Personal Research Database Bibliometric

Full Text: 2014\Tum Bio35, 2383.pdf

Abstract: the association between the epidermal growth factor receptor (EGFR) 142285G > A polymorphism and the susceptibility to breast cancer is unclear. We conducted a meta-analysis of all published studies to estimate the association of EGFR 142285G > A polymorphism and breast cancer risk. Systematic computerized searching of the PubMed, Web of Science, and Wanfang databases was performed for relevant publications. Overall, there were three eligible case-control studies with 1,360 cases and 1,522 controls included into our study. The pooled ORs showed that the EGFR 142285G > A variant genotypes did not increase or decrease the risk of breast cancer under the following gene models: A vs. G, OR = 1.07, 95 % CI 0.96-1.19, P (OR) = 0.240; AA vs. GG, OR = 1.14, 95 % CI 0.91-1.42, P (OR) = 0.239; GA vs. GG, OR = 0.99, 95 % CI 0.83-1.17, P (OR) = 0.892; GA + AA vs. GG, OR = 1.03, 95 % CI 0.87-1.21, P (OR) = 0.727; AA vs. GG + GA, OR = 1.17, 95 % CI 0.97-1.42, P (OR) = 0.096. The between-study heterogeneity was not significant among all studies. The current meta-analysis showed no evidence for significant association between EGFR 142285G > A polymorphism and breast cancer risk. Subsequent studies with large sample size are needed for further elucidation.

Keywords: Association, Bias, Breast Cancer, Cancer, Cancer Risk, Case-Control, Case-Control Studies, Databases, EGFR, Epidermal Growth Factor, Estrogen-Receptor, Evidence, Factor Receptor Family, Gene, Gene Polymorphisms, Graphical Test, Growth, Growth Factor, Heterogeneity, Mar, Meta Analysis, Meta-Analysis, Metaanalysis, Models, P, Polymorphism, Publications, Pubmed, Risk, Sample Size, Science, Size, Web of Science

? Liu, T., Chen, L.L., Sun, X.J., Wang, Y., Li, S., Yin, X., Wang, X.R., Ding, C.H., Li, H. and Di, W. (2014), Progesterone receptor PROGINS and +331G, A polymorphisms confer susceptibility to ovarian cancer: A meta-analysis based on 17 studies. Tumor Biology, 35 (3), 2427-2436.

Full Text: 2014\Tum Bio35, 2427.pdf

Abstract: Progesterone and its receptor, progesterone receptor (PGR), have been widely studied for their roles in the onset and development of ovarian cancer. Although numerous epidemiological studies have focused on the association of PGR PROGINS and +331G, A polymorphisms with ovarian cancer susceptibility, presently, available results remain controversial, in part due to low sample sizes. Thus, a meta-analysis is required to evaluate this association. A literature search of PubMed, Embase, Web of Science, CNKI, and CBM databases was performed to retrieve eligible studies published before August 15, 2013. Summary odds ratios (ORs) with 95 % confidence intervals (CIs) were used to evaluate the strength of this association. All analyses were done using STATA 12.0 software (Stata Corp., College Station, TX, USA). Seventeen case-control studies with a total of 6,365 cases and 9,998 controls were identified. While no statistically significant association between the PROGINS allele and ovarian cancer risk was found in an overall analysis, a stratified analysis revealed that for Caucasians, never-oral contraceptive (OC) users, and serous tumor patients, there were statistically significant ORs for ovarian cancer risk associated with the mutated PROGINS allele. No significant association, however, between the +331G, A polymorphism and ovarian cancer susceptibility was observed in the overall analyses and subgroup analyses based on ethnicity and histological type. This meta-analysis provides evidence that the PROGINS allele occurs more frequently in ovarian cancer patients and especially in non-OC users and serous cancer patients, indicating that PROGINS may be a risk modifier. No significant association between the +331G, A polymorphism and ovarian cancer was found, even in stratified analyses by ethnicity and histological type. More detailed and well-designed studies are still needed to confirm the role of the PROGINS allele in ovarian cancer development.

Keywords: Analyses, Analysis, Association, Brca1, Breast-Cancer, Cancer, Cancer Risk, Candidate, Carcinoma, Case-Control, Case-Control Studies, Confidence, Confidence Intervals, Databases, Development, Ethnicity, Evidence, Gene Polymorphism, Heterogeneity, Intervals, Literature, Literature Search, Mar, Meta Analysis, Meta-Analysis, Metaanalysis, Onset, Oral-Contraceptives, Ovarian Cancer, Patients, Polymorphism, Polymorphisms, Progesterone, Progesterone Receptor, Progesterone Receptor Gene, Promoter, Pubmed, Risk, Role, Science, Software, Stata, Strength, Tumor, USA, Web of Science

? Han, L., Chen, W. and Zhao, Q.C. (2014), Prognostic value of circulating tumor cells in patients with pancreatic cancer: A meta-analysis. Tumor Biology, 35 (3), 2473-2480.

