Israel state records י"ב באדר התשס"ו March 12, 2006
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- 132774 [21][11] הליך עבור ההכנה של מתיל α – (2 – הלופניל
- PROCESS FOR THE PREPARATION OF METHYL α - (2 - HALOPHENYL) - ( 4, 5 6, 7 - TETRAHYDROTHIENO [3, 2 - C] PYRIDINE - 5 - ACETATE)
- 132809 [21][11] תולדות של 9– דאוקסו – 9A – אזא
- 4" SUBSTITUTED - 9 - DEOXO - 9A - AZA - 9A - HOMOERYTHROMYCIN A DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
- 133811 [21][11] הרכב פולימרי למניעת הצטברות משקעים
- ANTIFOULING POLYMER COMPOSITION, A METHOD OF ANTIFOULING NATURAL AQUEOUS ENVIRONMENT AND AN ARTICLE COMPRISING THIS COMPOSITION
- 134508 [21][11] בקרה הניתנת להתאמה על אמצעי תקשורת
- תכשירים המכילים תרכובות קמפטוטצין לטיפול בסרטן בעלי תופעות לואי מופחתות
- 134633 [21][11] שיטה להכנת גלופוסינטים ותוצרי ביניים לכך
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[57] The compound of the formula 
or a tautomeric or solvated form thereof, in crystalline form. __________
[57] A process for the preparation of the racemic or optically active compounds of the formula 
wherein the meaning of X is a halogen atom, or their salts, characterized in that, a racemic or optically active compound of the formula 
wherein the meaning of X is a halogen atom, is transformed into the racemic or optically active compound of the formula 
wherein the meaning of X is a halogen atom, and if desired, the resulting racemic compounds of general formula (VIII) are resolved into their optically active isomers, and then by ring closure, the compounds of general formula (VIII) are transformed into the racemic or optically active compounds of general formula (VI), and if desired, the racemic compounds of general formula (VI) are resolved into their optical isomers, and/or they are transformed into their salts, and/or the racemic or optically active compounds are liberated from their salts. __________
[57] A compound of the formula 
or a pharmaceutically acceptable salt thereof, wherein: R1 is H, hydroxy or methoxy; R2 is hydroxy; R3 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, cyano, -CH2S(O)nR8 wherein n is an integer ranging from 0 to 2, -CH2OR8, -CH2N(OR9)R8, -CH2NR8R15, -(CH2)m(C6-C10 aryl), or –(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R3 groups are optionally substituted by 1 to 3 R16 groups; or R2 and R3 are taken together to form a 5,5-divalent oxazoline ring as shown below 
R4 is H, -C(O)R9, -C(O)OR9, -C(O)NR9R10 or a hydroxy protecting group; R5 is –SR8, -(CH2)nC(O)R8 wherein n is 0 or 1, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, -(CH2)m(C6-C10 aryl), or –(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R5 groups are optionally substituted by 1 to 3 R16 groups; each R6 and R7 is independently H, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -(CH2)m(C6-C10 aryl), or –(CH2)m (5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4; each R8 is independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, -(CH2)qCR11R12(CH2)rNR13R14 wherein q and r are each independently an integer ranging from 0 to 3 except q and r are not both 0, -(CH2)m(C6-C10 aryl), or –(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R8 groups, except H, are optionally substituted by 1 to 3 R16 groups; or where R8 is as –CH2NR8R15, R15 and R8 may be taken together to form a 4-10 membered monocyclic or polycyclic saturated ring or a 5-10 membered hteroaryl ring, wherein said saturated and heteroaryl rings optionally include 1 or 2 heteroatoms selected from O, S and – N(R8)-, in addition to the nitrogen to which R15 and R8 are attached, said saturated ring optionally includes 1 or 2 carbon-carbon double or triple bonds, and said saturated and heteroaryl rings are optionally substituted by 1 to 3 R16 groups; each R9 and R10 is independently H or C1-C6 alkyl; each R11, R12, R13 and R14 is independently selected from H, C1-C10 alkyl, -(CH2)m(C6-C10 aryl), and –(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R11, R12, R13 and R14 groups, except H, are optionally substituted by 1 to 3 R16 groups; or R11 and R13 are taken together to form –(CH2)p- wherein p is an integer ranging from 0 to 3 such that a 4-7 membered saturated ring is formed that optionally includes 1 or 2 carbon-carbon double or triple bonds; or R13 and R14 are taken together to form a 4-10 membered monocyclic or polycyclic