Tuskegee university 2014 College of Arts and Sciences Research Directory

Timothy Turner, Ph.D.

College of Arts & Sciences

Email: turner@mytu.tuskegee.edu

Office Phone: 334-727-8787

Office Address: George Washington Carver Hall Room 6

Tuskegee, Alabama 36088

TURNER

• Signaling mechanisms in cancer progression

• Targeted cancer drug delivery

Collaborations:

• 
  Dr. Alan Wells
  

University of Pittsburgh

Carnegie Mellon University

• 
  Dr. Uppender Manne
  

University of Alabama at Birmingham

• 
  Dr. James Lillard
  

Morehouse School of Medicine

• 
  Dr. Richard Allman
  

Division of Gerontology, Geriatrics, and Palliative Care

University of Alabama at Birmingham

Biographical Sketch:

Dr. Timothy Turner is the Deputy Director of Research and Training in the Tuskegee University National Center for Bioethics in Research and Health Care, Program Director of the Center for Biomedical Research/Research Centers at Minority Institutions, and the Lead Principal Investigator for the MSM/TU/UAB CCC Partnership. He received his B.S. degree in biology from Jackson State University, Jackson, MS and his Ph.D. degree in endocrinology/ tumor biology from the University of California, Berkeley.

His research interests focus on identifying and disrupting signaling mechanisms involved in the progression of prostate cancer to its invasive and metastatic stages. Within this approach, his lab has utilized luteinizing hormone releasing hormone receptors as the tumor target for the delivery of cancer drugs to prostate cancer cells. In addition to administrative, research and teaching obligations, Dr. Turner works to increase biomedical and cancer research ongoing at Tuskegee University.
Representative Publications:

1. 
   Abdalla, M.O., Aneja, R., Dean, D., Rangari, V., Russell, A., Jaynes, J., Yates, C., and Turner, T. (2010). Synthesis and Characterization of Noscapine-Loaded Magnetic Polymer Nanoparticles. Journal of Magnetism and Magnetic Materials, 322: 190-196. PMCID: PMC2784924
   
2. 
   Theodore, S.C., Rhim, J., Turner, T., and Yates, C. (2010). miRNA 26a Expression in a Novel Panel of African American Prostate Cancer Cell Lines. Journal of Ethnicity & Disease, 20: 96-100. PMCID: PMC3118047
   
3. 
   Josson, S., Sharp, S., Sung, S.-Y., Johnstone, P.A.S., Aneja, R., Wang, R., Gururajan, M., Turner, T., Chung, L.W.K., and Yates, C. (2010). Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- Versus Mesenchymal-Like Prostate Cancer Cells. Journal of Oncology: 2010. 1-10. PMCID: PMC2926670
   
4. 
   Yates, C., Sharp, S., Jones, J., Topps, D., Coleman, M., Aneja, R., Jaynes, J., and Turner, T. (2011). LHRH-Conjugated Lytic Peptides Directly Target Prostate Cancer Cells. Biochemical Pharmacology, 81: 104–110. PMCID: PMC2997383
   
5. 
   Wang, H., Jones, J., Turner, T., He, Q.P., Hardy, S., Grizzle, W.E., Welch, D.R., Yates, C. (2012). Clinical and Biological Significance of KISS1 Expression in Prostate Cancer. Am J Pathol. 2012 Mar;180(3):1170-8. Epub 2012 Jan 6. PMID: 2222674
   

Biology

WANG

Research Fields:

• 
  Cancer Biology
  
• 
  Cellular and Molecular Biology
  
• 
  Anti-cancer Drug Development
  

Collaborations:

• 
  Dr. Alan Perantoni, NIH, NCI, Frederick. MD.
  
• 
  Dr. Erik Lillehoj School of Medicine, University of Maryland
  
• 
  Dr. Byeng Min Department of Agricultural and Environmental Sciences, Tuskegee University
  
• 
  Dr. Yan Meng Alcorn University
  

Biographical Sketch:

Professor Honghe Wang obtained her academic success by attending Northeast Agricultural University (BS, MS) and Sun Yat-Sen University (PhD). Her research focuses on identification of transcription factors, microRNAs and cell signaling molecules which are critical for cell proliferation, migration, differentiation or metastasis in prostate cancer, breast cancer and kidney cancers.

Honghe Wang, Ph.D.

Assistant Professor, Biology

College of Arts and Sciences

Email: wangh@mytu.tuskegee.edu

Office Phone: 334-724-4986

Office Address: 21 Carver Research Hall

Tuskegee University

Tuskegee, Alabama 36088


Dr. Wang’s research interests also focus on targeting specific molecules for drug development related to cancer progression; identifying compounds from medicinal plants or design molecules with promising anti-cancer activity using cell-based assays and molecular biological techniques; comprehensive transcriptome and epigenome sequencing to reveal factors associated with cancer prognosis.
Representative Publications:

1. 
   Wang, Honghe, J. Jones, T. Turner, Q. He, …, and Clayton Yates. Clinical and Biological Significance of KISS1 Expression in Prostate Cancer. The American J. Pathology, 03/2012; 180(3):1170-8.
   
2. 
   J. Jones, Honghe Wang, J. Zhou, ….Clayton Yates. Nuclear kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells. The American Journal of Pathology. 2012, 181(5):1836-46.
   
3. 
   O.A. Timofeeva, N. I. Tarasova, X. ......, Honghe Wang, Milton L. Brown, and Anatoly Dritschilo. STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. PNAS 2013 110 (4) 1261-1266.
   
4. 
   J. Jones, Honghe Wang, ….Clayton Yates. Nuclear kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells. MS submitted. Clinical and Experimental Metastasis, 2014, Accepted.
   
5. 
   Wang, Honghe, et al., STAT1 activation regulates proliferation and differentiation of renal progenitors.. Cellular Signaling, 2010 Nov; 22(11):1717-26.
   
6. 
   W. Liu, Honghe Wang, et al., miR-23b* targets proline oxidase, a novel tumor suppressor protein in renal cancer. Oncogene, 2010 Jun 21.
   

Biology

WHITTINGTON

Research Fields:

• 
  Microbiology
  
• 
  Aquaculture
  

Collaborations:

• 
  Dr. Deidre Quinn-Gorham
  

School of Veterinary Medicine, Nursing, and Allied Health, Tuskegee University

• 
  Drs. Olga Bolden-Tiller and Deloris Alexander
  

College of Agricultural, Environmental and Natural Sciences, Tuskegee University

• 
  Dr. Covadonga Arias
  

College of Agriculture, Department of Fisheries and Allied Aquacultures, Auburn University

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