Title: World Journal of Surgical Oncology

Title: World Journal of Surgical Oncology

ISO Abbreviated Title:

JCR Abbreviated Title:

ISSN:

Journal Country/Territory:

Language:

Publisher:

Publisher Address:

Subject Categories:

: Impact Factor

? Gao, Y., Zhong, C.L., Wang, Y., Xu, S.Y., Guo, Y., Dai, C.Y., Zheng, Y., Wang, Y., Luo, Q.Z. and Jiang, J.Y. (2014), Endoscopic versus microscopic transsphenoidal pituitary adenoma surgery: A meta-analysis. World Journal of Surgical Oncology, 12, Article Number: 94.

Full Text: 2014\Wor J Sur Onc12, 94.pdf

Abstract: Background: Endoscopic transsphenoidal surgery has gradually come to be regarded as a preferred option in the treatment of pituitary adenomas because of its advantages of improved visualization and its minimal invasiveness. The aim of this study was to compare and evaluate the outcomes and complications of endoscopic and microscopic transsphenoidal surgery in the treatment of pituitary adenomas. Methods: We performed a systematic literature search of MEDLINE, EMBASE, the Cochrane Library and the Web of Science between January 1992 and May 2013. Studies with consecutive patients that explicitly and fully compared endoscopic and microscopic approaches in the treatment of pituitary adenomas were included. Results: A total of 15 studies (n = 1,014 patients) met the inclusion criteria among 487 studies that involved endoscopic surgery and 527 studies that dealt with microscopic surgery. The rate of gross tumor removal was higher in the endoscopic group than in the microscopic group. The post-operative rates of septal perforation were less frequent in patients who underwent endoscopic surgery. There was no significant difference between the two techniques in the incidence rates of meningitis, diabetes insipidus, cerebrospinal fluid leak, epistaxis or hypopituitarism. The post-operative hospital stay was significantly shorter for the endoscopic surgery group compared with the microscopic surgery group (P < 0.05). There was no significant difference in the length of the operation (P > 0.05). Conclusions: The present study indicates that the endoscopic transsphenoidal approach is safer and more effective than microscopic surgery in the treatment of pituitary adenomas.

Keywords: Adenoma, Approach, Cerebrospinal Fluid, Complications, Criteria, Diabetes, Embase, Endoscopic, Endoscopic Surgery, Experience, Hospital, Hospital Stay, Incidence, Learning-Curve, Length, Literature, Literature Search, Medline, Meningitis, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Microscopic, Microsurgery, Operation, Outcomes, P, Patients, Pituitary, Pituitary Adenoma, Postoperative, Rates, Removal, Results, Science, Single-Center, Skull Base, Surgery, Systematic, Systematic Literature Search, Techniques, Transnasal, Transsphenoidal, Transsphenoidal Surgery, Treatment, Tumor, Tumors, Visualization, Web Of Science

? Liao, G.X., Zhao, Z.H., Lin, S.H., Li, R., Yuan, Y.W., Du, S.S., Chen, J.R. and Deng, H.J. (2014), Robotic-assisted versus laparoscopic colorectal surgery: A meta-analysis of four randomized controlled trials. World Journal of Surgical Oncology, 12, Article Number: 122.