Full Text: 2014\Tum Bio35, 2473.pdf

Abstract: Increasing scientific evidences suggest that circulating tumor cells (CTC) in peripheral blood may be a powerful predictor of survival in patients with pancreatic cancer. However, many existing studies have yielded inconclusive results. This meta-analysis aims to assess the prognostic value of CTC in patients with pancreatic cancer. An extensive literary search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, CNKI, and CBM databases from their inception through July 1, 2013. The meta-analysis was then performed using the Stata 12.0 software. Crude hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated under a fixed or random effect model. Nine cohort studies were included in this meta-analysis with a total of 623 pancreatic cancer patients. This number included 268 CTC-positive patients and 355 CTC-negative patients. Our meta-analysis revealed that patients in the CTC-positive group were significantly associated with poor progression-free survival (PFS) (HR = 1.89, 95 % CI = 1.25-4.00, P < 0.001). Furthermore, pancreatic cancer patients in the CTC-positive group also showed worse overall survival (OS) than those in the CTC-negative group (HR = 1.23, 95 % CI = 0.88-2.08, P < 0.001). Subgroup analysis by ethnicity indicated that CTC-positive patients had poor OS among both Asian and Caucasian populations (all P < 0.05). Further subgroup analyses by detection and treatment methods also suggested that CTC-positive patients showed worser OS than CTC-negative patients in the majority of subgroups (all P < 0.05). No publication bias was detected in this meta-analysis. In conclusion, our meta-analysis suggests that CTC-positive pancreatic cancer patients may have worser PFS and OS than CTC-negative patients. Detection of CTC in peripheral blood may be a promising biomarker for the detection and prognosis of pancreatic cancer.

Keywords: Adenocarcinoma, Analyses, Analysis, Asian, Bias, Biomarker, Blood, Cancer, Caucasian, Circulating Tumor Cells, Cohort, Confidence, Confidence Intervals, Databases, Dissemination, Epidemiology, Ethnicity, Google, Google Scholar, Hazard, Heterogeneity, Intervals, Mar, Meta Analysis, Meta-Analysis, Metaanalysis, Metastatic Breast-Cancer, Methods, Model, P, Pancreatic Cancer, Patients, Peripheral Blood, Populations, Prognosis, Prognostic, Prognostic Value, Publication, Publication Bias, Pubmed, Science, Software, Stata, Survival, Treatment, Tumor, Value, Web of Science

? Shen, E.D., Liu, C., Wei, L., Hu, J.B., Weng, J., Yin, Q.H. and Wang, Y.J. (2014), The APE1 Asp148Glu polymorphism and colorectal cancer susceptibility: A meta-analysis. Tumor Biology, 35 (3), 2529-2535.

Full Text: 2014\Tum Bio35, 2529.pdf

Abstract: Published data regarding the association between the APE1 Asp148Glu polymorphism and colorectal cancer susceptibility remained controversial. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science with a time limit of August 19, 2013. Summary odds ratios (ORs) with 95 % CIs were used to assess the strength of association between the APE1 Asp148Glu polymorphism and colorectal cancer susceptibility using random-effects model. A total of eight case-control studies including 2,597 cases and 3,063 controls were included for analysis. Overall, no significant associations were found between the APE1 Asp148Glu polymorphism and colorectal cancer susceptibility for GG vs TT (OR = 1.00, 95 % CI = 0.73-1.36, p = 0.00 for heterogeneity), TG vs TT (OR = 1.17, 95 % CI = 0.88-1.55, p = 0.00 for heterogeneity), The dominant model GG + TG vs TT (OR = 1.21, 95 % CI = 0.91-1.60, p = 0.00 for heterogeneity) nor the recessive model GG vs TG + TT(OR = 0.95, 95 % CI = 0.75-1.20, p = 0.02 for heterogeneity). In subgroup analysis, no significant associations were found in the Asian or Caucasian populations. This meta-analysis suggested that the APE1 Asp148Glu polymorphism was not associated with colorectal cancer susceptibility among Asians or Caucasians.

