Exploiting species differences to understand the cftr cl channel
Date 03.03.2018 Size 57.84 Kb. #42180
Exploiting species differences to understand the CFTR Cl - channel
Samuel J. Bose, Toby S. Scott-Ward, Zhiwei Cai and David N. Sheppard
SUPPLEMENTARY MATERIAL
Supplementary Material Table 1 lists the accession numbers of the CFTR homologues used to construct the cladogram shown in Figure 2 and indicates their percentage shared amino acid identity to human CFTR.
Supplementary Material Table 1: Shared amino acid sequence identity of CFTR homologues
Common Name
Latin name
GenBank Accession No.
Shared amino acid identity with human CFTR
Human
Homo sapiens
NM_000492.3
100.00
Chimpanzee
Pan troglodytes
NM_001079917.1
99.73
Sumatran Orangutan
Pongo abelii
NM_001168545.1
98.92
Cynomolgus Monkey (Crab-eating Macaque)
Macaca fascicularis
XM_005550598.1
98.31
Rhesus Macaque
Macaca mulatta
AF013753.1
98.18
Horse
Equus caballus
NM_001110510.1
94.06
Pig
Sus scrofa
AY585334.1
92.31
Arabian Camel
Camelus dromedarius
XM_010975581.1
91.84
Cattle
Bos taurus
M76128.1
89.94
Sheep
Ovis aries
U20418.1
90.75
Rabbit
Oryctolagus cuniculus
AF189720.1
92.23
Brandt’s Bat
Myotis brandtii
XM_005871579.1
90.42
Chinese Tree Shrew
Tupaia chinensis
XM_006162386.1
85.48
African Savanna Elephant
Loxodonta africana
XM_003407018.1
90.01
Domestic Ferret
Mustela putorius furo
XM_004789405.1
91.78
Giant Panda
Ailuropoda melanoleuca
XM_011222604
89.59
Domestic Cat
Felis catus
AAR16237.1
91.02
Dog
Canis lupus familiaris
AY780429.1
89.89
Tammar Wallaby
Macropus eugenii
ABA02588.1
85.88
Common Bushtail Possum
Trichosurus vulpecula
AY916796.2
85.27
Platypus
Ornithorhynchus anatinus
NM_001242734.1
83.09
Chinese Alligator
Alligator sinensis
XM_006023627.1
79.62
Chicken
Gallus gallus
DP000235.1
79.45
Adelie Penguin
Pygoscelis adeliae
XM_009324103.1
77.94
Timber Rattlesnake
Crotalus horridus
GBKC01000886.1
76.55
House Mouse
Mus musculus
NM_021050.2
79.05
Norwegian Rat
Rattus norvegicus
NM_031506.1
77.84
African Clawed Frog
Xenopus laevis
X65256.1
76.43
Spiny Dogfish
Squalus acanthias
M83785.1
71.11
Atlantic Salmon 1
Salmo salar
AF155237.1
57.08
Atlantic Salmon 2
Salmo salar
AF161070.1
57.44
Fugu rubripes (Japanese Pufferfish)
Takifugu rubripes
AB362833.1
57.71
Mummichog (Killifish)
Fundulus heteroclitus
AF000271.1
59.08
Zebrafish
Danio rerio
NM_001044883.1
53.87
Supplementary Material Table 1: Shared amino acid sequence identity of CFTR homologues Details of the amino acid sequences used to generate the cladogram shown in Figure 2 are provided. Amino acid sequences with GenBank accession numbers carrying the prefix ‘XM_’ are predicted based on genomic sequence data ; all other amino acid sequences have been experimentally determined. Shared amino acid residue identity with human CFTR was calculated following ClustalO alignment.
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