Personal Research Database Bibliometric

Full Text: 2014\Tum Biol35, 5267.pdf

Abstract: Glutathione S-transferases (GSTs) are ubiquitous, multifunctional phase II metabolic enzymes responsible for the detoxification of estrogen involved in the development of ovarian cancer. Data from epidemiological studies show conflicting results that remain to be further clarified. We estimated in this study the genetic effects of GSTM1 and GSTT1 polymorphisms on ovarian cancer risk. Eligible studies of the two polymorphisms and ovarian cancer risk were identified from China National Knowledge Infrastructure (CNKI), PubMed, Embase, and Web of Science. We summarized all data and performed a meta-analysis. Odds ratio (OR) and 95 % CI was calculated by using the fixed effects model to estimate the associations. Eight eligible studies were finally identified providing 2,397 cases and 2,910 controls for GSTM1 polymorphism and 2,049 cases and 2,668 controls for GSTT1 polymorphism. The overall data showed that carries of the GSTM1 null genotype did not have significantly increased ovarian cancer risk compared with those who carried the GSTM1 present genotype (null vs. present-OR, 1.01; 95 % CI, 0.91-1.11; heterogeneity, P = 0.672). Similarly, for GSTT1 polymorphism, we observed no association under the investigated model in the overall analysis (null vs. present-OR, 1.02; 95 % CI, 0.89-1.17; heterogeneity, P = 0.372), and in the subgroup of Caucasian subjects (null vs. present-OR, 0.99; 95 % CI, 0.86-1.14; heterogeneity, P = 0.959). The meta-analysis does not provide a strong evidence for causal associations between GSTM1 and GSTT1 polymorphisms and risk of ovarian cancer in Caucasians.

Keywords: Analysis, Association, Cancer, Cancer Risk, Caucasian, China, Data, Detoxification, Development, Effects, Enzymes, Estrogen, Evidence, Fixed Effects Model, Gene, Genetic, Genotypes, Glutathione, GSTM1, GSTT1, Heterogeneity, Knowledge, Loci, M1, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Mu, Multifunctional, Ovarian Cancer, P, Phase Ii, Polymorphism, Polymorphisms, Pubmed, Risk, Science, Susceptibility, T1, Web Of Science

? Chang, D.F., Xu, Z.Q. and Sun, B. (2014), Relationship between VEGF protein expression and lymph node metastasis in papillary thyroid carcinoma among Asians: A meta-analysis. Tumor Biology, 35 (6), 5511-5518.

Full Text: 2014\Tum Biol35, 5511.pdf

Abstract: We carried out the current meta-analysis of relevant cohort studies in an attempt to investigate the relationships between vascular endothelial growth factor (VEGF) protein expression and lymph node (LN) metastasis in papillary thyroid carcinoma (PTC) among Asians. A range of electronic databases were searched, including Web of Science (1945 similar to 2013), The Cochrane Library Database (Issue 12, 2013), MEDLINE (1966 similar to 2013), EMBASE (1980 similar to 2013), CINAHL (1982 similar to 2013), and Chinese Biomedical Database (CBM) (1982 similar to 2013) with cross-referencing without language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Crude odds ratio (OR) with their 95 % confidence interval (95 %CI) was calculated. Twelve clinical cohort studies with a total of 1,045 PTC patients were included in our meta-analysis, The results of our meta-analysis revealed that patients with VEGF-positive tumors had a 3.02-fold higher risk of LN metastasis than that of patients with VEGF-negative tumors (OR = 3.02, 95 %CI = 2.05 similar to 4.43, P < 0.001). Furthermore, subgroup analysis by country suggested that VEGF-positive expression was associated with an increased risk of LN metastasis in PTC patients among Chinese populations (OR = 3.33, 95 %CI = 2.30 similar to 4.83, P < 0.001), but not among Korean, Turkish, and Japanese populations (all P > 0.05). Our findings support the view that VEGF protein expression may be correlated with LN metastasis in PTC patients, especially among Chinese populations.

