Table S5. Carbohydrate metabolism
A. Galactitol
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
HIT like protein (flanking gene same strand)
|
HS_1134
|
HD1023
|
HI0961
|
pflB(flanking gene opp strand)
|
HS_1136
|
HD0990
|
HI0180
|
conserved hypothetical (opp strand)
|
HS_1137
|
no
|
HI1602
|
conserved hypothetical (opp strand)
|
HS_1138
|
no
|
HI1600
|
conserved hypothetical (opp strand)
|
HS_1139
|
no
|
HI1599
|
gatR
|
HS_1140
|
no
|
no
|
gatD
|
HS_1141
|
no
|
no
|
gatC
|
HS_1142
|
no
|
no
|
gatB
|
HS_1143
|
no
|
no
|
gatA
|
HS_1144
|
no
|
no
|
gatZ
|
HS_1145
|
no
|
no
|
lacD (gatY)
|
HS_1146
|
no
|
no
|
pflA (flanking gene opp strand)
|
HS_1147
|
HD0989
|
HI0179
|
conserved hypothetical (flanking gene same strand)
|
HS_1155
|
HD0226
|
HI0019
|
mfd (same strand)
|
HS_1161
|
HD0975
|
HI1258
|
B. Glucitol/sorbitol
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
tyrA (flanking gene, same strand)
|
HS_0671
|
HD0443
|
HI1290
|
purE (flanking gene, opp strand)
|
HS_0672
|
HD1424
|
HI1615
|
srlR/gutR
|
HS_0673
|
HD1863
|
HI1009
|
conserved phosphatase
|
HS_0674
|
HD0176
|
HI0488
|
gutM
|
HS_0675
|
no
|
no
|
srlD/gutD
|
HS_0676
|
HD0708
|
HI0155
|
srlB/gutB
|
HS_0677
|
no
|
no
|
srlE/gutE
|
HS_0678
|
no
|
no
|
srlA/gutA
|
HS_0679
|
no
|
no
|
visC (flanking gene)
|
HS_0680
|
HD0582
|
no
|
ubiH/visB
|
HS_0681
|
HD0579
|
no
|
pepP
|
HS_0682
|
HD1418
|
HI0816
|
C. Mannose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
ampG
|
HS_0600
|
HD0827
|
HI0350
|
conserved hypothetical
|
HS_0602
|
no
|
no
|
dnaQ (same strand) this is a second copy of dnaQ in 129Pt
|
HS_0603
|
HD0223
|
no
|
ribonuclease H (flanking gene, opp strand)
|
HS_0604
|
no
|
no
|
manA
|
HS_0605
|
HD0765
|
no
|
conserved hypothetical
|
HS_0606
|
no
|
no
|
manZ
|
HS_0607
|
HD0766
|
no
|
manY
|
HS_0608
|
HD0767
|
no
|
manX
|
HS_0609
|
HD0768
|
no
|
conserved hypothetical (flanking gene)
|
HS_0610
|
HD1377
|
HI1168
|
serC (opp strand)
|
HS_0611
|
HD1382
|
HI1167
|
conserved hypothetical protein (same strand)
|
HS_0616
|
HD1854
(55% identity)
|
HI0282
(55% identity)
|
menD
|
HS_0617
|
HD1853
|
HI0283
|
D. Cellobiose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
celA
cellobiose-specific IIB
|
no
|
no
|
no
|
celB
cellobiose-specific IIC
|
HS_0437
|
no
|
no
|
celC
cellobiose-specific IIA
|
no
|
no
|
no
|
celD
|
no
|
no
|
no
|
celF
|
no
|
no
|
no
|
E. Glucose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
crr
glucose-specific IIA component
|
HS_1096
|
HD0227
|
HI1711
|
ptsI
|
HS_1097
|
HD0228
|
HI1712
|
ptsH
|
HS_1098
|
HD0229
|
HI1713
|
ptsG
glucose-specific IICB component
|
no
|
no
|
no
|
phosphotransferase system (PTS) glucose-specific enzyme IICBA component
|
no
|
no
|
no
|
F. Mannitol
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
fbp
(flanking gene, same strand) fructose-1,6-bisphosphatase
|
HS_1248
|
HD0702
|
HI1645
|
mpl
(flanking gene, opp strand)
|
HS_1249
|
HD0703
|
HI0121
|
mtlR
mannitol operon repressor
|
HS_1250
|
no
|
no
|
mtlD
mannitol 1-phosphate 5-dehydrogenase
|
HS_1251
|
no
|
no
|
mtlA
mannitol-specific IIABC component
|
HS_1252
|
no
|
no
|
cons hypo (flanking gene, opp strand)
|
HS_1253
|
no
|
HI0182?
