Paper 2000 Question: 1 (a) Al-Beruni
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| IV PRODUCTION AND ELIMINATION OF BLOOD CELLS
Blood is produced in the bone marrow, a tissue in the central cavity inside almost all of the bones in the body. In infants, the marrow in most of the bones is actively involved in blood cell formation. By later adult life, active blood cell formation gradually ceases in the bones of the arms and legs and concentrates in the skull, spine, ribs, and pelvis. Red blood cells, white blood cells, and platelets grow from a single precursor cell, known as a hematopoietic stem cell. Remarkably, experiments have suggested that as few as 10 stem cells can, in four weeks, multiply into 30 trillion red blood cells, 30 billion white blood cells, and 1.2 trillion platelets—enough to replace every blood cell in the body. Red blood cells have the longest average life span of any of the cellular elements of blood. A red blood cell lives 100 to 120 days after being released from the marrow into the blood. Over that period of time, red blood cells gradually age. Spent cells are removed by the spleen and, to a lesser extent, by the liver. The spleen and the liver also remove any red blood cells that become damaged, regardless of their age. The body efficiently recycles many components of the damaged cells, including parts of the hemoglobin molecule, especially the iron contained within it. The majority of white blood cells have a relatively short life span. They may survive only 18 to 36 hours after being released from the marrow. However, some of the white blood cells are responsible for maintaining what is called immunologic memory. These memory cells retain knowledge of what infectious organisms the body has previously been exposed to. If one of those organisms returns, the memory cells initiate an extremely rapid response designed to kill the foreign invader. Memory cells may live for years or even decades before dying. Memory cells make immunizations possible. An immunization, also called a vaccination or an inoculation, is a method of using a vaccine to make the human body immune to certain diseases. A vaccine consists of an infectious agent that has been weakened or killed in the laboratory so that it cannot produce disease when injected into a person, but can spark the immune system to generate memory cells and antibodies specific for the infectious agent. If the infectious agent should ever invade that vaccinated person in the future, these memory cells will direct the cells of the immune system to target the invader before it has the opportunity to cause harm. Platelets have a life span of seven to ten days in the blood. They either participate in clot formation during that time or, when they have reached the end of their lifetime, are eliminated by the spleen and, to a lesser extent, by the liver. V BLOOD DISEASES Many diseases are caused by abnormalities in the blood. These diseases are categorized by which component of the blood is affected. A Red Blood Cell Diseases One of the most common blood diseases worldwide is anemia, which is characterized by an abnormally low number of red blood cells or low levels of hemoglobin. One of the major symptoms of anemia is fatigue, due to the failure of the blood to carry enough oxygen to all of the tissues. The most common type of anemia, iron-deficiency anemia, occurs because the marrow fails to produce sufficient red blood cells. When insufficient iron is available to the bone marrow, it slows down its production of hemoglobin and red blood cells. The most common causes of iron-deficiency anemia are certain infections that result in gastrointestinal blood loss and the consequent chronic loss of iron. Adding supplemental iron to the diet is often sufficient to cure iron-deficiency anemia. Some anemias are the result of increased destruction of red blood cells, as in the case of sickle-cell anemia, a genetic disease most common in persons of African ancestry. The red blood cells of sickle-cell patients assume an unusual crescent shape, causing them to become trapped in some blood vessels, blocking the flow of other blood cells to tissues and depriving them of oxygen. B White Blood Cell Diseases Some white blood cell diseases are characterized by an insufficient number of white blood cells. This can be caused by the failure of the bone marrow to produce adequate numbers of normal white blood cells, or by diseases that lead to the destruction of crucial white blood cells. These conditions result in severe immune deficiencies characterized by recurrent infections. Any disease in which excess white blood cells are produced, particularly immature white blood cells, is called leukemia, or blood cancer. Many cases of leukemia are linked to gene abnormalities, resulting in unchecked growth of immature white blood cells. If this growth is not halted, it often results in the death of the patient. These genetic abnormalities are not inherited in the vast majority of cases, but rather occur