Keywords: Analysis, Asians, Biomedical, Cancer, Carcinoma, Chinese, Clinical, Cohort, Confidence, Country, Database, Databases, Disease, Embase, Endothelial Growth-Factor, Expression, Factor-C, Family, Growth, Growth Factor, Inhibitor, Interval, Language, Lymph Node Metastasis, Medline, Meta Analysis, Meta-Analysis, Metaanalysis, Metastasis, Odds Ratio, P, Papillary Thyroid Carcinoma, Patients, Populations, Protein, Restrictions, Risk, Science, Software, Support, Tissues, Tumor Angiogenesis, Vascular Endothelial Growth Factor, Vegf, Web Of Science

? Liang, Y.J., Deng, J., Xiong, Y., Wang, S.P. and Xiong, W. (2014), Genetic association between ERCC5 rs17655 polymorphism and lung cancer risk: Evidence based on a meta-analysis. Tumor Biology, 35 (6), 5613-5618.

Full Text: 2014\Tum Biol35, 5613.pdf

Abstract: The relationship between excision repair cross-complementing group 5 (ERCC5) rs17655 polymorphism and lung cancer risk remains controversial. To clarify the association, we conducted a comprehensive meta-analysis of all published case-control studies. PubMed, Web of Science, and CNKI were searched to identify the possibly eligible publications. Pooled odds ratio (OR) was estimated using the fixed effect model. Q test and I (2) index were used to evaluate heterogeneity between studies, and Egger’s and Begg’s tests were utilized to assess publication bias. Meta-analysis of nine case-control studies including 4,044 cases and 5,100 controls indicated that there was no global association between rs17655 polymorphism and lung cancer risk. Subgroup analyses according to ethnicity and histologic type revealed similar results. In summary, our meta-analysis suggests that ERCC5 rs17655 polymorphism may not contribute to genetic susceptibility for lung cancer.

Keywords: Analyses, Association, Bias, Cancer, Cancer Risk, Case-Control, Case-Control Studies, Dna-Repair, Ercc5, Ethnicity, Evidence, Evidence Based, Evidence-Based, Expression, Genetic, Global, Head, Heterogeneity, Index, Lung, Lung Cancer, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Neck, Nucleotide Excision-Repair, Odds Ratio, Pathways, Polymorphism, Publication, Publication Bias, Publications, Pubmed, Risk, Rs17655 Polymorphism, Science, Smoking, Squamous-Cell Carcinoma, Web Of Science, XPG Gene, XRCC1

? Zhang, X., Jiang, L.P., Yin, Y. and Wang, Y.D. (2014), XRCC1 and XPD genetic polymorphisms and clinical outcomes of gastric cancer patients treated with oxaliplatin-based chemotherapy: A meta-analysis. Tumor Biology, 35 (6), 5637-5645.

Full Text: 2014\Tum Biol35, 5637.pdf

Abstract: This meta-analysis aimed to obtain a comprehensive and reliable assessment of the relationships between XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms and the clinical outcomes of gastric cancer (GC) patients treated with oxaliplatin-based chemotherapy. The PubMed, CINAHL, Web of Science, CISCOM, EBSCO, Google Scholar, Cochrane Library, and CBM databases were searched for relevant articles published before September 1, 2013 without language restrictions. Crude odd ratios (ORs) or hazard risk (HR) [95 % confidence intervals (CI)] were calculated. Twelve clinical cohort studies were assessed with a total 1,024 GC patients treated with oxaliplatin-based chemotherapy. Our meta-analysis findings revealed that GC patients with the GA + AA (A carrier) genotypes of XRCC1 Arg399Gln showed a lower effective clinical response (CR + PR) than those with the GG (A non-carrier) genotype (OR = 0.41, 95 % CI 0.20 similar to 0.82, P = 0.012). However, there was no statistically significant difference in effective clinical response between those with XPD AC + CC (C carrier) genotypes and CC (C non-carrier) genotype (OR = 0.55, 95 % CI 0.28 similar to 1.07, P = 0.076). Furthermore, the GA + AA genotypes of XRCC1 Arg399Gln was associated with a worse progression-free survival (PFS) and overall survival (OS) compared with the CC genotype (PFS, HR = 1.90, 95 % CI 1.12 similar to 2.69, P < 0.001; OS, HR = 2.13, 95 % CI 0.79 similar to 3.47, P = 0.002, respectively). No relationships were found between XPD Lys751Gln polymorphism and both PFS and OS (all P > 0.05). No publication bias was detected in this meta-analysis. Results from the current meta-analysis indicate that XRCC1 Arg399Gln polymorphism may be associated with poor clinical outcomes in GC patients treated with oxaliplatin-based chemotherapy.

