Netherlands:
C. van der Zwaan, Ziekenhuis Rivierenland, Tiel; A. Oomen, Antonius Ziekenhuis, Sneek; R.
van de Wal, Ziekenhuis Bernhoven, Uden; M. Magro, Elisabeth-TweeSteden Ziekenhuis,
Tilburg; D. Boswijk, Noordwest Ziekenhuisgroep, Den Helder; C. Janus, Vasculair Onderzoek
Centrum Hoorn, Hoorn; R. Groutars, Sint Lucas Andreas Ziekenhuis, Locatie Sint Lucas,
Amsterdam; W. Tonino, Catharina Ziekenhuis, Eindhoven; J. H. Cornel, Noordwest
Ziekenhuisgroep, Alkmaar; A. Oude Ophuis, Canisius-Wilhelmina Ziekenhuis, Nijmegen; R.
Troquay, VieCuri Medisch Centrum, Venlo; A. Liem, Franciscus Gasthuis, Rotterdam; I. 838 Westendorp, Rode Kruis Ziekenhuis, Beverwijk; M. Van Hessen, Groene Hart Ziekenhuis, 839 Gouda; D. Lok, Deventer Ziekenhuis, Deventer; C. De Nooijer, Maxima Medisch Centrum, 840 Veldhoven; F. Den Hartog, Ziekenhuis Gelderse Vallei, Ede; E. Van Beek, Sint Jansdal
841 Ziekenhuis, Harderwijk; P. Bendermacher, Elkerliek Ziekenhuis, Helmond; R. Jansen,
842 Slingeland Ziekenhuis, Doetinchem; T. Römer, Alrijne Ziekenhuis, Leiden; B. Rensing, Sint
843 Antonius Ziekenhuis, locatie Nieuwegein, Nieuwegein; F. Hersbach, Maasstad Ziekenhuis,
844 Rotterdam; J. Herrman, Onze Lieve Vrouwe Gasthuis, Amsterdam; G. Ladyjanskaia, Ziekenhuis 845 Amstelland, Amstelveen; I. Karalis, Leids Universitair Medisch Centrum, Leiden; G. Linssen, 846 Ziekenhuisgroep Twente, Almelo; M. Bokern, Waterland Ziekenhuis, Purmerend; A. Visman, 847 Beatrix Ziekenhuis, Gorinchem; A. Kooij, Bethesda Diabetes Research Center, Hoogeveen; H. 848 Monajemi, Rijnstate, Arnhem; A. Lieverse, Maxima Medisch Centrum, Eindhoven.
849
850 New Zealand:
851 R. Scott, Lipid and Diabetes Research Group, Christchurch; J. Baker, Middlemore Hospital,
852 Papatoetoe, Auckland; S. Tie, Tauranga Hospital, Tauranga.
853
854 Norway:
855 K. Risberg, Skedsmo Medisinske Senter, Skedsmokorset; J. Hysing, Sykehuset Telemark, Skien;
856 T. Pedersen, Oslo universitetssykehus, Oslo; H. O. Hoivik, M3 Helse, Hamar; P. Norheim,
857 Forusakutten-Kolibri, Stavanger; L. Solnor, Heiaklinikken, Lierskogen; A. Hovland,
858 Nordlandssykehuset, Bodø; T. Kjaernli, Medi 3 Klinikk, Ålesund.
859
860 Philippines:
861 G. Jocson, J. Sibal, Angeles University Foundation, Angeles; R. M. Coching, Davao Doctors 862 Hospital, Davao City; E. Batalla, Davao Doctors Hospital, Davao City; A. Go, Baguio General 863 Hospital, Baguio City; R. Habaluyas, Amang Rodriguez Memorial Medical Center, Marikiina; 864 R. Barcinas, Alexian Brothers Health and Wellness Center, Davao City; R. A. Sy, Ospital ng
865 Makati, Makati City; R. A. Estepar, St Pauls Hospital Iloilo, Iloilo; G. Rogelio, St Lukes Medical
866 Center, Quezon City; A. Germar, Veterans Memorial Medical Center, Quezon City.
867
868 Poland:
869 J. Trebacz, Centrum Medyczne Zdrowa, Krakow; K. Szymkowiak, Synexus Polska Spzoo,
870 Wroclaw; R. Wnetrzak-Michalska, Synexus Polska Spzoo, Katowice; J. Kopaczewski, 871 Specjalistyczne Gabinety Lekarskie Medicor Plus - Jerzy Kopaczewski, Wloclawek; M. 872 Przekwas-Jaruchowska, Synexus Polska Spzoo, Gdynia; G. Kania, Centrum Medyczne 873 Ogrodowa, Skierniewice; M. Zabowka, Centrum Szybkiej Diagnostyki Kardiologicznej 874 Kardiomed M Zabowka E Zabowka Spolka cywilna, Tarnow; E. Mirek-Bryniarska,
875 Specjalistyczny Gabinet Lekarski Ewa Mirek-Bryniarska, Krakow; M. Dabrowska, Synexus
876 Polska Spzoo, Warszawa; P. Napora, Centrum Badan Klinicznych Przychodnia Badan
877 Klinicznych, Wroclaw; M. Konieczny, KO-MED Marek Konieczny Centrum
878 Wielospecjalistycznej Opieki Ambulatoryjnej z AmbulatorOsrodkZabieg, Pulawy; J. Spyra, 879 NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna, Ruda Slaska; 880 R. Lysek, Lecznice Citomed Spzoo, Torun; Z. Pijanowski, NZOZ Twoja Przychodnia Spzoo,
881 Lublin; B. Grzegorzewski, Centrum Medyczne Clinport, Katowice; Z. Bednarkiewicz, 882 Wojewodzki Specjalistyczny Szpital im dr Wl Bieganskiego w Lodzi, Lodz; Z. Gaciong, 883 Samodzielny Publiczny Centralny Szpital Kliniczny, Warszawa; L. Kinasz, Polsko-
884 Amerykanskie Kliniki Serca, Bielsko-Biala; K. Antkowiak-Piatyszek, Synexus Polska Spzoo, 885 Poznan; K. Stania, Nyskie Centrum Sercowo Naczyniowe Polsko-Amerykanskich Klinik Serca, 886 Nysa; M. Szpajer, Poliklinika Evi-Med, Gdynia; P. Staneta, NZOZ Specjalistyczna Przychodnia 887 Lekarska Medikard, Plock; G. Skonieczny, Wojewodzki Szpital Zespolony im Ludwika
888 Rydygiera w Toruniu, Torun; E. Ksiezycka-Majczynska, Instytut Kardiologii im Prymasa 889 Tysiaclecia Stefana Kardynala Wyszynskiego, Warszawa; T. Blicharski, Lubelskie Centrum 890 Diagnostyczne, Swidnik; M. Piepiorka, Gabinet Kardiologiczno-Internistyczny, Gdynia; B.