after birth. Although some causes of these abnormalities are known, for example exposure to high doses of radiation or the chemical benzene, most remain poorly understood. Treatment for leukemia typically involves the use of chemotherapy, in which strong drugs are used to target and kill leukemic cells, permitting normal cells to regenerate. In some cases, bone marrow transplants are effective. Much progress has been made over the last 30 years in the treatment of this disease. In one type of childhood leukemia, more than 80 percent of patients can now be cured of their disease. C Coagulation Diseases One disease of the coagulation system is hemophilia, a genetic bleeding disorder in which one of the plasma clotting factors, usually factor VIII, is produced in abnormally low quantities, resulting in uncontrolled bleeding from minor injuries. Although individuals with hemophilia are able to form a good initial platelet plug when blood vessels are damaged, they are not easily able to form the meshwork that holds the clot firmly intact. As a result, bleeding may occur some time after the initial traumatic event. Treatment for hemophilia relies on giving transfusions of factor VIII. Factor VIII can be isolated from the blood of normal blood donors but it also can be manufactured in a laboratory through a process known as gene cloning. VI BLOOD BANKS The Red Cross and a number of other organizations run programs, known as blood banks, to collect, store, and distribute blood and blood products for transfusions. When blood is donated, its blood type is determined so that only appropriately matched blood is given to patients needing a transfusion. Before using the blood, the blood bank also tests it for the presence of disease-causing organisms, such as hepatitis viruses and human immunodeficiency virus (HIV), the cause of acquired immunodeficiency syndrome (AIDS). This blood screening dramatically reduces, but does not fully eliminate, the risk to the recipient of acquiring a disease through a blood transfusion. Blood donation, which is extremely safe, generally involves giving about 400 to 500 ml (about 1 pt) of blood, which is only about 7 percent of a person’s total blood. VII BLOOD IN NONHUMANS One-celled organisms have no need for blood. They are able to absorb nutrients, expel wastes, and exchange gases with their environment directly. Simple multicelled marine animals, such as sponges, jellyfishes, and anemones, also do not have blood. They use the seawater that bathes their cells to perform the functions of blood. However, all more complex multicellular animals have some form of a circulatory system using blood. In some invertebrates, there are no cells analogous to red blood cells. Instead, hemoglobin, or the related copper compound heocyanin, circulates dissolved in the plasma. The blood of complex multicellular animals tends to be similar to human blood, but there are also some significant differences, typically at the cellular level. For example, fish, amphibians, and reptiles possess red blood cells that have a nucleus, unlike the red blood cells of mammals. The immune system of invertebrates is more primitive than that of vertebrates, lacking the functionality associated with the white blood cell and antibody system found in mammals. Some arctic fish species produce proteins in their blood that act as a type of antifreeze, enabling them to survive in environments where the blood of other animals would freeze. Nonetheless, the essential transportation, communication, and protection functions that make blood essential to the continuation of life occur throughout much of the animal kingdom. (IV) Heavy water Almost all the hydrogen in water has an atomic weight of 1. The American chemist Harold Clayton Urey discovered in 1932 the presence in water of a small amount (1 part in 6000) of so-called heavy water, or deuterium oxide (D2O); deuterium is the hydrogen isotope with an atomic weight of 2. In 1951 the American chemist Aristid Grosse discovered that naturally occurring water contains also minute traces of tritium oxide (T2O); tritium is the hydrogen isotope with an atomic weight of 3. See Atom. Microsoft ® Encarta ® 2006. © 1993-2005 Microsoft Corporation. All rights reserved. Hard Water Hardness of natural waters is caused largely by calcium and magnesium salts and to a small extent by iron, aluminum, and other metals. Hardness resulting from the bicarbonates and carbonates of calcium and magnesium is called temporary hardness and can be removed by boiling, which also sterilizes the water. The residual hardness is known as noncarbonate, or permanent, hardness. The methods of softening noncarbonate hardness include the addition of sodium carbonate and lime and filtration through natural or artificial zeolites which absorb the hardness-producing metallic ions and release sodium ions to the water See Ion Exchange; Zeolite. Sequestering agents in detergents serve to inactivate the substances that make water hard. Iron, which causes an