Keywords: Acid Substitution Variants, Analysis, APE1 Asp148glu, Asian, Association, Base Excision-Repair, Cancer, Case-Control, Case-Control Studies, Caucasian, Colorectal Cancer, Damage, Data, DNA, Genetic Association, Heterogeneity, Human-Population, Localization, Lung-Cancer, Mar, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Nucleotide, Polymorphism, Populations, Pubmed, Random Effects Model, Risk, Science, Strength, Web of Science

? Wen, F., Zhao, Z.Y., Liu, C., Yin, Q.H., Weng, J., Wang, Y.J. and Ma, Y.C. (2014), A pooled analysis of the ERCC2 Asp312Asn polymorphism and esophageal cancer susceptibility. Tumor Biology, 35 (4), 2959-2965.

Full Text: 2014\Tum Biol35, 2959.pdf

Abstract: Published data regarding the association between the excision repair cross-complimentary group 2 (ERCC2) Asp312Asn polymorphisms and esophageal cancer susceptibility remained controversial. This meta-analysis of literatures was performed to assess the strength of association between the ERCC2 and esophageal cancer susceptibility using random effects model. We systematically searched PubMed, Embase and Web of Science with a time limit of September 15, 2013. Summary odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of association between the ERCC2 Asp312Asn polymorphism and esophageal cancer susceptibility using random effects model. A total of seven case-control studies including 1,831 cases and 2,728 controls were included for analysis. Overall, a significant association was found between ERCC2 Asp312Asn polymorphism and esophageal cancer susceptibility for GA vs. GG (OR = 1.20, 95 % CI = 1.03-1.40) and for the dominant model GA/AA vs. GG (OR = 1.18, 95 % CI = 1.03-1.35). However, the ERCC2 Asp312Asn polymorphism was a protective factor for AA vs. GA/GG (OR = 0.63, 95 % CI = 1.15-2.65) in esophageal squamous cell carcinoma. Our meta-analysis suggested that the ERCC2 Asp312Asn polymorphism might be associated with increased risk of esophageal adenocarcinoma and a protective factor for esophageal squamous cell carcinoma.

Keywords: Adenocarcinoma, Adenocarcinoma Risk, Analysis, Asp312asn, Association, Biomarkers, Cancer, Carcinoma, Case-Control, Case-Control Studies, Cell, China, Confidence, Confidence Intervals, Data, Dna-Repair Genes, Effects, ERCC2, Esophageal Cancer, Intervals, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Polymorphism, Polymorphisms, Population, Pubmed, Random Effects Model, Risk, Science, Squamous Cell Carcinoma, Squamous-Cell Carcinoma, Strength, Web Of Science, XPD Polymorphisms, XRCC1

? Yan, Y.L., Liang, H.J., Li, T.J., Li, M., Li, R.L., Qin, X. and Li, S. (2014), The MMP-1, MMP-2, and MMP-9 gene polymorphisms and susceptibility to bladder cancer: A meta-analysis. Tumor Biology, 35 (4), 3047-3052.

Full Text: 2014\Tum Biol35, 3047.pdf

Abstract: The relationship between matrix metalloproteinase (MMP) polymorphisms and bladder cancer risk has become a hot topic and was studied extensively in recent years, but the results are still controversial. In order to estimate the relationship of MMP polymorphisms and the risk of bladder cancer, we performed this meta-analysis. We conducted a comprehensive search of databases; PubMed, Web of Science, Embase, Chinese Biomedical Literature Database (CBM, Chinese) and Wanfang Database (Chinese) were searched for all case-control studies which mainly study the relationship between MMP-1-1607 1G/2G, MMP-2-1306 C/T, and MMP-9-1562 C/T polymorphisms and the susceptibility of bladder cancer. The association between the MMP polymorphisms and bladder cancer risk was conducted by odds ratios (ORs) and 95 % confidence intervals (95 % CIs). At last, totally five literatures with 1,141 cases and 1,069 controls were contained in the meta-analysis. Among these articles, four articles with 1,103 cases and 1,053 controls were about MMP-1-1607 1G/2G polymorphism and three studies with 839 cases and 775 controls for MMP-2-1306 C/T polymorphism and MMP-9-1562 C/T polymorphism. With regard to MMP-1-1607 1G/2G polymorphism, significant association was found with bladder cancer susceptibility only under recessive model (2G2G vs. 1G2G/1G1G: OR = 1.44, 95 % CI = 1.05-1.97, P = 0.022), and as to the MMP-2-1306 C/T polymorphism, significant association was found with bladder cancer susceptibility only under homozygote model (TT vs. CC: OR = 2.10, 95 % CI = 1.38-3.10, P = 0), but no associations was found between MMP-9-1562 C/T polymorphism and bladder cancer susceptibility. The results suggest that the MMP-2-1306 C/T and MMP-9-1562 C/T polymorphisms are significantly associated with bladder cancer susceptibility, and no associations were found between MMP-9-1562 C/T polymorphism and bladder cancer susceptibility.

