Lipid and Choline in Cancer
Hall 4
M onday: 14:00 - 16:00
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2224.
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In Vivo 1H and 31P NMR Study of Hepatic Apoptosis in Anti-Fas Treated Mice
Michael Skalski1, Lesley May Foley1, Anne Baggley1, Melissa Yau1, Manfred Brauer1
1University of Guelph, Guelph, Ontario, Canada.
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2225.
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Malignant Cells Influence the Phospholipid Phenotype of Human Vascular Endothelial Cells
Noriko Mori1, Kshama Natarajan1, Vadappuram P. Chacko1, Dmitri Artemov1, Zaver M. Bhujwalla1
1Johns Hopkins University, Baltimore, MD, USA.
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2226.
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31P MRS of Thymoma Cell Extracts Indicates Increased Phospholipase Activity following Dexamethasone Treatment, in Correlation with Apoptotic Parameters
Margaret E. Tome1, Margaret M. Briehl1, Norbert W. Lutz1
1University of Arizona, Tucson, AZ, USA.
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2227.
|
Effects of Apoptosis on the Lipid Metabolism in KB Tumor Cells Studied by One- and Two-dimensional NMR Spectroscopy
Touraj Shokati1, Joern Engelmann1, Wieland Willker1, Dieter Leibfritz1
1University of Bremen, Bremen, Germany.
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2228.
|
1H and 31P Nuclear Magnetic Resonance Spectroscopy Study of Diamide-Induced Apoptosis in Tumors and Isolated Tumor Cells
Angele Viola1, Kevin Michael Brindle2
1Faculté de Médecine la Timone, Marseille, Marseille, France; 2University of Cambridge, Cambridge, England, UK,
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2229.
|
Imbalance of CDP Pathways and Up-Regulation of Phosphoethanolamine under CENU Treatment in Long Term Cultures of Malignant Melanoma Cells. A 1H-HRMAS MRS Study.
Daniel Morvan1, Aicha Demidem, Janine Papon, Jean Claude Madelmont
1INSERM U_484, Clermont-Ferrand, France.
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2230.
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L-Methionine Supplementation Disrupts Sequential Activation of Phospholipases during Tumor Growth in a Murine Model of Malignant Melanoma. A 1H-HRMAS MRS Study.
Aicha Demidem1, Daniel Morvan, Janine Papon, Jean Claude Madelmont
1INSERM U_484, Clermont-Ferrand, France,
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2231.
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Impact of Indomethacin on Phospholipid Metabolism in Malignant Human Mammary Epithelial Cells: 1H and 31P NMR Spectroscopic Study of Viable Cells
Kristine Glunde1, Ellen Ackerstaff1, Kshama Natarajan1, Dmitri Artemov1, Zaver M. Bhujwalla1
1Johns Hopkins University, Baltimore, MD, USA.
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Oxygenation, Hypoxia, and pH Studies of Cancer
Hall 4
Monday: 14:00 - 16:00
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2232.
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Effect of Carbogen Breathing on a Chemically Induced Hepatocarcinoma Model in Mice
Carole D. Thomas1, Evelyne Chenu1, Christine Walzcac1, Marie-Jose Plessis1, Francois Perin1, Andreas Volk1
1Curie Institute - Research, Orsay, France.
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2233.
|
Analysis of Human Tumor Xenograft Oxygenation and Correlation to Vascular Density, Viability and Necrosis with Functional MRI at 1.5T
Song Lai1, Geon-Ho Jahng1, Jiongjiong Wang1, Lahmer Lynds1, Gail R. Ramsby1, Kevin P. Claffey1, Anshu Agarwal1, Marty Keough1
1University of Connecticut Health Center, Farmington, CT, USA.
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2234.
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Increased Lactate Characterizes Malignant Transformation in Human Prostate Cancer Cells
Ellen Ackerstaff1, Beth R. Pflug2, Joel B. Nelson2, Zaver M. Bhujwalla1
1Johns Hopkins University, Baltimore, MD, USA; 2University of Pittsburgh, Shadyside Medical Center, Pittsburgh, PA, USA.
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2235.
|
Enhancement of Hyperglycemia-Induced Acidification of Human Melanoma Xenografts by Inhibitors of Respiration an Ion Transport
R. Zhou1, S. Pickup1, D. B. Leeper2, Jerry Glickson1
1University of Pennsylvania, Philadelphia, PA, USA; 2Thomas Jefferson University, Philadelphia, PA, USA.
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2236.
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Effect of Insulin on Tumor Oxygenation and Perfusion
Bénédicte Jordan1, Vincent Gregoire1, Roger Demeure1, Bernard Gallez1
1Université catholique de Louvain, Brussels, Belgium.
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2237.
|
Indirect Detection of Reactive Oxygen Species by 1H NMR: Monitoring of Reduced Form of Nitroxyl Spin Probes
Hideto Kuribayashi1, Hideo Utsumi1
1Kyushu University, Fukuoka, Japan.
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2238.
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Heparin-Induced Hemodynamic Alterations: A BOLD Contrast MRI Study
Galia Tsarfaty1, Tammar Kushnir1, Rinat Abramovitch1, Miriam Shaharabany2, Rotem Ron2, Judith Horev3, Yacov Itzchak1, Ilan Tsarfaty3
1The Chaim Sheba Medical Center, Tel Hashomer, Israel; 2fBIT Ltd., Ramat-Gan, Israel; 3Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel.
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Tumor Perfusion and Permeability
Hall 4
Monday: 14:00 - 16:00
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2239.
|
Simulation of the Effect of Impaired Renal Function on Contrast Enhanced MRI Measurements in Cancer
Trevor Ahearn1, Thomas W Redpath1, Roger Staff1
1University of Aberdeen, Aberdeen, Scotland, UK.
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2240.
|
Dynamic Contrast Enhanced Liver MRI Using a Motion Tracking Algorithm
Michael D. Noseworthy1, Marshall S. Sussman2, Masoom Haider3, Sylvain Baruchel1
1University of Toronto, The Hospital For Sick Children, Toronto, ON, Canada; 2University of Toronto, Sunnybrook Health Science Centre, Toronto, ON, Canada; 3University of Toronto, Princess Margaret Hospital, Toronto, ON, Canada.
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2241.
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B0-Dependence of the CR-Determined Exchange Regime for Equilibrium Transcytolemmal Water Transport: Implications for Bolus-Tracking Studies
Charles Springer1, William Rooney1
1Brookhaven National Laboratory, Upton, NY, USA.
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2242.
|
A Simple Model to Characterise Blood-Brain Barrier Leakage from T2*-weighed Bolus Tracking MRI Data
Paul Stephen Tofts1, G. Johnson2, S. Cha2
1University College London, Institute of Neurology, London, UK; 2New York University School of Medicine, New York, NY, USA.
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2243.
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Assessing Tumor Angiogenessis with Dynamic Susceptibility Contrast fMRI Which Morphologc Correlates Are Relevant?
A.P Pathak1, Kathleen (Donahue) Schmainda2, B. D. Ward2, K. J. Rebro2, Scott Rand2
1Marquette University, Milwaukee, WI, USA; 2Medical College of Wisconsin, Milwaukee, WI, USA.
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2244.
|
Determination of Vascular Permeability and Extracellular Volume Fraction in Human Breast Cancer Tumors Implanted in SCID Mice
Yael Bergknoff1, Raanan Margalit1, Dov Grobgeld1, Hadassa Degani1
1Weizmann Institute of Science, Rehovot, Israel.
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2245.
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Dynamic Contrast-Enhanced MRI: Image Analysis Techniques for Treatment Response Studies
Carmel Hayes1, Anwar R Padhani1, Martin O Leach1
1The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, UK.
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2246.
|
Identifying Tumor Permeability Heterogeneity with MRI Contrast Agents
Michael Aref1, Martin Brechbiel2, Erik Wiener1
1University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2National Institutes of Health, Bethesda, MD, USA.