|
valS (flanking gene)
|
HS_1259
|
HD0669
|
HI1391
|
G. Unidentified substrate sugar permease
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
sgaH
hexulose-6-phosphate synthase
|
HS_0771
|
HD1857
|
HI1024
|
PTS system Enzyme II-A permease component
|
no
|
HD1859
|
HI0448?
|
sgaT
carbohydrate transport protein SGAT
|
no
|
HD1860
|
no
|
H. Galactose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
galK galactokinase
|
HS_0235
|
no
|
HI0819
|
galM
aldose 1-epimerase
|
HS_0236
|
no
|
HI0818
|
galU
|
HS_1117
|
HD1431
|
HI0812
|
galE
UDP-galactose 4-epimerase
|
HS_0789
|
HD0829
|
HI0351
|
galT
galactose-1-phosphate uridylyltransferase
|
no
|
no
|
HI0820
|
galR
|
no
|
no
|
HI0821
|
I. Fucose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
gmd
GDP-D-mannose dehydratase
|
no
|
no
|
no
|
fucR
|
HS_1446
|
no
|
HI0615
|
fucP
fucose permease
|
HS_1447
|
no
|
HI0610
|
fucP
fucose permease
|
HS_0750
|
no
|
no
|
fucI
L-fucose isomerase
|
HS_1448
|
no
|
HI0614
|
fucK fucokinase, L-fuculose kinase
|
HS_1449
|
no
|
HI0613
|
fucU
|
HS_1450
|
no
|
HI0612
|
fucA
fucose-1-P aldolase
|
HS_1451
|
no
|
HI0611
|
fucA
fucose-1-P aldolase
|
HS_0014
|
no
|
HI1012
|
L-1,2-propanediol oxidoreductase
|
no
|
no
|
no
|
lactaldehyde dehydrogenase
|
no
|
no
|
no
|
J. Ribose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
rbsD
high affinity ribose transport protein
|
HS_0223
|
no
|
HI0501
|
poss transposase
|
HS_0224
|
no
|
no
|
poss transposase
|
HS_0224a
|
no
|
no
|
rbsK
|
HS_0225
|
no
|
HI0505
|
rbsR
|
HS_0226
|
no
|
HI0506
|
rbsA
ribose ABC transporter, ATP-binding protein
|
HS_0763
|
no
|
HI0502
|
rbsC
ribose ABC transporter, permease
|
HS_0764
|
no
|
HI0503
|
rbsB
ABC-type sugar-binding periplasmic protein
|
HS_0765
|
no
|
HI0504
|
cons hypo poss gluconolactonase precursor
|
HS_0766
|
no
|
no
|
sugar ABC transporter, periplasmic sugar-binding protein
|
HS_0767
opp strand
|
no
|
no
|
rbsA
ribose ABC transporter, ATP-binding protein
|
HS_0768
|
no
|
HI1110
|
rbsC
ribose transport system permease
|
HS_0769
|
no
|
HI0503
|
rbsC
ABC transporter, possible ribose permease
|
HS_1579
|
no
|
HI0503
|
sugar ABC transporter, ATP-binding protein
|
HS_1580
|
no
|
HI0823
|
ABC transporter, periplasmic sugar-binding protein
|
HS_1581
|
no
|
HI0504
|
K. Xylose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
xylH
D-xylose ABC transporter, permease
|
HS_0584
|
no
|
HI1109
|
xylG
D-xylose ABC transporter, ATP-binding protein
|
HS_0585
|
no
|
HI1110
|
xylF
D-xylose ABC transporter, periplasmic sugar-binding protein
|
HS_0586
|
no
|
HI1111
|
xylA
xylose isomerase
|
HS_0587
|
no
|
HI1112
|
xylB
xylulokinase
|
HS_0588
|
no
|
HI1113
|
xylR
|
HS_0794
|
no
|
HI1106
|
L. Xylulose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
NAD(P)H-dependent xylose reductase
|
no
|
no
|
no
|
xdh
xylitol dehydrogenase
|
no
|
no
|
no
|
zinc-binding xylitol/sorbitol dehydrogenase
|
no
|
no
|
no
|
xylitol (sorbitol) dehydrogenase
|
no
|
no
|
no
|
D-xylulose reductase (EC 1.1.1.9) (Xylitol dehydrogenase) (XDH)
|
no
|
no
|
no
|
L-xylulose reductase (EC 1.1.1.10) (XR)
|
no
|
no
|
no
|
sgbK/lyxK
L-xylulokinase
|
HS_0770
|
no
|
HI1027
|
sgbH
3-hexulose-6-phosphate synthase
|
HS_0771
|
HD1857
|
HI1024
|
sgbU
hexulose-6-phosphate isomerase
|
HS_0772
|
HD1864
|
HI1026
|
L-arabinitol 4-dehydrogenase (LAD1)
|
no
|
no
|
no
|
araD
ribulose phosphate 4-epimerase
|
HS_0773
|
HD1866
|
HI1025
|
M. Trehalose (pathways from MetaCyc (8))
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
trehalose degradation I
|
|
|
|
treC
trehalose 6-P hydrolase
|
no
|
no
|
no
|
trehalose degradation II
|
|
|
|
treA
trehalase, periplasmic
|
no
|
no
|
no
|
treF
trehalase, cytoplasmic
|
no
|
no
|
no
|
trehalose degradation III
|
|
|
|
trePP/otsB
trehalose-6-phosphate phosphatase
|
no
|
no
|
no
|
trehalose degradation IV and V
|
|
|
|
trehalose phosphorylase 2.4.1.64
|
no
|
no
|
no
|
synthesis
|
|
|
|
otsA
trehalose-6-phosphate synthase
|
no
|
no
|
no
|
transport
|
|
|
|
treB/treP
PTS family enzyme IIBC, trehalose(maltose)-specific
|
no
|
no
|
no
|
regulation
|
|
|
|
treR
repressor of treA,B,C
|
no
|
no
|
no
|
N. Fructose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
mak
Cryptic manno(fructo)kinase
|
HS_1041
|
no
|
HI0182
|
pfkB
6-phosphofructokinase II
|
no
|
no
|
no
|
pfkA
6-phosphofructokinase I
|
HS_0485
|
HD0465
|
HI0982
|
fbaA
fructose-bisphosphate aldolase, class II
|
HS_0206
|
HD0864
|
HI0524
|
fbaB
fructose-bisphosphate aldolase class I
|
possibly HS_0055
|
no
|
no
|
fruA
PTS system, fructose-specific IIBC component
|
no
|
no
|
HI0446
|
fruK
1-phosphofructokinase
|
no
|
no
|
HI0447
|
fruB
PTS system, fructose-specific IIA/FPr component
|
no
|
no
|
HI0448
|
O. Maltose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
malT
transcriptional regulator necessary for transcription of mal genes except malIXY
|
no
|
no
|
no
|
malQ
amylomaltase
|
HS_0890
|
no
|
HI1356
|
malE
|
no
|
no
|
no
|
malF
maltose transport protein (ABC superfamily, membrane)
|
no
|
no
|
no
|
malG
maltose transport protein (ABC superfamily, membrane)
|
no
|
no
|
no
|
malK
|
no
|
no
|
no
|
malP
maltodextrin phosphorylase
|
no
|
no
|
no
|
malS
alpha-amylase
|
no
|
no
|
no
|
lamB
maltodextrin pore
|
no
|
no
|
no
|
malX
PTS family enzyme IIC (N-terminal); enzyme IIB (C-terminal)
|
no
|
no
|
no
|
malZ
maltodextrin glucosidase
|
no
|
no
|
no
|
maltose phosphorylase
|
no
|
no
|
no
|
Beta-phosphoglucomutase
|
no
|
no
|
no
|
Table S6. Amino acid metabolism
A. Arginine and polyamine biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
argA
N-acetylglutamate synthase
|
no
|
HD1384
|
no
|
argB
N-acetylglutamate kinase
|
no
|
HD0891
|
no
|
argC
N-acetylglutamyl phosphate reductase
|
no
|
HD0890
|
no
|
argD
acetylornithine transaminase
|
no
|
HD0892
|
no
|
argE
acetylornithine deacetylase
|
no
|
HD0566
|
no
|
astC
acetylornithine transaminase, catabolic
|
no
|
no
|
no
|
argI
ornithine carbamoyltransferase
|
no
|
HD0232
|
HI0596
|
argF
ornithine carbamoyltransferase
|
no
|
no
|
no
|
argG
arginosuccinate synthase
|
HS_1362
|
HD1204
|
HI1727
|
argH
arginosuccinate lyase
