|
G. Arginine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
E. coli ast pathway (arginine degradation VI)
|
|
|
|
astA
arginine succinyltransferase
|
no
|
no
|
no
|
astB
succinylarginine dihydrolase
|
no
|
no
|
no
|
astC
acetylornithine delta-aminotransferase
|
no
|
no
|
no
|
astD
succinylglutamic semialdehyde dehydrogenase
|
no
|
no
|
no
|
astE
succinylglutamate desuccinylase
|
no
|
no
|
no
| B. subtilis
arginase pathway (arginine degradation I, IX, XIII, XII)
|
|
|
|
rocF
arginase
|
no
|
no
|
no
|
rocD
ornithine aminotransferase
|
no
|
no
|
no
|
rocA
pyrroline-5 carboxylate dehydrogenase
|
no
|
no
|
no
|
Pseudomonas aeruginosa arginine deiminase (arginine degradation X and XI)
|
|
|
|
arcA
arginine deiminase
|
no
|
no
|
no
|
arcB
ornithine carbamoyltransferase, catabolic
|
no
|
HD0232
|
HI0596
|
arcC
carbamate kinase
|
no
|
no
|
HI0595
|
arginine degradation II and XII Deinococcus radiodurans , Sulfolobus solfataricus, E.coli
|
|
|
|
speA
arginine decarboxylase, biosynthetic
NP_417413
|
no
|
no
|
no
|
adiA
arginine decarboxylase, degradative
NP_418541
|
no
|
no
|
no
|
speB
agmatinase
NP_417412
|
no
|
no
|
no
|
speC
ornithine
decarboxylase, biosynthetic
|
HS_1573
|
no
|
HI0591
|
arginine degradation V
|
|
|
|
Arginine 2-monooxygenase 1.13.12.1
|
no
|
no
|
no
|
arginine degradation IV
|
|
|
|
Gamma-guanidinobutyraldehyde dehydrogenase 1.2.1.54
|
no
|
no
|
no
|
H. Cysteine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
tnaA
tryptophanase
|
HS_0801
|
no
|
no
|
metC
cystathionine beta-lyase
|
HS_0475
|
no
|
HI0122
|
I. Glutamate and Glutamine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
L-glutamate to fumarate
|
|
|
|
aspC
aspartate aminotransferase
|
HS_0838
|
HD1419
|
HI1617
|
aspA
aspartate ammonia-lyase
|
HS_0466
|
HD0564
|
HI0534
|
L-glutamate to alpha-ketoglutarate
|
|
|
|
gdhA
glutamate dehydrogenase, NADP-specific
|
HS_1339
|
no
|
HI0189
|
L-glutamate to (2S, 3S)-3-methylaspartate
|
|
|
|
glmE
glutamate mutase epsilon subunit 5.4.99.1
|
no
|
no
|
no
|
L-glutamate to L-glutamine
|
|
|
|
glnA
glutamine synthetase
|
HS_0418
|
HD0750
|
HI0865
|
L-glutamine to L-glutamate
|
|
|
|
glutaminase 3.5.1.2
|
no
|
no
|
no
|
gltB
glutamate synthase, large subunit
|
no
|
no
|
no
|
gltD
glutamate synthase, small subunit
|
no
|
no
|
no
|
J. Aspartate degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
L-aspartate to NAD
|
|
|
|
nadA
quinolinate synthetase, A protein
|
no
|
no
|
no
|
nadE
NAD synthetase, prefers NH3 over glutamine
|
no
|
no
|
no
|
nadB
quinolinate synthetase, B protein
|
no
|
no
|
no
|
nadC
quinolinate phosphoribosyltransferase
|
no
|
no
|
no
|
nadD
NAMN adenylyltransferase
|
no
|
no
|
no
|
L-aspartate to beta-alanine
|
|
|
|
panD
Aspartate 1-decarboxylase
|
no
|
no
|
no
|
K.. Asparagine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Asparagine to aspartate
|
|
|
|
ansB
periplasmic L-asparaginase II
|
no
|
HD0372
|
no
|
ansA
cytoplasmic L-asparaginase I
|
no
|
no
|
no
|
L. Lysine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
lysine to cadaverine
|
|
|
|
ldcC
lysine decarboxylase 2, constitutive
|
HS_1007
|
no
|
no
|
cadA
lysine decarboxylase 1
|
HS_1007
|
no
|
no
|
cadB
cadaverine/lysine antiporter
|
HS_1006
|
no
|
no
|
M. Threonine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
threonine to glycine or aminoacetone
|
|
|
|
tdh
threonine dehydrogenase
|
no
|
no
|
no
|
threonine to homoserine, cystathione, o-succinyl-L-homoserine, propionate
|
|
|
|
ilvA
threonine deaminase (dehydratase)
|
HS_0183
|
no
|
HI0738.1
|
L-cysteine desulfhydrase
|
no
|
no
|
no
|
metB
2.5.1.48
cystathionine gamma-synthase
|
HS_1345
|
no
|
HI0086
|
2-oxobutanoate to propionate
|
|
|
|
pyruvate formate-lyase , formate acetyltransferase
|
HS_1136
|
HD0990
|
HI0180
|
ackA
|
HS_0803
|
HD1456
|
HI1204
|
N. Methionine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
metK see above
|
yes
|
yes
|
yes
|
DNA-cytosine methyltransferase
|
HS_1422
|
no
|
no
|
2.1.1.37
DNA (cytosine-5-)-methyltransferase
|
no
|
no
|
HI1041
|
3.3.1.1
adenosyl homocysteinase
|
no
|
no
|
no
|
4.2.1.22
serine sulfhydrolase
|
no
|
no
|
no
|
O. Leucine, Isoleucine and Valine degradation degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Common pathway
|
|
|
|
ilvE
branched-chain amino acid transaminase
|
HS_0494
|
no
|
HI1193
|
bfmBAA
2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4
|
no
|
no
|
no
|
bfmBAB
2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4
|
no
|
no
|
no
|
2-methylacyl-CoA dehydrogenase
1.3.99.12
|
no
|
no
|
no
|
Leucine
|
|
|
|
3-methylcrotonyl-CoA carboxylase, beta subunit
6.4.1.4
|
no
|
no
|
no
|
3-methylglutaconyl-CoA hydratase 4.2.1.18
|
no
|
no
|
no
|
Isoleucine
|
|
|
|
3-hydroxyacyl-CoA dehydrogenase 1.1.1.178
|
no
|
no
|
no
|
Valine
|
|
|
|
3-hydroxyisobutyryl-CoA hydrolase 3.1.2.4
|
no
|
no
|
no
|
P. Histidine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
hutH
histidase (histidine ammonia lyase) 4.3.1.3
|
no
|
no
|
no
|
hutU
urocanase (urocanate hydratase) 4.2.1.49
|
no
|
no
|
no
|
hutI
imidazolonepropionase
3.5.2.7
|
no
|
no
|
no
|
hutF
formiminoglutamate deiminase
3.5.3.13
|
no
|
no
|
no
|
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