Regional Body Composition Measured by Dual-Energy x-ray Absorptiometry (dxa) Relates to Insulin Resistance in a Sedentary Overweight and Obese Population

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• Table 1. Correlation of Body Composition Measurements with HOMA-IR and Matsuda Index.
• Correlation of Body Composition Measurements with HOMA-IR
• Correlation of Body Composition Measurements with Matsuda Index
• -0.30 0.02 -0.41 0.01 -0.48
• 0.02 -0.39 0.02 -0.48 0.02
• -0.25 0.05 -0.30 0.07 -0.49

Regional Body Composition Measured by Dual-Energy X-ray Absorptiometry (DXA) Relates to Insulin Resistance in a Sedentary Overweight and Obese Population DXA is a common tool for assessing body composition, with new capability to assess regional fat distribution. Using a cross-sectional design we evaluated the correlation between DXA regional body fat composition and insulin resistance in overweight/obese sedentary adults. DXA measures included fat free mass, visceral fat mass, visceral fat percent of total fat, android fat mass, and gynoid fat mass. Two indices of insulin resistance, HOMA-IR and Matsuda Index, were used. Linear correlation was tested using Pearson's correlation coefficient. Participants (n=68: 50 women/18 men) had mean age 28.8 ± 6.6 years and mean BMI 33.3 ± 7.1 kg/m2. Participants were categorized as insulin sensitive (mean ± SD: HOMA-IR 1.1 ± 0.4, Matsuda Index 8.3 ± 4.8) or insulin resistant (HOMA-IR 2.7 ± 2.0, Matsuda Index 3.6 ± 2.1). Of the DXA based body composition measures, visceral fat mass and visceral fat percent most consistently had a significant negative correlation (-0.30 to -0.48, P<0.05) with insulin resistance by Matsuda Index; this association was strongest in the insulin resistant group (R=-0.48, p<0.02). We conclude that DXA based measurement of visceral fat mass and percent of total fat could be used to predict insulin resistance by Matsuda Index in sedentary overweight/obese adults, reinforcing the expanding utility of DXA in clinical and research settings. Table 1. Correlation of Body Composition Measurements with HOMA-IR and Matsuda Index. Correlation of Body Composition Measurements with HOMA-IR Body Composition Measurement All Sedentary Overweight/Obese Participants (n = 68) Sedentary Overweight/Obese and Insulin Sensitive (n = 39) Sedentary Overweight/Obese and Insulin Resistant (n = 29) Correlation Coefficient p value Correlation Coefficient p value Correlation Coefficient p value BMI (kg/m2) 0.25 0.04 0.37 0.02 0.12 0.53 Fat Free Mass (g) 0.02 0.87 0.07 0.67 0.04 0.85 Visceral Fat Mass (g) 0.11 0.37 0.35 0.04 -0.13 0.52 Visceral Fat Percent of Total Fat Mass (%) 0.07 0.61 0.37 0.03 -0.08 0.72 Android Fat Mass (g) 0.15 0.22 0.48 0.002 0.05 0.79 Gynoid Fat Mass (g) 0.01 0.92 0.30 0.06 -0.07 0.74 Android-Gynoid Ratio 0.20 0.11 0.29 0.07 0.23 0.25 Correlation of Body Composition Measurements with Matsuda Index Body Composition Measurement All Sedentary Overweight/Obese Participants (n = 68) Sedentary Overweight/Obese and Insulin Sensitive (n = 39) Sedentary Overweight/Obese and Insulin Resistant (n = 29) Correlation Coefficient p value Correlation Coefficient p value Correlation Coefficient p value BMI (kg/m2) -0.18 0.14 -0.24 0.14 -0.35 0.08 Fat Free Mass (g) -0.02 0.87 -0.13 0.42 -0.05 0.82 Visceral Fat Mass (g) -0.30 0.02 -0.41 0.01 -0.48 0.01 Visceral Fat Percent of Total Fat Mass (%) -0.30 0.02 -0.39 0.02 -0.48 0.02 Android Fat Mass (g) -0.19 0.12 -0.39 0.02 -0.38 0.06 Gynoid Fat Mass (g) -0.04 0.72 -0.18 0.27 -0.16 0.43 Android-Gynoid Ratio -0.25 0.05 -0.30 0.07 -0.49 0.01 Directory: Forms Forms -> Form a-122 File No. Retirement homes act, 2010 application under section 116 of the act Forms -> Course overview Forms -> Pre-matric scholarship for students belonging to the minority communities Forms -> Cutting Greenhouse Gases Global warming Forms -> Bowl game blarney: Why Sports Tourism Trumps Logic in the Quest for a true College Football Champion in the United States” Prepared for: Dr. Tom Hinch Reviewed by: Tim Enger 0845772 Due Date: December 10, 2005 Word Count: 6,677 Forms -> Steven m. Glassman Forms -> Teresa k. Blodgett Forms -> Atlanta Falcons Internet Scavenger Hunt Forms -> Registration information Forms -> Learn free form Wikipedia’s selection and earn gcl, European Chamber’s world recognized commercial certificate Download 29.58 Kb. Share with your friends: