Title: Virchows Archiv fur Pathologische Anatomie und Physiologie und fur Klinische Medizin

Title: Virchows Archiv fur Pathologische Anatomie und Physiologie und fur Klinische Medizin

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? Boecker, E. (1910), Information on primary lung cancer. Virchows Archiv fur Pathologische Anatomie und Physiologie und fur Klinische Medizin, 202 (1), 38-56.

Full Text: -1959\Vir Arc Pat Ana Phy Kli Med202, 38.pdf

Title: Virology Journal

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? Chen, E.Q., Wang, L.C., Lei, J., Xu, L. and Tang, H. (2009), Meta-analysis: Adefovir dipivoxil in combination with lamivudine in patients with lamivudine-resistant hepatitis B virus. Virology Journal, 6, Article Number: 163.

Full Text: 2009\Vir J6, 163.pdf

Abstract: Background: Currently, there are no conclusive results on the efficacy of adefovir dipivoxil (ADV) plus lamivudine (LAM) in LAM-resistant patients with chronic hepatitis B (CHB). The aim of study was to evaluate the efficacy of rescue therapy with ADV plus LAM compared to ADV monotherapy in LAM-resistant CHB patients. Results: We searched PUBMED, EMBASE, Web of Science, CNKI (National Knowledge Infrastructure), VIP database, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews. Six eligible trials (442 patients in total) were included and evaluated for methodologic quality and heterogeneity. Greater virological response and lower emergence rate of ADV-associated mutants was observed in ADV plus LAM compared to ADV monotherapy (both P < 0.05). On the contrary, the rate of ALT normalization, HBeAg clearance and seroconversion were all similar between ADV plus LAM and ADV (all P > 0.05). Additionally, adding-on or switch-to ADV was both well tolerated. Conclusion: The combination of ADV with LAM was superior in inhibiting HBV replication and preventing drug resistance as compared to ADV alone for LAM-resistant CHB patients.

Keywords: Cochrane, Database, Drug, Drug Resistance, Efficacy, Embase, Failure, HBV, Knowledge, Meta Analysis, Meta-Analysis, Monotherapy, Mutants, Patients, Recommendations, Resistance, Science, Systematic, Therapy, Web of Science

? Zhao, S.S., Tang, L.H., Fan, X.G., Chen, L.Z., Zhou, R.R. and Dai, X.H. (2010), Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: A systematic review. Virology Journal, 7, Article Number: 211.

Full Text: 2010\Vir J7, 211.pdf

Abstract: Background: Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as lamivudine and telbivudine, are recommended for treatment of patients with chronic hepatitis B. However, there are no conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (LdT) in the treatment of chronic hepatitis B. Results: To evaluate the comparison of the efficacy of LAM and LdT in the treatment of chronic hepatitis B by a systematic review and meta-analysis of clinical trials, we searched PUBMED (from 1990 to April 2010), Web of Science (from 1990 to April 2010), EMBASE (from 1990 to April 2010), CNKI (National Knowledge Infrastructure) (from 1990 to April 2010), VIP database (from 1990 to April 2010), WANFANG database (from 1990 to April 2010), the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Review. At the end of one-year treatment, LdT was better than LAM at the biochemical response, virological response, HBeAg loss, therapeutic response, while less than at the viral breakthrough and viral resistance, but there was no significant difference in the HBeAg seroconversion and HBsAg response. LdT was better than LAM at the HBeAg seroconversion with prolonged treatment to two years. Conclusions: In summary, LdT was superior in inhibiting HBV replication and preventing drug resistance as compared to LAM for CHB patients. But LdT may cause more nonspecific adverse events and can lead to more CK elevation than LAM. It is thus recommended that the LdT could be used as an option for patients but adverse events, for example CK elevation, must be monitored.

Keywords: Adverse Events, Bias, Chinese Patients, Clinical Trials, Clinical-Trials, Cochrane, Database, Drug, Drug Resistance, Drugs, Efficacy, Embase, HBV, Knowledge, Lead, Meta Analysis, Meta-Analysis, Patients, Prevention, Public Health, Quality, Resistance, Review, Science, Systematic, Systematic Review, Treatment, Virus, Web of Science

? Zhao, S.S., Tang, L.H., Dai, X.H., Wang, W., Zhou, R.R., Chen, L.Z. and Fan, X.G. (2011), Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: A systematic review. Virology Journal, 8, Article Number: 111.

Full Text: 2011\Vir J8, 111.pdf

Abstract: Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as tenofovir and adefovir, are recommended for treatment of patients with chronic hepatitis B. tenofovir is a nucleoside analog with selective activity against hepatitis b virus and has been shown to be more potent in vitro than adefovir. But the results of trials comparing tenofovir and adefovir in the treatment of chronic hepatitis B were inconsistent. However, there was no systematic review on the comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B. To evaluate the comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B we conducted a systematic review and meta-analysis of clinical trials. We searched PUBMED, Web of Science, EMBASE, CNKI, VIP database, WANFANG database, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Review. Finally six studies were left for analysis which involved 910 patients in total, of whom 576 were included in tenofovir groups and 334 were included in adefovir groups. At the end of 48-week treatment, tenofovir was superior to adefovir at the HBV-DNA suppression in patients[RR = 2.59; 95%CI(1.01-6.67), P = 0.05]. While there was no significant difference in the ALT normalization[RR = 1.15; 95%CI(0.96-1.37), P = 0.14], HBeAg seroconversion[RR = 1.32; 95%CI(1.00-1.75), P = 0.05] and HBsAg loss rate[RR = 1.19; 95%CI(0.74-1.91), P = 0.48]. More high-quality, well-designed, randomized controlled, multi-center trails are clearly needed to guide evolving standards of care for chronic hepatitis B.

Keywords: Analysis, Clinical Trials, Clinical-Trials, Cochrane, Database, Dipivoxil, Disoproxil-Fumarate, Drugs, Efficacy, Embase, HIV, Interferon, Lamivudine, Meta Analysis, Meta-Analysis, Metaanalysis, Patients, Public Health, Quality, Review, Science, Standards, Systematic, Systematic Review, Telbivudine, Treatment, Virus Infection, Web of Science