13th balkan biochemical biophysical days & meeting on metabolic disorders’ programme & abstracts



Download 1.91 Mb.
Page1/40
Date conversion08.05.2017
Size1.91 Mb.
  1   2   3   4   5   6   7   8   9   ...   40

13th Balkan Biochemical Biophysical Days & Meeting on Metabolic Disorders’ Programme & Abstracts




13th BALKAN BIOCHEMICAL BIOPHYSICAL DAYS &
MEETING ON METABOLIC DISORDERS’ PROGRAMME & ABSTRACTS

COMMITTEES



Honorary Presidents

Engin Bermek

Şerafettin Özkurt



Executive Committee

Presiding Officials


Nazmi Özer

Feride Severcan



Secretariat

Ayşe Gül Çetin

Mesude İşcan

Treasurers

Necla Öztürk

A.Kevser Pişkin


Members

Hakan Aydın

Gürbüz Çelebi

Süleyman Daşdağ

Orhan Değer

Nezaket Eren

Nadide Kazancı

Fatma Z.Kutay

Sema T.Ozan



Scientific Committee

Pekcan Ungan , Coordinator

İ.Hamdi Öğüş, Co-Coordinator

Nurhan Puralı, Secretary

N.Leyla Açan

Nejat Dalay

Aleksandar Dimovski

Burak Erman

Ömer Güzel

Mustafa Gültepe

Vasıf N.Hasırcı

Ivan Ivanov

Dusanka Janazic

Beki Kan

Güldal Kırkali

Eugenia Kovacs

Zdravko Lalchev

Yahya Laleli

Ay Öğüş


H.Avni Öktem

Cihan Öner

İnci Özer

Asuman Özkara

Rüstem Nurten

Erhan Pişkin

Zehra Sayers

Vesna Svetlicic

Yusuf Tan

Tijen Tanyalçın

Azmi Telefoncu

Aslıhan Tolun

Belma Turan

Engin Ulukaya

Figen Zihnioğlu

Matjas Zorko



Advisory Board

Kıymet Aksoy

T.Aslan Aksu

Emel Arınç

Diler Aslan

Erol Atalay

Sevil Atasoy

Uğur Atik

Ebubekir Bakan

Oya Bayındır

Cumhur Bilgi

Bora Barutçu

Kutlay Burat

Gülden Burçak

Naime Canoruç

Gönenç Ciliv

Salih Çelik

Ömer Çolak

Işıl Çokur

İlhami Demirel

Mübeccel Durusoy

A.Kaya Emerk

Ahmet Eraslan

Füsun Erciyes

Nurten Erdal

Biltan Ersöz

Hamza Esen

Sina Gökçe

Şendoğan Gülen

İsmail Gülen

Gül Üner


Münire Hacıbekiroğlu

Levent Karaca

Baysal Karaca

Hilal Karagül

Levent Kayrın

Edip Keha

Nedret Kılınç

Yüksel Koca

Şebnem Kösebalaban

Mehmet Köseoğlu

Yusuf Kurtulmuş

Türker Kutluay

Sevnur Mandalcı

Taner Onat

Asuman Orçun

Sinan Önen

Tomris Özben

Meral Özgüç

Ferit Pehlivan

Gül Saydam

Ahmet Sivas

Zerrin Söylemez

Bolkan Şimşek

Yavuz Taga

E.Ferhan Tezcan

Demir Tiryaki

Asuman Tokullugil

Işık Türkalp

Suna Türkoğlu

Müjdat Uysal

Ali Yılmaz

Piraye Yargıçoğlu

Meral Yüce

Doğan Yücel

Güneş Yüreğir


SCIENTIFIC PROGRAM FOR BIOCHEMICAL & BIOPHYSICAL DAYS


OCTOBER 12, 2003 SUNDAY

09:00 - 17:00

Registration




Hall C

17:00

Opening Ceremony

17:30

Opening Lecture




Chair: Nazmi Özer




Novel approaches to genetic diseases

Pınar T. Özand



18:30

Break

20:00

Welcome Cocktail


OCTOBER 13, 2003 MONDAY




Hall A

Hall B




Chair: George Russev, Mesude İşcan

Chair: Stefan Szedlacsek, Beki Kan

09:00

Molecular Basis of Colorectal Cancer in The Republic of Macedonia

Alexander Dimovski



Exploring The Interaction of Seven-Transmembrane Receptors With G-Proteins By Using Synthetic Model Peptides

Matjaz Zorko



09:40

Irregular Ionisation of Proteins. An Alternative Interpretation of Experimental Observations