891 Wozakowska-Kaplon, NZOZ Centrum Usług Medycznych Promont-Med, Kielce; T. Zechowicz,
892 Zechowicz Medeusz-Plus Lekarska Spolka Partnerska, Olsztyn; J. Ilkowski, NZOZ Neuro-Kard,
893 Poznan; B. Lubiszewska, Instytut Kardiologii im Prymasa Tysiaclecia Stefana Kardynala 894 Wyszynskiego, Warszawa; J. Hiczkiewicz, NZOZ Kardiologia Nowa Sol, Nowa Sol; K. 895 Wierzbicka, Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Spzoo, Warszawa; D. 896 Kosior, Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych w Warszawie,
897 Warszawa; P. Garbocz, Medica Centrum Spzoo, Pszczyna; J. Kubica, Szpital Uniwersytecki nr 1
898 im dr Antoniego Jurasza w Bydgoszczy, Bydgoszcz; G. Raczak, Uniwersyteckie Centrum
899 Kliniczne, Gdansk; I. Wozniak, KO-MED Centra Kliniczne Staszow, Staszow; J. Cygler, NZOZ 900 Medica, Gizycko; E. Kramarczuk, KO-MED Centra Kliniczne Zamosc, Zamosc; L. Bystryk, 901 Wojewodzkie Centrum Szpitalne Kotliny Jeleniogorskiej, Jelenia Gora; J. Pentela-Nowicka,
902 Somed Lodzkie Centrum Osteoporozy, Lodz; M. Dabrowski, SPZOZ Szpital Bielanski im
903 Ksiedza Jerzego Popieluszki, Warszawa; P. Podolec, Krakowski Szpital Specjalistyczny im Jana
904 Pawła II, Krakow; B. Zieba, Gdanskie Centrum Zdrowia, Gdansk; J. Mosiewicz, Centrum
905 Medyczne Luxmed Spzoo, Lublin; T. Pasierski, Miedzyleski Szpital Specjalistyczny w
906 Warszawie, Warszawa; W. Dubaniewicz, Pomorskie Centra Kardiologiczne, Starogard Gdanski; 907 M. Banach, SPZOZ Uniwersytecki Szpital Kliniczny, Lodz; G. Tyszecka, Wromedica, Wroclaw; 908 T. Lepich, Indywidualna Specjalistyczna Praktyka Lekarska Roman Spyra, Katowice; A.
909 Rychlewska-Hanczewska, Ai Centrum Medyczne, Poznan; T. Guzik, Malopolskie Centrum
910 Alergii i Immunoterapii Allmedis Sp. z o.o, Krakow.
911
912 Portugal:
913 P. Monteiro, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra; H. Pereira, Hospital 914 Garcia de Orta, EPE, Almada; L. Oliveira, Centro Hospitalar Cova da Beira, EPE - Hospital Pero 915 da Covilha, Covilha; P. Matos, Hospital Cuf Infante Santo, Lisboa; S. Soares Goncalves, Centro 916 Hospitalar de Setubal EPE Hospital de Sao Bernardo, Setubal; A. Leitao, Centro Hospitalar de 917 Lisboa Ocidental, EPE - Hospital Sao Francisco Xavier, Lisboa; J. Ferreira, Centro Hospitalar de 918 Lisboa Ocidental, EPE - Hospital de Santa Cruz, Carnaxide; A. Vasco Salgado, Hospital
919 Professor Doutor Fernando Fonseca, EPE, Amadora; A. T. Timoteo, Centro Hospitalar de Lisboa
920 Central, E.P.E. - Hospital de Santa Marta, Lisboa.
921
922 Romania:
923 E. Pintilei, Consultmed SRL, Iasi; E. Badila, Policlinica Center for Clinical and Basic Research 924 SRL, Bucuresti; C. Militaru, Cardiomed SRL, Craiova; M. Tudoran, Spitalul Clinic Judetean de 925 Urgenta Timisoara, Timisoara; C. Arsenescu-Georgescu, Institutul de Boli Cardiovasculare Prof 926 Dr George I.M. Georgescu Iasi, Iasi; F. Mitu, Spitalul Clinic de Recuperare Iasi, Iasi; D.
927 Zdrenghea, Spitalul Clinic de Recuperare Cluj-Napoca, Cluj-Napoca; D. Lighezan, Spitalul
928 Clinic Municipal de Urgenta Timisoara, Timisoara; I. Teodorescu, Spitalul Clinic de Urgenta Sf 929 Ioan Bucuresti, Bucuresti; A. G. Dan, Spitalul Clinic Colentina, Bucharest; M. I. Popescu, Spital 930 Clinic Judetean de Urgenta Oradea, Oradea; I. Coman, Alcor Med SRL, Bucuresti; M. M.
931 Vintila, Spitalul Clinic de Urgenta Sfantul Pantelimon, Bucuresti.
932
933 Russia:
934 A. Vishnevsky, Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital, 935 Saint-Petersburg; Y. Lukyanov, SBEI of HPE First Saint-Petersburg State Medical University na 936 Academic I P Pavlov of MoH of the RF, Saint-Petersburg; A. Blokhin, FSBI Outpatient Clinic 3 937 of Russian Federation Presidents Management Department, Moscow; V. Kostenko, Saint
938 Petersburg State Budget Healthcare Institution City Polyclinic 109, Saint-Petersburg; Y. Shvarts, 939 Clinical Hospital named after S R Mirotvortsev, Saratov; V. Markov, FSBSI Research Institute 940 for ical Hospi, Tomsk; I. Motylev, SBHI of Nizhniy Novgorod region City Clinical Hospital 33 941 of city Nizhniy Novgorod Leninskyi region, Nizhniy Novgorod; D. Dronov, Budget Healthcare 942 Institution of Omsk region Medical-sanitary unit 9, Omsk; A. Sherenkov, Spb SBHI Medical and 943 sports dispensary of Krasnogvardeisky district of Saint Petersburg, Saint Petersburg; O.
Barbarash, FSBI Heart and Vessels Diseases complex problems Scientific Research Institution,
Kemerovo; E. Shutemova, Regional Budget Healthcare Institution Cardiology Dispensary,
Ivanovo; O. Bolshakova, SBEI of HPE First Saint-Petersburg State Medical University na
Academic I P Pavlov of MoH of the RF, Saint Petersburg; Z. Kobalava, SBHI of Moscow City
clinical hospital 64 of Moscow Healthcare department, Moscow; M. Ezhov, FSBI Russian
Cardiology Research and Production Complex, Moscow; M. Voevoda, FSBI SRI of Therapy of 950 Siberian Branch of RAMS, Novosibirsk; T. Treshkur, FSBI V.A.Almazov Federal Center of 951 heart, blood and endocrinology of Ministry of Health and SD of RF, Saint Petersburg; K.
952 Zrazhevskiy, Saint Petersburg SBHI City Hospital 38 named after N A Semashko, Saint-
953 Petersburg; L. Pimenov, BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of
954 healthcare of Republic Udmurtiya, Izhevsk; O. Solovev, Kirov Regional State Budget Healthcare
955 Institution Kirov City Clinical Hospital 1, Kirov; N. Tarasov, FSHI Medical-sanitary unit of
956 Chief Administration of IA of Kemerovo region, Kemerovo; M. Arkhipov, State Budget Medical 957 Institution Sverdlovsk Regional Clinical Hospital N1, Ekaterinburg; M. Freidlin, SBHI of SR 958 SPC of specialized types of medical care Ural cardiology institute, Ekaterinburg; S. Shalaev,
959 State Autonomy Health care Institution of Tyumen region Scientific and Practical Medical
960 Center, Tyumen; P. Yakhontova, SBHI of Novosibirsk Region Novosibirsk regional clinical 961 cardiology dispensary, Novosibirsk; S. Shustov, FSMEI of HPE Military Medical Academy n.a. 962 S.M.Kirov of Ministry of Defense of RF, St. Petersburg; B. Goloshchekin, St Petersburg State 963 Budget Institution of Public Health City Hospital 15, Saint Petersburg; A. Panov, FSBI
964 V.A.Almazov Federal Center of heart, blood and endocrinology of Ministry of Health and SD of 965 RF, Saint-Petersburg; B. Bart, Diagnostic and Clinical Center No1 Moscow Health Department, 966 branch No2, Moscow; M. Bubnova, FSBI State Scientific Research Center for Preventive
967 Medicine of MoH of RF, Moscow; I. Gordeev, Moscow SBHI City Clinical Hospital 15 n a O M 968 Filatov of Moscow Healthcare Department, Moscow; I. Osipova, NSHI Departmental Hospital at 969 the station Barnaul of OJSC Russian Railways, Barnaul; S. Tereshenko, FSBI Russian
970 Cardiology Research and Production Complex, Moscow; E. Solovieva, FSBI Russian
971 Cardiology Research and Production Complex, Moscow; A. Meshkov, FSBI State Scientific
972 Research Center for Preventive Medicine of MoH of RF, Moscow; D. Zateyshchikov, Moscow
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State Budget Healthcare Institution City Clinical Hospital 51 of Moscow Healthcare Department, Moscow.
