cells following dietary intervention. J. Pediatr Allergy Immunol 18: 276-280, 2007.




  1. Jyonouchi H, Geng L, Toruner GA, Vinekar K, Feng D, Fitzgerald-Bocarsly P: Monozygous twins with microdeletion syndrome involving BTK, DDPA, and two other genes; evidence of intact dendritic cell development and TLR responses. Eur J Pediatr 67:317-321, 2008.




  1. Jyonouchi H. Non-IgE mediated food allergy. Inflammation and Allergy Drug Discovery. Inflamm Allergy Drug Targets. 2008 3:173-80.




  1. Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H: Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study.




  1. Jyonouchi H Food Allergy and Autism Spectrum Disorders: Is There a Link? Curr Allergy Asthma Reports 9:194-201, 2009.




  1. Jyonouchi H, Geng L, Cushing-Ruby A, Monteiro I. Aberrant responses to TLR agonists in pediatric IBD patients: possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen. J. Ped J Allergy Immunol on line publication first 2009.




  1. Timothy Buie, MD; Daniel B. Campbell, PhD; George J. Fuchs III, MD; Glenn T. Furuta, MD; Joseph Levy, MD; Judy Van de Water, PhD; Agnes H. Whitaker, MD; Dan Atkins, MD; Margaret L. Bauman, MD; Arthur L. Beaudet, MD; Edward G. Carr, PhD; Michael D. Gershon, MD; Susan L. Hyman, MD; Pipop Jirapinyo, MD; Harumi Jyonouchi, MD; Koorosh Kooros, MD; Rafail Kushak, MD, PhD; Pat Levitt, PhD; Susan E. Levy, MD; Jeffery D. Lewis, MD; Katherine F. Murray, BSN, RN; Marvin R. Natowicz, MD, PhD; Aderbal Sabra, MD, PhD; Barry K. Wershil, MD; Sharon C. Weston, MS, RD, LDN; Lonnie Zeltzer, MD; and Harland Winter, MD. Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With Autism Spectrum Disorder: A Consensus Report. Pediatrics 125:S1-18, 2010.




  1. Jyonouchi, H. Autism spectrum disorders and allergy: Observation from a pediatric allergy/Immunology Clinic. Expert Review in Immunology. 6:397-411, 2010.




  1. Jyonouchi H, Cui C, Geng L, Yin Z, Fitzgerald-Bocarsly P. Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with antibody deficiency syndrome. Eur J Pediatrics. 169:1233-1239, 2010.




  1. Jyonouchi H, Geng L, Streck, D, Toruner, GA. Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and markedly fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcrioptional profiles of peripheral blood (PB) monocytes. J Neuroimmunol 15: 73-80, 2011.




  1. Jyonouchi H. Geng L, Streck D, Toruner GA. Immunological characterization and transcription profiling of peripheral blood monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide deficiency (SPAD); case study. J Neuroinflammation 2012 Jan 7;9:4.





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