Andrey Karshikoff



Oncogenic Signalling Pathways and Cell Death Based Tumour Therapies

Alexander Pintzas



10:20

From Microparticles to Giant Cells of Northern Adriatic

Vesna Swetlicic



Modelling of Cellular Receptor Signalling Pathways

Haluk Reşat



11:00

Coffee Break

Chair: Vladimir Mrsa, Figen Zihnioğlu

Chair: Dusanka Janezic, Kevser Pişkin

11:30

A Simple Spectro photometric Method for the determination of Selenium in Biological Materials

Burcu Okutucu



Human Interferon Gamma-Significance of the C-Terminal Flexible Domain for its Biological Activity

Genoveva Nacheva



11:50

FT-IR Spectroscopic Studies of Melatonin - Induced Changes in Rat Liver Microsomes

Güvenç Görgülü



Non-Enzymatic Glycosylation of Recombinant Human Interferon-Gama

Roumyana Mironova



12:10

Molecular Investigation of The Effect of Melatonin on Rat Brain Tissue

Sara Banu Akkaş



Noninvasive Optical Assay for Synthetic Hemoglobin Fluids

Mehmet Dinçer Bilgin



12:30

A Rat Dementia Model by Chronic Ethanol Consumption and Withdrawal: Validation by Passive Avoidance Measurement and Serum Cholinestrase Level

Erdinç Çakır



The Status of Patients with Diabetes Mellitus Monitored by Turkish Diabetes Society in Denizli / Turkey

Diler Aslan



13:00

Lunch

14:00

Poster

17:00

Free Time


OCTOBER 14, 2003 TUESDAY




Hall A

Hall B




Chair: Alexander Dimovski, Zoe Lygerou

Chair: Andrey Karshikoff, Gürbüz Çelebi

09:00

Global Genomic and Transcription-Coupled DNA Repair Rates in Human Cells

George Russev



Yeast Cell Wall Proteins: Localisation, Function, Application

Vladimir Mrsa



09:40

Cloning, Expression and Preliminary Characterization of Xylulose-5-Phosphate Phospoketolase From Lactococcus lactic.

Stefan Szedlacsek



Catabolic and Anabolic Agents of Bone Organ - Culture

Emina Sofic



10:20

Y-Chromosome Microdeletions Among Infertile Men From The Republic of Macedonia

Dijana Plaseska-Karanfilska



Electro-manipulation of The Biological Cells: Basics and Applications

Mihai Radu



11:00

Coffee Break




Chair: Ivan Ivanov, Dijana Plaseska-Karanfilska,
İ. Hamdi Öğüş

Chair: Ivan Ivanov, Azmi Telefoncu

11:30

Screening of RPGR Gene in Turkish Retinitis Pigmentosa Patients

Ceren Acar



Immunoliposomes Directed Toward VCAM-1 : Vehicles for Specific Drug Delivery to Activated Endothelial Cells

Manuela Vionea



11:50

Methylation Pattern and Dnasel Hypersensitivity within the Intregenic Spacer of Ribosomal RNA Genes in Excised Cotyledons of Cucurbita Pepo L. ( Zucchini ) after Cytokinin Treatment

Evgeni Ananiev



Development of two Amperometric Biosensors Based on Catalase Immobilized in Gelatin - Alignate and Gelatin-k-Carrageenan for Alcohol Determination

Erol Akyılmaz



12:10

Gene Polymorphism of Endothelial Markers in Renal Dysfunction

Constantina Heltianu



Determination of Chromium ( VI ) by a Catalytic Spectrophotometric Method in the Presence of p-Aminobenzoic Acid

Angelina Stoyanova



12:30

Expression of Estrogen in Breast Carcinomas

Vesna Vranic Mandusic



Altered Drug Resistance and Neurologic Disorders in Drosophila Melanogaster with a Deficient Histamine-Gated

Chloride Channel

Eugene Semenov


13:00

Lunch

14:00

Tour To Ephesus



OCTOBER 15, 2003 WEDNESDAY




Hall A

Hall B




Chair: Matjaz Zorko, Alexander Pintzas

Chair: Vesna Swetlicic, Mihai Radu

09:40

The Roles of CYP1A and CYP2E in Chemical Carcinogenesis

Emel Arınç



Inactivation of Melanoma Cells Irradiated with Gamma-Rays and Low Energy Protons

Alexandra Ristic-Fira



10:20

Cell Cycle Regulation and Genome Integrity

Zoe Lygerou



Large Scale Macromolecular Simulations By Simplectic Integration Methods

Dusanka Janezic



11:00

Coffee Break 




Chair: Alexandra Ristic-Fira, Leyla Açan

Chair: Necla Öztürk, Vassilj Goltsev

11:30

The Effect of Insulin Level on Steroid Receptors

Mojka Vulovic



Implementation of a Neovascular Coupling Model

Ata Akın


11:50

Molecular Analysis of the ABCA4 Gene in Turkish Patients with Stargardt Disease and Retinitis Pigmentosa