Singapore:
L. Tay, Changi General Hospital, Singapore; J. L. Tan, National Heart Centre Singapore, Singapore; T. Subramaniam, Khoo Teck Puat Hospital, Singapore.
Slovakia:
D. Pella, Cardio D and R sro Kosice, Kosice; P. Fulop, Interna SK sro, Svidnik; L. Antalik, Nemocnica s poliklinikou Brezno, no, Brezno; A. Dzupina, Alian sro, Bardejov; A. Banikova, KardioMed sro, Lucenec; D. Sosovec, Diab sro, Roznava; L. Urgeova, Kardiomed, NZ sro, Nove Zamky; J. Mazur, Kardio - Onkologia sro, Dolny Kubin; M. Hranai, Kardiocentrum Nitra s.r.o., Nitra; M. Banik, Medi M and M sro, Moldava nad Bodvou; D. Vinanska, Medispol sro, Presov; J. Lennerova, Medilex sro, Rimavska Sobota; F. Kovar, Univerzitna nemocnica Martin, Martin; E. Pastrnakova, Agto spol sro, Kosice; R. Uhliar, Nemocnica svateho Michala as, Bratislava; P. Blasko, MUDr Peter Blasko sro, Banovce nad Bebravou; S. Filipova, Narodny ustav srdcovych a cievnych chorob, a.s., Bratislava; J. Gonsorcik, NZZ - internistu, kardiologa, Kosice; J. Lukacova, Mediluk sro, Snina; R. Oriesek, CardiOr sro, Trencin; K. Hatalova, Cardioconsult sro, Bratislava.
South Africa:
M. du Toit, Synexus Clinical Research South Africa, Val de Grace; L. Burgess, Tygerberg Hospital, Parow; I. Ebrahim, Unitas Hospital, Centurion; G. Vawda, Inkosi Albert Luthuli Central Hospital, Durban; S. Lipschitz, Apollo Clinical Research Pty Ltd, Johannesburg; S. Blignaut, Paarl Research, Paarl; J. Engelbrecht, Doctor JM Engelbrecht, Somerset West; T. F. Coetzer, Clinresco Centres Suites, Kempton Park; M. Pretorius, Tiervlei Trial Centre, Cape Town; D. Urbach, Synexus Helderberg Clinical Research Centre, Somerset West; A. Badat, Wits Clinical Research, Soweto; S. Pillay, Seadoone Medical Centre, Amanzimtoti; L. Van Zyl, Clinical Projects Research South Africa, Worcester; M. Abelson, Vergelegen Mediclinic, Somerset West; E. van der Walt, Medicross Roodeport Research Centre, Johannesburg; R. Moodley, Umhlanga Hospital Netcare, Durban; A. Jacovides, Midrand Medical Centre, Midrand; W. M. Oosthuysen, Limaro Research, Bloemfontein; E. Klug, Sunninghill Hospital, Sunninghill; H. Lottering, SCION Clinical Research, Pretoria; J. Kok, Union Hospital, Alberton;
J. Saaiman, Kuils River Hospital, Kuils River; S. Dawood, Vincent Pallotti Hospital, Cape Town; D. M. De Jong, Jongaie Research, Pretoria west; C. Kapp, Cardiology Clinical Research, Alberton; E. Makotoko, Universitas Hospital, Bloemfontein; J. Bayat, Durban Medical Centre, Durban; A. Badat, Wits Clinical Research, Soweto; M. Sarvan, Mediclinic Victoria, Tongaat; E. Klug, Sunward Park Hospital, Boksburg; T. Vally, Synexus SA - Stanza Bopape Clinical Research Centre, Pretoria; A. Stapelberg, Syzygy Clinical Research Services Pty Ltd, Pretoria.
South Korea:
M. Kim, Dong-A University Hospital, Busan, Seo-gu; J. Bae, Konyang University Hospital, Daejeon; Y. Cho, Seoul National University Bundang Hospital, Seongnam-si; S. Kim, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul; K. H. Han, Asan Medical Center, Seoul; S. Her, The Catholic University of Korea Daejeon St Marys Hospital, Daejeon; D. Choi, Yonsei University Health System Severance Hospital, Seoul; B.
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Kim, Kangbuk Samsung Hospital, Seoul; S. Lee, Ilsan-Paik Hospital, Goyang-si, Gyeonggi-do;
B. Hong, Gangnam Severance Hospital, Seoul; W. Kim, Kyung Hee University Hospital, Seoul;
S. Rha, Korea University Guro Hospital, Seoul; M. Jeong, Chonnam National University Hospital, Gwangju; G. J. Shin, Ewha Womans University Mokdong Hospital, Seoul.
Spain:
M. Vida Gutierrez, Hospital Virgen del Mar, Almeria; J. Lopez Miranda, Hospital Universitario Reina Sofia, Cordoba; M. Valdes Chavarri, Hospital Universitario Virgen de la Arrixaca, El Palmar; X. Pinto Sala, Hospital Universitari de Bellvitge, L Hospitalet de Llobregat; J. R. Gonzalez Juanatey, Hospital Clinico Universitario de Santiago, Santiago de Compostela; F. Civeira Murillo, Hospital Universitario Miguel Servet, Zaragoza; J. L. Zamorano Gomez, Hospital Universitario Ramon y Cajal, Madrid; I. Lekuona Goya, Hospital de Galdakao, Galdakao; A. Iñiguez Romo, Hospital Alvaro Cunqueiro, Vigo; A. Cordero Fort, Hospital Universitario San Juan de Alicante, San Juan de Alicante; J. F. Ascaso Gimilio, Hospital Clinico Universitario de Valencia, Valencia; J. Millan Nuñez-Cortes, Hospital General Universitario Gregorio Marañon, Madrid.
Sweden:
C. Lindholm, Capio Citykliniken, Lund; L. Nilsson, University Hospital, Linköping; Å. Olsson, A-plus Science AB, Stockholm; S. Söderberg, Norrlands Universitetssjukhus, Umeå; A. Suutari, Höglandssjukhuset Eksjö, Eksjö; S. Berglund, Falu Lasarett, Falun; T. Mooe, Östersunds sjukhus, Östersund; D. Kusiak, Länssjukhuset Ryhov, Jönköping; S. Bandh, Västmanland sjukhus Västerås, Västerås; G. Dahlén, Vårdcentralen Silentzvägen, Uddevalla; S. Olsson, Helsingborgs lasarett, Helsingborg; N. Witt, Södersjukhuset, Stockholm; P. Tydén, Skånes Universitetssjukhus, Lund; P. Johansson, Sunderby Sjukhus, Luleå; S. Cizinsky, Universitetssjukhuset Örebro, Örebro; G. Falck, Aleris Specialistvård Bollnäs, Bollnäs; S. I. Pettersson, Mälarsjukhuset, Eskilstuna; G. Rasmanis, Karolinska Universitetssjukhuset Huddinge, Stockholm; J. Östergren, Karolinska University Hospital, Stockholm.