Keywords: Articles, Association, Bias, Biomedical, Bladder, Bladder Cancer, Cancer, Cancer Risk, Case-Control, Case-Control Studies, Chinese, Comt, Confidence, Confidence Intervals, Database, Databases, DNA-Repair, Gene, Intervals, Invasion, Literature, Matrix, Matrix Metalloproteinase, Matrix-Metalloproteinase Polymorphisms, Meta Analysis, Meta-Analysis, Metaanalysis, MMP, MMP-9, Model, NQO1, P, Polymorphism, Polymorphisms, Pubmed, Recent, Risk, Science, Topic, Web Of Science

? Zhu, W.J., Yao, J., Li, Y. and Xu, B.N. (2014), Assessment of the association between XRCC1 Arg399Gln polymorphism and glioma susceptibility. Tumor Biology, 35 (4), 3061-3066.

Full Text: 2014\Tum Biol35, 3061.pdf

Abstract: The Arg399Gln polymorphism, located in the region of the BRCT-I interaction domain of XRCC1, has been extensively explored in its function and association with glioma risk. However, these studies generated contradictory instead of conclusive results. A meta-analysis was performed to derive a more precise evaluation of the relationship between XRCC1 Arg399Gln polymorphism and glioma risk. We searched the PubMed, EMBASE, and Web of Science and extracted 12 eligible studies with 4,062 glioma cases and 5,302 glioma-free controls for this meta-analysis. The pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to assess the strength of the association. In the overall analysis, we found that the XRCC1 Arg399Gln polymorphism was statistically associated with the risk of glioma (ORGG vs. AG + AA = 0.90, 95 % CI = 0.84-0.97, P (heterogeneity) = 0.020; ORallele G vs. allele A = 0.96, 95 % CI = 0.91-1.00, P (heterogeneity) = 0.110). We also observed significant association between this polymorphism and glioma risk in Asian populations. The results of the meta-analysis suggest a potential decreased susceptibility to glioma in association with the XRCC1 Arg399Gln polymorphism, especially in Asians. Yet, it is necessary to conduct future prospective explorations to gain a better insight into the impact of XRCC1 Arg399Gln polymorphism on glioma risk.

Keywords: Adults, Ag, Analysis, Arg399gln, Asian, Assessment, Association, China, Confidence, Confidence Intervals, Dna, Embase, Evaluation, Function, Glioma, Heterogeneity, Impact, Interaction, Intervals, Meningioma, Meta Analysis, Meta-Analysis, Metaanalysis, P, Polymorphism, Populations, Potential, Primary Brain-Tumors, Prospective, Pubmed, Region, Repair Gene XRCC1, Risk, Science, Sensitivity, Strength, Web Of Science, XRCC1

? Wang, Y.F., Li, Z.P., Liu, N.B. and Zhang, G. (2014), Association between CCND1 and XPC polymorphisms and bladder cancer risk: A meta-analysis based on 15 case-control studies. Tumor Biology, 35 (4), 3155-3165.

Full Text: 2014\Tum Biol35, 3155.pdf

Abstract: Perturbations in cell cycle and DNA repair genes might affect susceptibility to cancer. The aim of this meta-analysis is to generate large-scale evidence to determine the degree to which common Cyclin D1 (CCND1) G870A (dbSNP: rs603965) and xeroderma pigmentosum group C (XPC) Ala499Val (dbSNP: rs2228000) polymorphisms are associated with susceptibility to bladder cancer. The electronic databases PubMed, Embase, Web of Science, and CNKI were searched for relevant studies (with an upper date limit of July 25, 2013). The principal outcome measure for evaluating the strength of association was crude odds ratios (ORs) along with their corresponding confidence intervals (95 %CIs). We found and reviewed nine case-control studies on CCND1 G870A with a total of 6,823 subjects and seven studies on XPC Ala499Val with a total of 7,674 subjects. Our meta-analysis provides evidence that the variant genotype of CCND1 G870A showed a significant association in the occurrence of invasive bladder tumors in former and current smokers. The XPC Ala499Val polymorphism correlated with significant differences between patients and unaffected subjects, but when the groups were stratified by ethnicity, the magnitude of the overall effect was similar only among Caucasian populations. Results from our meta-analysis support the view that the G870A polymorphism may modulate the risk of bladder cancer in conjunction with tobacco smoking and that the Ala499Val polymorphism may contribute to the susceptibility to bladder cancer in Caucasian populations. Our findings, however, warrant larger well-designed studies to investigate the significance of these two polymorphisms as markers of susceptibility to bladder cancer.

