Most of the band intensities were quantified by eye, confirmed by a second investigator, and expressed as a single digit numeric. A part of the bands were quantified using PhosphorImager System (Molecular Dynamics). The integrated density of each band above background was calculated as a “volume” by the PhosphorImager System, as described in Figure 1. A least-square linear regression model of the logarithm of the “volume” () in terms of the visually quantified band intensity () gives , with Pearson correlation