Rıza Köksal Özgül



Analysis of Millisecond Delayed Fluorerescene Dark Decay

Vassilj Goltsev



12:10

Mitochondrial Enzyme Activities and mtDNA Polymorphism in Parkinson's Disease

Gülnihal Kulaksız



Development of an Analogue Model Simulating the Portal Vein

Necla Öztürk



12:30

Determination of Steadt-State Levels of OxoGuanine in Calf Thymus DNA by Means of FPG Protein

Beran Yokuş



Purification and Characterization of A PSTS Hyperalkaline Phosphates from T.Thermophilus

Anastasia Pantazaki



13:00

Lunch

14:00

Poster




Closing Ceremony

17:30

Free Time

20:00

Farewell Dinner



SCIENTIFIC PROGRAM FOR MEETING ON METABOLIC DISORDERS


OCTOBER 13 , 2003 MONDAY




Hall C




Chairmen: A. Kaya Emerk, Işık Türkalp

09:00

Ortadoğuda Genel Problem Olan Homosistinürinin üç Tipi
Three Types of Homocystinuria A Common Problem in Middle East

Pınar T. Özand



10:05

Yenidoğanda Konjenital Hipotiroidi Taraması
Screening for Congenital Hypothyroidism in theNeonate

Alev Özön



10:20

Yenidoğanda Tandem-Mass Spektrometre ile Geniş Kapsamlı Kalıtsal Metabolik Hastalıkların Taranması
Expanded Newborn Screening for inborn Errors of Metabolism by Tandem Mass Spectrometry

İnci Karaaslan



10:40

Tartışma/ Discussion

11:00

Coffee Break




Chairmen: Fatma Z. Kutay, Nezih Hekim

11:30

Kitle Tarama Testlerinin Uygulanışında Kalite Kontrolunun Önemi ve Kitle Tarama Verilerinde Referans Aralığının Saptanması
The Use of Split-Sample Design for Performance Evaluation of Screening Kits: A Real Life Study

Tijen Tanyalçın



11:50

Fetusta Biyokimyasal Tanı
Foetal Biochemistry: Biochemical Diagnosis for Foetus

Nezih Hekim



12:10

Tartışma / Discussion

13:00

Lunch

14:00 - 16:30

Poster

17:00 - 19:00

Panel : Türkiye'de Neonatal Tarama Politikası
Neonatal Screening Policy of Turkey

Chair: Uğur Dündar / Mine Özbek

Pınar T. Özand, İmran Özalp, Münip Üstündağ, Yahya Laleli, Mine Özbek



OCTOBER 14 , 2003 TUESDAY




Hall C




Chairmen: Yahya Laleli, Tijen Tanyalçın

09:45

Amino Asit Metabolizması Bozukluğunda Kullanılan Metodlar ve Karşılaşılan Güçlükler
Amino Acid Analysis Methods-Details and Difficulties

Gürsel Biberoğlu



10:15

The Use of Tandem Mass Spectrometry in Newborn Mass Screening Programs: The Facts Beyond the Myth

François Eyskens



11:00

Coffee Break




Chairmen: Aslan Aksu, Sema T. Ozan

11:30

Karbohidrat Metabolizması Hastalıkları: Klinik Yaklaşım, Teşhis ve Tedavide Laboratuvardan Beklentiler
Disorders of Carbohydrate Metabolism : Clinical Approach
Future Prospects of Diagnosis and Treatment

Benal Büyükgebiz



12:00

Karbohidrat Metabolizması Hastalıkları: Metodlar ve Karşılaşılan Güçlükler
Disorders of Carbohydrate Metabolism Basic Concepts, Evaluation of Laboratory Methods and Difficulties Observed

Aslan Aksu



12:30

Tartışma / Discussion

13:00

Lunch

14:00

Tour to Ephesus


OCTOBER 15, 2003 WEDNESDAY




Hall C




Chairmen: Güldal Kırkalı, Hakan Aydın

09:00

Obesite, Polikistik Over ve İnsülin Direnci
Dsyregulation of P450C17 Enzyme in Polycystic Ovary Syndrome

Fahrettin Keleştimur



09:30

Obesite: Nöral Mekanizmalar
Neuroendocrine System and Obesity

Üstün Korugan



10:00

Obesite Bir İnflamasyon mudur?
Is Obesity an Inflammatory Disease ?