Keywords: 1st-Line Therapy, Adjuvant Chemotherapy, Arg399gln, Articles, Assessment, Bias, Cancer, Capecitabine, Chemotherapy, Chinese Population, Clinical, Clinical Outcomes, Cohort, Confidence, Confidence Intervals, Cr, Databases, Dna-Repair Genes, Docetaxel, Ercc1, Expression, Gastric, Gastric Cancer, Genetic, Genetic Polymorphisms, Google, Google Scholar, Hazard, Heterogeneity, Intervals, Language, Meta Analysis, Meta-Analysis, Metaanalysis, Outcomes, P, Patients, Phase-Iii, Polymorphism, Polymorphisms, Pr, Publication, Publication Bias, Pubmed, Response, Restrictions, Results, Risk, Science, Survival, Web Of Science, Xpd, Xrcc1

? Zou, L.Y., Yang, L., He, X.L., Sun, M. and Xu, J.J. (2014), Effects of aerobic exercise on cancer-related fatigue in breast cancer patients receiving chemotherapy: A meta-analysis. Tumor Biology, 35 (6), 5659-5667.

Full Text: 2014\Tum Biol35, 5659.pdf

Abstract: Increasing scientific evidences suggest that aerobic exercise may improve cancer-related fatigue in breast cancer patients, but many existing studies have yielded inconclusive results. This meta-analysis aimed to derive a more precise estimation of the effects of aerobic exercise on cancer-related fatigue in breast cancer patients receiving chemotherapy. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched from inception through July 1, 2013 without language restrictions. Crude standardized mean difference (SMD) with 95 % confidence interval (CI) was calculated. Twelve comparative studies were assessed with a total of 1,014 breast cancer patients receiving chemotherapy, including 522 patients in the aerobic exercise group (intervention group) and 492 patients in the usual care group (control group). The meta-analysis results revealed that the Revised Piper Fatigue Scale (RPFS) scores of breast cancer patients in the intervention group were significantly lower than those in the control group (SMD = -0.82, 95% CI = -1.04 aEuro parts per thousand a’0.60, P < 0.001). However, there was no significant difference in the Functional Assessment of Chronic Illness Treatment-Fatigue scale (FACIT-F) scores between the intervention and control groups (SMD = 0.09, 95% CI = -0.07 aEuro parts per thousand 0.25, P = 0.224). Subgroup analysis by ethnicity indicated that there were significant differences in RPFS and FACIT-F scores between the intervention and control groups among Asian populations (RPFS: SMD = -1.08, 95% CI = -1.35 aEuro parts per thousand a’0.82, P < 0.001; FACIT-F: SMD = 1.20, 95 % CI = 0.70 aEuro parts per thousand 1.71, P < 0.001), but not among Caucasian populations (all P > 0.05). The current meta-analysis indicates that aerobic exercise may improve cancer-related fatigue in breast cancer patients receiving chemotherapy, especially among Asian populations.

Keywords: Adjuvant Chemotherapy, Aerobic Exercise, Analysis, Asian, Assessment, Breast Cancer, Cancer, Cancer-Related Fatigue, Care, Caucasian, Chemotherapy, Confidence, Control, Control Groups, Databases, Effects, Ethnicity, Exercise, Fatigue, Google, Google Scholar, Groups, Interval, Intervention, Language, Management, Meta Analysis, Meta-Analysis, Metaanalysis, P, Patients, Physical-Activity, Populations, Practice Guidelines, Pubmed, Quality-Of-Life, Radiotherapy, Randomized Controlled-Trial, Restrictions, Rpf, Scale, Science, Survivors, Therapy, Web Of Science, Women

? Li, F.F., Yang, Y., Wang, X.L., Hong, Y.Y., Wang, N.F. and Chen, Z.D. (2014), Promoter methylation of DAPK gene may contribute to the pathogenesis of nonsmall cell lung cancer: A meta-analysis. Tumor Biology, 35 (6), 6011-6020.