|
HS_0692
|
HD1033
|
HI0811
|
argJ
Glutamate N-acetyltransferase (Ornithine acetyltransferase)
|
no
|
no
|
no
|
argR
arginine repressor
|
HS_1056
|
HD0262
|
HI1209
|
speA
arginine decarboxylase, biosynthetic
|
no
|
no
|
no
|
adiA
arginine decarboxylase, degradative
|
no
|
no
|
no
|
speB
agmatinase
|
no
|
no
|
no
|
speC
ornithine
decarboxylase, biosynthetic
|
HS_1573
|
no
|
HI0591
|
speF
ornithine
decarboxylase, degradative
|
HS_1573
|
no
|
HI0591
|
speD
S-adenosylmethionine decarboxylase
|
no
|
no
|
no
|
speE
spermidine synthase
|
no
|
no
|
no
|
carB
carbamoyl phosphate synthetase
|
no
|
HD0233
|
no
|
carA
carbamoyl phosphate synthetase
|
no
|
HD0235
|
no
|
B. Cysteine biosynthesis and sulfate assimilation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
cysE
serine acetyltransferase
|
HS_0154
|
HD0659
|
HI0606
|
cysM
O-acetylserine (thiol)-lyase B
|
no
|
no
|
no
|
cysK
O-acetylserine (thiol)-lyase A
|
HS_0369
|
HD0896
|
HI1103
|
cysZ
cysteine biosynthesis protein
|
HS_0370
|
HD0832
|
HI1102
|
cysQ
|
HS_1650
|
HD0840
|
HI0559
|
cysA
ATP-binding component of sulfate permease A protein; chromate resistance
|
no
|
no
|
no
|
cysC
adenosine 5'-phosphosulfate kinase
|
no
|
no
|
no
|
cysD
ATP-sulfurylase, subunit 2
|
no
|
no
|
no
|
cysG
siroheme synthase
|
no
|
no
|
no
|
cysH
3'-phosphoadenosine 5'-phosphosulfate (PAPS) reductase
|
no
|
no
|
no
|
cysI
sulfite reductase, alpha subunit
|
no
|
no
|
no
|
cysJ
sulfite reductase (NADPH), flavoprotein beta subunit
|
no
|
no
|
no
|
cysN
ATP-sulfurylase (ATP:sulfate
adenylyltransferase), subunit 1, probably a GTPase
|
no
|
no
|
no
|
C. Glutamate, Glutamine, Aspartate and Asparagine biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Glutamate and glutamine
|
|
|
|
gltB
glutamate synthase, large subunit
|
no
|
no
|
no
|
gltD
glutamate synthase, small subunit
|
no
|
no
|
no
|
gdhA
glutamate dehydrogenase, NADP-specific
|
HS_1339
|
no
|
HI0189
|
glnA
glutamine synthetase
|
HS_0418
|
HD0750
|
HI0865
|
glnB
nitrogen regulatory protein p-II
|
HS_1355
|
HD0062
|
HI0337
|
glnD
uridylyltransferase
|
HS_0829
|
HD1497
HD1496
|
HI1719
|
glnE
glutamate-ammonia-ligase adenylyltransferase
|
HS_1218
|
HD1709
|
HI0069
|
Aspartate and asparagine
|
|
|
|
aspA
aspartate ammonia-lyase
|
HS_0466
|
HD0564
|
HI0534
|
asnA
asparagine synthetase
|
HS_1440
|
HD1913
|
HI0564
|
asnB
asparagine synthetase B
|
no
|
no
|
no
|
aspC
aspartate aminotransferase
|
HS_0838
|
HD1419
|
HI1617
|
ansB
periplasmic L-asparaginase II
NP_417432
|
no
|
HD0372
|
no
|
ansA
cytoplasmic L-asparaginase I
|
no
|
no
|
no
|
asparaginase
|
no
|
no
|
no
|
rpoN
RNA polymerase, sigma(54 or 60) factor
|
no
|
no
|
no
|
ntrB
histidine protein kinase sensor for GlnG regulator
|
no
|
no
|
no
|
ntrC
response regulator for gln
|
no
|
no
|
no
|
serC
phosphoserine aminotransferase
|
HS_0611
|
HD1382
|
HI1167
|
D. Lysine, Threonine, Methionine biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Lysine
|
|
|
|
lysC
aspartokinase III
|
no
|
HD1375
|
no
|
thrA
aspartate kinase I
bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal)
|
HS_1214
|
no
|
HI0089
|
metL
aspartate kinase II
bifunctional: aspartokinase II and homoserine dehydrogenase II
|
no
|
no
|
no
|
asd
aspartate semialdehyde dehydrogenase
|
HS_1552
|
HD0847
|
HI0646
|
dapA
dihydrodipicolinate synthase
|
HS_0492
|
HD1107
|
HI0255
|
dapB
dihydrodipicolinate reductase
|
HS_0835
|
HD1398
|
HI1308
|
dapD
tetrahydrodipicolinate synthase
|
HS_0785
|
HD0630
|
HI1634
|
dapC
N-succinyldiaminopimelate-aminotransferase
|
HS_0926
|
no
|
no
|
dapE
N-succinyl-L-diaminopimelic acid desuccinylase
|
HS_0578
|
HD0642
|
HI0102
|
dapF
diaminopimelate epimerase
|
HS_1610
|
HD0026
|
HI0750
|
lysA
diaminopimelate decarboxylase
|
HS_1713
|
HD0036
|
HI0727
|
Threonine
|
|
|
|
thrA
homoserine dehydrogenase
|
HS_1214
|
no
|
HI0089
|
thrB
homoserine kinase
|
HS_1213
|
no
|
HI0088
|
thrC
threonine synthase
|
HS_1212
|
no
|
HI0087
|
Methionine
|
|
|
|
metA
homoserine O-succinyltransferase
|
no
|
no
|
no
|
metB
O-succinylhomoserine lyase
|
HS_1345
|
no
|
HI0086
|
malY
cystathionine beta-lyase
|
no
|
no
|
no
|
metC
L-cysteine desulfhydrase / cystathionine-beta-lyase
|
HS_0475
|
no
|
HI0122
|
metH
Cobalamin-dependent homocysteine transmethylase
|
no
|
no
|
no
|
metE
Cobalamin-independent homocysteine transmethylase
|
HS_1226
HS_0824
|
no
no
|
HI1702
|
metK
methionine adenosyltransferase I
|
HS_1623
|
HD0569
|
HI1172
|
metF
5,10-methylenetetrahydrofolate reductase
|
HS_1130
|
no
|
HI1444
|
metX
homoserine O-acetyltransferase
|
HS_1076
|
no
|
HI1263
|
metJ
met repressor
|
HS_0469
|
HD0675
|
HI0294
|
met2
Homoserine O-acetyltransferase (EC 2.3.1.31)
|
no
|
no
|
no
|
E. Leucine, Isoleucine and Valine biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
ilvA
threonine ammonia-lyase (threonine dehydratase, threonine deaminase)
|
HS_0183
|
no
|
HI0738.1
|
ilvB
acetolactate synthase I, large subunit, valine-sensitive
|
no
|
no
|
no
|
ilvC
ketol-acid reductoisomerase
|
HS_1671
|
no
|
HI0682
|
ilvD
dihydroxy-acid dehydratase (DAD)
|
HS_0342
|
no
|
HI0738
|
ilvE
branched-chain amino acid transaminase
|
HS_0494
|
no
|
HI1193
|
ilvG
acetohydroxy acid synthase II, large subunit
|
HS_0147
|
no
|
N-terminal of HI0737
|
ilvH
acetolactate synthase III, small subunit
|
no
|
no
|
HI1584
|
ilvI
acetolactate synthase III, valine sensitive, large subunit
|
no
|
no
|
HI1585
|
ilvM
acetohydroxy acid synthase II, small subunit
|
HS_0148
|
no
|
C-terminal of HI0737
|
ilvN
acetolactate synthase I, small subunit
|
no
|
no
|
no
|
leuA
2-isopropylmalate synthase (alpha-isopropylmalate synthetase)
|
HS_0392
|
no
|
HI0986
|
leuB
3-isopropylmalate dehydrogenase
|
HS_0391
|
no
|
HI0987
|
leuC
3-isopropylmalate dehydratase, large subunit
|
HS_0390
|
no
|
HI0988
|
leuD
3-isopropylmalate dehydratase, small subunit
|
HS_0389
|
no
|
HI0989
|
avtA
alanine-alpha-ketoisovalerate (or valine-pyruvate) transaminase, transaminase C
|
no
|
no
|
no
|
tdcB
threonine deaminase, catabolic, PLP-dependent
NP_417587
|
no
|
no
|
no
|
sdaA
L-serine deaminase I
|
no
|
HD1142
|
HI0288
|
sdaB