Switzerland:
F. Mach, Hopitaux Universitaires de Geneve, Geneva 14; T. Moccetti, G. Ponti, Fondazione Cardiocentro Ticino, Lugano; H. J. Beer, K. Steden, Kantonsspital Baden, Baden; F. Eberli, C. Liedtke, Stadtspital Triemli, Zurich; S. Krähenbühl, Universitaetsspital Basel, Basel; A. Linka,
B. Brinkers, Kantonsspital Winterthur, Winterthur; D. Ackermann, M. Winter-Pauling, Inselspital Bern, Bern; P. Michel, Centre Hospitalier Universitaire Vaudois, Lausanne.
Taiwan:
H. Yeh, Mackay Memorial Hospital Tamsui Branch, New Taipei City; C. F. Tsai, K. Ueng, Chung Shan Medical University Hospital, Taichung City; M. Charng, Taipei Veterans General Hospital, Taipei; C. Wu, C. J. Chen, C. I. Cheng, C. H. Yang, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung; C. Hsia, Changhua Christian Hospital, Changhua; J. Juang, F. Chiang, National Taiwan University Hospital, Taipei; I. Hsieh, Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan; W. Lai, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung; C. Huang, Cathay General Hospital, Taipei; Y. Hsieh, Chi Mei Medical Center, Tainan.
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Turkey:
T. Sahin, Kocaeli Universitesi Tip Fakultesi, Kocaeli; M. Duzenli, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya; Z. Yigit, Istanbul University Cardiology Institute, Istanbul; M. Demir, Cukurova Universitesi Tip Fakultesi, Adana; M. B. Yilmaz, Cumhuriyet Universitesi Tip Fakultesi, Sivas; I. H. Muderrisoglu, Baskent Universitesi Ankara Hastanesi, Ankara; C. Kirma, Kartal Kosuyolu Yuksek Ihtisas Egitim ve Arastirma Hastanesi, Istanbul; E. Ercan, Izmir Medicalpark Hastanesi, Izmir; L. Kayikcioglu, Ege Universitesi Tip Fakultesi, Izmir; Y. Balbay, Turkiye Yuksek Ihtisas Hastanesi, Ankara; S. Tokgozoglu, Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara.
Ukraine:
Kraydashenko, Communal Institution City Clinical Hospital No 6, Zaporizhzhia; I. Lymar, Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi, Kyiv; O. Kulynych, Communal Institution Zaporizhzhia Regional Clinical Hospital of Zaporizhzhia Regional Council, Zaporizhzhya; O. Prokhorov, Communal Healthcare Institution Kharkiv City Clinical Hospital No27, Kharkiv; O. Karpenko, Kyiv City Clinical
Hospital 1, Kyiv; I. Kraіz, Railway Transport Kharkiv Clinical Hospital No1 of Healthcare
Center Branch of Public Joint Stock, Kharkiv; I. Vakaliuk, vano-Frankivsk Regional Clinical Cardiological Dispensary, Ivano-Frankivsk; M. Stanislavchuk, Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University, Vinnytsia; O. Korzh, Medical and Sanitary Unit of Open Joint Stock Company Kharkiv S Ordzhonikidze Tractor Plant, Kharkiv; I. Rudyk, Government Institution L T Malaya Therapy National Institute of NAMS of Ukraine, Kharkiv; S. Zhurba, Cherkasy Region Cardiological Center, Cherkasy; Y. Svishchenko, State Institution National Scientific Center Acad Strazhesko Institute of Cardiology, Kyiv; V. Tseluyko, Communal Healthcare Institution Kharkiv City Clinical Hospital No8 Kharkiv Medical Academy of Post g, Kharkiv; O. Gyrina, Limited Liability Company Treatment and Diagnostic Center Adonis plus, Kyiv; D. Reshotko, Oleksandrivska Clinical Hospital of Kyiv, Kyiv; M. Kopytsya, Government Institution L T Malaya Therapy National Institute of NAMS of Ukraine, Kharkiv; V. Volkov, Government Institution L T Malaya Therapy National Institute of NAMS of Ukraine, Kharkiv; G. Myshanych, Synexus State Institution Road Clinical Hospital 2 of Kyiv Station, Kyiv; B. Rebrov, Luhansk Regional Clinical Hospital State Institution Luhansk State Medical University, Lugansk; M. Rishko, Transcarpathian Regional Clinical Cardiological Dispensary, Uzhgorod; L. Rudenko, Kyiv City Clinical Emergency Medical Care Hospital, Kyiv; V. Shatylo, State Institution D F Chebotariov Institute of Gerontology of NAMS of Ukraine, Kyiv; O. Parkhomenko, State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr, Kyiv; L. Yena, State Institution D F Chebotariov Institute of Gerontology of NAMS of Ukraine, Kyiv; O. Golovchenko, Medical Clinical Investigational Center of Medical Center Health Clinic LLC, Vinnytsia; I. Sorokina, Synexus Medical Center of Private Educational Institution Institute, Kyiv; Y. Malynovsky, Communal Inst regional Medical Centre of Cardiovascular Diseases of Zaporizhzhia Regional Council, Zaporizhzhia.
United Kingdom:
Ivan, Synexus Merseyside Clinical Research Centre, Liverpool; M. Blagden, Ashgate Medical Practice, Chesterfield; H. Dear, Synexus Scotland Clinical Research Centre, Glasgow; A. Mathew, Synexus Midlands Clinical Research Centre, Birmingham; S. Lagocki, Synexus
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1120
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1123
1124
1125
1126
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1128
1129
1130
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Lancashire Clinical Research Centre, Chorley; V. Kondagunta, Synexus Thames Valley Clinical Research Centre, Reading; A. Ahsan, Nottingham City Hospital, Nottingham; C. McKinnon, Castlemilk Group Practice, Glasgow; F. Douglas, Synexus North East Clinical Research Centre, Hexham; S. Thom, Imperial College Healthcare NHS Trust, London; G. Fiore, Synexus Manchester Clinical Research Centre, Manchester; M. Caulfield, D. Collier, Barts Health NHS Trust, London; M. Lynch, Lister Hospital, Stevenage; H. Thomas, Synexus Wales Clinical Research Centre, Cardiff; S. Bain, Singleton Hospital, Swansea; A. Hall, Leeds General Infirmary, Leeds; D. McNally, Ormeau Health Centre, Belfast; M. Fisher, Royal Liverpool University Hospital, Liverpool; P. Keeling, Torbay Hospital, Torquay; A. Al-Bahrani, A. Baksi, St Marys Hospital, Newport; G. Lip, City Hospital, Birmingham; A. Ellery, Cape Cornwall Surgery, Penzance; J. Purohit, Brannel Surgery, St Austell; C. Travill, Luton and Dunstable NHS Foundation Trust Hospital, Luton; F. Cappuccio, University Hospital Coventry, Coventry; G. Davis, Aintree University Hospital, Liverpool; R. Gaunt, Rowden Surgery, Chippenham; D. Adlam, Glenfield Hospital, Leicester; N. Asamoah, P. Harvey, S. Maxwell, Crouch Oak
Family Practice, Addlestone; F. Jaafar, R. Falk, South Axholme Practice, Haxey, Doncaster; T. McCormack, Whitby Group Practice, Whitby; B. Jupp, D. Jenkinson, Royal Bournemouth Hospital, Bournemouth; M. Pye, York Hospital, York; P. Ainsworth, Sherbourne Medical Centre, Leamington Spa; A. Chauhan, Blackpool Teaching Hospital, Blackpool; D. Connolly, Sandwell General Hospital, West Bromwich; N. Paul, Ashfield Primary Care Centre, Sandbach;