saturated ring or a 5-10 membered heteroaryl ring, wherein said saturated and heteroaryl rings optionally include 1 or 2 heteroatoms selected from O, S and –N(R8)-, in addition to the nitrogen to which R13 and R14 are attached, said saturated ring optionally includes 1 or 2 carbon-carbon double or triple bonds, and said saturated and heteroaryl rings are optionally substituted by 1 to 3 R16 groups; R15 is H, C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, wherein the foregoing R15 groups are optionally substituted by 1 to 3 subsitutents independently selected from halo and –OR9; each R 16 is independently selected from halo, cyano, nitro, trifluoromethyl, azido, -C(O)R17, -C(O)OR17, -C(O)OR17, -OC(O)OR17, -NH6C(O)R7, -C(O)NR6R7, -NR6R7, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -(CH2)m (C6-C10 aryl), and –(CH2)m (5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein said aryl and heteroaryl substituents are optionally substituted by 1 or 2 substituents independently selected from halo, cyano, nitro, trifluoromethyl, azido, -C(O)R17, -C(O)OR17, -C(O)OR17, -OC(O)OR17, -NR6C(O)R7, -C(O)NR6R7, -NR6R7, hydroxy, C1-C6 alkyl, and C1-C6 alkoxy; each R17 is independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, -(CH2)m(C6-C10 aryl), and –(CH2)m) (5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4; with the proviso that R8 is not H where R3 is –CH2S(O)nR8.
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[57] A polymer composition having broad-spectrum antifouling activity comprising a polymer selected from the group consisting of ethylene-vinyl acetate copolymer (EVA), high-density polyethylene (HDPE), sodium ionomer, copolymer of ethylene and acrylic acid, and mixtures thereof and one or more organic antifouling agents selected from the group consisting of antifouling agents belonging to the families of isothiazolones, furanones, and combinations thereof, wherein in use the polymer has broad-spectrum antifouling activity for a prolonged period of at least 100 days when the composition is substantially immersed in a natural aqueous environment. __________
[57] A method for media access control in a communication system which includes a plurality of communication stations which communicate over a shared communication medium comprising: assigning communication resources in accordance with quality of service requirements of a plurality of communication sessions, including determining polling pattern; polling each of the communication stations to transmit data over the shared communication medium for the plurality of communication sessions according to the polling pattern; monitoring data transmitted by the communication stations in response to the polling; adapting assignment of the communication resources in accordance with the monitoring, including adapting the polling pattern including for each of the communication sessions adapting a rate of polling associated with said session according to said monitoring and said quality of service requirements by: reducing a rate of polling for a session in response to the monitored transmission for that session corresponding to a reduction in actual rate of transmission for that session, increasing a rate of polling for a session in response to the monitored transmission for that session corresponding to an increase in actual rate of transmission for that session; and continuing polling of each of the communication stations according to the adapted polling pattern. 
__________
[57] Use of a bicarbonate, boric acid or urso-deoxycholic acid in the preparation of a composition for use in reducing a diarrheal side effect in a subject receiving a treatment of a camptothecin compound by maintaining the intestinal lumen of the subject at an alkaline pH, substantially as described in the specification. __________
Directory: Units -> RashamHaptentim -> Units -> patent -> yoman Units -> Perform and explain geodetic computations Units -> Demonstrate and apply advanced knowledge of programming techniques for electrotechnology Units -> Nzqa registered unit standard 22561 version 3 Units -> Nzqa registered unit standard 22528 version 2 Units -> Nzqa registered unit standard 26968 version 1 Units -> Nzqa registered unit standard 10212 version 5 Download 0.86 Mb. Share with your friends:
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