Participant Recruitment and Retention

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  Resource Allocation Program (RAP): Provides different levels of support or services for investigators in the form of CTSI services and resources, e.g., Clinical Research, biostatistics, bioinformatics, population health and other relevant services.
  
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  Targeted Resource Allocation Program (TRAP): Provides funding for targeted research needs not available as part of the CTSI’s menu of services and resources.
  
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  Pilot Project Program (PPP): Provides direct funding to support collaborative scientific studies to enable development of preliminary data to serve as a foundation for submission of translational research grant applications.
  

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  The Empire Clinical Research Investigator Program (ECRIP): A New York State Department of Health program intended to encourage clinical research and clinical research training at New York State Hospitals that support graduate medical education.
  
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  School of Medicine Fellowship in Primary Care Research: An interdisciplinary, two-year, HRSA-funded National Research Service Award (T32) fellowship program designed to prepare physicians for careers in primary care research.
  
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  KL2 Program in Translational Research: A University-wide post-doctoral training and career development opportunity for physicians, nurses, dentists, and other appropriate health professionals.
  
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  TL1 PhD Program in Clinical and Translational Research: A University-wide doctoral training opportunity for PhD students. The program focuses on the support and development of doctoral candidates seeking careers in translational research.
  
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  Physician Scientist Training Program (PSTP): Established to support and encourage the participation of physician-trainees in intensive experiences in translational research.
  
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  Mentor Development Program (MDP): The CTSI aims to ensure success of translational research at NYU by developing a cadre of research and career mentors through the Mentor Development Program.
  
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  Online Training Courses:
  
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  Introduction to Clinical Research
  
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  Introduction to Biostatistics
  
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  Masters of Science in Clinical Investigation for Board-Eligible Clinicians (Translational Research Track): This training program consists of a core curriculum and mentored research experiences for clinician-scientists interested in applying scientific discoveries to the clinical setting.
  
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  MD/MS in Clinical Investigation: The dual MD/MSCI is designed for students interested in translational research who wish to develop skills needed to succeed in their future careers.
  
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  Certificate in Translational Research: Intended to help individuals obtain the foundation, skills and knowledge essential for a career in translational research.
  
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  Summer Intensive Program in Translational Research Methodologies: Provides a cohesive foundation in clinical research methods, biostatistics, medical bioinformatics, and ethics and is designed for participants with limited formal didactic training in research methodologies who wish to rapidly develop skills for more advanced study and for participation in new or ongoing research projects.
  
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  Comparative Effectiveness Research:
  
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  Masters of Science in Clinical Investigation for Board Eligible Clinicians (Comparative Effectiveness Track). The goal of this program is to increase the nation’s supply of physician-investigators conducting Comparative Effectiveness Research centered around health decisions affecting urban under-served communities.
  
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  Certification in Comparative Effectiveness Research. The Comparative Effectiveness Research Certification Program provides education and career development in comparative effectiveness research training through mentorship and coursework.
  
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  Clinical Investigator & Development Education Resources (CIDER): Provides a cross-institutional training resource for investigators and research coordinators who are relatively new to clinical research, focusing on operational day-to-day responsibilities to ensure subject protection/compliance.
  

Collaboration: The CTSI fosters collaboration in many different ways; principal approaches include:

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  Science Interest Groups – Serve as "nucleation" point for sharing of ideas and resources
  
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    Ion Channels and Transporters Interest Group
    
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    Bones Interest Group
    
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    TR in Inflammation & Atherosclerotic Disease Interest Group
    
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    Crystal Diseases Study Group
    
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    Primary Immunodeficiency Science Interest Group
    
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  Team Science Working Group – Central resource for the development of team science and the study of team science
  
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  Translational Science Librarian – Facilitates collaborations and supports technology to promote collaboration including Find-A-Researcher and other research networking tools, Faculty Bibliography, and eagle-i, a resource discovery tool for synergizing resources and expertise across individual research teams/labs.
  
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  Seminars and Events that Bring Researchers Together – Including Translational Research in Progress Seminars (TRIP) and Networking events (e.g., Seminar/Poster Day - "Bioengineering at NYU Polytechnic School of Engineering: Opportunities for Collaborative Translational Research").
  

NYUSOM and Bellevue Hospital Division of Alcoholism and Drug Abuse comprise one of the nation’s largest divisions of substance abuse in terms of patient care visits, fellowship and residency training programs, and a number of affiliated faculty. The Division is a long-standing participant in research of the neurobiologic basis of addiction disorders, novel addiction treatments, and outcomes research among addicted and dually diagnosed populations. The Divisions’ principal research sites are Bellevue Hospital Center, the VA NYHHS, NYUSOM, and the Nathan Kline Institute.

The Mental Health and Addictive Disorders Research Program, under the direction of Dr. Rotrosen, has over 25 years of experience in biological psychiatry, clinical psychopharmacology and neuroimaging. It has contributed to the successful development of virtually all of the atypical antipsychotic agents, as well as buprenorphine and extended release naltrexone (Vivitrol), and has participated in studies with numerous agents for cocaine and methamphetamine dependence as well as novel agents for attention deficit hyperactivity disorder particularly in adult populations. Dr. Rotrosen was director of the NIDA/VA Medications Development Research Unit in NY and is currently the PI of the New York Node of NIDA CTN New York Node, which conducts studies with both pharmacological and behavioral (and combined) interventions in populations with addictive disorders treated in eight community-based programs in New York City. Together these academic and clinical programs provide expertise in clinical pharmacology and clinical trials implementation as well as a rich source of patient referrals.

