Title: Vanderbilt Law Review

Title: Vascular Medicine

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: Impact Factor

? Anand, S.S. (2003), Vascular viewpoint - Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis. Law MR, Wald NJ, Rudnicka AR. BMJ 2003; 326: 1407-408. Vascular Medicine, 8 (4), 289-290.

Abstract: Question: To determine by how much statins reduce serum concentrations of low density lipoprotein (LDL) cholesterol according to drug, dose, and duration of treatment. Population: Patients included in randomized, placebo-controlled trials of six statins (atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin, rosuvastatin). Design and methods: Meta analysis of 164 short-term, randomized trials including 24 000 drug-treated and 14000 placebo-treated patients. Studies were found by searching MEDLINE, the Cochrane Collaboration, Web of Science databases, and BMJ. com. All double-blind, placebo-controlled trials were considered eligible. Excluded trials were those with no placebo group, any which lasted less than 2 weeks, those that used titrated doses, those that used combination drugs to lower cholesterol, crossover trials, or those with chronic renal failure patients. The efficacy of each statin was defined as the reduction of LDL for a given dose of a statin expressed as the change in the treated group minus that in the placebo group. Results: the doses of atorvastatin, lovastatin, rosuvastatin and simvastatin used to lower LDL by an absolute amount of 1.8 mmol/l or 40% are shown in the table. Pravastatin and fluvastatin were a less effective treatment, with maximum doses (80 mg/day) lowering LDL by 1.58 mmol/l and 1.60 mmol/l, respectively. Statins increased high density lipoprotein cholesterol by 0.07 mmol/l on average with no dose effects observed. for safety outcomes, 1063/14 197 statin patients compared with 923/10 568 control patients reported one or more symptoms possibly associated with the drug. Rhabdomyolysis was observed in eight statin patients compared with five placebo patients. [GRAPHICS] Conclusion: Statins can lower the LDL cholesterol concentration by an average of 1.8 mmol/l, and the LDL lowering effect varies across statin type and dose: simvastatin, lovastatin, atorvastatin and rosuvastatin appearing more effective, and fluvastatin and pravastatin appearing less effective.

Keywords: Analysis, Cholesterol, Cochrane, Collaboration, Control, Databases, Disease, Drug, Drugs, Efficacy, Law, Ldl, Lipoprotein, Meta Analysis, Meta-Analysis, Outcomes, Patients, Review, Safety, Science, Statins, Stroke, Symptoms, Systematic, Systematic Review, Treatment, Web of Science

? Hruska, K. (2004), Research on paratuberculosis: Analysis of publications 1994-2004. Veterinarni Medicina, 49 (8), 271-282.

Abstract: the Web of Knowledge Results Analysis of papers published on paratuberculosis in 1994-2004 demonstrated the increasing interest in Mycobacterium avium subsp. para tuberculosis (MAP). In the analyzed period 1032 papers published by 2 519 authors affiliated with 738 institutions were indexed in the Web of Science database. The papers were published in 238 journals, 25 of which contained more than 55% of articles. The Top 50 authors, Top 50 institutions and Top 50 most frequently cited papers are listed in this review. The contribution of OIE Reference Laboratory for Paratuberculosis established in the Veterinary Research Institute, Brno, is assessed according to the number of publications (29), number of authors participating (79), number of institutions collaborating (41 from 17 countries) and their positions in the Top 50 lists. It is evident that the number of papers on Mycobacterium avium subsp. paratuberculosis, a species causing para tuberculosis in ruminants and possibly having a role in the development of Crohn’s disease in at least some humans is significantly increasing.

Keywords: Authors, Avium Subsp-Paratuberculosis, Bovine Tuberculosis, Contribution, Crohn’S Disease, Crohns-Disease, Development, Disease, Fragment-Length-Polymorphism, Humans, Interest, Journals, Knowledge, Mycobacterium-Paratuberculosis, Nucleotide-Sequence, Papers, Paratuberculosis, Passive Vectors, Peripheral-Blood, Polymerase Chain-Reaction, Publications, Research, Review, Science, Tuberculosis, Web of Knowledge, Web of Science, Wild Ruminants

? Franek, M. and Hruska, K. (2005), Antibody based methods for environmental and food analysis: A review. Veterinarni Medicina, 50 (1), 1-10.