Full Text: 2014\Tum Biol35, 6011.pdf

Abstract: We performed a meta-analysis of cohort studies to determine whether promoter methylation of the death-associated protein kinase (DAPK) gene contributes to the pathogenesis of nonsmall cell lung cancer (NSCLC). A range of electronic databases were searched: MEDLINE (1966 similar to aEuro parts per thousand 2013), The Cochrane Library Database (Issue 12, 2013), EMBASE (1980 similar to aEuro parts per thousand 2013), CINAHL (1982 similar to aEuro parts per thousand 2013), Web of Science (1945 similar to aEuro parts per thousand 2013), and the Chinese Biomedical Database (CBM; 1982 similar to aEuro parts per thousand 2013) without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Crude odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated. Our meta-analysis integrated results from 12 clinical cohort studies that met all inclusion criteria with a total of 1,027 NSCLC patients. We observed that the frequency of DAPK gene methylation in cancer tissues were significantly higher than that in the adjacent normal and benign tissues (cancer tissues vs. benign tissues: OR = 8.50, 95 % CI = 5.88 similar to aEuro parts per thousand 12.28, P < 0.001; cancer tissues vs. adjacent tissues: OR = 5.95, 95 % CI = 4.11 similar to aEuro parts per thousand 8.60, P < 0.001; cancer tissues vs. normal tissues: OR = 4.75, 95 % CI = 3.28 similar to aEuro parts per thousand 6.87, P < 0.001; respectively). Subgroup analysis by ethnicity demonstrated that DAPK gene methylation was closely associated with the development and progression of NSCLC among both Asians and Caucasians (all P < 0.05). Furthermore, we conducted a subgroup analysis based on sample source and discovered that DAPK gene methylation was implicated in the pathogenesis of NSCLC in both blood and tissue subgroups (all P < 0.05). Our results suggest that DAPK promoter methylation may be involved in NSCLC carcinogenesis. Thus, the detection of aberrant DAPK methylation may be helpful in the diagnosis and prognosis of NSCLC.

Keywords: Analysis, Apoptosis, Asians, Beta, Biomedical, Blood, Cancer, Cell, Chinese, Clinical, Cohort, Confidence, Criteria, Dapk, Database, Databases, Death, Development, Diagnosis, Dna Methylation, Embase, Ethnicity, Expression, Gene, Hypermethylation, Interval, Language, Lung, Lung Cancer, Medline, Meta Analysis, Meta-Analysis, Metaanalysis, Methylation, Nonsmall Cell Lung Cancer, Normal, Nsclc, Odds Ratio, P, Pathogenesis, Patients, Prognosis, Progression, Promoter Methylation, Protein, Protein-Kinase Dapk, Restrictions, Science, Software, Source, Tumor, Web Of Science

? Wu, H.Y. and Zhu, R. (2014), Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk. Tumor Biology, 35 (6), 6055-6063.

Full Text: 2014\Tum Biol35, 6055.pdf

Abstract: Several genome-wide association studies on lung cancer (LC) have reported similar findings of a new susceptibility locus, 5p15. After that, a number of studies reported that the rs2736100, rs401681, rs402710, and rs31489 polymorphisms at chromosome 5p15 have been implicated in LC risk. However, the studies have yielded contradictory results. To derive a more precise estimation of the relationship, we performed this meta-analysis. Databases including MEDLINE, PubMed, EMBASE, ISI Web of Science, and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of association. The random effect model was applied, addressing heterogeneity and publication bias. A total of 31 articles involving 72,401 cases and 141,258 controls were included. Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis. In the subgroup analysis by ethnicity, sample size, histology, sex, and smoking behavior, significantly increased risks were also detected for these polymorphisms. Our findings demonstrated that these common variations at 5p15 are a risk factor associated with increased LC susceptibility. However, these associations vary between different ethnicity.

Keywords: 5p15.33, Adenocarcinoma, Analysis, Articles, Assessment, Association, Behavior, Bias, Cancer, Cancer Risk, China, Chinese Population, Confidence, Confidence Intervals, Databases, Embase, Ethnicity, Family-History, Genetic, Genetic Variants, Genome-Wide Association, Heterogeneity, Histology, Identifies 2, Intervals, Isi, Isi Web Of Science, Japanese Population, Knowledge, Korean Population, Lung, Lung Cancer, Medline, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Polymorphism, Polymorphisms, Publication, Publication Bias, Pubmed, Quantitative Assessment, Risk, Risk Factor, Risks, Sample Size, Science, Sex, Size, Smoking, Strength, Susceptibility Loci, Tert-Clptm1l Locus, Web Of Science

? Meng, F.D., Ma, P., Sui, C.G., Tian, X., Li, Y., Fu, L.Y., Jiang, T., Wang, Y. and Jiang, Y.H. (2014), The association between VDR polymorphisms and renal cell carcinoma susceptibility: A meta-analysis. Tumor Biology, 35 (6), 6065-6072.