H. Fairlie, Connor Downs Surgery, Hayle; C. Fox, Northampton General Hospital, Northampton;
S. Muzulu, Rotherham General Hospital, Rotherham; J. Trevelyan, Worcestershire Royal Hospital, Worcester; R. Aggarwal, Basildon University Hospital, Basildon; B. Issa, Wythenshawe Hospital, Manchester; P. Saravanan, George Eliot Hospital, Nuneaton; K. Cruickshank, Guys and St Thomas NHS Foundation Trust, London; D. Gorog, Queen Elizabeth II Hospital, Welwyn Garden City; S. Heller, Northern General Hospital, Sheffield; D. Newby, Edinburgh Royal Infirmary, Edinburgh; A. Nicolson, West Suffolk Hospital, Bury St Edmunds;
P. O Hare, Hospital of St Cross, Rugby; P. Donnelly, Ulster Hospital, Belfast; S. Rutherfurd, N. Armstrong, Morrab Surgery, Penzance; M. de Belder, James Cook University Hospital, Middlesbrough; J. Finlayson, Highlands Clinical Research Facility, Inverness; J. Harvey, Wrexham Maelor Hospital, Wrexham; A. Hoye, Castle Hill Hospital, Cottingham; D. Kingston,
P. Cormie, Penalverne Surgery, Penzance; D. Sarkar, Derriford Hospital, Plymouth; A. Negahban, A. Ahmed, M. Al-Bazzaz, Barnsley Hospital, Barnsley; P. Saravanan, M. Banerjee, Arrowe Park Hospital, Wirral; J. Webster, Aberdeen Royal Infirmary, Aberdeen; N. Wyatt, The Bradford on Avon and Melsham Health Partnership, Wiltshire; S. Muir, Southern General Hospital, Glasgow; M. Cummings, Queen Alexandra Hospital, Portsmouth; I. Mackenzie, T. MacDonald, Ninewells Hospital and Medical School, Dundee; R. Senior, Northwick Park Hospital, Harrow; N. Capps, Princess Royal Hospital, Telford; K. Fotherby, New Cross Hospital, Wolverhampton; H. McIntyre, Conquest Hospital, St. Leonards-on-Sea; J. Aldegather, Portmill Surgery, Hitchin; L. Dixon, Royal Victoria Hospital, Belfast; R. Saksena, Colchester General Hospital, Colchester; R. Butler, University Hospital of North Staffordshire, Stoke-on-Trent.
United States:
D. Ramstad, Hampton Roads Center for Clinical Research, SUFFOLK, VA; B. Pierpont, Advance Medical Research, Saint Petersburg, FL; D. Levinson, Apex Medical Research Incorporate, Chicago, IL; A. Mohammed, Apex Medical Research, Inc, Springfield, OH; T. Haddad, Virginia Heart, Falls Church, VA; A. Goel, Kansas City Veterans Affairs Medical
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Center, Kansas City, MO; K. Dave, Heart Care Associates, Hopewell, VA; W. H. Haught, Heart Center Research LLC, Huntsville, AL; A. Desire, Andre P Desire MD PA, Wichita Falls, TX; K. Hershon, North Shore Diabetes and Endocrine Associates, New Hyde Park, NY; M. Napoli, Clinical Trials of America Inc, Monroe, LA; L. Tami, M. Abdurrahman, Research Physicians Network Alliance, Hollywood, FL; R. Rothschild, Cabrillo Cardiology Medical Group, Oxnard, CA; S. Khurana, Healthy Heart Cardiology, Grandville, MI; D. Gupta, Tennessee Center for Clinical Trials, Tullahoma, TN; D. Cheung, Long Beach Center for Clinical Research, Long Beach, CA; S. Hearne, Delmarva Heart Research Foundation Inc, Salisbury, MD; S. Grubb, Tabor City Family Medicine, Tabor City, NC; A. Miller, Alta Pharmaceutical Research Center Inc, Dunwoody, GA; I. Baird, Remington Davis Clinical Research Inc, Columbus, OH; A. Marcus, South Orange County Endocrinology, Laguna Hills, CA; S. Srivastava, Pentucket Medical Associates, Haverhill, MA; L. Forgosh, HealthEast Medical Research Institute, Saint Paul, MN; R. Fritz, Kootenai Heart Clinics, LLC, Coeur D'Alene, ID; M. Mays, Portland Preventive Cardiology, Portland, OR; B. Bertolet, Cardiology Associates Research LLC, Tupelo, MS; J. Reddy, Sierra Clinical Research, Roseville, CA; M. Khan, AngioCardiac Care of Texas, Houston, TX; S. Nakhle, Palm Research Center Inc, Las Vegas, NV; S. Dill, S Bar D Inc, Pryor, OK; G. Fishbein, Dayton Heart Center, Dayton, OH; B. Khan, Atlanta Clinical Research Centers LLC, Atlanta, GA; H. Marais, Beaver Medical Group, Banning, CA; M. Reschak, Medex Healthcare Research Inc- St Louis, Saint Louis, MO; M. Malone, Charlotte Heart Group Research Center, Port Charlotte, FL; V. Nadar, Capital Area Research LLC, Camp Hill, PA; R. Whitney, Bryan Heart, Lincoln, NE; A. Reichman, Clinical Trial Network, Houston, TX; H. Reyes, MediSphere Medical Research Center LLC, Evansville, IN; M. El Shahawy, Cardiovascular Center of Sarasota, Sarasota, FL; A. Rabinowitz, South Texas Cardiovascular Consultants, Kerrville, TX; D. Weinstein, Zasa Clinical Research, Boynton Beach, FL; N. Farhat, North Ohio Heart Center-Elyria, Elyria, OH; D. Onyema, Healthwise Medical Associates, NewYork, NY; R. Potu, Nature Coast Clinical Research LLC, Crystal River, FL; L. Runquist, Piedmont Medical Group Research of Charleston, Charleston, SC; O. Barnum, Keyser Avenue Medical Park Medical Research Inc, Natchitoches, LA; T. Crater, Hutchinson Clinic PA, Hutchinson, KS; J. Fialkow, Cardiovascular Research Center of South Florida, Miami, FL; A. Shah, Piedmont Research Partners, Indian Land, SC; C. Thompson, Craig S Thompson MD LLC, Marion, OH; A. Wiseman, Eastern Maine Medical Center, Bangor, ME; T. Doyle, Northeast Ohio Heart Associates, LLC, Willoughby, OH; D. Henderson, Cardiology Research Associates Daytona Beach, FL; W. Herzog, Johns Hopkins University, Columbia, MD; R. Schnitzler, Mercury Medical LLC, San Antonio, TX; K. Carr, Carr Cardiology, Oceanside, CA;
M. Davis, Rochester Clinical Research Inc, Rochester, NY; N. Nagajothi, Aultman Cardiology Clinical Trials, Canton, OH; S. Olsen, Utah Cardiology PC, Layton, UT; W. Rogers, University of Alabama at Birmingham Medical Center, Birmingham, AL; J. Rubino, Piedmont Medical Group Research of Raleigh, Raleigh, NC; I. Singh, Mercy Medical Group, Sacramento, CA; G. Tarleton, Clinical Trials of America Inc, Winston-Salem, NC; R. Bhagwat, Cardiovascular Research of Northwest Indiana LLC, Munster, IN; D. Clardy, Sanford Heart Center, Fargo, ND;
M. Jardula, Desert Medical Group, Palm Springs, CA; J. Robinson, The University of Iowa College of Public Health, Iowa City, IA; M. Torres, A Plus Research Inc, Miami, FL; N. Vijay, Aurora Denver Cardiology Associates PC, Denver, CO; N. Farris, The Research Group of Lexington LLC, Lexington, KY; J. Lillo, Elite Clinical Studies LLC, Phoenix, AZ; P. Moriarty, University of Kansas Medical Center, Kansas City, KS; C. Recknor, Chris Recknor MD PC,
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Gainesville GA; P. Berlacher, ProMedica Northwest Ohio Cardiology Consultants, Toledo, OH;