Abstract: Antibodies have widely been used as analytical tools in various assays and techniques developed for clinical chemistry and endocrinology and for food and environmental research and risk control. Antibody development in the Veterinary Research Institute, Brno, and their application in ELISA and related techniques such as immunosensors has been directed especially to phenoxyacetic acid herbicides, s-triazine herbicides, sulfonylurea herbicides, polychlorinated biphenyls, surfactants (linear alkylbenzene sulphonates) and toxic metabolites (nonylphenol), and selected veterinary drugs (namely nitrofurans and sulfonamides). This paper provides an overview of progress achieved in the production of key immunoreagents in this laboratory (and in some cooperating laboratories) during the last 15 years. A comprehensive analysis of papers published on immunoassays and biosensors used in food and environmental research since 1980 demonstrates a rapid increase of publications on “ELISA and immunoassays” since 1991 (more than 500 papers were published each year since 1996). More than 200 papers on “biosensors” have been published each year since 2001. Atrazine was the most frequently found key word with ELISA and immunoassays: 438 papers were written by 971 authors from 308 institutions. The Web of Science(R) database is a useful tool for an assessment of the researcher’s and institution’s interest in the specific topics of research.

Keywords: 2,4-Dichlorophenoxyacetic Acid, Analysis, Antibodies, Antibody, Assay Optimization, Assessment, Authors, Biosensor, Biosensors, Control, Development, Drugs, Elisa, Environmental, Environmental Research, Enzyme-Immunoassays, Food Analysis, Immunoassay, Interest, Metabolites, Monoclonal-Antibodies, Overview, Papers, Piezoelectric Immunosensors, Polarization Fluoroimmunoassay, Polychlorinated-Biphenyls, Publications, Research, Review, Risk, S-Triazine, Soil Samples, Structural Aspects, Topics

? Hruska, K. (2006), Veterinary Research Institute, Brno, Czech Republic: Analysis of papers published from 1990 to 2005. Veterinarni Medicina, 51 (5), 161-167.

Abstract: the Web of Science database searched results for papers published from the Veterinary Research Institute, Brno, Czech Republic, were analysed. The Veterinary Research Institute has increased publication activity in 2001-2005; more than 4 times in comparison with the period 1990-2004. The impact factor of journals has increased 5.5 times. The collaboration with 31 foreign countries and 175 institutions resulted in the publication of 277 papers in 93 journals during the past five years. Positioning of the Veterinary Research Institute is now among the worldwide leading teams is evident in twelve research profiles. The Web of Science is an efficient tool for record analysis and researcher’s and institution’s publication activities.

Keywords: Activities, Analysis, Bibliometric Analysis, Collaboration, Hemorrhagic-Disease, Impact, Impact Factor, Journals, Papers, Paratuberculosis, Publication, Publication Activity, Publications, Publications, Rabbits, Research, Research Evaluation, Science, Standardization, Virus, Web of Science

? Kaevska, M. and Hruska, K. (2010), Mycobacteria in water, feedstocks and food: Analysis of publications. Veterinarni Medicina, 55 (12), 571-580.

Abstract: Papers on mycobacteria in food, feed and water, published between 1945 and 2010 and indexed in the database Web of Science (R) (Thomson Reuters) were ranked according to authors, institutions, countries and source titles. The total number of papers on mycobacteria and food and mycobacteria and water were 1486 and 1419, respectively. More than 40% of papers have been published in the last five years. In addition to publications in peer reviewed journals the archives of ProMED-mail and the Rapid Alert System for Food and Feed of the European Union were also searched. It is evident that much attention is being paid to mycobacteria in food, feed and water as they likely pose a public health risk.

Keywords: Analysis, Attention, Authors, Avium Subsp Paratuberculosis, Beef, Cheese, Complex, Disease, Environment, Fish, Food Safety, Fruits, Humans, Identification, Journals, Meat, Milk, Milk, Nontuberculous Mycobacteria, Papers, Period, Products, Public Health, Publications, Risk, Science, Thomson Reuters, Vegetables, Web of Science