unpleasant taste in drinking water, may be removed by aeration and sedimentation or by passing the water through iron-removing zeolite filters, or the iron may be stabilized by addition of such salts as polyphosphates. For use in laboratory applications, water is either distilled or demineralized by passing it through ion-absorbing compounds. (v) Smallpox, highly contagious viral disease that is often fatal. The disease is chiefly characterized by a skin rash that develops on the face, chest, back, and limbs. Over the course of a week the rash develops into pustular (pus-filled) pimples resembling boils. In extreme cases the pustular pimples run together—usually an indication of a fatal infection. Death may result from a secondary bacterial infection of the pustules, from cell damage caused by the viral infection, or from heart attack or shock. In the latter stages of nonfatal cases, smallpox pustules become crusted, often leaving the survivor with permanent, pitted scars. Smallpox is caused by a virus. An infected person spreads virus particles into the air in the form of tiny droplets emitted from the mouth by speaking, coughing, or simply breathing. The virus can then infect anyone who inhales the droplets. By this means, smallpox can spread extremely rapidly from person to person. Smallpox has afflicted humanity for thousands of years, causing epidemics from ancient times through the 20th century. No one is certain where the smallpox virus came from, but scientists speculate that several thousand years ago the virus made a trans-species jump into humans from an animal—likely a rodent species such as a mouse. The disease probably did not become established among humans until the beginnings of agriculture gave rise to the first large settlements in the Nile valley (northeastern Africa) and Mesopotamia (now eastern Syria, southeastern Turkey, and Iraq) more than 10,000 years ago. Over the next several centuries smallpox established itself as a widespread disease in Europe, Asia, and across Africa. During the 16th and 17th centuries, a time when Europeans made journeys of exploration and conquest to the Americas and other continents, smallpox went with them. By 1518 the disease reached the Americas aboard a Spanish ship that landed at the island of Hispaniola (now the Dominican Republic and Haiti) in the West Indies. Before long smallpox had killed half of the Taíno people, the native population of the island. The disease followed the Spanish conquistadors into Mexico and Central America in 1520. With fewer than 500 men, the Spanish explorer Hernán Cortés was able to conquer the great Aztec Empire under the emperor Montezuma in what is now Mexico. One of Cortés's men was infected with smallpox, triggering an epidemic that ultimately killed an estimated 3 million Aztecs, one-third of the population. A similar path of devastation was left among the people of the Inca Empire of South America. Smallpox killed the Inca emperor Huayna Capac in 1525, along with an estimated 100,000 Incas in the capital city of Cuzco. The Incas and Aztecs are only two of many examples of smallpox cutting a swath through a native population in the Americas, easing the way for Europeans to conquer and colonize new territory. It can truly be said that smallpox changed history. Yet the story of smallpox is also the story of great biomedical advancement and of ultimate victory. As the result of a worldwide effort of vaccination and containment, the last naturally occurring infection of smallpox occurred in 1977. Stockpiles of the virus now exist only in secured laboratories. Some experts, however, are concerned about the potential use of smallpox as a weapon of bioterrorism. Thus, despite being deliberately and successfully eradicated, smallpox may still pose a threat to humanity. Microsoft ® Encarta ® 2006. © 1993-2005 Microsoft Corporation. All rights reserved. Measles, also rubeola, acute, highly contagious, fever-producing disease caused by a filterable virus, different from the virus that causes the less serious disease German measles, or rubella. Measles is characterized by small red dots appearing on the surface of the skin, irritation of the eyes (especially on exposure to light), coughing, and a runny nose. About 12 days after first exposure, the fever, sneezing, and runny nose appear. Coughing and swelling of the neck glands often follow. Four days later, red spots appear on the face or neck and then on the trunk and limbs. In 2 or 3 days the rash subsides and the fever falls; some peeling of the involved skin areas may take place. Infection of the middle ear may also occur. Measles was formerly one of the most common childhood diseases. Since the development of an effective vaccine in 1963, it has become much less frequent. By 1988 annual measles cases in the United States had been reduced to fewer than 3,500, compared with about 500,000 per year in the early 1960s. However, the number of new cases jumped to more than 18,000 in 1989 and to nearly 28,000 in 1990. Most