Keywords: Association, Bladder, Bladder Cancer, Cancer, Cancer Risk, Case-Control, Case-Control Studies, Caucasian, Ccnd1, Cell, Cell Cycle, Cell-Cycle, Cigarette-Smoking, Confidence, Confidence Intervals, D1, Damage, Databases, DNA, DNA-Repair Genes, Ethnicity, Evidence, Genes, Groups, Intervals, Invasive, Lung-Cancer, Magnitude, Measure, Meta Analysis, Meta-Analysis, Metaanalysis, Outcome, Outcome Measure, Overexpression, Patients, Polymorphism, Polymorphisms, Populations, Pubmed, Results, Risk, Science, Significance, Smoking, Strength, Support, Susceptibility, Tobacco, Tobacco-Smoke, Urinary-Bladder, Urothelial Carcinoma, Web Of Science, XPC

? Xu, Z.Q., Ma, W.B., Gao, L. and Xing, B. (2014), Association between ERCC1 C8092A and ERCC2 K751Q polymorphisms and risk of adult glioma: A meta-analysis. Tumor Biology, 35 (4), 3211-3221.

Full Text: 2014\Tum Biol35, 3211.pdf

Abstract: While the ERCC1 C8092A and ERCC2 K751Q polymorphisms have received much attention for their potential associations with adult glioma risk, inferences from such studies are hindered by their limited statistical power and conflicting results. The aim of this meta-analysis is to provide a relatively comprehensive account of the association between these two polymorphisms and adult glioma risk. A literature search for eligible studies published before September 1, 2013 was conducted in PubMed, Embase, Web of Science, Cochrane Library, and CNKI databases. Pooled odds ratios (ORs) with their corresponding 95 % confidence intervals (95 % CIs) were used to evaluate the strength of the association under a fixed or random effect model according to heterogeneity test results. All analyses were performed using STATA software, version 12.0. Ten case-control studies were included in this meta-analysis, with a total of 5,843 adult glioma patients and 8,139 healthy controls. For ERCC1 C8092A (dbSNP: rs3212986, C > A), The combined results show that carriers of the AA genotype may be associated with a higher risk of adult glioma than carriers of the CA and CC genotypes. Stratified analyses show that the magnitude of the effect was especially significant among Asians, indicating ethnicity differences in adult glioma susceptibility. For ERCC2 K751Q (dbSNP: rs13181, A > C), The pooled ORs were not significant in the overall population, although all of the ORs were greater than 1. However, Asians seem to be significantly more susceptible to adult glioma than Caucasians. The results of this meta-analysis indicate that the AA genotype of ERCC1 C8092A may be associated with a higher risk of adult glioma than the CA and CC genotypes and that the risk allele of ERCC2 K751Q confers a significant susceptibility to adult glioma, especially in Asian populations. These polymorphisms may be used along with other genetic markers to identify individuals at high risk for adult glioma.

Keywords: Adult, Adult Glioma, Analyses, Asian, Association, Attention, Brain, Cancer Risk, Case-Control, Case-Control Studies, Chinese Population, Confidence, Confidence Intervals, Damage, Databases, Dna-Repair Genes, ERCC1, ERCC2, Ethnicity, Genetic, Genome-Wide Association, Glioblastoma, Glioma, Heterogeneity, Intervals, Literature, Literature Search, Magnitude, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Patients, Polymorphisms, Population, Populations, Potential, Power, Pubmed, Radiation, Risk, Science, Software, Statistical Power, Strength, Susceptibility, Version, Web Of Science

? Shan, J.L., Dai, N., Yang, X.Q., Qian, C.Y., Yang, Z.Z., Jin, F., Li, M.X. and Wang, D. (2014), FokI polymorphism in vitamin D receptor gene and risk of breast cancer among Caucasian women. Tumor Biology, 35 (4), 3503-3508.