Full Text: 2014\Tum Biol35, 6065.pdf

Abstract: Vitamin D receptor (VDR) gene polymorphisms have previously been associated with susceptibility to renal cell carcinoma, although the findings are inconsistent. This study therefore evaluated the association of three single nucleotide polymorphisms (SNPs) in VDR (FokI, BsmI, and TaqI) with the risk of renal cell carcinoma in five previous studies of a total of 1,510 cases and 2,101 controls identified from PubMed, Web of Science, Embase, and Wanfang databases. Pooled odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were calculated, and stratified analysis by ethnicity was conducted for further estimation. All statistical analyses were conducted using STATA software. Obvious heterogeneity was noted among the five studies. The VDR BsmI polymorphism was not found to be associated with renal cell carcinoma risk, although subgroup analysis revealed a significant association with renal cell carcinoma risk in Asians (b vs B OR = 1.479, 95 % CI = 1.171-1.869, P (OR) = 0.001 and bb vs BB OR = 2.608, 95 % CI = 1.529-4.449, P (OR) = 0.001). No significant association was found between renal cell carcinoma risk and either FokI or TaqI polymorphisms in different models and populations. Further large-scale studies are required to confirm these conclusions.

Keywords: Analyses, Analysis, Asians, Association, Bias, Cancer-Risk, Carcinoma, Cell, Confidence, Confidence Intervals, D-Receptor Gene, Databases, Disease, Ethnicity, Foki, Gene, Graphical Test, Heterogeneity, Intervals, Japanese, Meta Analysis, Meta-Analysis, Metaanalysis, Models, P, Polymorphism, Polymorphisms, Population, Populations, Pubmed, Renal, Renal Cell Carcinoma, Risk, Science, Software, Statistical Analyses, Taqi, Vdr, Vitamin D, Vitamin D Receptor, Vitamin-D, Web Of Science, Women

? Yang, J.H. and Jiao, S.C. (2014), Increased lung cancer risk associated with the TERT rs2736100 polymorphism: An updated meta-analysis. Tumor Biology, 35 (6), 5763-5769.

Full Text: 2014\Tum Biol35, 5763.pdf

Abstract: The rs2736100 polymorphism in the telomerase reverse transcriptase (TERT) gene has been implicated in lung cancer risk in multiple populations, but the existing evidence lacks statistical power to draw a convincing conclusion. Therefore, the present study was devised to derive a more precise estimation of the association between rs2736100 and lung cancer risk. The PubMed, Embase, and Web of Science databases were comprehensively searched for papers concerning lung cancer risk in relation to rs2736100. Pooled odds ratios (ORs) and the 95 % confidence intervals (CIs) were appropriately calculated using the fixed or random effects model. Meta-analysis of 20 independent studies involving 39,715 cancer cases and 61,462 control subjects showed statistical evidence for an association between rs2736100 and increased risk of lung cancer. Subgroup analysis by ethnicity demonstrated a significant association among both Asian and Caucasian populations. We additionally found an increased risk of non-small cell lung cancer and lung adenocarcinoma strongly associated with rs2736100. These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.

Keywords: 5p15.33 Tert-Clptm1l, Adenocarcinoma, Analysis, Asian, Association, Cancer, Cancer Risk, Caucasian, Cell, Chinese Population, Confidence, Confidence Intervals, Control, Data, Databases, Development, Effects, Ethnicity, Evidence, Gene, Genetic, Genetic-Variants, Genome-Wide Association, Identifies 2, Intervals, Japanese Population, Korean Population, Lung, Lung Cancer, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Papers, Polymorphism, Populations, Power, Pubmed, Random Effects Model, Risk, Role, Science, Statistical Power, Susceptibility Loci, Telomerase Reverse Transcriptase, Telomere Length, Web Of Science, Web Of Science Databases

? Wang, C., Yu, C., Yang, F. and Yang, G. (2014), Diagnostic accuracy of contrast-enhanced ultrasound for renal cell carcinoma: A meta-analysis. Tumor Biology, 35 (7), 6343-6350.

