Israel state records י"ב באדר התשס"ו March 12, 2006
Download 0.86 Mb.
|
- Navigate this page:
- 130440 [21][11] ממסר למתח גבוהה
- 130888 [21][11] שיטה ומערכת לבקרת תהליך פוטוליטוגרפיה
- תכשיר המכיל פאקטור רקמה חסר הקרשה והשמוש בו להכנת תרופה להקרשה וטיפול לגידולים
- 131148 [21][11] תהליך להכנת הלו– 4– פנוקסיקינולינים
- 131756 [21][11] תולדות איזוקוינולין מותמרות
- SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE PREPARATION OF MEDICAMENTS
| [57] A metallic article (30) comprising a bond coating (34) on the metallic article and a ceramic thermal barrier coating (38) on the bond coating, the ceramic thermal barrier coating comprising a plurality of columnar grains (40) extending substantially perpendicularly to the surface of the metallic article, characterised in that the ceramic thermal barrier coating comprises an inner portion (44) adjacent the bond coating, a transition portion (46) on the inner portion and an outer portion (48) on the transition portion, the inner portion having columnar grains grown in a competitive manner, the outer portion having columnar grains grown in a steady state manner, the transition portion having columnar grains grown in transition from competitive manner to steady state manner, in the outer portion each columnar grain having substantially constant cross-sectional area throughout its length, each columnar grain having smooth sides without the presence of sub-grains projecting therefrom and each columnar grain being separated from adjacent columnar grains by uniform clearances (42) to minimize the stress/strain in the columnar grains and/or to minimize the stress/strain between adjacent columnar grains and thereby increase the resistance to spallation of the ceramic thermal barrier coating. 
__________
[57] High voltage reed switch relay consisting of a dielectric body with fixed (4) and movable (5) contacts and ferromagnetic core (10) as well as a first control coil (13) mounted on the body from the top in the area of ferromagnetic core wherein fixed contact, a second control coil (14), three permanent magnets (6, 7, 11) spring buffer (19) are added, furthermore the movable contact is formed as a bridge with a dielectric rod, connected to it in the center with allowed clearance, the rod in turn is connected to said ferromagnetic core, the first upper permanent magnet in its casing is fastened in the central part at the opposite lower side of the bridge, furthermore at the center of the body base in line with the first upper permanent magnet a second movable permanent magnet in a dielectric casing (8) is connected and directed towards the third fixed magnet with its opposite sign so that when the contacts are closed a gap of 1-3 mm is preserved between the second movable and the third fixed magnets; dielectric body is formed with two closed contacting cavities with a big and a small section and one more insulated open cavity (3) which is coaxial with the small cavity, furthermore the big cavity contains contacts and the second movable and the and the third fixed magnets and dielectric rod, while the small cavity holds the ferromagnetic core with the second movable permanent magnet at its end, allowed for coaxial movement, which is compressed between the support and the upper closed face with said spring buffer; in said concentric cavity two coaxial control coils are mounted on the walls of the small said cavity as if it was a core, furthermore the ferromagnetic core is longer than each one of the control coils by 20-30%, while the length of each control coil is set to about the half of the total clearance between the movable and fixed contacts which is determined by the level of the switched voltage; when the contacts are engaged the center of the ferromagnetic core lengthwise nearly coincides with the center of the first lower control coil, while the first said permanent magnet is withdrawn from the second upper control coil so that the entire ferromagnetic core whose face touches this magnet face is set inside the field of action of the magnetic field of the second upper control coil moreover, the vectors of the magnetic field of this coil and the magnet coincide; the big cavity and a part of the small cavity are filled with dielectric liquid, for example, transformer oil or gas, for example, SF6 gas, while the concentric cavity holding the control coils – with epoxy encapsulant. 
__________
[57] A method for automatic optical control of at least one of exposure and focus parameters of an exposure tool in a photolithography arrangement to be applied to a workpiece coated with a photoresist layer, the method comprising the steps of: (a) applying a measuring tool comprising a spectrophotometer to the workpiece prior to processing of the workpiece by the exposure tool; (b) measuring at least one parameter of the workpiece and generating measured data representative thereof, said at least one parameter of the workpiece being a parameter defining said at least one of the exposure and focus parameters of the exposure tool to enable obtaining desired parameters of the workpiece by exposing the workpiece with the exposure tool; and (c) analyzing said measured data and determining a required value of said at least one of the exposure and focus parameters of the exposure tool to provide said desired parameters of the workpiece resulting from applying the exposure tool to said workpiece. __________
[57] A composition comprising a biologically effective amount of a coagulation-deficient Tissue Factor compound that is at least 100-fold less active in coagulation than full length, native Tissue Factor and that has been modified to increase its biological half life; wherein the coagulation-deficient Tissue Factor compound is not attached to a targeting moiety. __________
[57] A process for preparing 4-oxysubstituted quinolines of formula 
wherein R1 and R3 are independently halo and R2 and R4 are H; or R3 is halo, R1 is halo or H, and R2 and R4 are H; or R4 is halo and R1 to R3 are H; A is a phenyl group of the formula
wherein R9 to R13 are independently H, CN, NO2, OH, halo, (C1-C4) alkyl, (C2-C4) alkanoyl, halo (C1-C7) alkyl, hydroxy (C1-C7) alkyl, (C1-C7) alkoxy, halo (C1-C7) alkoxy, (C1-C7) alkylthio, halo (C1-C7) alkylthio, phenyl, substituted phenyl, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, phenyl (C1-C4) alkyl, substituted phenyl (C1-C7) alkyl, benzoyl, SiR20R21R22, or OSiR20R21R22 where R20, R21, and R22 are H, a (C1-C6) alkyl group, phenyl, or substituted phenyl, provided that at least one of R20, R21 and R22 is other than H, or R11 and R12 and R13 combine to form a carbocyclic ring, and provided that unless all of R9 to R13 are H or F, then at least two of R9 and R13 are H; wherein in the foregoing definitions, the term substituted phenyl refers to phenyl substituted with up to three groups selected from halo, (C1-C10) alkyl, halo (C1-C7) alkyl, hydroxy (C1-C7) alkyl, (C1-C7) alkoxy, halo (C1-C7) alkoxy, phenoxy, phenyl, NO2, OH, CN, (C1-C4) alkanoyloxy, or benzyloxy; the term alkyl refers to linear, branched, or cyclic alkyl; the term halo refers to fluoro, chloro, bromo, or iodo; the term substituted phenoxy refers to a phenoxy group substituted with up to three groups selected from halo, (C1-C10) alkyl, halo (C1-C7) alkyl, hydroxy (C1-C7) alkyl, (C1-C7) alkoxy, halo (C1-C7) alkoxy, phenoxy, phenyl, NO2, OH, CN, (C1-C4) alkanoyloxy, or benzyloxy; and the term substituted phenylthio refers to a phenylthio group substituted with up to three groups selected from halo, (C1-C10) alkyl, halo (C1-C7) alkyl, hydroxy (C1-C7) alkyl, (C1-C7) alkoxy, halo (C1-C7) alkoxy, phenoxy, phenyl, NO2, OH, CN, (C1-C4) alkanoyloxy, or benzyloxy, which comprises: (a) reacting with an aniline of formula (5), 
with an (C1-C4) alkoxymethylene malonate di (C1-C4) alkyl ester to obtain a compound of formula (7),wherein E is (C1-C4) alkyl, 
(b) reacting the compound of formula (7) with application of heat to obtain an ester of the formula 
(c) reacting the ester of formula (8) with a base selected from the group consisting of sodium carbonate, potassium carbonate, sodium hydroxide, and potassium hydroxide, to obtain a salt of formula (9), wherein M is Na or K, 
(d) reacting the salt of formula (9) with a mineral acid selected from the group consisting of hydrochloric acid, sulfuric acid, and phosphoric acid, to obtain a 4-hydroxyquinoline acid of the formula 
(e) reacting the acid of formula (10) with the application of heat to obtain a 4-hydroxyquinoline of the formula 
(f) reacting the 4-hydroxyquinoline of formula (11) with thionyl chloride in the presence of N, N-dimethylformamide or N,N-diethylformamide under anhydrous conditions to obtain a 4-chloroquinoline of formula (12), the excess thionyl chloride and the sulfur dioxide are stripped from the mixture by distillation under reduced pressure at a temperature of 60-95o C, 
(g) reacting the 4-chloroquinoline of formula (12) with a phenol of the formula 
in the presence of a base selected from a group consisting of sodium carbonate, potassium carbonate, sodium hydroxide, and potassium hydroxide, to obtain a 4-oxysubstituted quinoline of formula (1) wherein the entire reaction sequence (a)-(g) is carried out in the presence of a single, inert high boiling polyether solvent, which is selected from the group consisting of diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, triethylene glycol diethyl ether, and tetraethylene glycol dimethyl ether. __________
Directory: Units -> RashamHaptentim -> Units -> patent -> yoman Units -> Perform and explain geodetic computations Units -> Demonstrate and apply advanced knowledge of programming techniques for electrotechnology Units -> Nzqa registered unit standard 22561 version 3 Units -> Nzqa registered unit standard 22528 version 2 Units -> Nzqa registered unit standard 26968 version 1 Units -> Nzqa registered unit standard 10212 version 5 Download 0.86 Mb. Share with your friends:
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||