Full Text: 2014\Tum Biol35, 3503.pdf

Abstract: Vitamin D plays a central role in cellular proliferation, apoptosis induction, and tumor growth suppression. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. A series of epidemiological studies have examined the association between the VDR FokI polymorphism and breast cancer risk, but the findings remain inconclusive. Fifteen eligible case-control studies involving 15,681 cancer cases and 20,632 control subjects were identified through searching PubMed, Embase, and Web of Science. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the association. Heterogeneity across studies was examined with the chi-square-based Q test and the I (2) index. Begg’s and Egger’s test were also performed to determine publication bias. All statistical data were analyzed by STATA software. The combined estimates did not show significant risks correlated with the FokI polymorphism. However, we found an increased risk in the subgroup analysis by source of control (OR = 1.11, 95 % CI = 1.01-1.22; heterogeneity test: P = 0.116, I (2) = 0.0 % for ff vs FF; OR = 1.10, 95 % CI = 1.01-1.21; heterogeneity test: P = 0.832, I (2) = 0.0 % for ff vs Ff + FF). This meta-analysis suggests that the presence of FokI polymorphism may contribute to the risk of breast cancer in Caucasians.

Keywords: 1,25-Dihydroxyvitamin-D, Analogs, Analysis, Apoptosis, Association, Bias, Breast Cancer, Cancer, Cancer Risk, Case-Control, Case-Control Studies, Caucasian, Confidence, Confidence Intervals, Control, D-3, Data, Effects, Estimates, Exposure, Foki, Gene, Growth, Haplotypes, Heterogeneity, Index, Induction, Intervals, Meta Analysis, Meta-Analysis, Metaanalysis, P, Polymorphism, Population, Proliferation, Publication, Publication Bias, Pubmed, Risk, Risks, Role, Science, Software, Source, Tumor, Variants, VDR, Vitamin, Vitamin D, Web Of Science, Women

? Liu, Y.Q., Tang, W.Z., Zhai, L.M., Yang, S., Wu, J.R., Xie, L., Wang, J., Deng, Y., Qin, X. and Li, S. (2014), Meta-analysis: Eating frequency and risk of colorectal cancer. Tumor Biology, 35 (4), 3617-3625.

Full Text: 2014\Tum Biol35, 3617.pdf

Abstract: Eating frequency has been implicated in the risk of colorectal cancer (CRC) in several epidemiological studies with contradictory and inconclusive findings. We performed a meta-analysis to evaluate their relationship. The pooled relative risk (RR) with 95 % confidence interval (CI) was calculated to estimate the effects. A total of 15 eligible studies with 141,431 subjects and 11,248 cases were retrieved after a comprehensive search of the PubMed, Cochrane Library, and Web of Science databases up to October 2013. The overall meta-analysis revealed no strong significant association between eating frequency and risk of CRC in different eating occasion categories (1 meal/day): RR = 1.01, 95 % CI 0.94-1.09, P = 0.709; 3 vs. < 3 daily meals: RR = 1.17, 95 % CI 0.93-1.46; 4 vs. < 3 daily meals: RR = 1.13, 95 % CI 0.92-1.38; a parts per thousand yen5 vs. < 3 daily meals: RR = 0.95, 95 % CI 0.61-1.47; 4 vs. a parts per thousand currency sign3 daily meals: RR = 1.18, 95 % CI 0.92-1.51; and 1-2 vs. 3 or 4 daily meals: RR = 0.82, 95 % CI 0.63-1.06). However, modest evidence of an increased risk of CRC in case-control studies (RR = 1.30; 95 % CI, 1.11-1.52) and a parts per thousand yen5 vs. a parts per thousand currency sign3 meals group (RR = 1.30; 95 % CI, 1.11-1.52) was observed. Our meta-analysis results do not support the hypothesis that eating frequency strongly reduced or increased the risk of CRC. Clinical randomized trials are required to evaluate this relationship further.

Keywords: Association, Bias, Cancer, Case-Control, Case-Control Studies, Coffee Intake, Colon-Cancer, Colorectal Cancer, Confidence, Databases, Diet, Eating, Eating Frequency, Effects, Evidence, Heterogeneity, Interval, Meal Frequency, Meta Analysis, Meta-Analysis, Metaanalysis, P, Patterns, Pubmed, Randomized, Relative Risk, Risk, Risk Factor, Science, Support, Web Of Science, Web Of Science Databases

? Wu, J.X., Wu, X., Liang, W.H., Chen, C.L., Zheng, L.L. and An, H.X. (2014), Clinicopathological and prognostic significance of chemokine receptor CXCR4 overexpression in patients with esophageal cancer: A meta-analysis. Tumor Biology,