Full Text: 2014\Tum Biol35, 6343.pdf

Abstract: This meta-analysis aimed to identify the accuracy of contrast-enhanced ultrasonography (CEUS) for the diagnosis of renal cell carcinoma (RCC). We searched PubMed, Web of Science, Google Scholar, Cochrane Library, CISCOM, CINAHL, EBSCO, and CBM databases from inception through August 1, 2013 without language restrictions. Meta-analysis was conducted using STATA version 12.0 and Meta-Disc version 1.4 softwares. We calculated the summary statistics for sensitivity (Sen), specificity (Spe), positive and negative likelihood ratio (LR+/LR-), diagnostic odds ratio (DOR), and receiver operating characteristic (SROC) curve. Eleven studies that met all inclusion criteria were included in this meta-analysis. A total of 567 RCC patients and 313 patients with benign renal tumors were assessed. All renal lesions were histologically confirmed after CEUS. The pooled Sen was 0.88 (95 %CI = 0.85 similar to aEuro parts per thousand 0.90); the pooled Spe was 0.80 (95 %CI = 0.75 similar to aEuro parts per thousand 0.85). The pooled LR+ was 4.30 (95 %CI = 2.65 similar to aEuro parts per thousand 6.99); the pooled negative LR- was 0.11 (95 %CI = 0.05 similar to aEuro parts per thousand 0.22). The pooled DOR of CEUS in the diagnosis of RCC was 46.97 (95 % CI = 16.72 similar to aEuro parts per thousand 131.97). The area under the SROC curve was 0.922 (standard error [SE] = 0.039). We found no evidence for publication bias (t = -1.00, P = 0.342). Our meta-analysis indicates that CEUS may have high diagnostic accuracy in differential diagnosis between benign and malignant renal tumors. Thus, CEUS may be a good tool for the diagnosis of RCC.

Keywords: Accuracy, Bias, Carcinoma, Cell, Criteria, Databases, Diagnosis, Diagnostic, Diagnostic Accuracy, Differential Diagnosis, Error, Evidence, Google, Google Scholar, Language, Likelihood Ratio, Meta Analysis, Meta-Analysis, Metaanalysis, Odds Ratio, P, Patients, Publication, Publication Bias, Pubmed, Renal, Restrictions, Science, Sensitivity, Specificity, Standard, Statistics, T, Ultrasonography, Ultrasound, Version, Web Of Science

? Xiao, W.Z., Han, D.H., Wang, F., Wang, Y.Q., Zhu, Y.H., Wu, Y.F., Liu, N.T. and Sun, J.Y. (2014), Relationships between PTEN gene mutations and prognosis in glioma: A meta-analysis. Tumor Biology, 35 (7), 6687-6693.

Full Text: 2014\Tum Biol35, 6687.pdf

Abstract: We conducted a meta-analysis in order to investigate the relationships between PTEN gene mutations and the prognosis in glioma. The following electronic databases were searched for relevant articles without any language restrictions: Web of Science (1945 similar to 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 similar to 2013), EMBASE (1980 similar to 2013), CINAHL (1982 similar to 2013), and the Chinese Biomedical Database (CBM) (1982 similar to 2013). Meta-analyses were conducted using the STATA software (Version 12.0, Stata Corporation, College Station, Texas USA). Hazard ratio (HR) with its corresponding 95 % confidence interval (95%CI) was calculated. Six independent cohort studies with a total of 357 glioma patients met our inclusion criteria. Our meta-analysis results indicated that glioma patients with PTEN gene mutations exhibited a significantly shorter overall survival (OS) than those without PTEN gene mutations (HR = 3.66, 95%CI = 2.02 similar to 5.30, P < 0.001). Ethnicity-stratified subgroup analysis demonstrated that PTEN gene mutations were closely linked to poor prognosis in glioma among Americans (HR = 3.72, 95%CI = 1.72 similar to 5.73, P < 0.001), while similar correlations were not observed among populations in Sweden, Italy, and Malaysia (all P > 0.05). Our meta-analysis provides direct and strong evidences for the speculation of PTEN gene mutations’ correlation with poor prognosis of glioma patients.

Keywords: Analysis, Articles, Biomedical, Chinese, Cohort, Confidence, Correlation, Correlations, Criteria, Database, Databases, Embase, Gene, Glioma, Interval, Italy, Language, Malaysia, Meta Analysis, Meta-Analyses, Meta-Analysis, Metaanalysis, Mutations, P, Patients, Populations, Prognosis, Pten, Pubmed, Restrictions, Science, Software, Stata, Survival, Sweden, Texas, Usa, Web Of Science

? Li, Y.W., Kong, F.M., Zhou, J.P. and Dong, M. (2014), Aberrant promoter methylation of the vimentin gene may contribute to colorectal carcinogenesis: A meta-analysis. Tumor Biology,