Raskin et al.7 2012
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Apathy in currently nondepressed patients treated with SSRI following randomized switch to either duloxetine or escitalopram
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RCT comparing apathy symptoms multi centred double blinded.
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483 Patients on SSRI for at least 3 months, with apathy, switched to
SNRI n= 244
or
Escitalopram n=239
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Switch from SSRI to another SSRI or SNRI/ Apathy Evaluation Scale
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Following 8 weeks of treatment both the duloxetine and escitalopram groups significantly improved from baseline on the AES-C score
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No placebo arm for comparison
Active intervention in the study design may have primed the expectation of improvement
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