of these cases occurred among inner-city preschool children and recent immigrants, but adolescents and young adults, who may have lost immunity (see Immunization) from their childhood vaccinations, also experienced an increase. The number of new cases declined rapidly in the 1990s and by 1999 fewer than 100 cases were reported. The reasons for this resurgence and subsequent decline are not clearly understood. In other parts of the world measles is still a common childhood disease and according to the World Health Organization (WHO), about 1 million children die from measles each year. In the U.S., measles is rarely fatal; should the virus spread to the brain, however, it can cause death or brain damage (see Encephalitis). No specific treatment for measles exists. Patients are kept isolated from other susceptible individuals, usually resting in bed, and are treated with aspirin, cough syrup, and skin lotions to lessen fever, coughing, and itching. The disease usually confers immunity after one attack, and an immune pregnant woman passes the antibody in the globulin fraction of the blood serum, through the placenta, to her fetus. Microsoft ® Encarta ® 2006. © 1993-2005 Microsoft Corporation. All rights reserved. (vi) PIG IRON The basic materials used for the manufacture of pig iron are iron ore, coke, and limestone. The coke is burned as a fuel to heat the furnace; as it burns, the coke gives off carbon monoxide, which combines with the iron oxides in the ore, reducing them to metallic iron. This is the basic chemical reaction in the blast furnace; it has the equation: Fe2O3 + 3CO = 3CO2 + 2Fe. The limestone in the furnace charge is used as an additional source of carbon monoxide and as a “flux” to combine with the infusible silica present in the ore to form fusible calcium silicate. Without the limestone, iron silicate would be formed, with a resulting loss of metallic iron. Calcium silicate plus other impurities form a slag that floats on top of the molten metal at the bottom of the furnace. Ordinary pig iron as produced by blast furnaces contains iron, about 92 percent; carbon, 3 or 4 percent; silicon, 0.5 to 3 percent; manganese, 0.25 to 2.5 percent; phosphorus, 0.04 to 2 percent; and a trace of sulfur. A typical blast furnace consists of a cylindrical steel shell lined with a refractory, which is any nonmetallic substance such as firebrick. The shell is tapered at the top and at the bottom and is widest at a point about one-quarter of the distance from the bottom. The lower portion of the furnace, called the bosh, is equipped with several tubular openings or tuyeres through which the air blast is forced. Near the bottom of the bosh is a hole through which the molten pig iron flows when the furnace is tapped, and above this hole, but below the tuyeres, is another hole for draining the slag. The top of the furnace, which is about 27 m (about 90 ft) in height, contains vents for the escaping gases, and a pair of round hoppers closed with bell-shaped valves through which the charge is introduced into the furnace. The materials are brought up to the hoppers in small dump cars or skips that are hauled up an inclined external skip hoist. Blast furnaces operate continuously. The raw material to be fed into the furnace is divided into a number of small charges that are introduced into the furnace at 10- to 15-min intervals. Slag is drawn off from the top of the melt about once every 2 hr, and the iron itself is drawn off or tapped about five times a day. The air used to supply the blast in a blast furnace is preheated to temperatures between approximately 540° and 870° C (approximately 1,000° and 1,600° F). The heating is performed in stoves, cylinders containing networks of firebrick. The bricks in the stoves are heated for several hours by burning blast-furnace gas, the waste gases from the top of the furnace. Then the flame is turned off and the air for the blast is blown through the stove. The weight of air used in the operation of a blast furnace exceeds the total weight of the other raw materials employed. An important development in blast furnace technology, the pressurizing of furnaces, was introduced after World War II. By “throttling” the flow of gas from the furnace vents, the pressure within the furnace may be built up to 1.7 atm or more. The pressurizing technique makes possible better combustion of the coke and higher output of pig iron. The output of many blast furnaces can be increased 25 percent by pressurizing. Experimental installations have also shown that the output of blast furnaces can be increased by enriching the air blast with oxygen. The process of tapping consists of knocking out a clay plug from the iron hole near the bottom of the bosh and allowing the molten metal to flow into a clay-lined runner and then into a large, brick-lined metal container, which may be either a ladle or a rail car capable of holding as much as 100 tons of metal. Any slag that may flow from the furnace with the metal is skimmed off before it