had given him only a in chance of recovery. Cousins suffered from tremendous pain and had such difficulty moving his limbs that he could barely turnover in bed. Grainy nodules appeared under his skin, and at his lowest point, his jaw nearly locked shut.
Convinced that a persistent negative emotional state
had contributed to his illness, he decided it was equally possible that a more positive emotional state could reverse the damage. While continuing to consult with his doctor, Cousins started a regimen of massive doses of vitamin C
and Marx Brothers movies (as well as other humorous films and comedy shows. He found that ten minutes of hearty laughter gave him two hours of pain-free sleep. Eventually, he made a complete recovery. Cousins,
quite simply, laughed himself to health.
How? Although scientists at the time didn’t have away to understand or explain such a miraculous recovery, research now tells us it’s likely that epigenetic processes were at work. Cousins’s shift of attitude changed his body chemistry, which
altered his internal state, enabling him to program new genes in new ways he simply
downregulated (or turned off ) the genes that were causing his illness and
upregulated (or turned on) the genes responsible for his recovery. (Ill go into more detail about turning genes on and off in the coming chapters.)
Many years later, research by Keiko Hayashi, PhD, of the University of
Tsukuba in Japan showed the same thing.
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In Hayashi’s study, diabetic patients watching an hour-long comedy program
upregulated a total of genes, 14 of which were related to natural killer cell activity. While none of these genes were directly involved in blood-glucose regulation,
the patients blood-glucose levels were better controlled than after they listened to a diabetes health lecture on a different day. Researchers surmised that laughter influences many genes involved with immune response, which in turn contributed to the improved glucose control. The elevated emotion, triggered by the patients brains, turned on the genetic variations, which activated the natural killer cells and also somehow improved their glucose response—probably in addition to many other beneficial effects.
As Cousins said of placebos back in 1979, The process works not because
of any magic in the tablet, but because the human body is its own best apothecary and because the most successful prescriptions are filled by the body itself.”
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Inspired by Cousins’s experience, and with alternative and mind-body medicine now in full swing, Yale University surgeon Bernie Siegel started to look at why some of his cancer patients with poor odds survived while
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others with better odds died. Siegel’s work defined cancer survivors largely as those who had a feisty, fighting spirit, and he concluded that there were no incurable diseases, only incurable patients. Siegel also began writing about hope as a powerful force for healing
and about unconditional love, with the natural pharmacy of elixirs it provides, as the most powerful stimulant of the immune system.
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