In addition to all standard equipment for molecular and cellular biology, additional equipment housed within the Cardiovascular Research space includes: Leica TCS SP5 confocal microscope; Ion Optix calcium and contractility measuring system; three fully equipped optical mapping stations for measuring voltage- and calcium-dependent activity; animal physiology stations with dissecting binocular microscope (Zeiss); ventilator (Harvard systems); Electrophysiology Station with Medtronic stimulator, NuMED octapolar EP catheters and Biopac monitoring system; Hemodynamics Station with 1.4F Millar catheters; Nanion Port-a-patch high through patch-clamp apparatus; PixCell IIe Laser Capture Microdissection System (Arcturus) laser-capture microscope as well as an ABI Prism real-time PCR system.

Lab animals are housed within the NYU Langone Medical Center at one of several facilities (Skirball, Berg, Smilow and Dental School), in accordance with the Animal Welfare Act, the U.S. Dept. of Agriculture Regulations and the NIH Guide for the Care and Use of Laboratory Animals. NYULMC has a currently approved Animal Welfare Assurance Agreement with the NIH. Services of full-time veterinarians and ancillary staff are available for investigators in this program.

A fully equipped AAALAC-accredited and staffed animal facility is available at the New York University School of Medicine, Division of Laboratory Animal Resources (DLAR). There are three central vivaria, including two rodent barriers and several ABSL2 areas. The DLAR is staffed by an ACLAM board-certified attending veterinarian, six veterinary medicine staff members, and an additional 40 operational and care staff personnel. Animal care is provided by DLAR seven days a week including emergency veterinary care available 24 hrs/day. There are 3 dedicated surgical suites for large animals and numerous procedure rooms and surgical areas for rodents.
Computers

NYUSOM provides each of the project’s key personnel with individual state of the art computers and printers and have access to the internet via the NYU {or Veterans’ Affairs} network{s}. The computer resources available to and supportive of the academic programs of the School of Medicine are extensive. NYU has the resources to expand access to information necessary for practitioners, teachers and researchers in its educational and clinical networks. The University’s computer resources are located throughout the campus in facilities that include the Academic Computing Facility, the NYU Langone Medical Center, the Frederick L. Ehrman Medical Library, and the Elmer Homes Bobst Library. All are maintained and coordinated by Medical Center Information Technology (MCIT), which manages the campus data communication network, NYU-NET, and provides internet access to the NYU Langone Medical Center community.

Information Technology Services supports over 30,000 users, and 4 general computer labs with a capacity of 400 computers, in addition to an estimated 8,600 networked computers throughout the campus. All certified users have an ID and password to access the Internet, the World Wide Web, email, and a variety of statistical, database, spreadsheet, graphics, and word processing programs. This network consists of high speed Cisco switches and routers using a 10 Gigabit standard.  The network connects all computers (both desktop office computers and laptop computers at individual student desks and lab benches), all printers and special devices, including flow cytometry, DNA sequencing and gene expression data storage. The network also allows the use of the central UNIX server farm, centralized storage devices such as IBM DS8300, EMC DMX3, and EMC NS480, and all internet services. NYULMC’s internal systems are protected by state of the art firewall systems including Juniper devices and intrusion detection software (Tipping Point).  Full data and system back up capabilities are handled through IBM tape library and TSM backup software.  Collaboration and teamwork are supported across multiple institutions using a Microsoft SharePoint architecture behind a secure VPN connection.  Other applications are available behind the VPN via a Citrix framework.  In addition, high performance computing is performed on Sun Blade 6000 with 10 nodes and 80 cores (64 cores usable). HPC capacity expansion is planned in the coming months.

Databases

Available databases for the conduct of research include: a) Infoshare: a cleaned, friendly set of all released public access social and health related data for NYC, NYS 1980-2010 census data; b) Health and Hospitals Corporation Databases: The public hospitals and clinics in the Southern Manhattan Healthcare Network use an electronic medical record (Misys), housed in a mirrored central server; c) AMDeC: This NY Cancer Project Data Repository is a work in progress and has recruited 18,000 participants (going to 300,000 over 3 years) NY area cancer patients, and provides complex data sets and DNA samples to member’s researchers; {Remove if not applicable: d) Geisinger Health System EMR serves as an integrated provider network located in 31 counties of north central Pennsylvania, with 52 clinic sites, 2 hospitals, 600 employed physician and a catchment area of 2.1 million and uses Epicare as its EMR platform}; e) National and local Veterans Administration Medical SAS Datasets, available indirectly through approved protocols, and various national data extraction sets such as the Veterans Information Resource Center, the Health Economics Resource Center and VA-Medicare Data for Research and; f) NYU’s hospitals utilize a Health Information System which captures all clinical, laboratory, and financial data.

The NYULMC HPCF provides support services and resources essential for the successful conduct of research within the Department of Population Health. The NYULMC HPCF maintains state-of-the-art resources that combine substantial computing and storage capabilities. Within HPCF we have the computational capacity to perform production, development and benchmarking of high-performance software and algorithms for high-throughput data analytics and scientific computations. In addition, HPCF staff provides consultation on best practices for utilization and current trends in high-performance computing. This allows our researchers to remain current on the state-of-the art in computational platforms and methodology for best utilization of available computing resources specific to their tasks and needs. Our new HPC cluster includes a total of 1170 of the latest Intel processing cores, 5 nodes with latest NVIDIA GPU accelerators (a total of 12,500 cores), a Field Programmable Gate Array (FPGA) server (BEECube) and one high memory server (with 1TeraByte RAM), providing an aggregate of over 10 Terabytes of memory and over 1PetaByte of high-throughput, scalable data storage. In addition, our facility provides access to commercial cloud computing resources.

Offices and conference rooms assigned for this project are located in the NYULMC Translational Research Building and on the 5^th floor of 650 First Avenue. The individual investigators each have their own offices for routine purposes.