Candeğer Yılmaz



10:30

Tartışma / Discussion

11:00

Coffee Break




Chairmen: Orhan Değer, Nezaket Eren

11:30

Hiperlipoproteinemiler ve Diğer Lipid Metabolizması Hastalıklar
Laboratory Diagnosis in Lipoprotein and Other Lipid Metabolism Disorders

Gülçin Eskandari



12:00

Glikosfingolipidozlar: Hastalıktan Metabolizmanın Temel İlkelerine
The Glycosphingolipidoses: From Disease to Basic Principles of Metabolism

Asuman Özkara



12:30

Tartışma / Discussion

13:00

Lunch

14:00

Poster

17:00

Closing

17:30

Free Time

20:00

Fairwell Party






OCTOBER 12, 2003 - SUNDAY

HALL C

OPENING LECTURE

NOVEL APPROACHES TO GENETIC DISEASES

Pinar T. Ozand MD,Ph. D., Chairman,

Department of Genetics, King Faisa Specialist
Hospital & Research Centre. PO Box 3354, Riyadh 11211, Saudi Arabia.

The  objective  of  this  presentation  is to present the novel  strategies  adopted to prevent genetic diseases in Saudi   Arabia.   The  genetic  diseases  either  due  to chromosome  defects  or  to  alterations  in  single gene structure  produce  infants with usually severe diseases.

The  management  of such disorders is: (A) usually costly due  to the fact the morbidity lasts for many years,  (B) not  always  successful  and  doesn’t always produce good results  and  (C)  disrupts  the  normal family function. These  diseases, particularly those inherited single gene disorders  plague  the  communities  with  consanguineous marriages.  Based  on  our  experience in the Kingdom, we have  adopted  several  strategies  to combat this public health  problem.  The  methods to combat genetic diseases include:   (1)  if  nothing else is possible to perform a neonatal  screening  program for treatable diseases. This must   be   done   within   2-3  days  after  birth.  (2) Preimplantation  diagnosis.  Initially we have focused on six  major  single  gene  diseases  of the country: MSUD, biopterin   dependent   PKU,   homocystinuria,  propionic acidemia, Niemann Pick disease type B and Gaucher disease type  A.  All  of  these diseases are either difficult to manage  requiring  the devotion of many clinical hours by the  physician  or  their procedures of management or are extremely  costly. (3) Premarital screening. Applying the mutations on a DNA chip and screening the extended family as well as population for carriers of these diseases. (4) Chromosome  abnormalities  to be studied by CGS (complete human  genome screening) that can be applied to a newborn as  well as in preimplantation efforts. This presentation will detail these approaches and our preliminary results.

The   result  with  preimplantation  intervention  in  an ataxia-telangiectasia family will be presented.



OCTOBER 13 , 2003 – MONDAY

HALL A

LECTURE 1

MOLECULAR BASIS OF COLORECTAL CANCER IN THE REPUBLIC OF MACEDONIA

Aleksandar J DIMOVSKI1,2, Dijana Plaseska-Karanfilska 1), Ana-Marija STEFANOVSKA1,


Georgi D.EFREMOV 1)

1) Macedonian Academy of Sciences and Arts, Research Center for Genetic Engineering and Biotechnology
2) Institute for Pharmaceutical Chemistry, Faculty of Pharmacy, Skopje, Republic of Macedonia


Correspondence: adimovski@baba.ff.ukim.edu.mk

Colorectal cancer (CRC) is one of the most common cancers and the second cause of death in developed countries. In addition to environmental factors, genetic predisposition has a significant role in the ethiopathogenesis of the disease. Apart from the two dominantly inherited syndromes (FAP and HNPCC) several low penetrance genes were implicated in the initiation of colorectal cancerogenesis. The aim of this study was to determine the molecular basis of FAP, the incidence of HNPCC and the frequency of polymorphisms in several low penetrance genes (I1307K and E1317Q in the APC gene, TRI(6A) and CCND1) associated with CRC. A total of 173 patients with CRC, of which six patients with multiple adenomatous polyposis, and a control group of 100 newborns and 100 aged individuals were included in this study. Out data indicate that FAP and HNPCC have relatively low frequency of 0.1% and <5%, respectively, in our population. Deletions of APC gene are relatively frequent in our patients with FAP. Also, we suggest that aberrant splicing of this gene is a probable mechanism in etiopathogenesis of the multiple adenomatous polyposis phenotype. Microsatellite instability was present in 13.4% of patients and was associated with absence of nodal infiltration, proximal localization, Dukes' A and B stage and mucionous histotype. No I1307K and E1317Q polymorphisms in the APC gene were detected among our patients. The frequency of the TRI(6A) polymorphism was identical among patients and controls thus excluding this variant as a tumor susceptibility allele in our population. A statistically significant difference in the frequency of the CCND1 polymorphism was found in the group of patients less than 60 years of age with MSI tumors, indicating that CCND1 polymorphism may influence the age at onset of colorectal cancer in young patients only when their tumors exhibit an MSI phenotype.


  1   2   3   4   5   6   7   8   9   ...   40


The database is protected by copyright ©ininet.org 2016
send message

    Main page