T. Christensen, Calabash Medical Center, Calabash, NC; N. Gabra, Burke Internal Medicine and Research, Burke, VA; M. Issa, Clinical Research of Hollywood PA, Pembroke Pines, FL; M. Janik, Piedmont Medical Group Research of Wilmington, Wilmington, NC; A. Lawless, Biofortis Inc, Addison, IL; D. Molter, North Myrtle Beach Family Practice, North Myrtle Beach, SC; E. Stout, Crossroads Clinical Research Inc, Mooresville, NC; B. Brezina, Southeastern Clinical Research and Management LLC, Augusta, GA; E. Claxton, Maine Research Associates, Auburn, ME; R. Linsky, University of Colorado Memorial Health System, Colorado Springs, CO; J. Poock, Northeast Iowa Medical Education Foundation, Waterloo, IA; R. Remler, Fellows Research Alliance Inc, Savannah, GA; H. Roseman, Cardiology Wellness Center, Nashville, TN;
E. Schramm, D. Schlager, St Johns Center for Clinical Research, Ponte Vedra, FL; T. Al-Joundi, Gateway Cardiovascular Research Center Inc, St Louis, MO; J. Amin, Clearwater Cardiovascular and Interventional Consultants Bardmoor, Largo, FL; J. Hitchcock, Belleville Family Medical Associates, Belleville, IL; S. Isserman, Clinical Trials of America Inc, Hickory, NC; J. Kirstein, Advanced Clinical Research, West Jordan, UT; J. Rider, Cardiology Associates of Bellin Health, Green Bay, WI; M. Shalek, Legacy Heart Center Plano, Plano, TX; H. Sherman, Southern Maine Health Care, Biddeford, ME; M. Bernstein, Louisiana Heart Center, Slidell, LA; L. Chandra, Chicago Medical Research LLC, Hazel Crest, IL; R. Hatharasinghe, Piedmont Healthcare, Statesville, NC; H. Ibrahim, North Ohio Heart Center-Sandusky, Sandusky, OH; B. Iteld, Louisiana Heart Center, Hammond, LA; K. Linzmeyer, St Lukes Idaho Cardiology Associates, Meridian, ID; B. Seaton, Research Institute of the Carolinas, Mooresville, NC; S. Zeig, Pines Clinical Research Inc, Hollywood, FL; E. Christofides, Endocrinology Associates Inc, Columbus, OH; R. Dunbar, Perelman Center for Advanced Medicine, Philadelphia, PA; S. Griffin, Head to Toe Research and Wellness LLC, Athens, GA;
N. Kohli, Discovery Clinical Trials, Austin, TX; M. Koren, Jacksonville Center for Clinical Research, Jacksonville, FL; W Pharr, Medication Management LLC, Greensboro, NC; D. Purdy, Black Hills Cardiovascular Research, Rapid City, SD; R. Spencer, Cardiology Consultants, Pensacola, FL; G. Yeoman, Founders Research Corporation, Philadelphia, PA; S. Banerjee, Veterans Affairs North Texas Health Care System, Dallas, TX; H. B. Cheek, University of North Carolina Regional Physicians Carolina Cardiology, High Point, NC; E. Engel, Bayview Research Group LLC, Valley Village, CA; G. Hamroff, New York University Langone at Hudson Valley Cardiology, Cortlandt Manor NY; R. Huling, Olive Branch Family Medical Center, Olive Branch, MS; L. Kozlowski, Buffalo Medical Group, Buffalo, NY; P. Levin, Model Clinical Research Inc, Baltimore, MD; S. Makam, Mid Hudson Medical Research PLLC, New Windsor, NY; M. Meengs, Mercy Health Partners, Muskegon, MI; R. Bhushan, Metabolic Center of Louisiana Research Foundation, Baton Rouge, LA; B. Erickson, Saint Cloud Hospital, Saint Cloud, MN; L. Herman, Herman Clinical Research LLC, Suwanee, GA; E. Lo, Edgewater Medical Research, Edgewater, FL; E. McDowell, Ilumina Clinical Associates, Indiana, PA; F. McGrew, Stern Cardiovascular Foundation Inc, Germantown, TN; M. Miller, University of Maryland Medical Center, Baltimore, MD; J. Ord, Aurora Denver Cardiology Associates, Aurora, CO; R. Webel, University of Missouri Health System, Columbia, MO; G. Wilhoit, PMG Research of Charleston, Moncks Corner, SC; J. Wise, Crescent City Clinical Research, Metairie, LA; E. Yang, University of Washington, Seattle, WA; M. Budoff, Harbor University of California Medical Center, Torrance, CA; J. Collins, Saint Marys of Michigan, Saginaw, MI; I. Dauber, South Denver Cardiology Associates, Littleton, CO; L. Dobkin, Clinical Trials Research Services LLC, Pittsburgh, PA; A. Focil, Diverse Research Solutions, Oxnard, CA; W. Gandy,
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Ellipsis Group, Atlanta, GA; J. Pasquini, Novant Health Heart and Vascular Institute, Charlotte, NC; M. Ramos, Intercoastal Medical Group, Sarasota, FL; D. Rodriguez, Advanced Research Institute Inc, New Port Richey, FL; R. Rosenson, Mount Sinai Medical Center, New York, NY;
Sanford, Project Management Institute of Health Inc, Atlanta, GA; A. Schlau, Palm Harbor Medical Associates, Palm Harbor, FL; B. Snyder, Southgate Medical Group, West Seneca, NY;
Stonesifer, Larry D Stonesifer MD Inc PS, Federal Way, WA; A. Tang, Chambersburg Hospital, Chambersburg, PA; J. De Souza, Glacier View Research Institute Endocrinology, Kalispell, MT; M. Elam III, Memphis Veterans Affairs Medical Center, Memphis, TN; J. French, Cor Healthcare Medical Associates, San Pedro, CA; J. Guyton, Duke University Medical Center, Durham, NC; E. Hage Korban, Kore Cardiovascular Research, Jackson, TN; D. Kereiakes, The Christ Hospital, Cincinnati, OH; M. King, Clearwater Cardiovascular Consultants, Clearwater, FL; I. Loh, Westlake Medical Research, Thousand Oaks, CA; J. Navarro, Genesis Clinical Research Inc, Tampa, FL; R. Simons, Nanticoke Cardiology Associates, Seaford, DE; T. Tobin, Portland Preventive Cardiology, LLC, Longview, TX; L. Younis, Gateway Cardiology, PC, Jerseyville, IL; R. Aboufakher, Altru Health System, Grand Forks, ND; D. Baldari, Cardiology Partners Clinical Research Institute, Wellington, FL; C. Ballantyne, Baylor College of Medicine, Houston, TX; S. Banerjee, University of Texas Southwestern Medical Center, Dallas, TX; R. Broughton, CB Flock Research Corporation, Mobile, AL; C. Eaton, Memorial Hospital of Rhode Island, Pawtucket, RI; J. Johnston, Arrowhead Health Centers, Glendale, AZ; W. Simon, Professional Research Network Of Kansas, Wichita, KS; S. Thomson, Southern Arizona Veterans Administration Health Care System, Tuscon, AZ; K. Vora, Research Integrity LLC, Owensboro, KY; D. Youngman, Kansas Nephrology Research Institute LLC, Wichita, KS; O. Alzohaili, Alzohaili Medical Consultants, Dearborn, MI; E. Auerbach, Oklahoma Heart Institute, Tulsa, OK; C. Brown, Mobile Heart Specialists PC, Mobile, AL; B. Burrough, McFarland Clinic PC, Ames, IA; Y. Chen, Bendel Medical Research Center, Lafayette, LA; M. Gilpatrick, Neurocare Center for Research, Newton, MA; J. Landzberg, Westwood Cardiology Associates, Westwood, NJ; C. Mitchell, MedTrial, LLC, Columbia, SC; L. Rice, Clinical Study Center of Asheville, LLC, Asheville, NC; M. Rubenfire, University of Michigan Health System, Dominos Farms, Ann Arbor, MI; C.