L-serine deaminase 2
|
no
|
no
|
no
|
tyrB
tyrosine aminotransferase, tyrosine-repressible,
PLP-dependent
|
no
|
no
|
no
|
F. Histidine, Glycine, Serine, Alanine, Proline, Phenylalanine, Tyrosine, Trptophan biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Histidine
|
|
|
|
hisG
ATP phosphoribosyltransferase
|
no
|
no
|
HI0468
|
hisI
bifunctional: phosphoribosyl-AMP cyclohydrolase (N-terminal); phosphoribosyl-ATP pyrophosphatase (C-terminal)
|
no
|
no
|
HI0475
|
hisA
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'- phosphoribosyl)-4-imidazolecarboxamide isomerase
|
no
|
no
|
HI0473
|
hisF
imidazole glycerol phosphate synthase subunit in heterodimer with HisH = imidazole glycerol pHS_phate synthase holoenzyme
|
no
|
no
|
HI0474
|
hisH
glutamine amidotransferase subunit of heterodimer with HisF = imidazole glycerol phosphate synthase holoenzyme
|
no
|
no
|
HI0472
|
hisB
bifunctional: histidinol-phosphatase (N-terminal); imidazoleglycerol-phosphate dehydratase (C-terminal)
|
no
|
no
|
HI0471
|
hisC
histidinol phosphate aminotransferase
|
HS_0612
|
no
|
HI0470
|
hisD
L-histidinal:NAD+ oxidoreductase; L-histidinol:NAD+ oxidoreductase
|
no
|
no
|
HI0469
|
Glycine and serine
|
|
|
|
glyA
glycine/serine hydroxymethyltransferase
|
HS_1627
|
no
|
HI0889
|
serA
phosphoglycerate dehydrogenase (D-3-phosphoglycerate dehydrogenase)
|
HS_0122
|
no
|
HI0465
|
serC
phosphoserine transaminase (phosphoserine aminotransferase)
|
HS_0611
|
HD1382
|
HI1167
|
serB
phosphoserine phosphatase
|
HS_0687
|
HD0207
|
HI1033
|
Alanine
|
|
|
|
ilvE
branched-chain amino acid transaminase
|
HS_0494
|
no
|
HI1193
|
avtA
alanine-alpha-ketoisovalerate (or valine-pyruvate) transaminase, transaminase C
|
no
|
no
|
no
|
dadX
alanine racemase 2, PLP-binding, catabolic
|
HS_0939
|
HD0624
|
HI1575
|
alr
alanine racemase
|
HS_0939
|
HD0624
|
HI1575
|
Proline
|
|
|
|
gdhA
NADP-specific glutamate dehydrogenase
|
HS_1339
|
no
|
HI0189
|
proA
glutamate-5-semialdehyde dehydrogenase
|
HS_0408
|
no
|
HI1239
|
proB
glutamate 5-kinase (gamma-glutamyl kinase)
|
HS_0192
|
no
|
HI0900
|
proC
pyrroline-5-carboxylate reductase
|
HS_1285
|
no
|
HI0307
|
Phenylalanine and tyrosine
|
|
|
|
pheA
bifunctional P-protein: chorismate mutase; prephenate dehydratase
|
HS_0365
|
HD0873
|
HI1145
|
tyrA
bifunctional protein: chorismate mutase; prephenate dehydrogenase
|
HS_0671
|
HD0443
|
HI1290
|
tyrB
tyrosine aminotransferase, tyrosine repressible
|
no
|
no
|
no
|
Tryptophan
|
|
|
|
trpE
anthranilate synthase component I
|
no
|
no
|
HI1387
|
trpD/ trpGD
anthranilate synthase component II, glutamine amidotransferase and phosphoribosylanthranilate transferase
|
no
|
no
|
HI1389
|
trpG
anthranilate synthase component II (para-aminobenzoate synthase component II)
|
HS_0130
|
HD0406
|
HI1171
HI1388
|
trpC
N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase
|
no
|
no
|
HI1389.1
|
trpA
tryptophan synthase, alpha protein
|
no
|
no
|
HI1432
|
trpB
tryptophan synthase, beta
|
no
|
no
|
HI1431
|
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