Full Text: 2014\Wor J Sur Onc12, 122.pdf

Abstract: Background: Robotic-assisted laparoscopy is popularly performed for colorectal disease. The objective of this meta-analysis was to compare the safety and efficacy of robotic-assisted colorectal surgery (RCS) and laparoscopic colorectal surgery (LCS) for colorectal disease based on randomized controlled trial studies. Methods: Literature searches of electronic databases (Pubmed, Web of Science, and Cochrane Library) were performed to identify randomized controlled trial studies that compared the clinical or oncologic outcomes of RCS and LCS. This meta-analysis was performed using the Review Manager (RevMan) software (version 5.2) that is provided by the Cochrane Collaboration. The data used were mean differences and odds ratios for continuous and dichotomous variables, respectively. Fixed-effects or random-effects models were adopted according to heterogeneity. Results: Four randomized controlled trial studies were identified for this meta-analysis. In total, 110 patients underwent RCS, and 116 patients underwent LCS. The results revealed that estimated blood losses (EBLs), conversion rates and times to the recovery of bowel function were significantly reduced following RCS compared with LCS. There were no significant differences in complication rates, lengths of hospital stays, proximal margins, distal margins or harvested lymph nodes between the two techniques. Conclusions: RCS is a promising technique and is a safe and effective alternative to LCS for colorectal surgery. The advantages of RCS include reduced EBLs, lower conversion rates and shorter times to the recovery of bowel function. Further studies are required to define the financial effects of RCS and the effects of RCS on long-term oncologic outcomes.

Keywords: Alternative, Blood, Bowel, Clinical, Cochrane Collaboration, Colectomy, Collaboration, Colorectal, Colorectal Cancer, Colorectal Surgery, Complication, Complication Rates, Controlled Trial, Conversion, Data, Databases, Disease, Effects, Efficacy, Experience, Function, Heterogeneity, Hospital, Laparoscopic, Laparoscopy, Literature, Long Term, Long-Term, Losses, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Models, Outcomes, Patients, Randomized, Randomized Controlled Trial, Randomized Controlled Trials, Rates, Recovery, Rectal-Cancer, Resection, Results, Review, Robotic, Safety, Science, Short-Term Outcomes, Software, Surgery, Techniques, Total Mesorectal Excision, Trial, Version, Web Of Science

? Chen, Q.L., Pan, Y., Cai, J.Q., Wu, D., Chen, K. and Mou, Y.P. (2014), Laparoscopic versus open resection for gastric gastrointestinal stromal tumors: An updated systematic review and meta-analysis. World Journal of Surgical Oncology, 12, Article Number: 206.

Full Text: 2014\Wor J Sur Onc12, 206.pdf

Abstract: Background: In past decades, laparoscopic surgery has been introduced for the treatment of gastrointestinal stromal tumors (GISTs). Recently, additional studies comparing laparoscopic versus open surgery for gastric GISTs have been published, and an updated meta-analysis of this subject is necessary. Methods: A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science. Comparative studies of laparoscopic and open surgery for gastric GISTs published before June 2014 were identified from databases. The Newcastle-Ottawa Quality Assessment Scale was used to perform quality assessment and original data were extracted. The statistical software STATA (version 12.0) was used for the meta-analysis. Results: Finally, 22 studies, including a total of 1,166 cases, meet the inclusion criteria for meta-analysis. The operation time was similar between laparoscopic and open surgery. Compared to open surgery, laparoscopic resection was associated withless blood loss (WMD = -58.91 ml; 95% CI, -84.60 to -33.22 ml; P < 0.01); earlier time to flatus (WMD = -1.31 d; 95% CI, -1.56 to -1.06, P < 0.01) and oral diet (WMD = -1.75 d; 95% CI, -2.12 to -1.39; P < 0.01); shorter hospital stay (WMD = -3.68 d; 95% CI, -4.47 to -2.88; P < 0.01); and decreased overall complications (relative risk = 0.57; 95% CI, 0.37 to 0.89; P = 0.01). For long-term outcomes, there were no significant differences between two surgical procedures on recurrence. Conclusion: Laparoscopic surgery for gastric GISTs is acceptable for selective patients with better short-term outcomes compared with open surgery. The long-term survival situation of patients mainly depends on the nature of tumor itself, and laparoscopic surgery was not associated with worse oncological outcomes.