W. Sofley, Internal Medicine Associates of Anderson PA, Anderson, SC; D. Strobl, Sparrow Clinical Research Institute, Lansing, MI; K. Atassi, Porter Physician Services, Valparaiso, IN;
W. Davila, Fleming Island Center for Clinical Research, Fleming Island, FL; J. Diogo, New England Center for Clinical Research/ Internal Medicine and Cardiology Associates, LLC, Fall River, MA; T. Fagan, Arizona Endocrine and Rheumatology Associates, Tucson, AZ; I. Joffe, Lourdes Cardiology Services, Voorhees, NJ; J. Krishna, UnityPoint Health Meriter Heart and Vascular Institute, Madison, WI; E. Osea, Innovative Clinical Research, Harbor City, CA; W. Penny, Veterans Affairs San Diego Healthcare System, San Diego, CA; W. Rowe, Great Falls Clinic LLP, Great Falls, MT; M. Shapiro, Oregon Health and Science University, Portland, OR;
J. Welker, Anne Arundel Medical Center, Annapolis, MD; R. Benton, Capital Cardiology Associates, Troy, NY; D. Dobratz, College Park Family Care Center Physicians Group, Overland Park, KS; F. Fortuin, Mayo Clinic Hospital, Phoenix, AZ; J. Graham, Saint Francis Medical Group Indiana Heart Physicians, Indianapolis, IN; B. Henry, Therapeutic Research Institute of Orange County, Laguna Hills, CA; B. Kusnick, Cardiovascular Associates Research LLC, Covington, LA; M. Lutskiy, Beacon Clinical Research LLC, Quincy, MA; A. McRae, Centennial Heart Cardiovascular Consultants, LLC, Nashville, TN; K. Sanford, Health First Physicians Inc, Atlanta; W. Saway, Columbia Medical Practice, Columbia, MD; J. Scott,
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National Clinical Research Richmond Inc, Richmond, VA; M. Shah, Shah Associates, MD LLC, Charlotte Hall, MD; B. Weinberg, Community Hospital South, Indianapolis, IN; S. Zarich, Bridgeport Hospital, Bridgeport, CT; R. Acheatel, Escondido Cardiology Associates Incorporated, Escondido, CA; C. Case, Jefferson City Medical Group PC, Jefferson City, MO; J. Earl, Piedmont Medical Group Research of Hickory LLC, Hickory, NC; S. Fernandez, State University of New York- University at Buffalo, Buffalo, NY; G. Giugliano, Baystate Medical Practice, Springfield, MA; Y. Handelsman, Metabolic Institute of America, Tarzana, CA; P. Hermany, Grand View Lehigh Valley Health Services, Sellersville, PA; S. Holder, International Clinical Research LLC, Sanford, FL; M. Kashyap, Veterans Affairs Long Beach Healthcare System, Long Beach, CA; A. Khan, The Iowa Clinic, PC, Des Moines, IA; E. Lader, Mid Valley Cardiology, Kingston, NY; J. Peniston, Feasterville Family Health Care Center, Feasterville, PA;
T. Raoof, TJoseph Raoof MD Inc Encino Research Center, Encino, CA; J. Sacco, Stratton Veterans Affairs Medical Center, Albany, NY; K. Shore, Kenneth A Shore, MD, Plano, TX; D. Spriggs, Clearwater Cardiovascular and Interventional Consultants Countryside, Safety Harbor, FL; S. Stringam, Saint Lukes Regional Medical Center, Nampa, ID; N. Tahirkheli, South Oklahoma Heart Research, Oklahoma City, OK; E. Delgado, Family Medical Center dba Discovery Clinical Trials, Orlando; W. Derian, Quincy Medical Group, Quincy, IL; J. Greenwald, Medex Healthcare Research Inc, New York, NY; M. Harris, Bend Memorial Clinic, Bend, OR; R. Jackson, Dominion Medical Associates Incorporated, Richmond, VA; G. Marhefka, Thomas Jefferson University Hospital, Philadelphia, PA; W. McElveen, Bradenton Research Center, Bradenton, FL; A. Mooss, Chi Health Alegent Creighton Clinic, Omaha, NE;
P. Morris, Medical University of South Carolina, Charleston, SC; J. Murray, Meharry Medical College, Nashville, TN; P. Pearlstein, Pearl Clinical Research Inc, Norristown, PA; A. Raisinghani, University of California San Diego Medical Center, San Diego, CA; S. Rezkalla, Marshfield Clinic, Marshfield, WI; L. Sakhrani, Comprehensive Research Institute, Alhambra;
D. Schreibman, Sarasota Memorial Hospital Clinical Research Center, Sarasota, FL; E. Shaoulian, Pacific Coast Cardiology and Research, Newport Beach, CA; J. Steinsapir, Metabolic Research Institute Inc, West Palm Beach, FL; A. Yataco, IRC Clinics Inc, Towson, MD; A. De La Cruz, Genesis Research Center LLC, Miami, FL; M. Fredrick, HealthCare Partners Department of Research, Huntington Beach, CA; E. Goldenberg, Christiana Care Health System, Christiana Hospital, Newark, DE; D. Lee, California Cardiac Institute Medical Group, Glendale, CA; K. McCullum, York Hospital, York, PA; B. McLellan, Saint Charles Heath Center, Bend, OR; L. Stephens, Palmetto Clinical Trial Services, LLC, Fountain Inn, SC; S. Wilson, Partners in Clinical Research, Cumberland, RI; A. Alfieri, Alfieri Cardiology Research Company Inc, Wilmington, DE; M. Mandviwala, Northwest Heart Center, Tomball, TX; D. ORourke, Veterans Affairs Medical Center, White River Junction, VT; A. Samal, Northwest Houston Cardiology, Houston, TX; K. Sanford, Blair Medical Associates, Atlanta, GA; J. Schmedtje, Roanoke Heart Institute, Roanoke, VA; F. Waxman, GSA Medical Research LLC, Hollywood; R. Carhart, State University of New York Upstate Medical University, Syracuse, NY; B. Clements, Intermountain Medical Center, Murray, UT; C. Dyke, Alaska Heart Institute, Anchorage, AK; J. Ghali, Mercer University School of Medicine, Macon, GA; L. Gruberg, Stony Brook University Medical Center, Stony Brook, NY; T. Hack, Primary Care Cardiology Research, Inc, Ayer; A. Jehle, International Heart Institute of Montana, Missoula, MT; B. Pogue, Selah Medical Center, Boise;
C. Schooley, Centrura Health Research Center, Colorado Springs, CO; G. Shifrin, Cleveland Clinic Cardiology Associates, Atlantis.
