100 mg/dL, and in Patients Already



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Primary Composite Endpoint




All Patients

On maximum intensity statin


On less intense statin

0.4
Secondary Composite Endpoint


All Patients
On maximum intensity statin

On less intense statin

I

0



I

I
1.0


I



I


I I I
---

I

-fr



I

I

HR (95°/o Cl)


0.85 (0.79-0.92)
0.86 (0.75-0.98)
0.85 (0.78-0.93)

2.5


0.80 (0.73-0.88)
0.78 (0.66-0.92)

0.81 (0.72-0.90)


Pinteraction

0.88

0.71


OA 1D 2.5

Evolocumab better Placebo better

Figure 28. Cardiovascular Death, Myocardial Infarction, or Stroke in Patients on Maximal Potency Background Statin
10%


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