Keywords: Assessment, Blood, Blood Loss, Comparative, Complications, Criteria, Data, Databases, Diet, Flatus, Gastric, Hospital, Hospital Stay, Laparoscopic, Laparoscopic Surgery, Long Term, Long-Term, Long-Term Outcomes, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Oncological Outcomes, Open, Operation, Oral, Outcomes, P, Patients, Procedures, Pubmed, Quality, Recurrence, Relative Risk, Results, Review, Risk, Scale, Science, Software, Surgery, Surgical Procedures, Survival, Systematic, Systematic Review, Treatment, Tumor, Version, Web Of Science

? Yang, J., Zhang, J.Y., Chen, J., Chen, C., Song, X.M., Xu, Y. and Li, J. (2014), Prognostic role of microRNA-145 in various human malignant neoplasms: A meta-analysis of 18 related studies. World Journal of Surgical Oncology, 12, Article Number: 254.

Full Text: 2014\Wor J Sur Onc12, 254.pdf

Abstract: Background: Recent studies show that microRNA-145 (miR-145) might be an attractive tumor biomarker of considerable prognostic value. To clarify the preliminary predictive value of miR-145 for prognosis in various malignant neoplasms, we conducted a meta-analysis of 18 relevant studies. Methods: Eligible studies were identified by searching the online databases PubMed, EMBASE, and Web of Science up to March 2014. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for patient survival and disease progress were calculated to investigate the association with miR-145 expression. Results: In total, 18 eligible studies were included in this meta-analysis. Our results showed that upregulated miR-145 significantly predicted a favorable overall survival (OS) (HR = 0.47, 95% CI 0.31 to 0.72), but failed to show a significant relation with disease prognosis. In stratified analyses, high miR-145 expression predicted favorable OS in both Whites and Asians but the intensity of the association in Whites (HR = 0.67, 95% CI 0.47 to 0.95) was not as strong as in Asians (HR = 0.35, 95% CI 0.19 to 0.64). High miR-145 expression also predicted better progression-free survival (PFS) in Asians (HR = 0.43, 95% CI 0.21 to 0.89), but not in Whites. In addition, a significantly favorable OS associated with upregulated miR-145 expression was observed in both squamous cell (SCC) (HR = 0.34, 95% CI 0.13 to 0.93) and glioblastoma (HR = 0.72, 95% CI 0.52 to 0.99). Conclusions: Our findings indicate that high miR-145 expression is better at predicting patient survival rather than disease progression for malignant tumors, especially for SCC and glioblastoma in Asians. Considering the insufficient evidence, further investigations and more studies are needed.

Keywords: Analyses, Asians, Association, Biomarker, Cell, Cell-Growth, Colorectal-Cancer, Confidence, Confidence Intervals, Databases, Disease, Disease Progression, Embase, Evidence, Expression, Glioblastoma, Hazard, Hepatocellular-Carcinoma, Human, Intensity, Intervals, Investigations, Lung-Cancer, Malignant Neoplasm, Malignant Neoplasms, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Mir-145, Neoplasms, Online, Overall Survival, P53, Pathway, Predictive, Predictive Value, Predicts Survival, Prognosis, Prognostic, Progress, Progression, Progression-Free Survival, Prostate-Cancer, Pubmed, Recent, Results, Role, Science, Survival, Tumor, Tumor-Suppressor Mir-145, Value, Web Of Science

? Han, J.C., Li, X.D., Du, J., Xu, F., Wei, Y.J., Li, H.B. and Zhang, Y.J. (2015), Elevated matrix metalloproteinase-7 expression promotes metastasis in human lung carcinoma. World Journal of Surgical Oncology, 13, Article Number: 5.