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2247.
|
A Marker of Vascular Tortuosity (Relative Recirculation) in Gliomas: Comparison with Blood Volume and Tumor Grade
Andrea Kassner1, Xiaoping Zhu2, Ka-Loh Li2, Alan Jackson2
1Philips Medical Systems, Leeds, England, UK; 2University of Manchester, Manchester, England, UK.;
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2248.
|
MR-Derived Cerebral Blood Volume Maps: Issues Regarding Histological Validation and Assessment of Tumor Angiogenesis
A.P Pathak1, Kathleen (Donahue) Schmainda2, B. D. Ward3, K. J. Rebro3, Andrew S. Greene2
1Marquette University, Milwaukee, WI, USA; 2Medical College of Wisconsin, and Marquette University, Milwaukee, WI, USA; 3Medical College of Wisconsin, Milwaukee, WI, USA.
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2249.
|
Identifying High 'Metastatic Risk' Vascular and Physiological Regions in Solid Tumors
Zaver M Bhujwalla1, Dmitri Artemov1, Paloma Ballesteros2, Sebastian Cerdan3, Robert Gillies4, Meiyappan Solaiyappan1
1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2UNED, Madrid, Spain; 3Inst Investigaciones Biomedicas CSIC, Madrid, Spain; 4University of Arizona, Arizona Health Science Center, Tucson, AZ, USA
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2250.
|
Dynamic Contrast-Enhanced Subtraction and Delayed MRI of Gastric Tumors: Radiologic-Pathologic Correlation
Gin Chung Liu1, Chien Kuo Wang1, Yu Ting Kuo1
1Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
|
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2251.
|
CR Bolus-Tracking Pharmacokinetic Parameters: The Effects of Equilibrium Transcytolemmal Water Exchange
Thomas E. Yankeelov1, William Rooney1, Charles Springer,Jr.1
1Brookhaven National Laboratory, State University of New York, Upton, NY, USA.
|
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2252.
|
Multi-section Dynamic MR Imaging Covering Whole Volume of the Prostate
Masayuki Yamaguchi1, Mamoru Niitsu2, Yuji Itai3
1University of Tsukuba Hospital, Tsukuba, Ibaraki Japan; 2Institute of Clinical Medicine, Ibaraki, Japan; 3Tsukuba, Ibaraki, Japan;
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2253.
|
A Model for Mapping Angiogenesis using Dynamic Contrast-Enhanced MRI
Q.G. de Lussanet1, W.H. Backes1, R. G. H. Beets-Tan1, J. W. Maas1, H. A. Struyker-Boudier1, J. L. Evers1, J. M. A. van Engelshoven1
1University Hospital Maastricht, Maastricht, Netherlands.
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2254.
|
Saturation Steady-State Weighting of MRI Intensity: Tracking Instantaneous T1 Changes
Jing-Huei Lee1
1Brookhaven National Laboratory, Upton, NY, USA.
|
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2255.
|
Comparison of Propeller, Spiral And Variable Density Spiral Trajectories for Dynamic Contrast Enhanced MRI of Cancer
Ergun Ahunbay1, James Pipe2, Jeffrey L. Evelhoch1
1Wayne State University, Harper Hospital, Detroit, MI, USA; 2Barrow Neurological Institute, Phoenix, AZ, USA
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2256.
|
H215O PET Validation of Tumor Blood Flow Determined by Double Echo Dynamic Perfusion-Weighted MR Imaging
Satoshi Muramoto1, Hidemasa Uematsu1, Norihiro Sadato1, T. Tsuchida1, Hirohiko Kimura1, Tsuyoshi Matsuda2, Yoshiharu Yonekura1, H. Itoh
1Fukui Medical University, Fukui, Japan; 2GE Yokogawa Medical Systems Ltd., Tokyo, Japan.