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Table S1 – Efficacy Outcomes With Evolocumab vs. Placebo Stratified by Baseline LDL-C
|
Baseline LDL-C <70 mg/dLa
(N=2034)
|
Baseline LDL-C >70 mg/dL (N=25529)
|
|
Outcome
|
Evolocumab (N=1030)
|
Placebo (N=1004)
|
Hazard Ratio (95% CI)
|
Evolocumab (N=12754)
|
Placebo (N=12775)
|
Hazard Ratio (95% CI)
|
PINT
|
Primary endpointb
|
86 (8.3)
|
106 (10.6)
|
0.80 (0.60-1.07)
|
1258 (9.9)
|
1457 (11.4)
|
0.86 (0.79-0.92)
|
0.65
|
Key secondary endpointc
|
48 (4.7)
|
68 (6.8)
|
0.70 (0.48-1.01)
|
768 (6.0)
|
945 (7.4)
|
0.81 (0.73-0.89)
|
0.44
|
Other endpoints
|
|
|
|
|
|
|
|
Cardiovascular death
|
14 (1.4)
|
14 (1.4)
|
0.97 (0.46-2.04)
|
237 (1.9)
|
226 (1.8)
|
1.05 (0.87-1.26)
|
0.88
|
Myocardial infarction
|
25 (2.4)
|
43 (4.3)
|
0.58 (0.35-0.94)
|
443 (3.5)
|
596 (4.7)
|
0.74 (0.65-0.84)
|
0.32
|
Stroke
|
17 (1.7)
|
20 (2.0)
|
0.85 (0.44-1.62)
|
190 (1.5)
|
242 (1.9)
|
0.78 (0.65-0.95)
|
0.84
|
Hospitalized for unstable angina
|
16 (1.6)
|
19 (1.9)
|
0.84 (0.43-1.64)
|
220 (1.7)
|
220 (1.7)
|
1.00 (0.83-1.20)
|
0.63
|
Coronary revascularization
|
51 (5.0)
|
65 (6.5)
|
0.78 (0.54-1.13)
|
708 (5.6)
|
900 (7.0)
|
0.78 (0.71-0.86)
|
0.97
|
Baseline LDL-C data were not available for one patient randomized to placebo. To convert LDL-C to millimoles per liter, multiply by 0.0259.
Data shown are n (%)
a By trial design, these patients had non-HDL-C > 100 mg/dL
b Cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization
c Cardiovascular death, myocardial infarction, stroke
1349
Table S2: Patient Characteristics Stratified Potency of Background Statina
Characteristics
|
Maximal (N=7533)
|
Submaximal (N=20031)
|
P-value
|
Age, mean + SD – yr
|
61.1 + 8.9
|
63.0 +9.0
|
<0.001
|
Male
|
5722 (76.0)
|
15073 (75.2)
|
0.22
|
White raceb
|
7027 (93.3)
|
16431 (82.0)
|
<0.001
|
Region
|
|
|
<0.001
|
North America
|
1877 (24.9)
|
2694 (13.4)
|
|
Europe
|
4862 (64.5)
|
12473 (62.3)
|
|
Latin America
|
180 (2.4)
|
1643 (8.2)
|
|
Asia, Pacific, South Africa
|
614 (8.2)
|
3221 (16.1)
|
|
Type of atherosclerosisc
|
|
|
|
Myocardial infarction
|
6499 (86.3)
|
15852 (79.1)
|
<0.001
|
Non-hemorrhagic stroke
|
1182 (15.7)
|
4155 (20.7)
|
<0.001
|
Peripheral artery disease
|
1012 (13.4)
|
2630 (13.1)
|
0.51
|
Cardiovascular risk factors
|
|
|
|
Hypertension
|
6019 (79.9)
|
16065 (80.2)
|
0.57
|
Diabetes mellitus
|
2536 (33.7)
|
7545 (37.7)
|
<0.001
|
Current cigarette use
|
2067 (27.4)
|
5710 (28.5)
|
0.079
|
Statin intensity at baselined
|
|
|
NA
|
High
|
7533 (100)
|
11570 (57.8)
|
|
Moderate
|
0
|
8392 (41.9)
|
|
Low, unknown, or no data
|
0
|
69 (0.3)
|
|
Ezetimibe
|
672 (8.9)
|
768 (3.8)
|
<0.001
|
Other cardiovascular medications
|
|
|
|
Aspirin, P2Y12 inhibitor, or both
|
7122 (94.6)
|
18310 (91.5)
|
<0.001
|
Beta-blocker
|
6056 (80.4)
|
14759 (73.8)
|
<0.001
|
Renin-angiotensin-aldosterone inhibitor
|
6016 (79.9)
|
15517 (77.5)
|
<0.001
|
Median lipid measures in mg/dL [IQR]
|
|
|
|
LDL cholesterol
|
93.0 [80.0,
111.5]
|
91.0 [79.5, 107.5]
|
<0.001
|
Total cholesterol
|
168.0 [150.5,
190.5]
|
167.0 [151.0, 187.5]
|
0.004
|
HDL cholesterol
|
43.0 [36.5, 51.5]
|
44.0 [37.0, 53.0]
|
<0.001
|
Triglycerides
|
133.0 [98.5, 181.0]
|
133.0 [100.0, 182.0]
|
0.19
|
LDL cholesterol < 70 mg/dL at baseline
|
524 (7.0)
|
1510 (7.5)
|
0.10
|
1350
1351
1352
1353
1354
1355
Table S2 – Efficacy Outcomes With Evolocumab vs. Placebo Stratified by Potency of Background Statin
|
Maximal Potency Background Statin
|
Submaximal Potency Background Statin
|
|
Outcome
|
Evolocumab (N=3758)
|
Placebo (N=3775)
|
Hazard Ratio (95% CI)
|
Evolocumab (N=10026)
|
Placebo (N=10005)
|
Hazard Ratio (95% CI)
|
PINT
|
Primary endpointa
|
421 (11.2)
|
489 (13.0)
|
0.86 (0.75-0.98)
|
923 (12.4)
|
1074 (13.9)
|
0.85 (0.78-0.93)
|
0.88
|
Key secondary endpointb
|
246 (6.5)
|
315 (8.3)
|
0.78 (0.66-0.92)
|
570 (7.9)
|
698 (9.7)
|
0.81 (0.72-0.90)
|
0.71
|
Other endpoints
|
|
|
|
|
|
|
|
Cardiovascular death
|
74 (2.0)
|
67 (1.8)
|
1.11 (0.80-1.54)
|
177 (2.6)
|
173 (2.3)
|
1.02 (0.83-1.26)
|
0.67
|
Myocardial infarction
|
141 (3.8)
|
222 (5.9)
|
0.63 (0.51-0.78)
|
327 (4.3)
|
417 (5.8)
|
0.78 (0.67-0.90)
|
0.11
|
Stroke
|
60 (1.6)
|
60 (1.6)
|
1.00 (0.70-1.44)
|
147 (2.3)
|
202 (2.8)
|
0.72 (0.58-0.89)
|
0.11
|
Hospitalized for unstable angina
|
75 (2.0)
|
90 (2.4)
|
0.84 (0.62-1.14)
|
161 (2.4)
|
149 (1.9)
|
1.08 (0.86-1.35)
|
0.20
|
Coronary revascularization
|
248 (6.6)
|
316 (8.4)
|
0.78 (0.66-0.93)
|
511(6.5)
|
649 (8.8)
|
0.78 (0.69-0.88)
|
0.95
|
Maximal potency statin = atorvastatin 80 mg or rosuvastatin 40 mg daily. Data shown are n (%).
aCardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization
bCardiovascular death, myocardial infarction, stroke
70>
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