Full Text: 2015\Wor J Sur Onc13, 5.pdf

Abstract: Background: Matrix metalloproteinase 7 (MMP-7) promotes tumor invasion and metastasis in several cancers. However, its role in lung cancer progression is understudied. In this study, we investigated the correlation between MMP-7 expression and lung cancer pathology. Methods: We searched the databases PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, China BioMedicine (CBM) and China National Knowledge Infrastructure (CNKI) for scientific literature relevant to MMP-7 and lung cancer. Carefully selected studies were pooled and ORs with 95% CI were calculated. Subgroup analyses and publication bias were analyzed to understand the retrieved data in greater detail. Version 12.0 STATA software was used for statistical analysis. Results: We retrieved a total of 121 studies through database searches. Finally, 14 cohort studies satisfied our inclusion/exclusion criteria, and these 14 studies, published between 2004 and 2012, were selected for meta-analysis to understand the influence of MMP-7 expression in lung cancer progression. Our results showed consistent differences in MMP-7 expression when comparisons were made between TNM I-II versus III-IV (OR = 1.82, 95% CI: 1.19 to 2.78, P = 0.006); histologic grade 1 to 2 versus 3 to 4 (OR = 1.67, 95% CI: 1.14 to 2.42, P = 0.008); and lymph node-negative versus lymph node-positive samples (OR = 2.81, 95% CI: 1.73 to 4.58, P < 0.001), with significantly higher MMP-7 expression levels found in the more advanced stages. Subgroup analysis showed that age was not the factor influencing the associations between histologic grade, LN metastasis and MMP-7 expression in lung cancer patients, as both under 60 and over 60 age groups showed strong correlations (all P < 0.05). However, when TNM staging was analyzed for its association with MMP-7 expression, only patients under age 60 showed a statistically significant correlation. Conclusions: Our meta-analysis results revealed that MMP-7 overexpression is associated with advanced TNM and histological grades, and is linked to aggressive LN metastasis in lung cancer patients; thus MMP-7 is a useful biomarker to assess the disease status in lung cancers.

Keywords: Age, Analyses, Analysis, Association, Bias, Biomarker, Cancer, Cancer Cells, Carcinoma, China, Cohort, Correlation, Correlations, Criteria, Data, Database, Databases, Disease, Expression, Groups, Heterogeneity, Human, Influence, Knowledge, Literature, Lung, Lung Cancer, Matrix, Matrix Metalloproteinase-7, Meta Analysis, Meta-Analysis, Metaanalyses, Metaanalysis, Metastasis, Methods, Mmp-7, Mmp-7 Expression, NSCLC, Overexpression, P, Pathology, Patients, Population, Prognosis, Progression, Protein Expression, Publication, Publication Bias, Pubmed, Results, Risk, Role, Science, Scientific Literature, Software, Squamous-Cell Carcinoma, Statistical Analysis, TNM Staging, Tumor, Web, Web Of Science

? Li, L.Y., Luo, Y., Lu, M.D., Xu, X.W., Lin, H.D. and Zheng, Z.Q. (2015), Cruciferous vegetable consumption and the risk of pancreatic cancer: A meta-analysis. World Journal of Surgical Oncology, 13, Article Number: 44.

Full Text: 2015\Wor J Sur Onc13, 44.pdf

Abstract: Background: Previous studies regarding the association between cruciferous vegetable intake and pancreatic cancer risk have reported inconsistent results. We conducted a meta-analysis to demonstrate the potential association between them. Methods: A systematic literature search of papers was conducted in March 2014 using PubMed, EMBASE, and Web of Science, and the references of the retrieved articles were screened. The summary odds ratios (ORs) with 95% confidence interval (CI) for the highest versus the lowest intake of cruciferous vegetables were calculated. Results: Four cohort and five case-control studies were eligible for inclusion. We found a significantly decreased risk of pancreatic cancer associated with the high intake of cruciferous vegetables (OR 0.78, 95% CI 0.64-0.91). Moderate heterogeneity was detected across studies (P = 0.065). There was no evidence of significant publication bias based on Begg’s funnel plot (P = 0.917) or Egger’s test (P = 0.669). Conclusions: Cruciferous vegetable intake might be inversely associated with pancreatic cancer risk. Because of the limited number of studies included in this meta-analysis, further well-designed prospective studies are warranted to confirm the inverse association between cruciferous vegetable intake and risk of pancreatic cancer.