reaches the container. The container of molten pig iron is then transported to the steelmaking shop. Modern-day blast furnaces are operated in conjunction with basic oxygen furnaces and sometimes the older open-hearth furnaces as part of a single steel-producing plant. In such plants the molten pig iron is used to charge the steel furnaces. The molten metal from several blast furnaces may be mixed in a large ladle before it is converted to steel, to minimize any irregularities in the composition of the individual melts. Microsoft ® Encarta ® 2006. © 1993-2005 Microsoft Corporation. All rights reserved. STAINLESS STEEL Stainless steels contain chromium, nickel, and other alloying elements that keep them bright and rust resistant in spite of moisture or the action of corrosive acids and gases. Some stainless steels are very hard; some have unusual strength and will retain that strength for long periods at extremely high and low temperatures. Because of their shining surfaces architects often use them for decorative purposes. Stainless steels are used for the pipes and tanks of petroleum refineries and chemical plants, for jet planes, and for space capsules. Surgical instruments and equipment are made from these steels, and they are also used to patch or replace broken bones because the steels can withstand the action of body fluids. In kitchens and in plants where food is prepared, handling equipment is often made of stainless steel because it does not taint the food and can be easily cleaned. Microsoft ® Encarta ® 2006. © 1993-2005 Microsoft Corporation. All rights reserved. (VII) Alloy, substance composed of two or more metals. Alloys, like pure metals, possess metallic luster and conduct heat and electricity well, although not generally as well as do the pure metals of which they are formed. Compounds that contain both a metal or metals and certain nonmetals, particularly those containing carbon, are also called alloys. The most important of these is steel. Simple carbon steels consist of about 0.5 percent manganese and up to 0.8 percent carbon, with the remaining material being iron. An alloy may consist of an intermetallic compound, a solid solution, an intimate mixture of minute crystals of the constituent metallic elements, or any combination of solutions or mixtures of the foregoing. Intermetallic compounds, such as NaAu2, CuSn, and CuAl2, do not follow the ordinary rules of valency. They are generally hard and brittle; although they have not been important in the past where strength is required, many new developments have made such compounds increasingly important. Alloys consisting of solutions or mixtures of two metals generally have lower melting points than do the pure constituents. A mixture with a melting point lower than that of any other mixture of the same constituents is called a eutectic. The eutectoid, the solid-phase analog of the eutectic, frequently has better physical characteristics than do alloys of different proportions. The properties of alloys are frequently far different from those of their constituent elements, and such properties as strength and corrosion resistance may be considerably greater for an alloy than for any of the separate metals. For this reason, alloys are more generally used than pure metals. Steel is stronger and harder than wrought iron, which is approximately pure iron, and is used in far greater quantities. The alloy steels, mixtures of steel with such metals as chromium, manganese, molybdenum, nickel, tungsten, and vanadium, are stronger and harder than steel itself, and many of them are also more corrosion-resistant than iron or steel. An alloy can often be made to match a predetermined set of characteristics. An important case in which particular characteristics are necessary is the design of rockets, spacecraft, and supersonic aircraft. The materials used in these vehicles and their engines must be light in weight, very strong, and able to sustain very high temperatures. To withstand these high temperatures and reduce the overall weight, lightweight, high-strength alloys of aluminum, beryllium, and titanium have been developed. To resist the heat generated during reentry into the atmosphere of the earth, alloys containing heat-resistant metals such as tantalum, niobium, tungsten, cobalt, and nickel are being used in space vehicles. Directory: 2014 2014 -> For want of a nail 2014 -> The Global Warming that Wasn’t 2014 -> Assembly, No. 3901 state of new jersey 216th legislature 2014 -> Stop Militarizing Law Enforcement Act of 2014 2014 -> Ihbb asian Championships 2014 middle school bowl Round 4 First Quarter 2014 -> Unit: Automotive and Auto Body 2014 -> Ihbb european Championships 2014 Bowl Round 4 First Quarter 2014 -> International History Bee and Bowl 2013-14 Asian Division Question Set Bowl Round Six 2014 -> United states patent and trademark office 2014 -> Walnut creek, ca branch executive committee meeting minutes Download 0.98 Mb. 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