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Cancer Treatment: Anti-angiogenesis and Anti-vascular
Hall 4
Monday: 14:00 - 16:00
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2257.
|
Effect of Dexamethasone Treatment on Dynamic Susceptibility CBV Measurements in a Rat Brain Tumor Model
K.M. (Donahue) Schmainda1, A. P. Pathak1, M. Badruddoja1, S. D. Rand1, K. Rebro1, H. G. Krouwer1
1Medical College of Wisconsin, Milwaukee, WI, USA.
|
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2258.
|
Evaluation of the Anti-Vascular Effects of Combretastatin in Rodent Tumours by Dynamic Contrast Enhanced MRI.
Ross J Maxwell1, John Wilson1, Gillian M Tozer1
1Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK.
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2259.
|
Assessment of Tumour Response to Matrix Metalloproteinases Inhibitors Treatment Using Dynamic Gd-DTPA Enhanced MR Imaging.
Nathalie Just1, Carmel Hayes1, Ian J Rowland1, Suzanne Eccles2, Martin O Leach1
1Institute of Cancer Research, The Royal Marsden Hospital, Sutton, England, UK; 2Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, England, UK.
|
|
2260.
|
Differential Sensitivity of a Tumor Model to Two Anti-Vascular Drugs
Daniel A. Beauregard1, R. Barbara Pedley2, Sally A. Hill3, Kevin M. Brindle1
1University of Cambridge, Cambridge, UK; 2University College London, School of Medicine, London, UK; 3Gray Laboratory Cancer Research Trust, Middlesex, UK.
|
|
2261.
|
Contrast Enhanced MRI Perfusion Evaluation of Vascular Response: Results of a Phase I Clinical Trial of Combretastatin A4
Niusha Rafie1, John A. Jesberger2, Jeffrey L. Duerk2, Matthew M. Mendez1, Scott C. Remick2, Jonathan S. Lewin2
1Case Western Reserve University, Cleveland, OH, USA; 2Case Western Reserve University/ University Hospital of Cleveland, Cleveland, OH, USA.
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2262.
|
Assessing Perfusion and Capillary Permeability Changes Induced by a VEGF Inhibitor in Human Tumor Xenografts Using Macromolecular MR Imaging Contrast Media
Clément Pradel1, Nathalie Siauve1, Charles-André Cuénod1, Frédérique Frouin1, Gaëlle Bruneteau1, Edmond Kahn1, Olivier Clément1, Guy Frija1
1University of Necker, Paris, France.
|
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2263.
|
Changes in Vasculature Detected in a Breast Cancer Model Following Treatment with an Anti-inflammatory Agent
Kshama Natarajan1, Dmitri Artemov1, Zaver Bhujwalla1
1Johns Hopkins University, School of Medicine, Baltimore, MD USA.
|
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2264.
|
Cerebral Blood Flow in Rat is Reduced by Antitumor Agent, Arsenic Trioxide(As2O3)
J. C. Lin1, R. J. Griffin1, S.-G. Kim1, Michael Garwood1
1University of Minnesota, Minneapolis, MN, USA.
|
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2265.
|
Assessment of The Novel Tumour Vascular Targeting Agent ZD6126 By Non-Invasive Multi-Gradient Echo MRI
Simon Robinson1, Dominick McIntyre1, Franklyn Howe1, John R. Griffiths1, David C. Blakey2, John Waterton2
1St. George's Hospital Medical School, London, England, UK; 2AstraZeneca, Macclesfield, Cheshire, UK.
|
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2266.
|
Dynamic Contrast Enhanced Imaging Assessment of the Effects of Antiangiogenic Agent SU5416 in Inflammatory Breast Cancer: Preliminary Results
John A. Jesberger1, Niusha Rafie1, Matt Mendez2, Jeffrey L. Duerk2, Scot Remick2, Beth Overmoyer2, Jonathan S. Lewin2
1Case Western Reserve University, Cleveland, OH, USA; 2University Hospitals Of Cleveland, Case Western Reserve University, Cleveland, OH, USA.
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