Keywords: Apoptosis, Articles, Association, Bias, Body-Mass Index, Cancer, Cancer Risk, Case-Control, Case-Control Studies, Cells, Cohort, Confidence, Consumption, Cruciferous Vegetables, Diabetes-Mellitus, Diet, Dietary, Embase, Epidemiology, Epidemiology, Evidence, Heterogeneity, Induction, Interval, Isothiocyanate, Literature, Literature Search, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, P, Pancreatic Cancer, Papers, Potential, Prospective, Prospective Studies, Publication, Publication Bias, Pubmed, References, Results, Risk, Science, Systematic, Systematic Literature Search, Vegetables, Web, Web Of Science

? Hu, J.M., Xu, H., Zhu, W.H., Wu, F., Wang, J.Q., Ding, Q. and Jiang, H.W. (2015), Neo-adjuvant hormone therapy for non-metastatic prostate cancer: A systematic review and meta-analysis of 5,194 patients. World Journal of Surgical Oncology, 13, Article Number: 73.

Full Text: 2015\Wor J Sur Onc13, 73.pdf

Abstract: Background: Neo-adjuvant hormone therapy (NHT) following radical prostatectomy (RP) or radiotherapy has been utilized in the multimodal approach to patients with intermediate-to high-risk prostate cancer (PCa). Herein, we performed a systematic review and meta-analysis of published randomized trials to evaluate the clinical efficacy of NHT. Methods: Literatures were searched from PubMed, EMBASE, Web of Science, and Cochrane Library for comparing neo-adjuvant therapy group (NHT plus radiotherapy or radical prostatectomy) with traditional therapy (radiotherapy or prostatectomy) alone. Quality of the research was assessed on the basis of the Cochrane’s risk of bias of randomized controlled trial. Comparable information were obtained from eligible trials and assembled for meta-analysis up to 31 August 2014. RevMan 5.2 software was used for statistical analysis. Results: Fifteen randomized controlled trials (RCTs) (total 5,194 patients) were included in this study. Meta-analysis showed there was a significant improvement in overall survival (OS) (Odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.22 to 1.87, P = 0.0002), positive surgical margin (PSM) rate (OR = 0.30, 95% CI 0.24 to 0.38, P < 0.00001), and biochemical disease-free survival (bDFS) (OR = 1.95, 95% CI 1.13 to 3.39, P = 0.02), but no significant difference in disease-free survival (OR = 1.52, 95% CI 0.90 to 2.59, P = 0.12) and clinical disease-free survival (cDFS) (OR = 0.96, 95% CI 0.22 to 4.18, P = 0.95). Heterogeneity and risk of bias were observed between different studies. Conclusions: Patients with aggressive prostate cancer would better benefit from the receipt of neo-adjuvant therapy. Physicians should make individualized treatment strategies according to adverse reactions, financial capacities, and personal wishes.

Keywords: Ablation, Analysis, Androgen-Deprivation Therapy, Approach, Bias, Cancer, Clinical, Confidence, Controlled Trial, Efficacy, Embase, Follow-Up, From, Hormone Therapy, Improvement, Information, Interval, Leuprolide Acetate, Locally Advanced-Carcinoma, Meta Analysis, Meta-Analysis, Metaanalysis, Methods, Neo-Adjuvant, Neo-Adjuvant Hormone Therapy, Overall Survival, P, Patients, Pca, Prostate Cancer, Prostatectomy, Pubmed, Quality, Radiation-Therapy, Radical Prostatectomy, Radiotherapy, Radiotherapy, Randomized, Randomized Controlled Trial, Randomized Controlled Trials, Randomized Controlled-Trial, Research, Results, Review, Risk, Science, Software, Stage, Statistical Analysis, Survival, Systematic, Systematic Review, Therapy, Treatment, Trial, Web, Web Of Science